Category: 60463-12-9

Photoactivation of Ligands for Extrinsically and Intrinsically Triggered Disassembly of Amphiphilic Nanoassemblies was written by Gao, Jingjing;Liu, Xiaochi;Secinti, Hatice;Jiang, Ziwen;Munkhbat, Oyuntuya;Xu, Yisheng;Guo, Xuhong;Thayumanavan, S.. And the article was included in Chemistry – A European Journal in 2018.HPLC of Formula: 60463-12-9 This article mentions the following:

Specific response to the concurrent presence of two different inputs is one of the hallmarks of incorporating specificities in nature. Artificial nanoassemblies that concurrently respond to two very different inputs are of great interest in a variety of applications, especially in biomedicine. Here, we present a design strategy for amphiphilic nanoassemblies with such capabilities, enabled by photocaging a ligand moiety that is capable of binding to a specific protein. New mol. designs that offer nanoassemblies that respond to either of two inputs or only to the concurrent presence of two inputs are outlined. Such biomimetic nanoassemblies could find use in many applications, including drug delivery and diagnostics. In the experiment, the researchers used many compounds, for example, 3-(Hydroxymethyl)-4-nitrophenol (cas: 60463-12-9HPLC of Formula: 60463-12-9).

3-(Hydroxymethyl)-4-nitrophenol (cas: 60463-12-9) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.HPLC of Formula: 60463-12-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthesis, Characterization, and Application in HeLa Cells of an NIR Light Responsive Doxorubicin Delivery System Based on NaYF₄:Yb,Tm@SiO₂-PEG Nanoparticles was written by Alonso-Cristobal, Paulino;Oton-Fernandez, Olalla;Mendez-Gonzalez, Diego;Diaz, J. Fernando;Lopez-Cabarcos, Enrique;Barasoain, Isabel;Rubio-Retama, Jorge. And the article was included in ACS Applied Materials & Interfaces in 2015.Synthetic Route of C7H7NO4 This article mentions the following:

Herein, we present a phototriggered drug delivery system based on light responsive nanoparticles, which is able to release doxorubicin upon NIR light illumination. The proposed system is based on upconversion fluorescence nanoparticles of β-NaYF₄:Yb,Tm@SiO₂-PEG with a mean diameter of 52 ± 2.5 nm that absorb the NIR light and emit UV light. The UV radiation causes the degradation of photodegradable ortho-nitrobenzyl alc. derivates, which are attached on one side to the surface of the nanoparticles and on the other to doxorubicin. This degradation triggers the doxorubicin release. This drug delivery system has been tested “in vitro” with HeLa cells. The results of this study demonstrated that this system caused negligible cytotoxicity when they were not illuminated with NIR light. In contrast, under NIR light illumination, the HeLa cell viability was conspicuously reduced. These results demonstrated the suitability of the proposed system to control the release of doxorubicin via an external NIR light stimulus. In the experiment, the researchers used many compounds, for example, 3-(Hydroxymethyl)-4-nitrophenol (cas: 60463-12-9Synthetic Route of C7H7NO4).

3-(Hydroxymethyl)-4-nitrophenol (cas: 60463-12-9) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Synthetic Route of C7H7NO4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Photocleavage of Covalently Immobilized Amphiphilic Block Copolymer: From Bilayer to Monolayer was written by Gungor, Eda;Armani, Andrea M.. And the article was included in Macromolecules (Washington, DC, United States) in 2016.Reference of 60463-12-9 This article mentions the following:

We developed and verified a method to create a photocleavable smart surface. Using the grafting to approach, we covalently attached an intelligently designed tailor-made diblock copolymer to a silicon wafer. The photocleavable moiety, o-nitrobenzyl (ONB) ester, was integrated into the copolymer at the junction point between the hydrophilic poly(ethylene oxide) (PEO) and the hydrophobic polystyrene (PS) chains. The well-defined azide bearing amphiphilic block copolymer was synthesized via a general stepwise strategy that combines atom transfer radical polymerization (ATRP) and copper(I)-catalyzed azide-alkyne cycloaddition reaction (CuAAC), ending with azidation. The azide end-functionalized copolymer chains were covalently bound to the alkyne-immobilized silicon wafer by CuAAC. The smart surface was exposed to UV irradiation, resulting in photocleavage of the grafted ONB linker. As a result of the photocleavage and subsequent removal of the o-nitrosobenzaldehyde bearing PEO, the PS layer remained on the surface. To confirm the behavior, film thickness and wettability changes were investigated before and after UV irradiation using AFM and contact angle measurements. Integration of photocleavable polymers through covalent grafting to solid surfaces contributes responsiveness to such materials that can find a wide array of applications in advanced devices. In the experiment, the researchers used many compounds, for example, 3-(Hydroxymethyl)-4-nitrophenol (cas: 60463-12-9Reference of 60463-12-9).

3-(Hydroxymethyl)-4-nitrophenol (cas: 60463-12-9) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Reference of 60463-12-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

A possible novel link between organophosphorus and DDT insecticide resistance genes in Anopheles: supporting evidence from fenitrothion metabolism studies was written by Hemingway, J.;Miyamoto, J.;Herath, P. R. J.. And the article was included in Pesticide Biochemistry and Physiology in 1991.COA of Formula: C7H7NO4 This article mentions the following:

Fenitrothion metabolism studies on a multiple organophosphorus resistant strain of A. subpictus from Sri Lanka indicated that oxidases and glutathione S-transferases play a major role in the detoxication of this insecticide. The oxidases, as well as producing detoxication products, also produce two highly active acetylcholinesterase inhibitors, fenitrooxon and 3-hydroxymethyl fenitrooxon. Further metabolism studies on fenitrooxon indicated that the glutathione S-transferases in A. subpictus were able to detoxify these activation products. DDT resistance in the field population of A. subpictus has increased since 1983, although there has been no direct DDT selection pressure during this period. DDT resistance in this species is due to an increase in DDT dehydrochlorination which is correlated with an increase in glutathione S-transferase activity. It is possible that the same enzyme is responsible for both DDT and secondary organophosphate (fenitrothion) metabolism If so, organophosphorus insecticide selection pressure will actively maintain, or select for, DDT resistance in this population. Linkage disequilibrium between the oxidase and glutathione S-transferase-based resistance genes would be expected if the same glutathione S-transferase fulfils both functions, and this is now being investigated in the field population in Sri Lanka. In the experiment, the researchers used many compounds, for example, 3-(Hydroxymethyl)-4-nitrophenol (cas: 60463-12-9COA of Formula: C7H7NO4).

3-(Hydroxymethyl)-4-nitrophenol (cas: 60463-12-9) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.COA of Formula: C7H7NO4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthesis of N-protected serine ethers as precursors of new photoactivatable amino acids cleavable by hydrogenolysis was written by Dugave, Christophe;Kessler, Pascal;Colas, Christophe;Hirth, Christian. And the article was included in Tetrahedron Letters in 1994.Name: 3-(Hydroxymethyl)-4-nitrophenol This article mentions the following:

Protected serine amino(hydroxy)benzyl ethers I (Boc = Me₃CO₂C, Fmoc = 9-fluorenylmethoxycarbonyl, MEM = 2-methoxyethoxymethyl) were synthesized. Spectral characteristics of the corresponding photoactivatable 4-diazocyclohexa-2,5-dienones II were determined In the experiment, the researchers used many compounds, for example, 3-(Hydroxymethyl)-4-nitrophenol (cas: 60463-12-9Name: 3-(Hydroxymethyl)-4-nitrophenol).

3-(Hydroxymethyl)-4-nitrophenol (cas: 60463-12-9) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Name: 3-(Hydroxymethyl)-4-nitrophenol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Flexible UV Exposure Sensor Based on UV Responsive Polymer was written by Lee, Michele E.;Armani, Andrea M.. And the article was included in ACS Sensors in 2016.Recommanded Product: 3-(Hydroxymethyl)-4-nitrophenol This article mentions the following:

One critical challenge facing society is balancing the pos. and neg. effects of UV exposure. While UV exposure contributes to Vitamin D production, in excess, UV exposure is linked to skin cancer. Therefore, methods to monitor UV exposure and help society achieve this delicate balance have been the focus of numerous research efforts. Here, we leverage advances in functional materials to create a wearable UV light sensor. The flexible, lightweight trilayer sensor, which is composed of a UV responsive polymer layer sandwiched between two transparent protective layers made from FDA-approved polymers, changes color from transparent to yellow upon UV exposure. Notably, the entire trilayer system is less than 250mm thick, allowing it to maintain mech. flexibility. The UV responsive material leverages the photocleavable ortho-nitrobenzyl (ONB) moiety. Because a singular ONB cleaving group is centrally located along the polymer backbone, the colorimetric response is very controlled. Using an AM1.5 solar simulator, the sensor’s linear working range is demonstrated to cover the medically relevant range of 15 min to 1 h. Addnl., we determine the sensor’s robustness to potential environmental and mech. stress as well as long-term storage. After mech. bending and water immersion, the performance is unchanged. Storage in ambient conditions also does not degrade the behavior. When combined with sunscreen, the sensor’s response is predictably decreased due to the attenuation of the UV light. This flexible colorimetric sensor based on a smart polymer system can greatly aid society in achieving a balance in sufficient UV exposure. In the experiment, the researchers used many compounds, for example, 3-(Hydroxymethyl)-4-nitrophenol (cas: 60463-12-9Recommanded Product: 3-(Hydroxymethyl)-4-nitrophenol).

3-(Hydroxymethyl)-4-nitrophenol (cas: 60463-12-9) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Recommanded Product: 3-(Hydroxymethyl)-4-nitrophenol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Traceless Photolabile Linker Expedites the Chemical Synthesis of Complex Oligosaccharides by Automated Glycan Assembly was written by Le Mai Hoang, Kim;Pardo-Vargas, Alonso;Zhu, Yuntao;Yu, Yang;Loria, Mirco;Delbianco, Martina;Seeberger, Peter H.. And the article was included in Journal of the American Chemical Society in 2019.Electric Literature of C7H7NO4 This article mentions the following:

Automated glycan assembly (AGA) aims at accelerating access to synthetic oligosaccharides to meet the demand for defined glycans as tools for mol. glycobiol. The linkers used to connect the growing glycan chain to the solid support play a pivotal role for the synthetic strategy as they determine all chem. conditions used during the synthesis and the form of the glycan obtained at the end of it. Here, we describe a traceless photolabile linker to prepare carbohydrates with a free reducing end. Modification of the o-nitrobenzyl scaffold of the linker is key to high yields and compatibility with the AGA work-flow. The assembly of an asym. bi-antennary N-glycan from oligosaccharide fragments prepared by AGA and linear as well as branched β-oligoglucans are described to illustrate the power of the method. These substrates will serve as standards and biomarkers to examine the unique specificity of glycosyl hydrolases. In the experiment, the researchers used many compounds, for example, 3-(Hydroxymethyl)-4-nitrophenol (cas: 60463-12-9Electric Literature of C7H7NO4).

3-(Hydroxymethyl)-4-nitrophenol (cas: 60463-12-9) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Electric Literature of C7H7NO4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Nonprotein Based Enrichment Method to Analyze Peptide Cross-Linking in Protein Complexes was written by Yan, Funing;Che, Fa-Yun;Rykunov, Dmitry;Nieves, Edward;Fiser, Andras;Weiss, Louis M.;Hogue Angeletti, Ruth. And the article was included in Analytical Chemistry (Washington, DC, United States) in 2009.Computed Properties of C7H7NO4 This article mentions the following:

Crosslinking anal. of protein complexes and structures by tandem mass spectrometry (MS/MS) has advantages in speed, sensitivity, specificity, and the capability of handling complicated protein assemblies. However, detection and accurate assignment of the cross-linked peptides are often challenging due to their low abundance and complicated fragmentation behavior in collision-induced dissociation (CID). To simplify the MS anal. and improve the signal-to-noise ratio of the cross-linked peptides, the authors developed a novel peptide enrichment strategy that utilizes a cross-linker with a cryptic thiol group and using beads modified with a photocleavable cross-linker. The functional cross-linkers were designed to react with the primary amino groups in proteins. Human serum albumin was used as a model protein to detect intra- and intermol. cross-linkages. Use of this protein-free selective retrieval method eliminates the contamination that can result from avidin-biotin based retrieval systems and simplifies data anal. These features may make the method suitable to investigate protein-protein interactions in biol. samples. In the experiment, the researchers used many compounds, for example, 3-(Hydroxymethyl)-4-nitrophenol (cas: 60463-12-9Computed Properties of C7H7NO4).

3-(Hydroxymethyl)-4-nitrophenol (cas: 60463-12-9) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Computed Properties of C7H7NO4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts