Category: 599-64-4

Tang, Xiaowen;Luo, Xiang;Su, Qiong;Wei, Gaofei;Meng, Shan-Shui;Chan, Albert S. C. published 《Chemoselective dual functionalization of phenols via relay catalysis of borane with different forms》 in 2021. The article was appeared in 《CCS Chemistry》. They have made some progress in their research.Application In Synthesis of 4-(2-Phenylpropan-2-yl)phenol The article mentions the following:

A highly efficient and chemoselective dual functionalization of unprotected phenols with α- or β- hydroxyl acids was presented. A variety of valuable benzofuranones and dihydrocoumarins were delivered in moderate to high yields. D. functional theory (DFT) calculations and control experiments indicated that an untypical Friedel-Crafts alkylation and the subsequent lactonization were catalyzed by the Lewis acid form and the Bronsted acid form of borane, resp. Gram-scale experiments and late-stage functionalization of complex mols. were performed to highlight the utility of this reaction. And 4-(2-Phenylpropan-2-yl)phenol (cas: 599-64-4) was used in the research process.

4-(2-Phenylpropan-2-yl)phenol(cas:599-64-4) is a natural product found in Panax ginseng.Application In Synthesis of 4-(2-Phenylpropan-2-yl)phenol 4-(2-Phenylpropan-2-yl)phenol is a useful reagent for preparing and characterizing aromatic polyphosphonates as high refractive index polymers.

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Liu, Xufang;Rong, Xianle;Liu, Shihan;Lan, Yu;Liu, Qiang published 《Cobalt-Catalyzed Desymmetric Isomerization of Exocyclic Olefins》. The research results were published in《Journal of the American Chemical Society》 in 2021.COA of Formula: C15H16O The article conveys some information:

Chiral cyclic olefins, 1-methylcyclohexenes, are versatile building blocks for the synthesis of pharmaceuticals and natural products. Despite the prevalence of these structural motifs, the development of efficient synthetic methods remains an unmet challenge. Herein the authors report a novel desym. isomerization of exocyclic olefins using a series of newly designed chiral cobalt catalysts, which enables a straightforward construction of chiral 1-methylcyclohexenes with diversified functionalities. The synthetic utility of this methodol. is highlighted by a concise and enantioselective synthesis of a natural product, β-bisabolene. The versatility of the reaction products is further demonstrated by multifarious derivatization. To complete the study, the researchers used 4-(2-Phenylpropan-2-yl)phenol (cas: 599-64-4) .

4-(2-Phenylpropan-2-yl)phenol(cas:599-64-4) is a natural product found in Panax ginseng.COA of Formula: C15H16O 4-(2-Phenylpropan-2-yl)phenol is a useful reagent for preparing and characterizing aromatic polyphosphonates as high refractive index polymers.

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Tan, Haoyue;Chen, Qinchang;Hong, Huixiao;Benfenati, Emilio;Gini, Giuseppina C.;Zhang, Xiaowei;Yu, Hongxia;Shi, Wei published 《Structures of Endocrine-Disrupting Chemicals Correlate with the Activation of 12 Classic Nuclear Receptors》. The research results were published in《Environmental Science & Technology》 in 2021.Quality Control of 4-(2-Phenylpropan-2-yl)phenol The article conveys some information:

Endocrine-disrupting chems. (EDCs) can inadvertently interact with 12 classic nuclear receptors (NRs) that disrupt the endocrine system and cause adverse effects. There is no widely accepted understanding about what structural features make thousands of EDCs able to activate different NRs as well as how these structural features exert their functions and induce different outcomes at the cellular level. This paper applies the hierarchical characteristic fragment methodol. and high-throughput screening mol. docking to comprehensively explore the structural and functional features of EDCs for the 12 NRs based on more than 7000 chems. from curated datasets. EDCs share three levels of key fragments. The primary and secondary fragments are associated with the binding of EDCs to four groups of receptors: steroidal nuclear receptors (SNRs, including androgen, estrogen, glucocorticoid, mineralocorticoid, and progesterone), retinoic acid receptors, thyroid hormone receptors, and vitamin D receptors. The tertiary fragments determine the activity type by interacting with two key locations in the ligand-binding domains of NRs (N-H5-H3-C and N-H7-H11-C for SNRs and N-H5-H5′-H2′-H3-C and N-H6′-H11-C for non-SNRs). The resulting compiled structural fragments of EDCs together with elucidated compound NR binding modes provide a framework for understanding the interactions between EDCs and NRs, facilitating faster and more accurate screening of EDCs for multiple NRs in the future. The experimental procedure involved many compounds, such as 4-(2-Phenylpropan-2-yl)phenol (cas: 599-64-4) .

4-(2-Phenylpropan-2-yl)phenol(cas:599-64-4) is a natural product found in Panax ginseng.Quality Control of 4-(2-Phenylpropan-2-yl)phenol 4-(2-Phenylpropan-2-yl)phenol is a useful reagent for preparing and characterizing aromatic polyphosphonates as high refractive index polymers.

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Jia, Jialin;Liu, Dongmei;Wang, Songxue;Li, Huarui;Ni, Jiaxin;Li, Xiaobo;Tian, Jiayu;Wang, Qiao published 《Visible-light-induced activation of peroxymonosulfate by TiO₂ nano-tubes arrays for enhanced degradation of bisphenol A》. The research results were published in《Separation and Purification Technology》 in 2020.Reference of 4-(2-Phenylpropan-2-yl)phenol The article conveys some information:

TiO₂ photocatalysis and peroxymonosulfate (PMS) oxidation can exhibit a good performance in UV light but a less activity in visible light (VL). Herein, the TiO₂ nano-tubes arrays (TiO₂NTAs) and PMS were combined to degrade bisphenol A (BPA) under VL irradiation Surprisingly, about 94.6% of BPA was removed in TiO₂NTAs/PMS/VL system within 30 min, which was much higher than that of TiO₂NTAs/VL (20.1%) and PMS/VL (9.4%) systems. A series of spectroscopic characterizations and photoelectrochem. measurements confirmed the formation of PMS-TiO₂ complex with VL response, which can be excited by VL to transfer electrons to the conduction band (CB) of TiO₂ for activating PMS. The quenching tests and ESR (ESR) spectra indicated that SO^·-₄ and ·OH were responsible for BPA degradation, and then the possible degradation pathways of BPA were proposed. Humic acid (HA) and chloride ions (Cl^–) significantly enhanced the BPA degradation, while bicarbonate (HCO^–₃) and phosphate (H₂PO^–₄) exhibited an inhibition effect. Moreover, TiO₂NTAs/PMS/VL system displayed an enhanced BPA degradation in tap water and drinking water compared with deionized water, and as an immobilization catalyst which fabricated on Ti plate, TiO₂NTAs exhibited excellent stability and separability without complex catalyst separation/recovery processes. We believe this work will provide a new insight of the VL-induced photocatalytic PMS activation in practical water treatment. The experimental procedure involved many compounds, such as 4-(2-Phenylpropan-2-yl)phenol (cas: 599-64-4) .

4-(2-Phenylpropan-2-yl)phenol(cas:599-64-4) is a natural product found in Panax ginseng.Reference of 4-(2-Phenylpropan-2-yl)phenol 4-(2-Phenylpropan-2-yl)phenol is a useful reagent for preparing and characterizing aromatic polyphosphonates as high refractive index polymers.

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Duijndam, Britt;Goudriaan, Annabel;van den Hoorn, Tineke;van der Stel, Wanda;Le Devedec, Sylvia;Bouwman, Peter;van der Laan, Jan Willem;van de Water, Bob published 《Physiologically relevant estrogen receptor alpha pathway reporters for single-cell imaging-based carcinogenic hazard assessment of estrogenic compounds》 in 2021. The article was appeared in 《Toxicological Sciences》. They have made some progress in their research.Name: 4-(2-Phenylpropan-2-yl)phenol The article mentions the following:

Estrogen receptor alpha (ERα) belongs to the nuclear hormone receptor family of ligand-inducible transcription factors and regulates gene networks in biol. processes such as cell growth and proliferation. Disruption of these networks by chem. compounds with estrogenic activity can result in adverse outcomes such as unscheduled cell proliferation, ultimately culminating in tumor formation. To distinguish disruptive activation from normal physiol. responses, it is essential to quantify relationships between different key events leading to a particular adverse outcome. For this purpose, we established fluorescent protein MCF7 reporter cell lines for ERα-induced proliferation by bacterial artificial chromosome-based tagging of 3 ERα target genes: GREB1, PGR, and TFF1. These target genes are inducible by the non-genotoxic carcinogen and ERα agonist 17β-estradiol in an ERα-dependent manner and are essential for ERα-dependent cell-cycle progression and proliferation. The 3 GFP reporter cell lines were characterized in detail and showed different activation dynamics upon exposure to 17β-estradiol. In addition, they demonstrated specific activation in response to other established reference estrogenic compounds of different potencies, with similar sensitivities as validated OECD test methods. This study shows that these fluorescent reporter cell lines can be used to monitor the spatial and temporal dynamics of ERα pathway activation at the single-cell level for more mechanistic insight, thereby allowing a detailed assessment of the potential carcinogenic activity of estrogenic compounds in humans. To complete the study, the researchers used 4-(2-Phenylpropan-2-yl)phenol (cas: 599-64-4) .

4-(2-Phenylpropan-2-yl)phenol(cas:599-64-4) is a natural product found in Panax ginseng.Name: 4-(2-Phenylpropan-2-yl)phenol 4-(2-Phenylpropan-2-yl)phenol is a useful reagent for preparing and characterizing aromatic polyphosphonates as high refractive index polymers.

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Related Products of 599-64-4《Teaching an Old Poly(arylene ether) New Tricks: Efficient Blue Thermally Activated Delayed Fluorescence》 was published in 2019. The authors were Liu, Xinrui;Rao, Jiancheng;Li, Xuefei;Wang, Shumeng;Ding, Junqiao;Wang, Lixiang, and the article was included in《iScience》. The author mentioned the following in the article:

Polymer light-emitting diodes are attractive for optoelectronic applications owing to their brightness and ease of processing. However, often metals have to be inserted to increase the luminescence efficiency, and producing blue emitters is a challenge. Here we present a strategy to make blue thermally activated delayed fluorescence (TADF) polymers by directly embedding a small mol. blue TADF emitter into a poly(aryl ether) (PAE) backbone. Thanks to the oxygen-induced negligible electronic communication between neighboring TADF fragments, its corresponding blue delayed fluorescence can be inherited by the developed polymers. These polymers are free from metal catalyst contamination and show improved thermal stability. Through device optimization, a current efficiency of 29.7 cd/A (21.2 lm/W, 13.2%) is realized together with Commission Internationale de L′Eclairage coordinates of (0.18, 0.32). The value is competitive with blue phosphorescent polymers, highlighting the importance of the PAE backbone in achieving high-performance blue delayed fluorescence at a macromol. level. And 4-(2-Phenylpropan-2-yl)phenol (cas: 599-64-4) was used in the research process.

4-(2-Phenylpropan-2-yl)phenol(cas:599-64-4) is a natural product found in Panax ginseng.Related Products of 599-64-4 4-(2-Phenylpropan-2-yl)phenol is a useful reagent for preparing and characterizing aromatic polyphosphonates as high refractive index polymers.

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Kodama, Susumu;Yoshii, Nao;Ota, Akihiro;Takeshita, Jun-ichi;Yoshinari, Kouichi;Ono, Atsushi published 《Association between in vitro nuclear receptor-activating profiles of chemical compounds and their in vivo hepatotoxicity in rats》 in 2021. The article was appeared in 《Journal of Toxicological Sciences》. They have made some progress in their research.Product Details of 599-64-4 The article mentions the following:

The liver plays critical roles to maintain homeostasis of living organisms and is also a major target organ of chem. toxicity. Meanwhile, nuclear receptors (NRs) are known to regulate major liver functions and also as a critical target for hepatotoxic compounds In this study, we established mammalian one-hybrid assay systems for five rat-derived NRs, namely PXR, PPARα, LXRα, FXR and RXRα, and evaluated a total of 326 compounds for their NR-activating profiles. Then, we assessed the association between their NR-activating profile and hepatotoxic endpoints in repeated-dose toxicity data of male rats from Hazard Evaluation Support System. In the in vitro cell-based assays, 68, 38, 20, 17 and 17 compounds were identified as positives for PXR, PPARα, LXRα, FXR and RXRα, resp. The association analyses demonstrated that the PXR-pos. compounds showed high frequency of endpoints related to liver hypertrophy, such as centrilobular hepatocellular hypertrophy, suggesting that PXR activation is involved in chem.-induced liver hypertrophy in rats. It is intriguing to note that the PXR-pos. compounds also showed statistically significant associations with both prolonged activated partial thromboplastin time and prolonged prothrombin time, suggesting a possible involvement of PXR in the regulation of blood clotting factors. Collectively, our approach may be useful for discovering new functions of NRs as well as understanding the complex mechanism for hepatotoxicity caused by chem. compounds4-(2-Phenylpropan-2-yl)phenol (cas: 599-64-4) were involved in the experimental procedure.

4-(2-Phenylpropan-2-yl)phenol(cas:599-64-4) is a natural product found in Panax ginseng.Product Details of 599-64-4 4-(2-Phenylpropan-2-yl)phenol is a useful reagent for preparing and characterizing aromatic polyphosphonates as high refractive index polymers.

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Related Products of 599-64-4《Microscopic mechanism about the selective adsorption of Cr(VI) from salt solution on O-rich and N-rich biochars》 was published in 2021. The authors were Zhao, Nan;Zhao, Chuanfang;Tsang, Daniel C. W.;Liu, Kunyuan;Zhu, Ling;Zhang, Weihua;Zhang, Jing;Tang, Yetao;Qiu, Rongliang, and the article was included in《Journal of Hazardous Materials》. The author mentioned the following in the article:

The adsorption of Cr(VI) on biochars can be suppressed by coexisting anions, but the roles of O-containing functional groups and in particular N-containing functional groups are unclear. In this study, we combined spectroscopic and mol. simulation approaches to investigate the selective adsorption of Cr(VI) on the O-rich (PB, UB1) and N-rich (UB3, UB5) biochars under strong competition of anions. The elemental anal. and pyrolysis-gas chromatog./mass spectrometry indicated that the structures of PB and UB1 were similar, and so were the UB3 and UB5. Quantification of functional groups showed that for UB1, 75.3% of Cr(VI) removal was attributed to O-containing groups, while 53.3-72.7% of that was mediated by N-containing groups in UB3 and UB5. X-ray photoelectron spectra and d. functional theory calculations confirmed that for O-rich biochars, surface complexation and strong H-bonds between carboxyl/hydroxyl and HCrO-4 improved Cr(VI) removal in the presence of anions, while for N-rich biochars, Cr(VI) adsorption was depressed by coexisting anions in the order of Cl->NO-3 >SO2-4 because of the weaker H-bond between protonated amino groups and HCrO-4. This study presents a novel approach for quant., mol.-level evaluation of the roles of biochar functional groups in the Cr(VI) removal from complex environmental systems. To complete the study, the researchers used 4-(2-Phenylpropan-2-yl)phenol (cas: 599-64-4) .

4-(2-Phenylpropan-2-yl)phenol(cas:599-64-4) is a natural product found in Panax ginseng.Related Products of 599-64-4 4-(2-Phenylpropan-2-yl)phenol is a useful reagent for preparing and characterizing aromatic polyphosphonates as high refractive index polymers.

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Rose, Levi D.;Akob, Denise M.;Tuberty, Shea R.;Corsi, Steven R.;DeCicco, Laura A.;Colby, Jeffrey D.;Martin, Derek J. published 《Use of high-throughput screening results to prioritize chemicals for potential adverse biological effects within a West Virginia watershed》 in 2019. The article was appeared in 《Science of the Total Environment》. They have made some progress in their research.Formula: C15H16O The article mentions the following:

Organic chems. from industrial, agricultural, and residential activities can enter surface waters through regulated and unregulated discharges, combined sewer overflows, stormwater runoff, accidental spills, and leaking septic-conveyance systems on a daily basis. The impact of point and nonpoint contaminant sources can result in adverse biol. effects for organisms living in or near surface waters. Assessing the adverse or toxic effects that may result when exposure occurs is complicated by the fact that many commonly used chems. lack toxicity information or water quality standards To address these challenges, an exposure-activity ratio (EAR) screening approach was used to prioritize environmental chem. data in a West Virginia watershed (Wolf Creek). Wolf Creek is a drinking water source and recreation resource with documented water quality impacts from point and nonpoint sources. The EAR screening approach uses high-throughput screening (HTS) data from ToxCast as a method of integrating environmental chem. occurrence and biol. effects data. Using water quality schedule 4433, which targets 69 organic waste compounds typically found in domestic and industrial wastewater, chems. were screened for potential adverse biol. affects at multiple sites in the Wolf Creek watershed. Cumulative EAR mixture values were greatest at Sites 2 and 3, where bisphenol A (BPA) and pentachlorophenol exhibited maximum EAR values of 0.05 and 0.002, resp. Site 2 is downstream of an unconventional oil and gas (UOG) wastewater disposal facility with documented water quality impacts. Low-level organic contaminants were found at all sample sites in Wolf Creek, except Site 10, where Wolf Creek enters the New River. The application of an EAR screening approach allowed our study to extend beyond traditional environmental monitoring methods to identify multiple sites and chems. that warrant further investigation. The experimental procedure involved many compounds, such as 4-(2-Phenylpropan-2-yl)phenol (cas: 599-64-4) .

4-(2-Phenylpropan-2-yl)phenol(cas:599-64-4) is a natural product found in Panax ginseng.Formula: C15H16O 4-(2-Phenylpropan-2-yl)phenol is a useful reagent for preparing and characterizing aromatic polyphosphonates as high refractive index polymers.

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HPLC of Formula: 599-64-4《Palladium-Catalyzed Perfluoroalkylative Carbonylation of Unactivated Alkenes: Access to β-Perfluoroalkyl Esters》 was published in 2021. The authors were Zhang, Youcan;Geng, Hui-Qing;Wu, Xiao-Feng, and the article was included in《Angewandte Chemie, International Edition》. The author mentioned the following in the article:

Transition-metal-catalyzed multi-component carbonylation represents an efficient strategy for the preparation of various functionalized carbonyl-containing compounds Herein, authors report a general palladium-catalyzed perfluoroalkylative carbonylation of unactivated alkenes using inexpensive and readily available carbon monoxide as the C1 source and perfluoroalkyl halides as the coupling partner. A wide range of phenols and alcs. were transformed into the corresponding β-perfluoroalkyl esters in high yields with broad functional group tolerance and good chemoselectivity. Addnl., alkyl halides can be utilized as alkoxy source as well to give the desired esters. Moreover, several pharmaceutical and bio-active mols. were also suitable substrates for this one-pot multi-component carbonylation process to give the targeted products in good yields. The experimental procedure involved many compounds, such as 4-(2-Phenylpropan-2-yl)phenol (cas: 599-64-4) .

4-(2-Phenylpropan-2-yl)phenol(cas:599-64-4) is a natural product found in Panax ginseng.HPLC of Formula: 599-64-4 4-(2-Phenylpropan-2-yl)phenol is a useful reagent for preparing and characterizing aromatic polyphosphonates as high refractive index polymers.

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