Category: 59960-32-6

2-Arylpropionic CXC Chemokine Receptor 1 (CXCR1) Ligands as Novel Noncompetitive CXCL8 Inhibitors was written by Allegretti, Marcello;Bertini, Riccardo;Cesta, Maria Candida;Bizzarri, Cinzia;Di Bitondo, Rosa;Di Cioccio, Vito;Galliera, Emanuela;Berdini, Valerio;Topai, Alessandra;Zampella, Giuseppe;Russo, Vincenzo;Di Bello, Nicoletta;Nano, Giuseppe;Nicolini, Luca;Locati, Massimo;Fantucci, Piercarlo;Florio, Saverio;Colotta, Francesco. And the article was included in Journal of Medicinal Chemistry in 2005.Formula: C16H16O3 This article mentions the following:

The CXC chemokine CXCL8/IL-8 plays a major role in the activation and recruitment of polymorphonuclear (PMN) cells at inflammatory sites. CXCL8 activates PMNs by binding the seven-transmembrane (7-TM) G-protein-coupled receptors CXC chemokine receptor 1 (CXCR1) and CXC chemokine receptor 2 (CXCR2). (R)-Ketoprofen (1) was previously reported to be a potent and specific noncompetitive inhibitor of CXCL8-induced human PMNs chemotaxis. The authors report here mol. modeling studies showing a putative interaction site of 1 in the TM region of CXCR1. The binding model was confirmed by alanine scanning mutagenesis and photoaffinity labeling experiments The mol. model driven medicinal chem. optimization of 1 led to a new class of potent and specific inhibitors of CXCL8 biol. activity. Among these, repertaxin was selected as a clin. candidate drug for prevention of postischemia reperfusion injury. In the experiment, the researchers used many compounds, for example, 2-(3-(Hydroxy(phenyl)methyl)phenyl)propanoic acid (cas: 59960-32-6Formula: C16H16O3).

2-(3-(Hydroxy(phenyl)methyl)phenyl)propanoic acid (cas: 59960-32-6) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Formula: C16H16O3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

2-Arylpropionic CXC Chemokine Receptor 1 (CXCR1) Ligands as Novel Noncompetitive CXCL8 Inhibitors was written by Allegretti, Marcello;Bertini, Riccardo;Cesta, Maria Candida;Bizzarri, Cinzia;Di Bitondo, Rosa;Di Cioccio, Vito;Galliera, Emanuela;Berdini, Valerio;Topai, Alessandra;Zampella, Giuseppe;Russo, Vincenzo;Di Bello, Nicoletta;Nano, Giuseppe;Nicolini, Luca;Locati, Massimo;Fantucci, Piercarlo;Florio, Saverio;Colotta, Francesco. And the article was included in Journal of Medicinal Chemistry in 2005.Formula: C16H16O3 This article mentions the following:

The CXC chemokine CXCL8/IL-8 plays a major role in the activation and recruitment of polymorphonuclear (PMN) cells at inflammatory sites. CXCL8 activates PMNs by binding the seven-transmembrane (7-TM) G-protein-coupled receptors CXC chemokine receptor 1 (CXCR1) and CXC chemokine receptor 2 (CXCR2). (R)-Ketoprofen (1) was previously reported to be a potent and specific noncompetitive inhibitor of CXCL8-induced human PMNs chemotaxis. The authors report here mol. modeling studies showing a putative interaction site of 1 in the TM region of CXCR1. The binding model was confirmed by alanine scanning mutagenesis and photoaffinity labeling experiments The mol. model driven medicinal chem. optimization of 1 led to a new class of potent and specific inhibitors of CXCL8 biol. activity. Among these, repertaxin was selected as a clin. candidate drug for prevention of postischemia reperfusion injury. In the experiment, the researchers used many compounds, for example, 2-(3-(Hydroxy(phenyl)methyl)phenyl)propanoic acid (cas: 59960-32-6Formula: C16H16O3).

2-(3-(Hydroxy(phenyl)methyl)phenyl)propanoic acid (cas: 59960-32-6) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Formula: C16H16O3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Controlling Chemoselectivity of Catalytic Hydroboration with Light was written by Bergamaschi, Enrico;Lunic, Danijela;McLean, Liam A.;Hohenadel, Melissa;Chen, Yi-Kai;Teskey, Christopher J.. And the article was included in Angewandte Chemie, International Edition in 2022.Product Details of 59960-32-6 This article mentions the following:

The ability to selectively react one functional group in the presence of another underpins efficient reaction sequences. Despite many designer catalytic systems being reported for hydroboration reactions, which allow introduction of a functional handle for cross-coupling or act as mild method for reducing polar functionality, these platforms rarely deal with more complex systems where multiple potentially reactive sites exist. Here authors demonstrate, for the first time, the ability to use light to distinguish between ketones and carboxylic acids in more complex mols. By taking advantage of different activation modes, a single catalytic system can be used for hydroboration, with the chemoselectivity dictated only by the presence or absence of visible light. In the experiment, the researchers used many compounds, for example, 2-(3-(Hydroxy(phenyl)methyl)phenyl)propanoic acid (cas: 59960-32-6Product Details of 59960-32-6).

2-(3-(Hydroxy(phenyl)methyl)phenyl)propanoic acid (cas: 59960-32-6) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Product Details of 59960-32-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The novel ketoprofen amides – synthesis and biological evaluation as antioxidants, lipoxygenase inhibitors and cytostatic agents was written by Rajic, Zrinka;Hadjipavlou-Litina, Dimitra;Pontiki, Eleni;Kralj, Marijeta;Suman, Lidija;Zorc, Branka. And the article was included in Chemical Biology & Drug Design in 2010.Application of 59960-32-6 This article mentions the following:

The novel amides of ketoprofen and its reduced derivatives (5a-f, 4a-n, 6a-g) with aromatic and cycloalkyl amines or hydroxylamines were prepared and screened for their reducing and cytostatic activity as well as for their ability to inhibit soybean lipoxygenase and lipid peroxidation 1,1-Diphenyl-picrylhydrazyl test for reducing ability revealed that ketoprofen amides were more potent antioxidants than the amides of the reduced ketoprofen derivatives The most active compound was benzhydryl ketoprofen amide 5f. Lipoxygenase inhibition of the tested compounds varied from strong to very weak. The most potent compound was benzhydryl derivative 6f (IC₅₀ = 20.5 μM). Aromatic and cycloalkyl amides 4 and 5 were more potent lipoxygenase inhibitors than derivatives with carboxylic group. Aromatic amides of series 4 and 5 showed excellent lipid peroxidation inhibition (92.2-99.9%). On the other hand, the most pronounced cytostatic activity was exerted by O-benzyl derivative 4i, although in general all tested reduced and non-reduced lipophilic derivatives showed similar activity. In the experiment, the researchers used many compounds, for example, 2-(3-(Hydroxy(phenyl)methyl)phenyl)propanoic acid (cas: 59960-32-6Application of 59960-32-6).

2-(3-(Hydroxy(phenyl)methyl)phenyl)propanoic acid (cas: 59960-32-6) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Application of 59960-32-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

White-rot fungus-mediated degradation of the analgesic ketoprofen and identification of intermediates by HPLC-DAD-MS and NMR was written by Marco-Urrea, Ernest;Perez-Trujillo, Miriam;Cruz-Morato, Carles;Caminal, Gloria;Vicent, Teresa. And the article was included in Chemosphere in 2010.Synthetic Route of C16H16O3 This article mentions the following:

Ketoprofen is a nonsteroidal anti-inflammatory drug that has been detected in the environment in the range of ng L^-1-μg L^-1 due to its low degradability in some wastewater treatment plants. In this study, the use of the white-rot fungus Trametes versicolor to effectively degrade ketoprofen in a defined liquid medium was assessed. The fungus eliminated ketoprofen to nondetectable levels in 24 h when it was added at 10 mg L^-1 whereas at low concentration of 40 μg L^-1 it was almost completely removed (95%) after 5 h. Low extracellular laccase activity was detected in the T. versicolor cultures but the addition of the laccase-mediator system did not lead to ketoprofen oxidation The cytochrome P 450 inhibitor 1-aminobenzotriazole reduced ketoprofen oxidation These data suggest that the first oxidation step is cytochrome P 450 mediated. During time-course degradation experiments, three intermediates were structurally elucidated and quantified by HPLC-DAD-MS and NMR: 2-[3-(4-hydroxybenzoyl)phenyl]-propanoic acid, 2-[(3-hydroxy(phenyl)methyl)phenyl]-propanoic acid, and 2-(3-benzoyl-4-hydroxyphenyl)-propanoic acid. The latter was reported for the first time in biol. systems. After 7 d of incubation, only small amounts of 2-[(3-hydroxy(phenyl)methyl)phenyl]-propanoic acid (0.08 mg) remained in the liquid medium in comparison with the initial ketoprofen dose (1.0 mg), suggesting possible mineralization of ketoprofen. In the experiment, the researchers used many compounds, for example, 2-(3-(Hydroxy(phenyl)methyl)phenyl)propanoic acid (cas: 59960-32-6Synthetic Route of C16H16O3).

2-(3-(Hydroxy(phenyl)methyl)phenyl)propanoic acid (cas: 59960-32-6) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Synthetic Route of C16H16O3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts