Category: 60666-70-8

Related Products of 60666-70-8, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.60666-70-8, name is (2-Bromo-5-chlorophenyl)methanol, molecular formula is C7H6BrClO, molecular weight is 221.48, as common compound, the synthetic route is as follows.

A solution of the alcohol (1.0 mmol; 1.0 eq.) in dry THF (4 mL) in a round-bottomed flask, under inert atmosphere (N2), is treated with TEA (1.5 eq.) and a solution of methanesulfonic anhydride (1.5 eq.) in dry THF (1 mL) at 0C. The reaction mixture is stirred at rt and monitored by LC-MS. Upon reaction completion, the reaction mixture is concentrated under reduced pressure and diluted with EA and water. The layers are separated and the aq. layer is extracted with EA. The combined org. layers are washed with water and brine, dried over MgS04, filtered and concentrated under reduced pressure. Purification of the residue gives the desired product. Starting from intermediate S. l (23.48 g) and proceeding in analogy to Procedure AG, the title compound was obtained, without additional purification, as a white solid (34.53 g). 1H NMR (d6-DMSO) delta: 7.72 (d, J = 8.5 Hz, 1H); 7.67 (d, J = 2.6 Hz, 1H); 7.44 (dd, J = 8.5, 2.6 Hz, 1H); 5.27 (s, 2H); 3.29 (s, 3 H).

The chemical industry reduces the impact on the environment during synthesis 60666-70-8, I believe this compound will play a more active role in future production and life.

Reference:
Patent; ACTELION PHARMACEUTICALS LTD; BUR, Daniel; GUDE, Markus; HUBSCHWERLEN, Christian; PANCHAUD, Philippe; WO2011/121555; (2011); A1;,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.60666-70-8, name is (2-Bromo-5-chlorophenyl)methanol, molecular formula is C7H6BrClO, molecular weight is 221.48, as common compound, the synthetic route is as follows.Recommanded Product: 60666-70-8

Synthesis of l-bromo-4-chloro-2-(methoxymethyl)benzene 6c [00180] To a solution of (2-bromo-5-chloro-phenyl)methanol (3.16 g, 14.25 mmol) in THF (50 mL) at room temperature was added sodium hydride (684 mg, 17.10 mmol). The mixture was stirred for 30 min and then iodomethane (3.04 g, 1.33 mL, 21.38 mmol) was added and the reaction stirred overnight. The mixture was diluted with saturated aqueous ammonium chloride and EtOAc and the organic washed with water, then brine, and dried ( a2S04) and concentrated to afford the title compound 6c as an oil (3.36 g, quant). XH NMR (500 MHz, CDC13) delta 7.40 – 7.48 (2H, m), 7.1 1 – 7.14 (1H, m), 4.47 (2H, s), 3.48 (3H, s).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,60666-70-8, (2-Bromo-5-chlorophenyl)methanol, and friends who are interested can also refer to it.

Reference:
Patent; VERTEX PHARMACEUTICALS INCORPORATED; BOYALL, Dean; DAVIS, Christopher; DODD, James; EVERITT, Simon; MILLER, Andrew; WEBER, Peter; WESTCOTT, James; YOUNG, Stephen; WO2014/81689; (2014); A1;,
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Synthetic Route of 60666-70-8, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 60666-70-8, name is (2-Bromo-5-chlorophenyl)methanol. A new synthetic method of this compound is introduced below.

General procedure: A mixture of64(1.075g, 5.5mmol), 1-bromo-4-chlorobenzene (1.03g, 5.4mmol), Cs2CO3(2.28g, 7mmol) and BINAP (0.05 equiv) in toluene (60mL) was purged with N2, Pd(OAc)2(110mg, 0.22mmol) was added and the mixture was stirred under reflux for 16h, then cooled, diluted with EtOAc, filtered and evaporated. The residue was chromatographed on silica gel, with EtOAc/CH2Cl2(2:1) eluting24(0.62g. 37percent)

At the same time, in my other blogs, there are other synthetic methods of this type of compound,60666-70-8, (2-Bromo-5-chlorophenyl)methanol, and friends who are interested can also refer to it.

Reference:
Article; Flanagan, Jack U.; Atwell, Graham J.; Heinrich, Daniel M.; Brooke, Darby G.; Silva, Shevan; Rigoreau, Laurent J.M.; Trivier, Elisabeth; Turnbull, Andrew P.; Raynham, Tony; Jamieson, Stephen M.F.; Denny, William A.; Bioorganic and Medicinal Chemistry; vol. 22; 3; (2014); p. 967 – 977;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts