Category: 6054-98-4

Kumar, Ravi; Rajarajeshwari, N.; Swamy V. B., Narayana published the artcile< Borassus flabellifer fruit mucilage: potential biodegradable carrier for colon specific drug delivery>, Formula: C14H8N2Na2O6, the main research area is olsalazine sodium Borassus mucilage colon matrix tablet drug delivery.

The present study was undertaken to assess the potential of Borassus flabellifer mucilage (BFM) to act as a biodegradable carrier for colon specific drug delivery. Hence an attempt was made to develop matrix tablet of olsalazine sodium based formulation using BFM which protects the drug in upper GIT and release the major amount of drug in colon due to degradation by bacterial enzymes. Colon targeted matrix tablets of olsalazine sodium were prepared by direct compression method using different concentrations viz; 5, 10, 15, 20 and 25 % weight/weight of BFM. Tablets were evaluated for hardness, friability, weight variation, drug content, in vitro dissolution test in simulated gastric, intestinal and colonic fluid with and without 4% (w/v) rat cecal matter and stability study. FT-IR and DSC studies confirmed the absence of any drug polymer interaction. In vitro studies revealed that the tablets containing 25% weight/weight of BFM (F5) have limited the drug release in stomach and small intestinal environment and released maximum amount of drug in the colonic environment. Optimized formulation (F5) showed no change either in phys. appearance, drug content or in dissolution pattern after storage at 40°C/RH 75% for 3 mo. Math. modeling showed that release pattern follows the Peppas model. X-ray images were taken to investigate the movement, location and the integrity of the tablets in different parts of gastro intestinal tract in rabbits and it clearly supported the in vitro study. The study showed that BFM can be used successfully for colon specific drug delivery system.

International Journal of Pharmacy and Pharmaceutical Sciences published new progress about Biodegradability. 6054-98-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H8N2Na2O6, Formula: C14H8N2Na2O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Mantzaris, Gerassimos J.; Sfakianakis, Michael; Archavlis, Emmanuel; Petraki, Kalliopi; Christidou, Angeliki; Karagiannidis, Alexandros; Triadaphyllou, George published the artcile< A prospective randomized observer-blind 2-year trial of azathioprine monotherapy versus azathioprine and olsalazine for the maintenance of remission of steroid-dependent ulcerative colitis>, Reference of 6054-98-4, the main research area is azathioprine olsalazine ulcerative colitis.

The aim of this prospective study was to assess whether the coadministration of azathioprine (AZA) and olsalazine is superior to AZA monotherapy in maintaining remission of steroid-dependent ulcerative colitis (UC). Patients with steroid-dependent UC in remission were randomized to receive AZA alone (2.2 mg/kg) or in combination with olsalazine (0.5 g tid). Remission was defined as steroid withdrawal, an Ulcerative Colitis Clin. Activity Index (UCCAI) score of <2, an Ulcerative Colitis Disease Activity Index (UCDAI) score of 0, and a neg. colonoscopy and histol. Patients were followed in the outpatient clinic every month for 2 yr. The study protocol included (1) monthly clin. examination, assessment of UCCAI, hematol. and biochem. tests, and compliance with treatment; (2) a sigmoidoscopy and completion of inflammatory bowel disease quality-of-life questionnaire (IBD-Q) and UCDAI every 3 mo; and (3) total colonoscopy with biopsies at the end of the first and second year of the trial. Seventy patients were randomized to receive AZA alone (n = 34) or with olsalazine (n = 36). Three patients in each group developed side effects or could not comply with treatment and were withdrawn from the study. Three patients receiving AZA relapsed after the first year of the study and three after the second year of the study (19%). In the combination therapy group four patients relapsed after the first year of study and two after the second year of the study (18%). Relapse rates were not significant whether analyzed by intention-to-treat or per protocol. There were no significant differences between groups in time to relapse or discontinuation of treatment, UCCAI, UCDAI, or IBD-Q scores. However, the number of adverse events and the cost of treatment were significantly higher, whereas compliance with treatment was poorer in the combination therapy. Patients with steroid-dependent UC successfully maintained in remission on AZA are not in need of 5-aminosalicylic acid compounds American Journal of Gastroenterology published new progress about Combination chemotherapy. 6054-98-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H8N2Na2O6, Reference of 6054-98-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

McKay, G.; Blair, H. S.; Gardner, J. published the artcile< Rate studies for the adsorption of dyestuffs onto chitin>, Application In Synthesis of 6054-98-4, the main research area is dye adsorption chitin model; film mass transfer dye model.

The rate of adsorption of dyestuffs on chitin in the initial stages of the adsorption process depends on the film mass transfer coefficient A model has been developed to determine the film mass transfer coefficients The anal. is based on a nonlinear equilibrium isotherm and utilizes a computer program to predict theor. concentration vs. time curves. The overall average external mass transfer coefficients are 2.8 × 10-3, 2.9 × 10-3, 3.8 × 10-3, and 0.9 × 10-3 cm/s for Acid Blue 25  [6408-78-2], Acid Blue 158  [6370-08-7], Mordant Yellow 5  [6054-98-4], and Direct Red 84  [6409-83-2], resp. Equilibrium data for the adsorption of the 4 dyestuffs on chitin are presented and analyzed using the Langmuir, Freundlich, and general isotherm expressions. The adsorption capacity of chitin at monolayer coverage is 190 and 200 mg dye/g for Acid Blue 25 and Acid Blue 158, resp. Mordant Yellow 5 and Direct Red 84 adsorption capacities are 50 and 40 mg dye/g chitin, resp.

Journal of Colloid and Interface Science published new progress about Adsorptive wastewater treatment. 6054-98-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H8N2Na2O6, Application In Synthesis of 6054-98-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Patel, Rikin D.; Prasanth Kumar, Sivakumar; Pandya, Himanshu A.; Solanki, Hitesh A. published the artcile< MDCKpred: a web-tool to calculate MDCK permeability coefficient of small molecule using membrane-interaction chemical features>, Application of C14H8N2Na2O6, the main research area is MDCK cell permeability small mol membrane interaction MDCKpred tool; Caco-2; MDCK; QSAR; permeability; permeability coefficient; web-tool.

Structure-based models to understand the transport of small mols. through biol. membrane can be developed by enumerating intermol. interactions of the small mol. with a biol. membrane, usually a dimyristoylphosphatidylcholine (DMPC) monolayer. This ADME (absorption, distribution, metabolism, and excretion) property based on Madin-Darby Canine Kidney (MDCK) cell line demonstrates intestinal drug absorption of small mols. and correlated to human intestinal absorption which acts as a determining factor to forecast small-mol. prioritization in drug-discovery projects. We present here the development of MDCKpred web-tool which calculates MDCK permeability coefficient of small mol. based on the regression model, developed using membrane-interaction chem. features. The web-tool allows users to calculate the MDCK permeability coefficient (nm/s) instantly by providing simple descriptor inputs. The chem.-interaction features are derived from different parts of the DMPC mol. viz. head, middle, and tail regions and accounts overall intermol. contacts of the small mol. when passively diffused through the phospholipid-rich biol. membrane. The MDCKpred model is both internally (R2 = .76; = .68; Rtrain = .87; Rtest = .69) and externally (Rext = .55) validated. Furthermore, we used natural mols. as application examples to demonstrate its utility in lead exploration and optimization projects. The MDCKpred web-tool can be accessed freely at http://www.mdckpred.in. This web-tool is designed to offer an intuitive way of prioritizing small mols. based on calculated MDCK permeabilities.

Toxicology Mechanisms and Methods published new progress about Absorption. 6054-98-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H8N2Na2O6, Application of C14H8N2Na2O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

McKay, G.; Blair, H. S.; Gardner, J. published the artcile< Rate studies for the adsorption of dyestuffs onto chitin>, Application In Synthesis of 6054-98-4, the main research area is dye adsorption chitin model; film mass transfer dye model.

The rate of adsorption of dyestuffs on chitin in the initial stages of the adsorption process depends on the film mass transfer coefficient A model has been developed to determine the film mass transfer coefficients The anal. is based on a nonlinear equilibrium isotherm and utilizes a computer program to predict theor. concentration vs. time curves. The overall average external mass transfer coefficients are 2.8 × 10-3, 2.9 × 10-3, 3.8 × 10-3, and 0.9 × 10-3 cm/s for Acid Blue 25  [6408-78-2], Acid Blue 158  [6370-08-7], Mordant Yellow 5  [6054-98-4], and Direct Red 84  [6409-83-2], resp. Equilibrium data for the adsorption of the 4 dyestuffs on chitin are presented and analyzed using the Langmuir, Freundlich, and general isotherm expressions. The adsorption capacity of chitin at monolayer coverage is 190 and 200 mg dye/g for Acid Blue 25 and Acid Blue 158, resp. Mordant Yellow 5 and Direct Red 84 adsorption capacities are 50 and 40 mg dye/g chitin, resp.

Journal of Colloid and Interface Science published new progress about Adsorptive wastewater treatment. 6054-98-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H8N2Na2O6, Application In Synthesis of 6054-98-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Patel, Rikin D.; Prasanth Kumar, Sivakumar; Pandya, Himanshu A.; Solanki, Hitesh A. published the artcile< MDCKpred: a web-tool to calculate MDCK permeability coefficient of small molecule using membrane-interaction chemical features>, Application of C14H8N2Na2O6, the main research area is MDCK cell permeability small mol membrane interaction MDCKpred tool; Caco-2; MDCK; QSAR; permeability; permeability coefficient; web-tool.

Structure-based models to understand the transport of small mols. through biol. membrane can be developed by enumerating intermol. interactions of the small mol. with a biol. membrane, usually a dimyristoylphosphatidylcholine (DMPC) monolayer. This ADME (absorption, distribution, metabolism, and excretion) property based on Madin-Darby Canine Kidney (MDCK) cell line demonstrates intestinal drug absorption of small mols. and correlated to human intestinal absorption which acts as a determining factor to forecast small-mol. prioritization in drug-discovery projects. We present here the development of MDCKpred web-tool which calculates MDCK permeability coefficient of small mol. based on the regression model, developed using membrane-interaction chem. features. The web-tool allows users to calculate the MDCK permeability coefficient (nm/s) instantly by providing simple descriptor inputs. The chem.-interaction features are derived from different parts of the DMPC mol. viz. head, middle, and tail regions and accounts overall intermol. contacts of the small mol. when passively diffused through the phospholipid-rich biol. membrane. The MDCKpred model is both internally (R2 = .76; = .68; Rtrain = .87; Rtest = .69) and externally (Rext = .55) validated. Furthermore, we used natural mols. as application examples to demonstrate its utility in lead exploration and optimization projects. The MDCKpred web-tool can be accessed freely at http://www.mdckpred.in. This web-tool is designed to offer an intuitive way of prioritizing small mols. based on calculated MDCK permeabilities.

Toxicology Mechanisms and Methods published new progress about Absorption. 6054-98-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H8N2Na2O6, Application of C14H8N2Na2O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhang, Huiping; Fan, Yaling; Krishna, Rajamani; Feng, Xuefeng; Wang, Li; Luo, Feng published the artcile< Robust metal-organic framework with multiple traps for trace Xe/Kr separation>, Synthetic Route of 6054-98-4, the main research area is metal organic framework adsorption direct separation simulation.

Direct separation of Xe and Kr from air or UNF off-gas by means of porous adsorbents is of industrial importance but is a very challenging task. In this work, we show a robust metal-organic framework (MOF), namely ECUT-60, which renders not only high chem. stability, but also unique structure with multiple traps. This leads to the ultrahigh Xe adsorption capacity, exceeding most reported porous materials. Impressively, this MOF also enables high selectivity of Xe over Kr, CO2, O2, and N2, leading to the high-performance separation for trace quantitites of Xe/Kr from a simulated UNF reprocessing off-gas. The separation capability has been demonstrated by using dynamic breakthrough experiments, giving the record Xe uptake up to 70.4 mmol/kg and the production of 19.7 mmol/kg pure Xe. Consequently, ECUT-60 has promising potential in direct production of Xe from UNF off-gas or air. The separation mechanism, as unveiled by theor. calculation, is attributed to the multiple traps in ECUT-60 that affords rigid restrict for Xe atom via van der Waals force.

Science Bulletin published new progress about Adsorption. 6054-98-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H8N2Na2O6, Synthetic Route of 6054-98-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Eriksson, A.; Nyholm, L. published the artcile< Coulometric and spectroscopic investigations of the oxidation and reduction of some azosalicylic acids at glassy carbon electrodes>, Safety of Sodium 5,5′-(diazene-1,2-diyl)bis(2-hydroxybenzoate), the main research area is coulometry spectroscopy oxidation reduction azosalicylic acid glassy carbon electrode.

Constant potential coulometry in combination with cyclic voltammetry, UV-visible, 1H and 13C NMR spectroscopy were used to identify the oxidation and reduction products for some structurally similar azosalicylic acids, including the azosalicylic drugs Sulfasalazine and Olsalazine. The experiments were carried out in aqueous solutions at pH 4.5 to 10.0. Voltammetric and UV-visible spectroscopic comparisons involving standard substances confirm that all compounds studied, except 4,4′-azobis[2-hydroxybenzoic acid], are reduced in an overall four-electron process to their corresponding amines. For 4,4′-azobis[2-hydroxybenzoic acid], the reduction involves only two electrons and most likely gives rise to the corresponding hydrazo compound The oxidations of 3,3′-azobis[6-hydroxybenzoic acid] (Olsalazine), 3,3′-azoxybis[6-hydroxybenzoic acid] and 2-hydroxy-5-[(3′-carboxy-2′-hydroxyphenyl)azo]benzoic acid involve an initial two-electron step. Based on UV and NMR spectroscopic data, probably the oxidation of 3,3′-azobis-[6-hydroxybenzoic acid] gives rise to a 2,2′-dicarboxy-1,4-dibenzoquinone azine.

Electrochimica Acta published new progress about Coulometry. 6054-98-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H8N2Na2O6, Safety of Sodium 5,5′-(diazene-1,2-diyl)bis(2-hydroxybenzoate).

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Niu, Yanfen; Li, Hongjian; Gao, Lihui; Lin, Hua; Kung, Hsiangfu; Lin, Marie Chia-mi; Leung, Kwong-Sak; Wong, Man-Hon; Xiong, Wenyong; Li, Ling published the artcile< old drug, new indication: olsalazine sodium reduced serum uric acid levels in mice via inhibiting xanthine oxidoreductase activity>, Recommanded Product: Sodium 5,5′-(diazene-1,2-diyl)bis(2-hydroxybenzoate), the main research area is olsalazine sodium xanthine oxidase dehydrogenase inhibitor hyperuricemia; Hyperuricemia; Olsalazine sodium; Uric acid; Xanthine oxidase.

Hyperuricemia, a long-term purine metabolic disorder, is a well-known risk factor for gout, hypertension and diabetes. In maintaining normal whole-body purine levels, xanthine oxidase (XOD) is a key enzyme in the purine metabolic pathway, as it catalyzes the oxidation of hypoxanthine to xanthine and finally to uric acid. Here we used the protein-ligand docking software idock to virtually screen potential XOD inhibitors from 3167 approved small compounds/drugs. The inhibitory activities of the ten compounds with the highest scores were tested on XOD in vitro. Interestingly, all the ten compounds inhibited the activity of XOD at certain degrees. Particularly, the anti-ulcerative-colitis drug olsalazine sodium demonstrated a great inhibitory activity for XOD (IC50 = 3.4 mg/L). Enzymic kinetic studies revealed that the drug was a hybrid-type inhibitor of xanthine oxidase. Furthermore, the drug strikingly decreased serum urate levels, serum/hepatic activities of XOD at a dose-dependent manner in vivo. Thus, we demonstrated a successful hunting process of compounds/drugs for hyperuricemia through virtual screening, supporting a potential usage of olsalazine sodium in the treatment of hyperuricemia.

Journal of Pharmacological Sciences (Amsterdam, Netherlands) published new progress about Gout. 6054-98-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H8N2Na2O6, Recommanded Product: Sodium 5,5′-(diazene-1,2-diyl)bis(2-hydroxybenzoate).

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Peladeau, Christine; Adam, Nadine; Bronicki, Lucas M.; Coriati, Adele; Thabet, Mohamed; Al-Rewashdy, Hasanen; Vanstone, Jason; Mears, Alan; Renaud, Jean-Marc; Holcik, Martin; Jasmin, Bernard J. published the artcile< Identification of therapeutics that target eEF1A2 and upregulate utrophin A translation in dystrophic muscles>, HPLC of Formula: 6054-98-4, the main research area is muscular dystrophy relaxant utrophin A eEF1A2 therapeutic target.

Abstract: Up-regulation of utrophin in muscles represents a promising therapeutic strategy for the treatment of Duchenne Muscular Dystrophy. We previously demonstrated that eEF1A2 associates with the 5’UTR of utrophin A to promote IRES-dependent translation. Here, we examine whether eEF1A2 directly regulates utrophin A expression and identify via an ELISA-based high-throughput screen, FDA-approved drugs that upregulate both eEF1A2 and utrophin A. Our results show that transient overexpression of eEF1A2 in mouse muscles causes an increase in IRES-mediated translation of utrophin A. Through the assessment of our screen, we reveal 7 classes of FDA-approved drugs that increase eEF1A2 and utrophin A protein levels. Treatment of mdx mice with the 2 top leads results in multiple improvements of the dystrophic phenotype. Here, we report that IRES-mediated translation of utrophin A via eEF1A2 is a critical mechanism of regulating utrophin A expression and reveal the potential of repurposed drugs for treating DMD via this pathway.

Nature Communications published new progress about Anterior tibial muscle. 6054-98-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H8N2Na2O6, HPLC of Formula: 6054-98-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts