Category: 597-52-4

Yasin Tabatabaei Dakhili, S. published the artcileRecombinant silicateins as model biocatalysts in organosiloxane chemistry, Category: alcohols-buliding-blocks, the publication is Proceedings of the National Academy of Sciences of the United States of America (2017), 114(27), E5285-E5291, database is CAplus and MEDLINE.

The family of silicatein enzymes from marine sponges (phylum Porifera) is unique in nature for catalyzing the formation of inorganic silica structures, which the organisms incorporate into their skeleton. However, the synthesis of organosiloxanes catalyzed by these enzymes has thus far remained largely unexplored. To investigate the reactivity of these enzymes in relation to this important class of compounds, their catalysis of Si-O bond hydrolysis and condensation was investigated with a range of model organosilanols and silyl ethers. The enzymes’ kinetic parameters were obtained by a high-throughput colorimetric assay based on the hydrolysis of 4-nitrophenyl silyl ethers. These assays showed unambiguous catalysis with k_cat/K_m values on the order of 2-50 min^-1 μM^-1. Condensation reactions were also demonstrated by the generation of silyl ethers from their corresponding silanols and alcs. Notably, when presented with a substrate bearing both aliphatic and aromatic hydroxy groups the enzyme preferentially silylates the latter group, in clear contrast to nonenzymic silylations. Furthermore, the silicateins are able to catalyze transetherifications, where the silyl group from one silyl ether may be transferred to a recipient alc. Despite close sequence homol. to the protease cathepsin L, the silicateins seem to exhibit no significant protease or esterase activity when tested against analogous substrates. Overall, these results suggest the silicateins are promising candidates for future elaboration into efficient and selective biocatalysts for organosiloxane chem.

Proceedings of the National Academy of Sciences of the United States of America published new progress about 597-52-4. 597-52-4 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is Triethylsilanol, and the molecular formula is C4H6N2, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ibba, Francesco published the artcilePhotoinduced Multicomponent Synthesis of α-Silyloxy Acrylamides, an Unexplored Class of Silyl Enol Ethers, Recommanded Product: Triethylsilanol, the publication is Organic Letters (2018), 20(4), 1098-1101, database is CAplus and MEDLINE.

The photoinduced, multicomponent reaction of α-diazoketones, silanols, and isocyanides affords α-silyloxy acrylamides, formally derived from α-keto amides. The presence of a secondary amido group makes classic preparative methods for silyl enol ethers unfeasible in this case, while the mild conditions required by this photochem. approach allow their synthesis in good yields; moreover, the general structure can be easily modified by varying each component of the multicomponent reaction. Fine-tuning of the reaction conditions (i.e., solvents, radiation, additives) can be exploited to obtain complete Z selectivity. The reactivity of this overlooked class of silyl enol ethers has been investigated, and features that could pave the way to new applications have been found.

Organic Letters published new progress about 597-52-4. 597-52-4 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is Triethylsilanol, and the molecular formula is C6H16OSi, Recommanded Product: Triethylsilanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Bergamaschi, Enrico published the artcileStereoselective Synthesis of 3,5-Dihydroxypyrrolidin-2-ones Through a Photoinduced Multicomponent Reaction Followed by Dimerization, Application In Synthesis of 597-52-4, the publication is European Journal of Organic Chemistry (2019), 2019(34), 5992-5997, database is CAplus.

A photoinduced reaction between diazoketones, isocyanides and silanols, followed by aldol dimerization of the resulting multicomponent adduct, affords polyfunctionalized 3,5-dihydroxypyrrolidin-2-one heterocycles in a straightforward manner. Six new bonds and two quaternary carbons are formed in just two steps with this complexity-generating methodol. A high degree of stereoselectivity is also observed, as a result of the mild conditions employed. Moreover, the 3,5-dihydroxypyrrolidin-2-one scaffold can be found in two families of biol. relevant natural products, namely anchinopeptolides and eusynstyelamides. The synthetic approach herein described appears to be a very convenient route for the preparation of their analogs.

European Journal of Organic Chemistry published new progress about 597-52-4. 597-52-4 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is Triethylsilanol, and the molecular formula is C6H16OSi, Application In Synthesis of 597-52-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Baehr, Susanne published the artcileSelective Enzymatic Oxidation of Silanes to Silanols, Quality Control of 597-52-4, the publication is Angewandte Chemie, International Edition (2020), 59(36), 15507-15511, database is CAplus and MEDLINE.

Compared to the biol. world’s rich chem. for functionalizing carbon, enzymic transformations of the heavier homolog silicon are rare. We report that a wild-type cytochrome P 450 monooxygenase (P 450_BM3 from Bacillus megaterium, CYP102A1) has promiscuous activity for oxidation of hydrosilanes to give silanols. Directed evolution was applied to enhance this non-native activity and create a highly efficient catalyst for selective silane oxidation under mild conditions with oxygen as the terminal oxidant. The evolved enzyme leaves C-H bonds present in the silane substrates untouched, and this biotransformation does not lead to disiloxane formation, a common problem in silanol syntheses. Computational studies reveal that catalysis proceeds through hydrogen atom abstraction followed by radical rebound, as observed in the native C-H hydroxylation mechanism of the P 450 enzyme. This enzymic silane oxidation extends nature’s impressive catalytic repertoire.

Angewandte Chemie, International Edition published new progress about 597-52-4. 597-52-4 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is Triethylsilanol, and the molecular formula is C6H16OSi, Quality Control of 597-52-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Rahal, Mahmoud published the artcileRapid estimation of vibrational zero-point energies of silicon compounds, Recommanded Product: Triethylsilanol, the publication is Computational & Theoretical Chemistry (2013), 182-187, database is CAplus.

In this paper, we extended the application of our empirical formula for the calculation of vibrational zero-point energies (ZPEs) to silicon compounds The bond contribution of Si-C, Si-H, Si-O, Si-Cl and Si-Si were determined The results obtained for more than 90 chem. systems containing these bonds are in good agreement with the exptl. available values. The estimated zero-point energies were compared with the results obtained by application of the extended empirical formula of Schulmann and Disch and with the scaled values obtained using the semi-empirical method (AM1) and the DFT method (B3LYP/6-31G^*), in all cases with satisfactory results.

Computational & Theoretical Chemistry published new progress about 597-52-4. 597-52-4 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is Triethylsilanol, and the molecular formula is C6H16OSi, Recommanded Product: Triethylsilanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Lin, Jian-Dong published the artcileWettability-Driven Palladium Catalysis for Enhanced Dehydrogenative Coupling of Organosilanes, Quality Control of 597-52-4, the publication is ACS Catalysis (2017), 7(3), 1720-1727, database is CAplus.

Direct coupling of Si-H bonds has emerged as a promising strategy for designing chem. and biol. useful organosilicon compounds Heterogeneous catalytic systems sufficiently active, selective, and durable for dehydrosilylation reactions under mild conditions have been lacking to date. Herein, we report that the hydrophobic characteristics of the underlying supports can be advantageously utilized to enhance the efficiency of palladium nanoparticles (Pd NPs) for the dehydrogenative coupling of organosilanes. As a result of this prominent surface wettability control, the modulated catalyst showed a significantly higher level of efficiency and durability characteristics toward the dehydrogenative condensation of organosilanes with water, alcs., or amines in comparison to existing catalysts. In a broader context, this work illustrates a powerful approach to maximize the performance of supported metals through surface wettability modulation under catalytically relevant conditions.

ACS Catalysis published new progress about 597-52-4. 597-52-4 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is Triethylsilanol, and the molecular formula is C6H16OSi, Quality Control of 597-52-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Gitis, Vitaly published the artcileOrganosilane oxidation by water catalysed by large gold nanoparticles in a membrane reactor, Recommanded Product: Triethylsilanol, the publication is Catalysis Science & Technology (2014), 4(7), 2156-2160, database is CAplus.

We show that gold nanoparticles catalyze the oxidation of organosilanes using water as oxidant at ambient conditions. Remarkably, monodispersions of small gold particles (3.5 nm diameter) and large ones (6-18 nm diameter) give equally good conversion rates. This is important because separating large nanoparticles is much easier, and can be done using ultrafiltration instead of nanofiltration. We introduce a simple setup, constructed inhouse, where the reaction products are extracted through a ceramic membrane under pressure, leaving the gold nanoparticles intact in the vessel. The nominal substrate/catalyst ratios are ca. 1800 : 1, with typical TONs of 1500-1600, and TOFs around 800 h^-1. But the actual activity of the large nanoparticles is much higher, because most of their gold atoms are “inside”, and therefore unavailable. Control experiments confirm that no gold escapes to the membrane permeate. The role of surface oxygen as a possible co-catalyst is discussed. Considering the ease of product separation and the robustness of the ceramic membrane, this approach opens opportunities for actual applications of gold catalysts in water oxidation reactions.

Catalysis Science & Technology published new progress about 597-52-4. 597-52-4 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is Triethylsilanol, and the molecular formula is C6H16OSi, Recommanded Product: Triethylsilanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts