Category: 6054-98-4

Misik, Vladimir; Miyoshi, Norio; Riesz, Peter published the artcile< EPR spin trapping study of the decomposition of azo compounds in aqueous solutions by ultrasound: potential for use as sonodynamic sensitizers for cell killing>, Recommanded Product: Sodium 5,5′-(diazene-1,2-diyl)bis(2-hydroxybenzoate), the main research area is ultrasound azo compound free radical formation.

Sonodynamic therapy, a promising new approach to cancer treatment, is based on synergistic cell killing by combination of certain drugs (sonosensitizers) and ultrasound. Although the mechanism of sonodynamic action is not understood, the role of free radicals produced from sonosensitizers by ultrasound is implicated. In this work, we studied formation of free radicals during the decomposition of several water-soluble azo compounds by 50 kHz ultrasound in aqueous solutions Using the spin trp 3,5-dibromo-4-nitrosobenzene sulfonate (DBNBS) tertiary carbon-centered radicals from 2,2′-azobis (N,N’-bimethyleneisobutyramidine) dihydrochloride (VA-044), 2-(carbamoylazo)isobutyronitrile (V-30), and 2,2′-azobis(2-amidinopropane) dihydrochloride (AAPH) and •CH3 radicals from 1,1′-azobis(N,N’-dimethylformamide) (ADMF) were detected in argon-saturated solutions and the corresponding oxygen-centered radicals (alkoxyl and peroxyl) from VA-044, V-30, and AAPH were identified using the spin trap 5,5′-dimethyl-1-pyrroline-N-oxide (DMPO) in aerated sonicated solutions No free radicals from 4,4′-dihydroxyazobenzene-3,3′-dicarboxylic acid, disodium salt (DHAB) could be found in either system. While VA-044 and AAPH could also be readily decomposed by heat (42.5 °C and 80 °C), V-30 decomposition only occurred in the ultrasound-exposed solutions The most likely mechanism of decomposition of azo compounds by ultrasound is their thermolysis in the heated shell of the liquid surrounding cavitating bubbles driven by ultrasound and/or by pyrolysis inside these bubbles. Experiments using scavengers of •OH and •H, which are produced by sonolysis in aqueous solutions, demonstrated that these radicals are not involved in the ultrasound-mediated radical production from the azo compounds Due to the known cytotoxic potential of free radicals produced from azo compounds, the use of these compounds as ultrasound sensitizers appears to be a promising approach for sonodynamic cell killing.

Free Radical Research published new progress about Azo compounds Role: RCT (Reactant), RACT (Reactant or Reagent). 6054-98-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H8N2Na2O6, Recommanded Product: Sodium 5,5′-(diazene-1,2-diyl)bis(2-hydroxybenzoate).

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

McKay, G.; Blair, H. S.; Gardner, J. R. published the artcile< Adsorption of dyes on chitin. I. Equilibrium studies>, Synthetic Route of 6054-98-4, the main research area is adsorption dye chitin; particle size chitin dye adsorption.

Equilibrium isotherms were studied for the adsorption of 4 dyes (Acid Blue 258, Acid Blue 158, Mordant Yellow 5, and Direct Red 84) on chitin. Langmuir and Freundlich constants were determined, and the effects of chitin particle size and solution temperature were investigated. Theor. isotherms are compared with exptl. data; good agreement was obtained with a composite isotherm of the general form: Ye = iCe/(1 + jCem).

Journal of Applied Polymer Science published new progress about Adsorption. 6054-98-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H8N2Na2O6, Synthetic Route of 6054-98-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ravetkar, D. D.; Ambeskar, V. D.; Mashelkar, R. A. published the artcile< Diffusion-adsorption problems in macromolecular systems: new techniques for parameter estimation>, Synthetic Route of 6054-98-4, the main research area is diffusion adsorption polymer parameter estimation; polyacrylamide adsorption parameter estimation; chitin dye adsorption parameter estimation.

The techniques used for estimation of diffusion-adsorption parameters in the past have certain basic flaws. New and efficient techniques for parameter estimation were proposed having many advantages such as using the full concentration-time profile (rather than part of it), time saving, etc. The validity of these techniques was demonstrated by the anal. of the data generated in our laboratory on adsorption of polyacrylamide and also the data on adsorption of dyes on chitin reported in the literature.

Journal of Applied Polymer Science published new progress about Adsorption. 6054-98-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H8N2Na2O6, Synthetic Route of 6054-98-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Dahlund, Mats; Olin, Aake published the artcile< Chemical equilibria in aqueous solutions of olsalazine, 3,3'-azo-bis(6-hydroxybenzoic acid)>, Quality Control of 6054-98-4, the main research area is olsalazine chem equilibrium; azodisalicylate chem equilibrium; acidity azodisalicylate.

The protolytic reactions of olsalazine (I) were studied by solubility and spectrophotometric measurements at 25°. The I di-Na salt is the active component in a new drug against ulcerative colitis. The carboxylic acidity constants are pKa1 = 2.07 and pKa2 = 2.85 (0.1M NaCl) and the phenolic constants are pKa3 = 11.00 and pKa4 = 11.99 (0.25M NaCl). The solubility of H4A is 3.8 . 10-8M (0.1M NaCl). Two Na salts of the acid were studied. The solubility of NaH3A is moderate and can be calculated from its solubility product defined as Ks = [Na+][H+][H2A2-] = 1.7 x 10-10 M3. At total concentrations exceeding about 1 x 10-3 M, H2A2- starts to aggregate to form a dimer and also higher polymers. Diagrams are included to show the distribution of the I species as a function of log[H+] and total concentration, as well as the stability ranges of the solid phases.

Acta Pharmaceutica Suecica published new progress about Acidity. 6054-98-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H8N2Na2O6, Quality Control of 6054-98-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Nigovic, Biljana; Simunic, Branimir; Hocevar, Samo published the artcile< Voltammetric measurements of aminosalicylate drugs using bismuth film electrode>, Recommanded Product: Sodium 5,5′-(diazene-1,2-diyl)bis(2-hydroxybenzoate), the main research area is sulfasalazine olsalazine determination voltammetry bismuth film electrode tablet capsule.

A bismuth film electrode (BiFE) prepared ex-situ on a supporting glassy carbon electrode exhibited convenient electroanal. performance for voltammetric measurement of selected aminosalycilate drugs. The reduction behavior of aminosalycilate drugs was studied in aqueous solutions within the pH range of 4-6. The voltammetric responses were compared with those obtained at the bare glassy carbon electrode under identical conditions. In the square-wave voltammetric operation mode the BiFE showed a linear response in the concentration range of 5 × 10-6 to 3.5 × 10-4 and 1 × 10-6 to 5 × 10-4 M for sulfasalazine and olsalazine, resp. Its electrode surface revealed auspiciously high stability and remarkable reproducibility in the rapid anal. of aminosalycilate drugs. Finally, the BiFE was satisfactorily applied for direct quantitation of azo prodrugs in real pharmaceutical samples.

Electrochimica Acta published new progress about Film electrodes. 6054-98-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H8N2Na2O6, Recommanded Product: Sodium 5,5′-(diazene-1,2-diyl)bis(2-hydroxybenzoate).

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Odlind, Bo; Eriksson, O. published the artcile< Olsalazine sodium stimulates chloride transport across the bullfrog cornea>, Formula: C14H8N2Na2O6, the main research area is olsalazine sodium chloride transport bullfrog cornea.

Olsalazine sodium consists of 2 mols. of 5-aminosalicylic acid coupled with an azo-bond. It has been shown to act as a secretagogue in intestine and a stimulation of chloride secretion has been suggested for the mechanism of this effect. The purpose of this study was to examine this possibility by exposing olsalazine to the “”pure”” chloride-transporting epithelium of the bullfrog cornea. The results show that the drug has a stimulatory effect on the chloride transport of a model tissue, the frog corneal epithelium.

Acta Physiologica Scandinavica published new progress about Biological transport. 6054-98-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H8N2Na2O6, Formula: C14H8N2Na2O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Xu, Changtai; Li, Shanqu; Pan, Borong published the artcile< Current drug therapy in ulcerative colitis>, Formula: C14H8N2Na2O6, the main research area is review antiinflammatory ulcerative colitis.

A review. Ulcerative colitis(UC)and Crohn’s disease(CD)are two primary types of inflammatory bowel disease (IBD). UC is an inflammatory destructive disease of the large intestine occurred usually in the rectum and lower part of the colon as well as the entire colon. Drug therapy is a main choice for UC treatment and medical management should be as a comprehensive one. Several types of medications are used to control the inflammation or reduce symptoms caused by ulcerative colitis. The treatment of UC depends on its severity, location and the presence of complications, so drug therapies must be custom-designed for each patient. Findings which medications best alleviate the symptoms may take time. The goal of medical treatment is to reduce the inflammation that triggers the signs and symptoms. In the best cases, this may lead not only to symptom relief but also to long-term remission. Azulfidine, Asacol, Pentasa, Dipentum, and Rowasa all contain 5-aminosalicylate (5-ASA), which is the topical anti-inflammatory ingredient. In UC patients with moderate to severe disease and in patients who failed to respond to 5-ASA compounds, systemic corticosteroids should be used. To minimize side effects, corticosteroids should be gradually reduced as soon as the disease remission is achieved. Surgery or immunomodulator is considered for patients with corticosteroid-dependent or unresponsive to corticosteroid treatment. Immunomodulators used for treating severe UC include azathioprine/6-MP, methotrexate, and cyclosporine. Integrated traditional Chinese and Western medicine is safe and effective in maintaining remission in patients with UC.

Journal of Chinese Clinical Medicine published new progress about Anti-inflammatory agents. 6054-98-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H8N2Na2O6, Formula: C14H8N2Na2O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Schroeder, K. W. published the artcile< Role of mesalazine in acute and long-term treatment of ulcerative colitis and its complications>, Application In Synthesis of 6054-98-4, the main research area is review mesalazine aminosalicylate sulfasalazine Calazar Pentasa antiinflammatory ulcerative colitis.

A review. Sulfasalazine, consisting of 5-aminosalicylic acid bound to sulfapyridine by a diazo bond, was first used for treatment of ulcerative colitis in the early 1940s and later found effective in placebo-controlled trials for acute disease and for long-term maintenance of remission. Later studies found that the active moiety is 5-ASA (mesalazine, mesalamine) and the sulfapyridine moiety acts as a carrier mol. but causes many of the symptomatic adverse reactions. This study used information from a review of the literature. The finding that 5-ASA in the active motility led to the development of mesalazine prodrugs, olsalazine (Dipentum) and balsalazide (Colazide, Colazal), and targeted release mesalazine preparations, such as Asacol, Pentasa, and Salofalk, as well as enemas and suppository preparations for distal disease. Most patients with adverse effects from sulfasalazine will tolerate mesalazine. Mesalazine has been shown equivalent or superior to sulfasalazine, and superior to placebo, with a dose-response benefit, in inducing remission of acute disease, and comparable to sulfasalazine and superior to placebo for long-term maintenance of remission. Better tolerance of mesalazine and the ability to use higher doses favor its use in patients intolerant of sulfasalazine and in patients failing to respond to usual doses of sulfasalazine. Adverse effects from mesalazine are uncommon, but include idiosyncratic worsening of the colitis symptoms and renal toxicity. Mesalazine is safe to use during pregnancy and for nursing mothers. As maintenance therapy, mesalazine may reduce the risk of developing colorectal carcinoma. Mesalazine represents effective and well-tolerated first-line therapy for mildly to moderately acute disease as well as for the long-term maintenance treatment in the patient with ulcerative colitis.

Scandinavian Journal of Gastroenterology, Supplement published new progress about Anti-inflammatory agents. 6054-98-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H8N2Na2O6, Application In Synthesis of 6054-98-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Dahlund, Mats; Olin, Aake published the artcile< An estimate of the complexing ability of olsalazine from a study of its complexation of copper(2+)>, Recommanded Product: Sodium 5,5′-(diazene-1,2-diyl)bis(2-hydroxybenzoate), the main research area is olsalazine complexation copper.

The di-Na salt of olsalazine, Na2H2A, is the essential component in a new drug for the treatment of ulcerative colitis. An attempt was made to elucidate the complex chem. of H2A2- from a study of its complexation of Cu2+. The values of the equilibrium constants were β1 = 1.3 x 10-2 and β2 = 3 x 10-5 (25°, 0.1M NaNO3) as determined by spectrophotometric measurements. The value of β1 is discussed with reference to the corresponding value for salicylic and 5-sulfosalicylic acid. The formation constants of metal complexes of H2A2-, which in general are difficult to determine, can be estimated from the known values for 5-sulfosalicylic acid.

Acta Pharmaceutica Suecica published new progress about 6054-98-4. 6054-98-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H8N2Na2O6, Recommanded Product: Sodium 5,5′-(diazene-1,2-diyl)bis(2-hydroxybenzoate).

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

McKay, G.; Blair, H. S.; Gardner, J. published the artcile< The adsorption of dyes in chitin. III. Intraparticle diffusion processes>, Application of C14H8N2Na2O6, the main research area is intraparticle diffusion dye adsorption chitin.

Intraparticle diffusion processes for the adsorption of dyes, i.e. C.I. Acid Blue 25  [6408-78-2], C.I. Acid Blue 158  [6370-08-7], C.I. Mordant Yellow 5  [6054-98-4], and C.I. Direct Red 84  [6409-83-2], onto chitin (I) [1398-61-4] were studied. Intraparticle diffusion rate, defined as the slope of the plot of the amount of dye adsorbed per g I vs. square root of time (t), was determined for a number of process variables, including initial dye concentration, agitation, I particle size and mass, temperature, and solution pH. Intraparticle diffusion was rate controlling for the adsorption process; initially the plots of dye adsorbed against t were nonlinear, indicating that boundary layer resistance is predominant; however, after this relatively short period, the plots became linear and were valid for up to several h depending on dye-I system, and the different gradients observed indicated that the internal pore size of I particles offers resistance to dye adsorption.

Journal of Applied Polymer Science published new progress about Adsorption. 6054-98-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H8N2Na2O6, Application of C14H8N2Na2O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts