Category: 6054-98-4

Tang, Yun-Zhi; Tan, Yu-Hui; Chen, Shao-Hu; Chao, Yan-Wen; Wang, Ping published the artcile< Synthesis, characterization and crystal structures of two alkaline-earth metal complexes of olsalazine>, Reference of 6054-98-4, the main research area is olsalazine magnesium calcium aqua polymer complex preparation structure; crystal structure magnesium calcium olsalazine aqua polymer complex.

Two one-dimensional linear coordination polymers, [Mg(L)·4(H2O)] (1, H2L = olsalazine) and [Ca(L)·4(H2O)] (2) were obtained from self-assembly of CaCl2 or MgSO4 with olsalazine and their structures determined by single crystal x-ray diffraction. Both complexes are one-dimensional polymers, with crystal data for complex 1: P2(1)/c, a 9.5224(18), b 11.309(2), c 16.211(3) Å, β 106.648(3)°, V 1672.6(6) Å3, Z = 4, space group R1 = 0.0695, wR2 = 0.2183, for complex 2: space group P4(3)2(1)2, a 10.4006(2), b 10.4006(2), c 32.0746(10) Å, V 3469.59(14) Å3, Z = 8, R1 = 0.0332, wR2 = 0.1015. In the complexes, Mg and Ca adopt totally different coordination modes. Alk.-earth Mg has a six-coordinate octahedral geometry, however, in 2, the local coordination geometry around calcium atom can be best described as a slightly distorted pentagonal bipyramid crystallizing in a homo-chiral space group. Olsalazine in both compounds also adopts dissimilar coordination modes.

Journal of Coordination Chemistry published new progress about Crystal structure. 6054-98-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H8N2Na2O6, Reference of 6054-98-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Simpson, W. S. published the artcile< Photoprotection of wool fabrics by dyestuffs>, Application In Synthesis of 6054-98-4, the main research area is photodegradation prevention wool yellow dye; fading dye wool.

Photodegradation of wool fabrics was retarded by yellow dyes, presumably because their absorption spectra extend to the near-UV wavelengths. The effects of >50 dyes on the photodegradation of wool were determined by monitoring tensile strength, work-to-break, and alkali solubility Fading of a great majority of the dyes occurred as rapidly as the wool substrate was degraded. A small number of yellow dyes of the highest lightfastness gave good appearance retention of the fabric and extended its phys. useful by a factor of ≥2.

Wool Research Organisation of New Zealand Communications published new progress about Dyes. 6054-98-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H8N2Na2O6, Application In Synthesis of 6054-98-4.

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Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Sandberg-Gertzen, H.; Kjellander, J.; Sundberg-Gillaa, B.; Jaarnerot, G. published the artcile< In vitro effects of sulphasalazine, azodisal sodium, and their metabolites on Clostridium difficile and some other fecal bacteria>, Quality Control of 6054-98-4, the main research area is Clostridium sulphasalazine azodisal sodium sensitivity; fecal bacteria sulphasalazine azodisal sodium sensitivity.

The effects of sulphasalazine (SASP), azodisal sodium (ADS), and their metabolites were tested in vitro on aerobic and anaerobic fecal bacterial strains. Sulphapyridine (SP) had a mild-to-moderate effect on Escherichia coli and Streptococcus faecalis. SASP also had a growth-inhibitory effect on S. faecalis. The other substances had no effect on aerobic strains. SASP, SP, 5-aminosalicylic acid, and, to a certain extent, N-acetyl-5-aminosalicylic acid exerted a growth-inhibitory effect on anaerobic strains. Of special interest was the inhibitory effect on Clostridium difficile strains. Some studies suggested that SASP treatment could predispose to C. difficile superinfection, whereas others found SASP more probable to exert a prophylactic effect. The findings support the theory that SASP treatment reduces rather than promotes the risk of C. difficile superinfection.

Scandinavian Journal of Gastroenterology published new progress about Clostridium difficile. 6054-98-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H8N2Na2O6, Quality Control of 6054-98-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Eriksson, Alf; Nyholm, Leif published the artcile< Electrochemical detection of disodium 3,3'-azobis-(6-hydroxy-)benzoate (olsalazine sodium)>, Synthetic Route of 6054-98-4, the main research area is olsalazine sodium electrochem detection liquid chromatog; solubility olsalazine sodium electrochem detection LC.

Electrochem. detection of disodium 3,3′-azobis-(6-hydroxy-)benzoate, olsalazine sodium, in reversed phase liquid chromatog. is shown to provide a detection limit of 40 fmol and a linear range extending up to 4 nmol for an injection volume of 20 μL. The method has been used for the determination of the solubility of olsalazine sodium in aqueous solutions The solubility was found to be 2 × 10-8 M and 4 × 10-6 M at pH 1.0 and 3.5, resp.

Electroanalysis published new progress about Reversed phase liquid chromatography. 6054-98-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H8N2Na2O6, Synthetic Route of 6054-98-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ullah, Shafi; Khan, Shafi Ullah; Khan, Abbas; Junaid, Muhammad; Rafiq, Humaira; Htar, Thet Thet; Zhao, Yaxue; Shah, Syed Adnan Ali; Wadood, Abdul published the artcile< Prospect of Anterior Gradient 2 homodimer inhibition via repurposing FDA-approved drugs using structure-based virtual screening>, Related Products of 6054-98-4, the main research area is anterior Gradient homodimer inhibition FDA approved drug structure screening; AGR2 homodimer; Cancer; Dimer inhibitor; Drug repositioning; Virtual screening.

Anterior Gradient 2 (AGR2) has recently been reported as a tumor biomarker in various cancers, i.e., breast, prostate and lung cancer. Predominantly, AGR2 exists as a homodimer via a dimerization domain (E60-K64); after it is self-dimerized, it helps FGF2 and VEGF to homo-dimerize and promotes the angiogenesis and the invasion of vascular endothelial cells and fibroblasts. Up till now, no small mol. has been discovered to inhibit the AGR2-AGR2 homodimer. Therefore, the present study was performed to prepare a validated 3D structure of AGR2 by homol. modeling and discover a small mol. by screening the FDA-approved drugs library on AGR2 homodimer as a target protein. Thirteen different homol. models of AGR2 were generated based on different templates which were narrowed down to 5 quality models sorted by their overall Z-scores. The top homol. model based on PDB ID = 3PH9 was selected having the best Z-score and was further assessed by Verify-3D, ERRAT and RAMPAGE anal. Structure-based virtual screening narrowed down the large library of FDA-approved drugs to ten potential AGR2-AGR2 homodimer inhibitors having FRED score lower than – 7.8 kcal/mol in which the top 5 drugs’ binding stability was counter-validated by mol. dynamic simulation. To sum up, the present study prepared a validated 3D structure of AGR2 and, for the first time reported the discovery of 5 FDA-approved drugs to inhibit AGR2-AGR2 homodimer by using structure-based virtual screening. Moreover, the binding of the top 5 hits with AGR2 was also validated by mol. dynamic simulation. A validated 3D structure of Anterior Gradient 2 (AGR2) was prepared by homol. modeling, which was used in virtual screening of FDA-approved drugs library for the discovery of prospective inhibitors of AGR2-AGR2 homodimer.

Molecular Diversity published new progress about Anterior gradient protein 2 Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 6054-98-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H8N2Na2O6, Related Products of 6054-98-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Tang, Yun-Zhi; Tan, Yu-Hui; Ge, Zong-Tang; Liu, Zhen-Xin; Liao, Chun-Fa; Xie, Xiao-Bin published the artcile< Synthesis and crystal structures of two rare-earth metal polymers of olsalazine>, Safety of Sodium 5,5′-(diazene-1,2-diyl)bis(2-hydroxybenzoate), the main research area is rare earth olsalazine phenanthroline polymer complex preparation structure; europium gadolinium olsalazine phenanthroline polymer complex preparation structure; crystal structure europium gadolinium olsalazine phenanthroline polymer complex.

Two 1-dimensional linear coordination polymers, {[Gd2(L)2·(Phen)2·2(H2O)·2(NO3)]·2(EtOH)}n (1, H2L = olsalazine) and {[Eu2(L)2·(Phen)2·2(H2O)·2(NO3)]·EtOH}n (2), were obtained from self-assembly of Gd(NO3)3·8H2O or Eu(NO3)3·8H2O with olsalazine. Both complexes are 1-dimensional polymers, for 1 with crystal data: space group P1̅, a 11.651(4), b 11.865(4), and c 12.296(4) Å, α 77.984(4), β 65.559(4), and γ 74.558(5)°, Z = 1, R1 = 0.0389, wR2 = 0.0793, and 2 with crystal data: space group P1̅, a 11.626(3), b 11.834(3), c 12.287(4) Å, α 77.743(3), β 65.576(3), γ 74.371(3)°, Z = 1, R1 = 0.0609, wR2 = 0.1185. Central atoms (Gd or Eu) in both complexes adopt nine-coordinate tricapped trigonal prismatic geometry.

Journal of Coordination Chemistry published new progress about Crystal structure. 6054-98-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H8N2Na2O6, Safety of Sodium 5,5′-(diazene-1,2-diyl)bis(2-hydroxybenzoate).

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kishore, M.; VijayaKumar, B.; NarasimhaReddy, Y. published the artcile< Formulation and evaluation of olsalazine sodium enteric coated tablets in ulcerative colitis>, Computed Properties of 6054-98-4, the main research area is olsalazine sodium enteric tablet coating ulcerative colitis.

Aim: To formulate and evaluate the fabricated olsalazine sodium enteric coated tablets in ulcerative colitis and also compare the In-vitro dissolution profile of optimized Olsalazine sodium enteric coated tablets in the presence of β- glycosidase at targeted colonic region. Materials: Olsalazine sodium, obtained as a gift sample from Aurbindo Pharmaceuticals Hyderabad, Telangana, and India. Et cellulose, Chitosan, PVP K30, Magnesium stearate, Lactose, Eudragit S-100, Acetone, Tri-Et citrate was used as a plasticizer etc. All the above polymers and excipients are obtained from S.D Fine Chems., Mumbai. Conclusion: The present study was fabricated to observe the drug release of Olsalazine sodium enteric coated tablets at targeted site specific colon region. These tablets were formulated from F1-F8 by selecting time dependent and release retard biodegrable polymers such as Et cellulose-chitosan composite by combining with different concentrations by wet granulation. This composite was included in this study to control the solubility of premature drug release in gastrointestinal fluid and in this regard, the above formulation F6 was optimized and coated with Eudragit-S 100 as enteric polymer as to retard the drug release at specified site colon by changing suitable concentration as like 1, 3, 5, and7 %. From which F6 containing 5% Eudragit-S 100 was shown only 75.6 % drug release in 24 h and also it was compared with dissolution medium containing β-glycosidase. In which enzymic condition the above formulation enhanced the drug release i.e, 98.3% was found in 24 h. Finally the current study was contributed to evaluated all pre, post compressional parameters of optimized formulation with various release kinetic mechanism such as zero order, first order, higuchi plot and peppas mayer equations studies.

International Journal of Pharmacy and Technology published new progress about Compressibility. 6054-98-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H8N2Na2O6, Computed Properties of 6054-98-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Singer, M. V.; Schmausser, H.; Schoenfeld, G. published the artcile< Efficacy and tolerability of olsalazine (dipentum) in the treatment of patients with ulcerative colitis-results of a field study>, Formula: C14H8N2Na2O6, the main research area is Dipentum ulcerative colitis.

Background/Aims: In the treatment of ulcerative colitis, 5-aminosalicylic acid is the standard therapy for both acute exacerbations of the disease and the maintenance of remission. Clin. studies have shown that olsalazine (Dipentum) – a prodrug converted to two mols. of 5-ASA by colonic bacteria – induces and maintains remission. This study aimed to investigate the efficacy and tolerability of olsalazine in patients with ulcerative colitis who were being treated in daily practice by private physicians specializing in gastroenterol. Methodol.: A total of 260 patients with ulcerative colitis (aged 17-77 years, 116 men) were studied. The doses of olsalazine and the clin. data (including acute disease symptoms and the occurrence of adverse events) were recorded over a 6-mo period. Results: Twenty per cent of patients had pancolitis, 48% had left-sided disease and 32% had proctitis or proctosigmoiditis. At study entry, 86% of patients had active disease; the percentages of these patients in remission after 6 wk and 6 mo were 42% and 91%, resp. Patients with active disease received a mean dose of olsalazine – 2324mg per day initially and 1325mg per day at 6 mo. The corresponding figures for patients in remission at study entry were 1386mg and 1162mg per day, resp. Seventy-three per cent of patients took olsalazine with food, as recommended. The overall rate of adverse events was low; no serious adverse events occurred. Conclusions: Olsalazine therapy resulted in a rapid regression in the acute symptoms of ulcerative colitis. Olsalazine was also effective in maintaining remission. The drug was well tolerated.

Hepato-Gastroenterology published new progress about Gastrointestinal agents. 6054-98-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H8N2Na2O6, Formula: C14H8N2Na2O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Sandberg-Gertzen, H.; Ryde, M.; Jaernerot, G. published the artcile< Absorption and excretion of azodisal sodium and its metabolites in man after rectal administration of a single 2-g dose>, Safety of Sodium 5,5′-(diazene-1,2-diyl)bis(2-hydroxybenzoate), the main research area is azodisal sodium pharmacokinetics.

The behavior of azodisal sodium (ADS)(I) [6054-98-4] and its metabolites after a single 2-g rectal dose was investigated in 10 healthy volunteers. Blood samples were drawn frequently, and urine was collected during intervals of 24 h. The ADS absorption gave a mean peak serum concentration of 2.1 μg/mL. The urinary excretion of ADS was 0.8% of the given dose. After rectal administration, 5-aminosalicylic acid (5-ASA) [89-57-6] could be detected in the serum only in 2 of the subjects, with a mean concentration of <0.5 μg/mL. N-Acetyl-5-aminosalicylic acid  [51-59-2] was present in increasing serum concentrations, being 0.93 μg/mL at 24 h. The mean 24-h urinary excretion of these 2 metabolites was only 2.7% of the given dose. In another study, the azo bond of ADS has been shown to be split by anaerobic and aerobic bacteria. The low absorption of its metabolites indicates that ADS is a suitable mol. for delivering the presumed pharmacol. active moiety, 5-ASA. Scandinavian Journal of Gastroenterology published new progress about Rectum. 6054-98-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H8N2Na2O6, Safety of Sodium 5,5′-(diazene-1,2-diyl)bis(2-hydroxybenzoate).

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Boekman, C. Fredrik; Zettersten, Camilla; Sjoeberg, Per J. R.; Nyholm, Leif published the artcile< A setup for the coupling of a thin-layer electrochemical flow cell to electrospray mass spectrometry>, Name: Sodium 5,5′-(diazene-1,2-diyl)bis(2-hydroxybenzoate), the main research area is thin layer electrochem flow cell electrospray mass spectrometer coupling; Olsalazine hexanethiol electrochem oxidation electrospray mass spectrometry.

A novel setup for the coupling of a com. available thin-layer cell to electrospray mass spectrometry (ESI-MS) which allows the electrochem. reactions at the counter electrode to be straightforwardly separated from the flow into the mass spectrometer was developed. In this way, interferences from reaction products formed at the counter electrode can be minimized. This reduces the risk of changes in the mass spectra as a result of electrochem. reactions in the solution The described setup also enables the working electrode to be positioned close to the electrospray (ESI) emitter without the need for a grounding point or a long transfer line between the electrochem. cell and the electrospray emitter. By decoupling the electrochem. reactions in the flow cell and those in the electrospray emitter, improved facilities for studies of electrochem. reactions were obtained through a better control of the potential of the working electrode. The setup was used to study the oxidation of a drug (Olsalazine), which previously was found to involve chem. follow-up reactions. Also uncharged thiols can be detected in ESI-MS after spontaneous adsorption on a gold working electrode, followed by oxidative desorption to yield sulfinates or sulfonates. This adsorption and potential-controlled desorption was used for the preconcentration of micromolar concentrations of 1-hexanethiol as well as for desalting of solutions containing micromolar concentrations of thiols. The present online coupling of an electrochem. cell to ESI-MS provides promising possibilities for sample preconcentration, matrix exchange (including desalting), and ionization of neutral compounds, such as thiols.

Analytical Chemistry published new progress about Electrochemical oxidation. 6054-98-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H8N2Na2O6, Name: Sodium 5,5′-(diazene-1,2-diyl)bis(2-hydroxybenzoate).

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts