Category: 6054-98-4

Witman, Matthew; Ling, Sanliang; Anderson, Samantha; Tong, Lianheng; Stylianou, Kyriakos C.; Slater, Ben; Smit, Berend; Haranczyk, Maciej published the artcile< In silico design and screening of hypothetical MOF-74 analogs and their experimental synthesis>, Name: Sodium 5,5′-(diazene-1,2-diyl)bis(2-hydroxybenzoate), the main research area is MOF 74 olsalazine sodium in silico Monte Carlo simulation.

In this work we present the in silico design of metal-organic frameworks (MOFs) exhibiting 1-dimensional rod topologies. We introduce an algorithm for construction of this family of MOF topologies, and illustrate its application for enumerating MOF-74-type analogs. Furthermore, we perform a broad search for new linkers that satisfy the topol. requirements of MOF-74 and consider the largest database of known chem. space for organic compounds, the PubChem database. Our in silico crystal assembly, when combined with dispersion-corrected d. functional theory (DFT) calculations, is demonstrated to generate a hypothetical library of open-metal site containing MOF-74 analogs in the 1-D rod topol. from which we can simulate the adsorption behavior of CO2. We finally conclude that these hypothetical structures have synthesizable potential through computational identification and exptl. validation of a novel MOF-74 analog, Mg2(olsalazine).

Chemical Science published new progress about Adsorption. 6054-98-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H8N2Na2O6, Name: Sodium 5,5′-(diazene-1,2-diyl)bis(2-hydroxybenzoate).

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Jelicic, Mario-Livio; Brusac, Edvin; Klaric, Daniela Amidzic; Nigovic, Biljana; Turk, Niksa; Mornar, Ana published the artcile< A chromatographic approach to development of 5-aminosalicylate/folic acid fixed-dose combinations for treatment of Crohn's disease and ulcerative colitis>, Quality Control of 6054-98-4, the main research area is chromatog aminosalicylate folic acid treatment Crohn disease ulcerative colitis.

Medication adherence is an important factor in inflammatory bowel disease therapy, which includes regular supplementation of malabsorbed vitamins. Absorption of folic acid is limited due to the damaging of the gastrointestinal tract, which can increase the chances to develop megaloblastic anemia and colorectal cancer. In this work, 5-aminosalicylates (mesalazine, balsalazide, sulfasalazine and olsalazine) and folic acid were characterized regarding their pharmacokinetic related properties (hydrophobicity, phospholipid and plasma protein binding) using the biomimetic chromatog. approach. Despite the high binding percentage of 5-aminosalicylates for human serum albumin (> 61.44%), results have shown that folic acid binding to human serum albumin protein is far greater (69.40%) compared to alpha 1-acid-glycoprotein (3.45%). Frontal anal. and zonal elution studies were conducted to provide an insight into the binding of folic acid to human serum albumin and potential competition with 5-aminosalicylates. The anal. method for the simultaneous determination of assay in proposed fixed-dose combinations was developed and validated according to ICH Q2 (R1) and FDA method validation guidelines. Separation of all compounds was achieved within 16 min with satisfactory resolution (Rs > 3.67) using the XBridge Ph column (150 x 4.6 mm, 3.5μm). High linearity (r > 0.9997) and precision (RSD < 2.29%) was obtained, while all recoveries were within the regulatory defined range by British (100.0 ± 5.0%) and USP (100.0 ± 10.0%). Scientific Reports published new progress about Absorption. 6054-98-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H8N2Na2O6, Quality Control of 6054-98-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Alderborn, G.; Lang, P. O.; Sagstrom, A.; Kristensen, A. published the artcile< Compression characteristics of granulated materials. I. Fragmentation propensity and compactibility of some granulations of a high dosage drug>, Safety of Sodium 5,5′-(diazene-1,2-diyl)bis(2-hydroxybenzoate), the main research area is granule compactibility fragmentation ethanol binder; azobishydroxybenzoate granule tablet property.

Three granulations of a fairly water-soluble high-dosage drug, di-Na 3,3′-azobis(6-hydroxybenzoate), were produced by intensive mixing with poly(vinylpyrrolidone), and dissolved in 3 liquids with different amounts of EtOH and water, as binder. The granulations were mixed with dry binders or with a lubricant and granulations and mixtures were compressed at 30 MPa and the tablet strength was measured. The tablet strength increased with increasing amount of EtOH in the binder solution The increase and decrease in tablet strength due to the addition of dry binder and lubricant, resp., were also dependent on the amount of EtOH in the binder solution and indicated that the degree of fragmentation varied between the granulations. Heckel plots and tablet surface area-compaction pressure profiles confirmed the finding that the degree of fragmentation of the granules increased with increasing amount of EtOH in the binding solution A good correlation between fragmentation propensity of the granulations and tensile strength of the tablets was found.

International Journal of Pharmaceutics published new progress about Pharmaceutical granules. 6054-98-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H8N2Na2O6, Safety of Sodium 5,5′-(diazene-1,2-diyl)bis(2-hydroxybenzoate).

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Maines, Lynn W.; Fitzpatrick, Leo R.; French, Kevin J.; Zhuang, Yan; Xia, Zuping; Keller, Staci N.; Upson, John J.; Smith, Charles D. published the artcile< Suppression of Ulcerative Colitis in Mice by Orally Available Inhibitors of Sphingosine Kinase>, Computed Properties of 6054-98-4, the main research area is sphingosine kinase ABC294640 ABC747080 ulcerative colitis anticolitis antiinflammatory signaling.

A critical step in the mechanism of action of inflammatory cytokines is the stimulation of sphingolipid metabolism, including activation of sphingosine kinase (SK), which produces the mitogenic and proinflammatory lipid sphingosine 1-phosphate (S1P). We have developed orally bioavailable compounds that effectively inhibit SK activity in vitro in intact cells and in cancer models in vivo. In this study, we assessed the effects of these SK inhibitors on cellular responses to tumor necrosis factor alpha (TNFα) and evaluated their efficacy in the dextran sulfate sodium (DSS) model of ulcerative colitis in mice. Using several cell systems, it was shown that the SK inhibitors block the ability of TNFα to activate nuclear factor kappa B (NFκB), induce expression of adhesion proteins, and promote production of prostaglandin E2 (PGE2). In an acute model of DSS-induced ulcerative colitis, SK inhibitors were equivalent to or more effective than Dipentum in reducing disease progression, colon shortening, and neutrophil infiltration into the colon. The effects of SK inhibitors were associated with decreased colonic levels of inflammatory cytokines TNFα, interleukin (IL)-1β, interferon gamma (IFN)-γ, IL-6, and reduction of S1P levels. A similar reduction in disease progression was provided by SK inhibitors in a chronic model of ulcerative colitis in which the mice received 3-wk-long cycles of DSS interspaced with week-long recovery periods. In the chronic model, immunohistochem. for SK showed increased expression in DSS-treated mice (compared with water-treated controls) that was reduced by drug treatment. S1P levels were also elevated in the DSS group and significantly reduced by drug treatment. Together, these data indicate that SK is a critical component in inflammation and that inhibitors of this enzyme may be useful in treating inflammatory bowel diseases.

Digestive Diseases and Sciences published new progress about Anti-inflammatory agents. 6054-98-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H8N2Na2O6, Computed Properties of 6054-98-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Bernstein, Charles N.; Nugent, Zoann; Blanchard, James F. published the artcile< 5-Aminosalicylate Is Not Chemoprophylactic for Colorectal Cancer in IBD: A Population Based Study>, Recommanded Product: Sodium 5,5′-(diazene-1,2-diyl)bis(2-hydroxybenzoate), the main research area is Asacol chemopreventive agent prophylaxis colorectal cancer inflammatory bowel disease.

OBJECTIVES: We aimed to determine if use of 5-aminosalicylates (5-ASA) was associated with a reduced risk of colorectal cancer (CRC) in people with inflammatory bowel disease (IBD). METHODS: We used the population-based University of Manitoba IBD Epidemiol. Database that tracks all health-care visits from 1984 to 2008 of all Manitobans with IBD and all prescription medication use since 1995. In 2008, there were 8,744 subjects with IBD (ulcerative colitis 4,325, Crohn’s disease 4,419, females 4,851, males 3,893). In study I, we assessed the incidence of CRC among 5-ASA users (≥1 yr, ≥5 years of cumulative use) compared with nonusers. In study II, we assessed a cohort of those with CRC (n=101) diagnosed in 1995-2008, matched to a control cohort by age, sex, disease duration, and disease diagnosis without CRC (n=303), and logistic anal. was undertaken. RESULTS: For study I, the hazard ratio for CRC among 5-ASA users was 1.04 (95% confidence interval (CI) 0.67-1.62, P=0.87) at ≥1 yr of use and 2.01 (95% CI 1.04-3.9, P=0.038) at ≥5 years of use with no difference when assessing by diagnosis. Males, but not females, using 5-ASA for ≥5 years had an increased risk of CRC. In study II, CRC cases had similar use of any 5-ASA compared with controls for ≥1 yr of use (1.02, 95% CI 0.60-1.74) or ≥5 years (1.96, 95% CI 0.84-4.55), and a similar mean number of 5-ASA prescriptions at 10 vs. 11 (P=0.8) and a similar mean number of dose days at 330 vs. 410 (P=0.69). CONCLUSIONS: Our results support the majority of studies to date that 5-ASA is not chemoprophylactic in IBD for CRC. Am J Gastroenterol 2011; 106:731-736; doi:10.1038/ajg.2011.50; published online 15 March 2011.

American Journal of Gastroenterology published new progress about Colorectal neoplasm. 6054-98-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H8N2Na2O6, Recommanded Product: Sodium 5,5′-(diazene-1,2-diyl)bis(2-hydroxybenzoate).

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

McKay, Gordon published the artcile< Mass transport processes for the adsorption of dyes onto chitin>, HPLC of Formula: 6054-98-4, the main research area is dye adsorption chitin.

The adsorption of 4 dyestuffs onto chitin was studied. A model was developed to explain the mass transport of dyestuffs onto chitin. The 2-resistance mass transfer model is based on external film mass transfer and pore diffusion. Two solutions are presented: the first is a rapid anal. model which may be applied to adsorption systems in which the operating lines and tie lines terminate on the monolayer of the isotherm, assumed pseudo-irreversible; the second is a model which can be applied for any operating conditions but necessitates differentiation of the exptl. concentration decay curve.

Chemical Engineering and Processing published new progress about Adsorption. 6054-98-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H8N2Na2O6, HPLC of Formula: 6054-98-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Irvine, Jennifer D.; Takahashi, Lori; Lockhart, Karen; Cheong, Jonathan; Tolan, John W.; Selick, H. E.; Grove, J. Russell published the artcile< MDCK (Madin-Darby canine kidney) cells: a tool for membrane permeability screening>, Safety of Sodium 5,5′-(diazene-1,2-diyl)bis(2-hydroxybenzoate), the main research area is membrane permeability drug screening MDCK Caco2; high throughput screening MDCK Caco2 drug bioavailability; assay membrane permeability screening drug pharmacokinetics.

The goal of this work was to investigate the use of MDCK (Madin-Darby canine kidney) cells as a possible tool for assessing the membrane permeability properties of early drug discovery compounds Apparent permeability (Papp) values of 55 compounds with known human absorption values were determined using MDCK cell monolayers. For comparison, Papp values of the same compounds were also determined using Caco-2 cells, a well-characterized in vitro model of intestinal drug absorption. Monolayers were grown on 0.4-μm Transwell-COL membrane culture inserts. MDCK cells were seeded at high d. and cultured for 3 days, and Caco-2 cells were cultured under standard conditions for 21 to 25 days. Compounds were tested using 100 μM donor solutions in transport medium (pH 7.4) containing 1% DMSO. The Papp values in MDCK cells correlated well with those in Caco-2 cells (r2 = 0.79). Spearman’s rank correlation coefficient for MDCK Papp and human absorption was 0.58 compared with 0.54 for Caco-2 Papp and human absorption. These results indicate that MDCK cells may be a useful tool for rapid membrane permeability screening.

Journal of Pharmaceutical Sciences published new progress about Analysis. 6054-98-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H8N2Na2O6, Safety of Sodium 5,5′-(diazene-1,2-diyl)bis(2-hydroxybenzoate).

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Eriksson, Alf; Nyholm, Leif published the artcile< A comparison of the electrochemical properties of some azosalicylic acids at glassy carbon electrodes by cyclic and hydrodynamic voltammetry>, Product Details of C14H8N2Na2O6, the main research area is azo salicylic acid glassy carbon electrode cyclic hydrodynamic voltammetry; electrochem reduction azo salicylic acid glassy carbon electrode 21345678; oxidation electrochem azo salicylic acid glassy carbon electrode 21345678.

The electrochem. properties of a number of azosalicylic acid derivatives were compared at glassy carbon electrodes using cyclic and hydrodynamic voltammetry. The reduction of all studied compounds, except one, is irreversible giving rise to disruption of the azo bridge and formation of the corresponding amines. The rate of cleavage of the azo bridge depended on the position of the hydroxy substituents on the aromatic rings of the azosalicylic compounds A reoxidation wave, most likely due to the oxidation of a hydrazo intermediate, was observed for compounds with either only one hydroxyl group, or hydroxyl groups in the meta-para or meta-meta positions relative to the azo bridge. The oxidation of the azosalicylic compounds with no, or only one, hydroxy group in the para position was generally found to be irreversible yielding poorly defined oxidation waves. Azosalicylic acids with two hydroxy groups, either in the para position of both rings or in the ortho position of one ring and para position of the other, gave rise to well defined oxidation peaks at significantly less pos. potentials. For the compounds with the hydroxyl groups in the para position of both rings, reredn. waves were also seen on the return scan, indicating that the oxidation products were stable on the voltammetric time scale.

Electrochimica Acta published new progress about Amines Role: FMU (Formation, Unclassified), PRP (Properties), FORM (Formation, Nonpreparative). 6054-98-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H8N2Na2O6, Product Details of C14H8N2Na2O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Uslu, B.; Yilmaz, S.; Ozkan, S. A. published the artcile< Determination of olsalazine sodium in pharmaceuticals by differential pulse voltammetry>, Application of C14H8N2Na2O6, the main research area is olsalazine sodium determination pharmaceutical voltammetry.

The electrochem. oxidation of olsalazine Na was studied by cyclic, linear sweep, differential pulse and square wave voltammetry using glassy C disk electrode in different buffer systems. Best results were obtained for the determination of olsalazine using the differential pulse voltammetric technique in phosphate buffer at pH 7.0. The electroactive species exhibits a diffusion-controlled voltammetric wave and its differential pulse peak current shows a linear dependence on olsalazine concentration in the range between 2 × 10-6 M and 2 × 10-4 M. This relation was applied to the determination of olsalazine in com. capsule dosage forms. The recovery study shows good accuracy and precision for the assay developed. A UV spectrophotometric assay is also reported for comparison.

Pharmazie published new progress about Differential pulse voltammetry. 6054-98-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H8N2Na2O6, Application of C14H8N2Na2O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

McKay, G.; Blair, H. S.; Gardner, J. G.; McConvey, I. F. published the artcile< Two-resistance mass transfer model for the adsorption of various dyestuffs onto chitin>, Name: Sodium 5,5′-(diazene-1,2-diyl)bis(2-hydroxybenzoate), the main research area is dye adsorption chitin wastewater; mass transfer model chitin dye.

The kinetics of the adsorption of various dyes onto chitin (I) [1398-61-4] were studied. The dyes used are Neoland Blue 2G (II) [6370-08-7], Eriochrome Flavin A (III) [6054-98-4], and Solophenyl Brown 3RL (IV) [6409-83-2] and a number of process variables were considered, such as adsorbent mass and dye concentration The mass transfer model is based on the assumption of a pseudoirreversible isotherm and 2 resistances to mass transfer. These are external mass transfer and internal pore diffusion mass transfer. The rate of adsorption of dyes onto I can be described by an external mass transfer coefficient and a pore diffusion coefficient The external mass transfer coefficients are 5.0 × 10-5, 5.0 × 10-5, and 1.0 × 10-5 m/s and the pore diffusivities are 3.0 × 10-10 and 4.0 × 10-11 m2/s for II, III, and IV, resp.

Journal of Applied Polymer Science published new progress about Adsorptive wastewater treatment. 6054-98-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H8N2Na2O6, Name: Sodium 5,5′-(diazene-1,2-diyl)bis(2-hydroxybenzoate).

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts