Category: 61487-25-0

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 61487-25-0, name is (2-Amino-3-chlorophenyl)methanol, the common compound, a new synthetic route is introduced below. Quality Control of (2-Amino-3-chlorophenyl)methanol

Example 83 – Preparation of 2-acetoxymethyl-6-chloro aniline This material was prepared from 2-amino-3-chlorobenzyl alcohol and acetyl chloride by the general procedure outlined in Example 82. The product was isolated as an amber oil and was characterized by IR and 1H NMR spectroscopy and combustion analysis.

The synthetic route of 61487-25-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; THE DOW CHEMICAL COMPANY; EP142152; (1991); B1;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 61487-25-0, name is (2-Amino-3-chlorophenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows. Application In Synthesis of (2-Amino-3-chlorophenyl)methanol

EXAMPLE 100 Preparation of 2-benzyloxymethyl-6-chloroaniline This material was prepared from 2-amino-3-chlorobenzyl alcohol and benzyl bromide by the general procedure outlined in Example 98. The product was purified by Kugelrohr distillation to yield an oil, b.p. 118-125 C. (0.1 mm). The product was characterized by IR and 1 H NMR spectroscopy.

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Reference:
Patent; The Dow Chemical Company; US4818273; (1989); A;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 61487-25-0, name is (2-Amino-3-chlorophenyl)methanol. A new synthetic method of this compound is introduced below., Product Details of 61487-25-0

General procedure: The 2-aminobenzylalcohol 4a (12.3 g, 0.10 mol) was dissolved in 60 mL dichloromethane, and pyridine (10 mL, 0.13 mol) was added to the solution. Then 4-methylbenzene-1-sulfonyl chloride (22.9 g, 0.12 mol) was added and the solution was refluxed for 12 h. The solution was allowed to cool to room temperature and washed with dilute hydrochloric acid (50 mL, 1 mol/L), brine (3×50 mL) and dried over Na2SO4. After removal of the solvent, the residue was crystallized from CH2Cl2/toluene to give the intermediate 5a (24.4 g, 88% yield).

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Reference:
Article; Jiang, Feng; Wu, Zhengxing; Zhang, Wanbin; Tetrahedron; vol. 67; 7; (2011); p. 1501 – 1505;,
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Related Products of 61487-25-0, Adding some certain compound to certain chemical reactions, such as: 61487-25-0, name is (2-Amino-3-chlorophenyl)methanol,molecular formula is C7H8ClNO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 61487-25-0.

EXAMPLE 82 Preparation of 2-chloro-6-methoxymethylaniline A solution of 4.00 g (25.4 mmol) of 2-amino-3-chlorobenzyl alcohol in 30 ml of dry THF was cooled to -78 C., treated with 16.7 ml (26.7 mmol) of 1.60M n-butyllithium in hexane, warmed to 0-5 C., treated with 3.61 g (25.4 mmol) of methyl iodide and heated at reflux for 5.5 hours. The solvent was removed by evaporation at reduced pressure. The residue was partitioned between 175 ml of ether and water, and the organic phase was separated and dried (MgSO4). The solvent was removed by evaporation at reduced pressure, and the residue was purified by HPLC eluding with ETOAc (5:95, v/v) to afford 1.1 g of the desired product as a pale brown oil. IR and 1 H NMR spectra were in agreement with the assigned structure. Analysis: Calculated for C8 H10 ClNO: C, 56.00; H, 5.87; N, 8.16; Found: C, 56.25; H, 5.98; N, 8.28.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 61487-25-0, (2-Amino-3-chlorophenyl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; The Dow Chemical Company; US4755212; (1988); A;,
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Adding a certain compound to certain chemical reactions, such as: 61487-25-0, (2-Amino-3-chlorophenyl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, name: (2-Amino-3-chlorophenyl)methanol, blongs to alcohols-buliding-blocks compound. name: (2-Amino-3-chlorophenyl)methanol

Example 82 Preparation of 2-chloro-6-methoxymethylaniline A solution of 4.00 g (25.4 mmol) of 2-amino-3-chlorobenzyl alcohol in 30 ml of dry THF was cooled to -78C, treated with 16.7 ml (26.7 mmol) of 1.60 M n-butyllithium in hexane, warmed to 0-5C, treated with 3.61 g (25.4 mmol) of methyl iodide and heated at reflux for 5.5 hours. The solvent was removed by evaporation at reduced pressure. The residue was partitioned between 175 ml of ether and water, and the organic phase was separated and dried (MgSO4). The solvent was removed by evaporation at reduced pressure, and the residue was purified by HPLC eluding with EtoAc-hexane (5:95, v/v) to afford 1.1 g of the desired product as a pale brown oil. IR and 1H NMR spectra were in agreement with the assigned structure.

The synthetic route of 61487-25-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; THE DOW CHEMICAL COMPANY; EP142152; (1991); B1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 61487-25-0, name is (2-Amino-3-chlorophenyl)methanol. A new synthetic method of this compound is introduced below., Product Details of 61487-25-0

N-(2-Chloro-6-(hydroxymethyl)phenyl)pivalamide; To the crude (2-amino-3-chlorophenyl)methanol(1.08 g, 6.88 mmol) in CH2Cl2(15 mL) was fast dropwise added trimethylacetyl chloride(0.89 mL, 7.23 mmol), followed by DIEA(2.4 mL, 13.8 mmol) at 0 C. 5 min later, the reaction mixture was stirred at room temperature for 1 hr. Normal aqueous work-up to afford the expected product as a white solid(1.58 g, 95% yield), which was pure enough to be used in next step; 1H NMR (400 MHz, CDCl3) delta ppm 1.30 (s, 9 H), 3.35 (s, 2 H), 4.36 (d, J=6.29 Hz, 1 H), 7.06-7.22 (m, J=7.81, 7.81 Hz, 1 H), 7.29-7.33 (m, 2 H), 7.58 (s, 1 H); Mass spec. 242.08 (MH+), Calc. for C12H16ClNO2 241.09.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 61487-25-0, (2-Amino-3-chlorophenyl)methanol.

Reference:
Patent; Bristol-Myers Squibb Company; US2007/259850; (2007); A1;,
Alcohol – Wikipedia,
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Related Products of 61487-25-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.61487-25-0, name is (2-Amino-3-chlorophenyl)methanol, molecular formula is C7H8ClNO, molecular weight is 157.6, as common compound, the synthetic route is as follows.

Example 84 – Preparation of 2-benzyloxymethyl-6-chloro aniline This material was prepared from 2-amino-3-chlorobenzyl alcohol and benzyl bromide by the general procedure outlined in Example 82. The product was purified by Kugelrohr distillation to yield an oil, bp 118-125C (0.1 mm). The product was characterized by IR and 1H NMR spectroscopy.

The chemical industry reduces the impact on the environment during synthesis 61487-25-0, I believe this compound will play a more active role in future production and life.

Reference:
Patent; THE DOW CHEMICAL COMPANY; EP142152; (1991); B1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 61487-25-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.61487-25-0, name is (2-Amino-3-chlorophenyl)methanol, molecular formula is C7H8ClNO, molecular weight is 157.6, as common compound, the synthetic route is as follows.

EXAMPLE 84 Preparation of 2-benzyloxymethyl-6-chloro aniline This material was prepared from 2-amino-3-chlorobenzyl alcohol and benzyl bromide by the general procedure outlined in Example 82. The product was purified by Kugelrohr distillation to yield an oil, bp 118-125 C. (0.1 mm). The product was characterized by IR and 1 H NMR spectroscopy.

The chemical industry reduces the impact on the environment during synthesis 61487-25-0, I believe this compound will play a more active role in future production and life.

Reference:
Patent; The Dow Chemical Company; US4755212; (1988); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts