Category: 60666-70-8

Feng, Jie et al. published their research in Journal of Organic Chemistry in 2014 | CAS: 60666-70-8

(2-Bromo-5-chlorophenyl)methanol (cas: 60666-70-8) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Synthetic Route of C7H6BrClO

Palladium-Catalyzed Annulation of Alkynes with Ortho-Halide-Containing Benzyl Alcohols in Aqueous Medium was written by Feng, Jie;Lu, Guoping;Lv, Meifang;Cai, Chun. And the article was included in Journal of Organic Chemistry in 2014.Synthetic Route of C7H6BrClO This article mentions the following:

The Pd-catalyzed annulations of ortho-halide-containing benzyl alcs. with alkynes for the synthesis of indenones were achieved in aqueous Triton X-100 micelles with good yields and wide substrate scopes. Moreover, the indenones obtained in this procedure can be further functionalized to form some more synthetic useful derivatives via an environmental-friendly way. In the experiment, the researchers used many compounds, for example, (2-Bromo-5-chlorophenyl)methanol (cas: 60666-70-8Synthetic Route of C7H6BrClO).

(2-Bromo-5-chlorophenyl)methanol (cas: 60666-70-8) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Synthetic Route of C7H6BrClO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Della Ca’, Nicola et al. published their research in Tetrahedron in 2015 | CAS: 60666-70-8

(2-Bromo-5-chlorophenyl)methanol (cas: 60666-70-8) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Safety of (2-Bromo-5-chlorophenyl)methanol

Formation of a carbonyl group ortho to a biaryl structure or a 6H-dibenzopyran by a palladium/norbornene-catalyzed ordered reaction sequence was written by Della Ca’, Nicola;Fontana, Marco;Xu, Di;Cremaschi, Mirko;Lucentini, Riccardo;Zhou, Zhi-Ming;Catellani, Marta;Motti, Elena. And the article was included in Tetrahedron in 2015.Safety of (2-Bromo-5-chlorophenyl)methanol This article mentions the following:

Developments are reported in the catalytic synthesis of biaryls containing an ortho-carbaldehyde or 6H-dibenzopyrans in the presence of palladium/norbornene as catalyst. The reaction of o-substituted aryl iodides and o-bromobenzyl alcs. proceeds by unsym. aryl-aryl coupling to form a seven-membered oxapalladacycle intermediate, which may undergo an intramol. redox process to form carbonyl groups or a C-O coupling to six-membered cyclic ethers. The predominant formation of dibenzopyrans as well as of biaryl structures containing the oxidized CHO group in one ring and the reduced CH2OH in the other is described along with some mechanistic insights. In the experiment, the researchers used many compounds, for example, (2-Bromo-5-chlorophenyl)methanol (cas: 60666-70-8Safety of (2-Bromo-5-chlorophenyl)methanol).

(2-Bromo-5-chlorophenyl)methanol (cas: 60666-70-8) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Safety of (2-Bromo-5-chlorophenyl)methanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Feng, Jie et al. published their research in Journal of Organic Chemistry in 2014 | CAS: 60666-70-8

(2-Bromo-5-chlorophenyl)methanol (cas: 60666-70-8) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Synthetic Route of C7H6BrClO

Palladium-Catalyzed Annulation of Alkynes with Ortho-Halide-Containing Benzyl Alcohols in Aqueous Medium was written by Feng, Jie;Lu, Guoping;Lv, Meifang;Cai, Chun. And the article was included in Journal of Organic Chemistry in 2014.Synthetic Route of C7H6BrClO This article mentions the following:

The Pd-catalyzed annulations of ortho-halide-containing benzyl alcs. with alkynes for the synthesis of indenones were achieved in aqueous Triton X-100 micelles with good yields and wide substrate scopes. Moreover, the indenones obtained in this procedure can be further functionalized to form some more synthetic useful derivatives via an environmental-friendly way. In the experiment, the researchers used many compounds, for example, (2-Bromo-5-chlorophenyl)methanol (cas: 60666-70-8Synthetic Route of C7H6BrClO).

(2-Bromo-5-chlorophenyl)methanol (cas: 60666-70-8) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Synthetic Route of C7H6BrClO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Della Ca’, Nicola et al. published their research in Tetrahedron in 2015 | CAS: 60666-70-8

(2-Bromo-5-chlorophenyl)methanol (cas: 60666-70-8) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Safety of (2-Bromo-5-chlorophenyl)methanol

Formation of a carbonyl group ortho to a biaryl structure or a 6H-dibenzopyran by a palladium/norbornene-catalyzed ordered reaction sequence was written by Della Ca’, Nicola;Fontana, Marco;Xu, Di;Cremaschi, Mirko;Lucentini, Riccardo;Zhou, Zhi-Ming;Catellani, Marta;Motti, Elena. And the article was included in Tetrahedron in 2015.Safety of (2-Bromo-5-chlorophenyl)methanol This article mentions the following:

Developments are reported in the catalytic synthesis of biaryls containing an ortho-carbaldehyde or 6H-dibenzopyrans in the presence of palladium/norbornene as catalyst. The reaction of o-substituted aryl iodides and o-bromobenzyl alcs. proceeds by unsym. aryl-aryl coupling to form a seven-membered oxapalladacycle intermediate, which may undergo an intramol. redox process to form carbonyl groups or a C-O coupling to six-membered cyclic ethers. The predominant formation of dibenzopyrans as well as of biaryl structures containing the oxidized CHO group in one ring and the reduced CH2OH in the other is described along with some mechanistic insights. In the experiment, the researchers used many compounds, for example, (2-Bromo-5-chlorophenyl)methanol (cas: 60666-70-8Safety of (2-Bromo-5-chlorophenyl)methanol).

(2-Bromo-5-chlorophenyl)methanol (cas: 60666-70-8) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Safety of (2-Bromo-5-chlorophenyl)methanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Tan, Qiuyuan et al. published their research in Angewandte Chemie, International Edition in 2019 | CAS: 60666-70-8

(2-Bromo-5-chlorophenyl)methanol (cas: 60666-70-8) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.SDS of cas: 60666-70-8

Copper-Catalyzed Aerobic Oxidative Cyclization Cascade to Construct Bridged Skeletons: Total Synthesis of (-)-Suaveoline was written by Tan, Qiuyuan;Yang, Zhao;Jiang, Dan;Cheng, Yuegang;Yang, Jiao;Xi, Song;Zhang, Min. And the article was included in Angewandte Chemie, International Edition in 2019.SDS of cas: 60666-70-8 This article mentions the following:

Based on the discovery of copper-catalyzed cyclopropanol ring-opening addition to iminium ions, an unprecedented catalytic aerobic C-H oxidation/cyclopropanol cyclization cascade using CuCl2 as the multifunctional catalyst and air as the oxidant was developed to construct the azabicyclo[3.3.1]nonane skeleton, which is widespread in natural products and medicines. Using this method, concise asym. total synthesis of the indole alkaloid (-)-suaveoline was achieved. This study not only provides an efficient, low-cost, and environmentally benign method for constructing such bridged frameworks, but also enriches the realm of cyclopropanol chem. and C-H functionalization. In the experiment, the researchers used many compounds, for example, (2-Bromo-5-chlorophenyl)methanol (cas: 60666-70-8SDS of cas: 60666-70-8).

(2-Bromo-5-chlorophenyl)methanol (cas: 60666-70-8) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.SDS of cas: 60666-70-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

16-Sep News New downstream synthetic route of 60666-70-8

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 60666-70-8, (2-Bromo-5-chlorophenyl)methanol.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 60666-70-8, name is (2-Bromo-5-chlorophenyl)methanol. A new synthetic method of this compound is introduced below., HPLC of Formula: C7H6BrClO

Compound 17-3 (0421) To a solution of compound 17-2 (8.0 g, 36.1 mmol) in THF (60 mL) was added NaH (60percent, 1.88 g, 46.9 mmol) at 0° C. After addition, the reaction mixture was stirred at room temperature for 30 min. Iodomethane (10.25 g, 72.2 mmol) was added and stirred for another 30 min. The reaction was then quenched with sat. ammonium chloride (50 mL) and extracted with ethyl acetate (50 mL×3). The combined organic layers were washed with brine (60 mL), dried over Na2SO4, filtered, concentrated to afford 17-3 as a white solid (7.23 g, yield 85percent).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 60666-70-8, (2-Bromo-5-chlorophenyl)methanol.

Reference:
Patent; Nivalis Therapeutics, Inc.; Wasley, Jan; Rosenthal, Gary J.; Sun, Xicheng; Strong, Sarah; Qiu, Jian; US9138427; (2015); B2;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

9 Sep 2021 News The origin of a common compound about 60666-70-8

The synthetic route of 60666-70-8 has been constantly updated, and we look forward to future research findings.

Reference of 60666-70-8 , The common heterocyclic compound, 60666-70-8, name is (2-Bromo-5-chlorophenyl)methanol, molecular formula is C7H6BrClO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: A DMF solution (8mL) of the o-substituted aryl iodide (0.36mmol), the o-bromobenzyl alcohol (0.36mmol) and norbornene (34mg, 0.36mmol) was added under nitrogen to a Schlenck-type flask, containing Pd(OAc)2 (4mg, 0.018mmol), the phosphine (0.036mmol), when required, and K2CO3 (124mg, 0.90mmol) or CsOPiv (211mg, 0.90). The reaction mixture was stirred at 105°C for 24h. After cooling to room temperature the organic layer was diluted with EtOAc (20mL), washed twice with water (20mL) and dried over Na2SO4. The solvent was removed under reduced pressure and the resulting residue was purified by flash chromatography on silica gel using mixtures of hexane-EtOAc as eluent.

The synthetic route of 60666-70-8 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Della Ca, Nicola; Fontana, Marco; Xu, Di; Cremaschi, Mirko; Lucentini, Riccardo; Zhou, Zhi-Ming; Catellani, Marta; Motti, Elena; Tetrahedron; vol. 71; 37; (2015); p. 6389 – 6401;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

8 Sep 2021 News Analyzing the synthesis route of 60666-70-8

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 60666-70-8, (2-Bromo-5-chlorophenyl)methanol.

Synthetic Route of 60666-70-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 60666-70-8, name is (2-Bromo-5-chlorophenyl)methanol, molecular formula is C7H6BrClO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Step 1. ((2-Bromo-5-chlorobenzyl)oxy)(tert-butyl)dimethylsilane. Triethylamine (0.30 mL, 2.15 mmol), DMAP (97 mg, 0.79 mmol) and tert-butyldimethylsilyl chloride (TBSCl; 698 mg, 4.63 mmol) were added to a solution of (2-bromo-5-chlorophenyl)methanol (500 mg, 2.26 mmol) in CH2Cl2 (11.3 mL) at room temperature. After stirring overnight, the reaction mixture was partitioned between saturated aqueous sodium bicarbonate (50 mL) and CH2Cl2 (200 mL). The phases were separated and the aqueous phase was extracted with CH2Cl2 (2*100 mL). The combined organic phase was washed with brine, dried (MgSO4), filtered and concentrated in vacuo.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 60666-70-8, (2-Bromo-5-chlorophenyl)methanol.

Reference:
Patent; Allergan, Inc.; Ngo, Vinh X.; Old, David W.; Burk, Robert M.; (55 pag.)US9540357; (2017); B1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Analyzing the synthesis route of 60666-70-8

The synthetic route of 60666-70-8 has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 60666-70-8, (2-Bromo-5-chlorophenyl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: alcohols-buliding-blocks, blongs to alcohols-buliding-blocks compound. category: alcohols-buliding-blocks

Example 74 Synthesis of 2-bromo-5-chloro-3-t-butyldimethylsilyloxy-methylbenzene To the solution of 2-bromo-5-chlorobenzylalcohol (10 g) from Example 73 and imidazole (3.23 g) in dry DMF (50ml) was added dropwise t-butyl chloro dimethylsilane in dry DMF (10 ml) for 20 minutes at -0° C. After addition, the mixture was stirred for 30 minutes at room temperature. The mixture was diluted with ether, and washed with saturated sodium chloride solution, dried over anhydrous sodium sulfate. After removal of the solvent under reduced pressure, the residue was purified by chromatography on a silica gel column (hexane:methylene chloride=4:1) to give the title compound (13.3 g; 88percent).

The synthetic route of 60666-70-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Mochida Pharmaceutical Co., Ltd.; US5587392; (1996); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Introduction of a new synthetic route about (2-Bromo-5-chlorophenyl)methanol

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 60666-70-8, (2-Bromo-5-chlorophenyl)methanol, other downstream synthetic routes, hurry up and to see.

Application of 60666-70-8, Adding some certain compound to certain chemical reactions, such as: 60666-70-8, name is (2-Bromo-5-chlorophenyl)methanol,molecular formula is C7H6BrClO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 60666-70-8.

Add compound 3 (500 mg, 2.26 mmol) in DCM (40 mL) and DIPEA (1.12 mL, 6.77 mmol)DMAP (55.16 mg, 451.51 mumol) was added. Then, pivaloyl chloride (416.65 uL, 3.39 mmol) was added dropwise at 0 ° C to react.The mixture was stirred at 10 ° C for 0.1 hour and then at room temperature overnight. The reaction mixture was diluted with DCM and then usedWater, 10percent citric acid and brine were washed with MgSO4 and filtered. The filtrate was concentrated to give a crude product which was purified by CC.The compound 4 (605 mg, 87.69percent) was obtained as a pale yellow oil.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 60666-70-8, (2-Bromo-5-chlorophenyl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Chinese Academy Of Sciences Tianjin Industry Bio-technology Institute; Lin Jianping; Liu Pi; Li Jinlong; Wang Zhonghua; Liu Cui; (15 pag.)CN108264467; (2018); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts