Category: 612-16-8

Electric Literature of 612-16-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 612-16-8, name is (2-Methoxyphenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: The mixture of benzyl alcohol (1a, 0.3244 g, 3.0 mmol,1.5 equiv.), 2-aminopyridine (6a, 0.1882 g, 2.0 mmol), and NaOH (0.0400 g, 1.0 mmol, 50 mol%)was sealed under air in a 20 mL Schlenk tube and then stirred at 150 oC for 24 h. After completion,the reaction was monitored by TLC and/or GC-MS (>99% GC conversion) and the crude productwas purified by column chromatography using ethyl acetate and petroleum ether as eluent. Thetarget product 7a was obtained in 89% isolated yield. White solid. 1H NMR (500 MHz, CDCl3): delta 8.10 (dd,J = 5.0 Hz, J = 1.0 Hz, 1H), 7. 39-7.36 (m, 1H), 7.31 (d, J = 7.5 Hz, 1H), 7.26-7.23 (m, 1H),6.92-6.87 (m, 2H), 6.56-6.54 (m, 1H), 6.39 (d, J = 7.5 Hz, 1H), 5.01 (b, 1H), 4.48 (d, J = 6.0 Hz,2H), 3.85 (s, 3H). 13C NMR (125.4 MHz, CDCl3): delta 158.9, 157.4, 148.2, 137.3, 128.8, 128.3, 127.1,120.5, 112.8, 110.2, 106.7, 55.3, 41.7. MS (EI): m/z (%) 214 (60), 183 (92), 136 (45), 121 (35), 105(31), 91 (100), 78 (48), 65 (25), 51 (14).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 612-16-8, (2-Methoxyphenyl)methanol.

Reference:
Article; Li, Xiaohui; Li, Shuangyan; Li, Qiang; Dong, Xu; Li, Yang; Yu, Xiaochun; Xu, Qing; Tetrahedron; vol. 72; 2; (2016); p. 264 – 272;,
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Application of 612-16-8 , The common heterocyclic compound, 612-16-8, name is (2-Methoxyphenyl)methanol, molecular formula is C8H10O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: Reactions were performed in a magnetically stirred round bottomed flask fitted with acondenser and placed in a temperature controlled oil bath. 1,2-Diamine (2 mmol)was added to alcohol (3 mmol) and the reaction mixture was allowed to stir at 135C in an open (air) atmosphere. After disappearance of the diamine (reaction was monitored by TLC)or after the appropriate time, the reaction mixture was cooled to roomtemperature. The crude residue was further purified by column chromatography using silica gel (100-200 mesh) to afford pure products. All the products wereidentified on the basis of NMR and mass spectral data

The synthetic route of 612-16-8 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Marri, Mahender Reddy; Peraka, Swamy; Macharla, Arun Kumar; Mameda, Naresh; Kodumuri, Srujana; Nama, Narender; Tetrahedron Letters; vol. 55; 48; (2014); p. 6520 – 6525;,
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Related Products of 612-16-8, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.612-16-8, name is (2-Methoxyphenyl)methanol, molecular formula is C8H10O2, molecular weight is 138.16, as common compound, the synthetic route is as follows.

Add 2-methylquinoline (1mmol), 2-methoxybenzyl alcohol (2.5mmol), TEMPO (0.1mmol), Fe (NO3) 3.9H2O (0.1mmol) andt-BuOK (2mmol) was sequentially added to a flask containing 2mL of THF,The air in the flask was replaced with oxygen, and the reaction was stirred at 50 C.The reaction process was monitored by thin layer chromatography. After the reaction was completed, it was quenched with water (10 mL).The reaction product was extracted with ethyl acetate (3 × 20 mL), washed with saturated brine (20 mL), dried over anhydrous Na2SO4, filtered, and the resulting filtrate was concentrated, and passed through silica gel column chromatography (200-300 mesh, the developing solvent was petroleum ether). (20: 1 mixed solution with ethyl acetate in volume ratio) yielded 215.0 mg of product with a yield of 82%.

Statistics shows that 612-16-8 is playing an increasingly important role. we look forward to future research findings about (2-Methoxyphenyl)methanol.

Reference:
Patent; Hebei University of Science and Technology; Zhang Zhiguang; Zhang Yong; Li Ling; Dai Siwei; Li Xingxi; (18 pag.)CN110804015; (2020); A;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 612-16-8, name is (2-Methoxyphenyl)methanol. A new synthetic method of this compound is introduced below., Product Details of 612-16-8

The reactants used were o-methoxybenzyl alcohol (i.e., R1 in the formula (I) was ortho OCH3) 1.0 mmol(138.2 mg), experimental procedure and procedure with Example 1, aqueous ammonia (1.7 mol / L) 5.0 mL,The amount of catalyst used in cuprous chloride was 8 mol% (7.9 mg)TEMPO is used in an amount of 8 mol% (12.5 mg)The reaction temperature was 120 and the reaction time was 24h. The crude product was purified by column chromatography (petroleum ether: ethyl acetate = 10: 1) to give the target product as 123.9 mgYield 93%.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 612-16-8, (2-Methoxyphenyl)methanol.

Reference:
Patent; Zhejiang University of Technology; Zhang Guofu; Zhao Yiyong; Zhang Guihua; Ding Chengrong; Yu Yidong; Lv Jinghui; (10 pag.)CN106866326; (2017); A;,
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Reference of 612-16-8 ,Some common heterocyclic compound, 612-16-8, molecular formula is C8H10O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: In a round-bottom flask, benzylic alcohol 1a (10 mmol, 2.0 equiv.), benzenesulfonyl chloride 2a (13 mmol, 1.3 equiv.) and NMP (2.5 equiv.). Then, DCE (3 mL) were added. The mixture was stirred at 80 C for 1.5 h. After completion of the reaction (monitoredby TLC), water (10 mL) was added and the mixture was extracted with ethyl acetate (3*10 mL). The combined organic phase was dried over anhydrous Na2SO4, filtered, and evaporated under reduced pressure. The crude product was purified by flash chromatography on silica gel to give the desired alkyl chlorides 3.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 612-16-8, (2-Methoxyphenyl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Zheng, Dagui; Mao, Liu-Liang; Zhu, Xian-Hong; Zhou, An-Xi; Synthetic Communications; vol. 48; 21; (2018); p. 2793 – 2800;,
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Reference of 612-16-8 ,Some common heterocyclic compound, 612-16-8, molecular formula is C8H10O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: In a round-bottom flask, benzylic alcohol 1a (10 mmol, 2.0 equiv.), benzenesulfonyl chloride 2a (13 mmol, 1.3 equiv.) and NMP (2.5 equiv.). Then, DCE (3 mL) were added. The mixture was stirred at 80 C for 1.5 h. After completion of the reaction (monitoredby TLC), water (10 mL) was added and the mixture was extracted with ethyl acetate (3*10 mL). The combined organic phase was dried over anhydrous Na2SO4, filtered, and evaporated under reduced pressure. The crude product was purified by flash chromatography on silica gel to give the desired alkyl chlorides 3.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 612-16-8, (2-Methoxyphenyl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Zheng, Dagui; Mao, Liu-Liang; Zhu, Xian-Hong; Zhou, An-Xi; Synthetic Communications; vol. 48; 21; (2018); p. 2793 – 2800;,
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Related Products of 612-16-8, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 612-16-8 as follows.

In the glove box, Mn(CO)5Br (0.005mmol), [(E)-2-(2-(1-(2-pyridyl)ethylidene)-indenyl)pyridinium](0.006 mmol),Add 1.0 mL of toluene, stir for two hours, add 2-methylquinoline 4 (2 mmol),2i (1 mmol), after reacting at 135 C for 48 hours, the reaction was stopped, and the solvent was evaporated to dryness.Column chromatography ethyl acetate / petroleum ether (1:10),Trans-disubstituted olefin derivative 3ai. The product was a white solid with a yield of 93%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,612-16-8, its application will become more common.

Reference:
Patent; Qingdao University of Science and Technology; Zhang Chunyan; (19 pag.)CN108250153; (2018); A;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 612-16-8, name is (2-Methoxyphenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows. 612-16-8

1.02 g (7.38 mmol, 1.0 eq) compound 13c was dissolved in 40 ml CH2Cl2, then 0.84 ml (8.90 mmol, 1.2 eq) PBr3 was added under the condition of ice water bath. After reacting for an hour, a little saturated sodium bicarbonate solution was added to wash the organic phase followed by twice wash with saturated sodium chloride solution, then dried over anhydrous sodium sulfate and desolventizing to gain 1.15 g reddish colored oily material (Compound 8-2c), yield 77.5%. The crude product was used without purification in the next step directly. Compound 8-2a, 8-2b, and 8-2d can be obtained in the same way from compound 13a, 13b, and 13d.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 612-16-8, (2-Methoxyphenyl)methanol.

Reference:
Patent; Fudan University; YE, Deyong; LI, Yali; ZHOU, Lu; WANG, Penghui; CHU, Yong; GONG, Haojun; HUANG, Qi; CHEN, Yan; ZHANG, Zhikuan; (40 pag.)EP3196191; (2017); A1;,
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In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 612-16-8 as follows., 612-16-8

General procedure: The solution of ionic-liquid-supported DMI 7 (2.2 mmol) in[bmim]PF6 (2 mL) was added to oxalyl chloride (2.0 mmol), andthe mixture was stirred at 60 C for 2 h. The mixture was then added to the appropriate alcohol (1.5 mmol), and the resultingmixture was stirred at r.t. overnight. Finally, the mixture wasextracted with hexane 10 mL x 3, and the organic layer wasconcentrated.

The chemical industry reduces the impact on the environment during synthesis 612-16-8, I believe this compound will play a more active role in future production and life.

Reference:
Article; Koguchi, Shinichi; Shibuya, Yuga; Igarashi, Yusuke; Takemura, Haruka; Synlett; vol. 30; 8; (2019); p. 943 – 946;,
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612-16-8, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 612-16-8, name is (2-Methoxyphenyl)methanol. A new synthetic method of this compound is introduced below.

Step 2: Preparation of 1-(chloromethyl)-2-methoxybenzene To a solution of (2-methoxyphenyl)methanol (1.15 g, 8.32 mmol) and triethylamine (1.24 g, 12.3 mmol, 1.7 mL) in methylene chloride (16 mL) at 0 C. was added dropwise chlorotrimethylsilane (0.939 g, 8.65 mmol). The reaction mixture was stirred in the cooling bath for an additional 30 min after which the cooling bath was removed and stirred at room temperature for 18 h. The reaction mixture was washed with water (10 mL*2), dried over sodium sulfate, filtered and concentrated to give crude 1-(chloromethyl)-2-methoxybenzene (1.36 g, crude) as an orange oil. The material was used directly in the next step without further purification.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,612-16-8, (2-Methoxyphenyl)methanol, and friends who are interested can also refer to it.

Reference:
Patent; Yumanity Therapeutics, Inc.; WRONA, Iwona; TIVITMAHAISOON, Parcharee; TARDIFF, Daniel; PANDYA, Bhaumik; OZBOYA, Kerem; LUCAS, Matthew; BOURDONNEC, Bertrand Le; (259 pag.)US2019/330198; (2019); A1;,
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