Category: 596-38-3

Taljaard, Benjamin published the artcileSynthesis of hydrogen peroxide: acid-catalysed decomposition of 9-hydroperoxy-9-phenylxanthene and its derivatives, Related Products of alcohols-buliding-blocks, the publication is South African Journal of Chemistry (1987), 40(2), 139-45, database is CAplus.

9-Aryl-9-hydroperoxyxanthenes and the corresponding dixanthenyl peroxides were decomposed with various acids under different conditions. Excess strong acid is required for optimum xanthenyl cation and hydrogen peroxide production Inductive effects of the aryl p-substituents in the 9-aryl-9-hydroperoxyxanthenes influence the course of the reaction. Treatment of the hydroperoxides with acetic acid gives the corresponding dialkyl peroxides. Increased conjugation was investigated, with 14-aryl-14-hydroperoxydibenzo[a,j]xanthenes, and has been shown to inhibit carbocation and hydrogen peroxide formation.

South African Journal of Chemistry published new progress about 596-38-3. 596-38-3 belongs to alcohols-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Benzene,Alcohol, name is 9-Phenyl-9H-xanthen-9-ol, and the molecular formula is C4H10OS, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Glover, Stephen A. published the artcileStable hydroperoxide synthesis, Synthetic Route of 596-38-3, the publication is South African Journal of Chemistry (1984), 37(4), 164-70, database is CAplus.

The photooxidation of 9-phenylxanthene to its 9-hydroperoxy derivative was shown to be ketone-sensitized and sensitive to the wavelength of the irradiation Highest yields are obtained from irradiation at wavelengths > 310 nm. Prolonged irradiation produces bis(9-phenylxanthen-9-yl) peroxide. 5-Phenyltribenzo[a,c,e]cycloheptene could not be converted into peroxidic products, and dioxolanes produced labile peroxides under irradiation

South African Journal of Chemistry published new progress about 596-38-3. 596-38-3 belongs to alcohols-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Benzene,Alcohol, name is 9-Phenyl-9H-xanthen-9-ol, and the molecular formula is C19H14O2, Synthetic Route of 596-38-3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Giri, Rajan published the artcileSynthesis and cancer cell cytotoxicity of substituted xanthenes, Category: alcohols-buliding-blocks, the publication is Bioorganic & Medicinal Chemistry (2010), 18(4), 1456-1463, database is CAplus and MEDLINE.

A series of substituted xanthenes was synthesized and screened for activity using DU-145, MCF-7, and HeLa cancer cell growth inhibition assays. The most potent compound, 9g (I) ([N,N-diethyl]-9-hydroxy-9-(3-methoxyphenyl)-9H-xanthene-3-carboxamide), was found to inhibit cancer cell growth with IC₅₀ values ranging from 36 to 50 μM across all three cancer cell lines. Structure-activity relationship (SAR) data is presented that indicates addnl. gains in potency may be realized through further derivatization of the compounds (e.g., the incorporation of a 7-fluoro substituent to 9g). Results are also presented that suggest the compounds function through a unique mechanism of action as compared to that of related acridine and xanthone anticancer agents (which have been shown to intercalate into DNA and inhibit topoisomerase II activity). A structural comparison of these compounds suggests the differences in function may be due to the structure of the xanthene heterocycle which adopts a nonplanar conformation about the pyran ring.

Bioorganic & Medicinal Chemistry published new progress about 596-38-3. 596-38-3 belongs to alcohols-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Benzene,Alcohol, name is 9-Phenyl-9H-xanthen-9-ol, and the molecular formula is C19H14O2, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ginzburg, O. F. published the artcileProducts of condensation of arylcarbinols with 1-phenyl-3-methyl-5-pyrazolone. III, Product Details of C19H14O2, the publication is Zhurnal Obshchei Khimii (1957), 993-7, database is CAplus.

cf. C.A. 49, 1049a. Refluxing 0.3 g. 1-phenyl-3-methyl-5-pyrazolone and 0.4 g. 9-phenylxanthhydrol in dry MeOH 2 hrs. gave 95.8% 9-phenyl-9-(1-phenyl-3-methyl-4,5-dihydro-5-oxo-4-pyrazolyl)xanthene (I), m. 220-1°; also formed in AcOH solution The product can be dissolved in aqueous alc. NaOH, refluxed, and regenerated on acidification; it is also recovered readily after being refluxed in AcOH containing a little HCl. I (0.43 g.) in 10 ml. 60% EtOH containing 1 g. NaOH was treated with 0.001 mole diazosulfanilic acid and the resulting precipitate separated; the filtrate contained the azo dye from sulfanilic acid and the pyrazolone as shown by the absorption spectrum, while the precipitate was 9-phenylxanthhydrol, m. 159°. 1-Phenyl-3-methyl-4-triphenylmethyl-5-pyrazolone treated similarly gave the same azo compound in solution and a precipitate of Ph₃COH. Similar results were obtained with 1-phenyl-3-methyl-4-(9-phenyl-10-methyl-9,10-dihydro-9-acridyl)-5-pyrazolone (II), diphenyl-p-dimethylaminophenyl(1-phenyl-3-methyl-4,5-dihydro-5-oxo-4-pyrazolyl)methane, and bis(p-dimethylaminophenyl)phenyl(1-phenyl-3-methyl-4,5-dihydro-5-oxo-4-pyrazolyl)methane (III), all of which yielded the same azo compound in the solution Conductivity of II and III was determined in PhNO₂ over a period of time; a constant value is established only after 24 hrs. The results indicate that the increasing conductivity of such solutions is caused by cleavage between the 4-position of the pyrazolone and the arylcarbinyl group with formation of expected ionic charges. The process is unusually slow.

Zhurnal Obshchei Khimii published new progress about 596-38-3. 596-38-3 belongs to alcohols-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Benzene,Alcohol, name is 9-Phenyl-9H-xanthen-9-ol, and the molecular formula is C19H14O2, Product Details of C19H14O2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Cozens, F. L. published the artcileSpontaneous carbocation generation on clays, Safety of 9-Phenyl-9H-xanthen-9-ol, the publication is Langmuir (1993), 9(3), 874-6, database is CAplus.

Stable carbocations were generated from arylfluorenols I (R = R¹ = H, Me; R = H, R¹ = Me), phenylxanthenol II, and tritylamine incorporated on smectic montmorillonite. Diffuse reflectance spectra were obtained.

Langmuir published new progress about 596-38-3. 596-38-3 belongs to alcohols-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Benzene,Alcohol, name is 9-Phenyl-9H-xanthen-9-ol, and the molecular formula is C19H14O2, Safety of 9-Phenyl-9H-xanthen-9-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Arnett, Edward M. published the artcileTriarylmethanes and 9-arylxanthenes as prototypes amphihydric compounds for relating the stabilities of cations, anions and radicals by C-H bond cleavage and electron transfer, Synthetic Route of 596-38-3, the publication is Journal of Physical Organic Chemistry (1997), 10(7), 499-513, database is CAplus.

Thermodn. stability properties of 11 p-substituted trityl and seven 9-phenylxanthyl carbocations are reported in sulfolane and of their conjugate carbanions in DMSO. The cations are compared by calorimetric heats of hydride transfer from cyanoborohydride ion, their first and second reduction potentials, their pK_R⁺s in aqueous sulfuric acid, ¹³C chem. shifts and free energies of methoxy exchange. Carbanions are compared by their heats and free energies (pK_HA) of deprotonation and their first and second oxidation potentials. Radicals are compared by their oxidation and reduction potentials. Their bond dissociation energies are derived by alternative routes: from the carbocation and its reduction potential and from the carbanion and its oxidation potential. The various properties are correlated against each other and against appropriate Hammett-type substituent parameters. Correlations between the different measured properties reported here range from fair to excellent. Despite their importance as historic prototypes for the three trivalent oxidation states of carbon, trityl and xanthyl systems are atypical models for comparing transmission of electron demand in other series of carbocations, radicals or carbanions with significantly different structures. The 9-arylxanthyl series is especially poor because of its insensitivity to substituent effects. The effects of substituents on various properties which represent the stabilities of R⁺s correlate surprisingly well against those for corresponding R^–s. Accordingly, compensating effects on the oxidation and reduction of a series of related R^.s may lead to a nearly constant electron transfer energy and absolute hardness for the series. In contrast, the free energies for interconversion of the carbocations and carbanions which determine the gap between pK_R+ and pK_HA are very sensitive to structural change.

Journal of Physical Organic Chemistry published new progress about 596-38-3. 596-38-3 belongs to alcohols-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Benzene,Alcohol, name is 9-Phenyl-9H-xanthen-9-ol, and the molecular formula is C19H14O2, Synthetic Route of 596-38-3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Aki, Sudhir N. V. K. published the artcileGeneration of Xanthenium and 9-Phenylxanthenium Carbocations in Subcritical Water and Reactivity with Amylamine, Product Details of C19H14O2, the publication is Journal of Physical Chemistry A (2001), 105(34), 8046-8052, database is CAplus.

The ability of subcritical water to support ionic chem. is evident from the successful generation of 9-R-xanthenium (R = H and C₆H₅) carbocations at temperatures up to 330° from their resp. alc. precursors using laser flash photolysis. The intrinsic carbocation decay in the solvent was found to follow simple Arrhenius behavior at all temperatures, from ambient up to 330 °C. In addition, we determined the bimol. rate constants for the reactions of xanthenium cation and 9-phenylxanthenium cations with amylamine, a neutral nucleophile. The activation energies of the two reactions were 21.6 ± 1.2 kJ mol^-1 and 18.2 ± 3.9 kJ mol^-1, resp. More importantly, we found that the rate equations determined at high temperatures extrapolated extremely well to ambient conditions. Thus, we conclude that for ion/neutral isoCoulombic reactions, it would be reasonable to use low-temperature Arrhenius parameters to predict the rate constants in water at higher temperatures Finally, we found that the effect of pressure on the bimol. rate constants at 22-330° was negligible.

Journal of Physical Chemistry A published new progress about 596-38-3. 596-38-3 belongs to alcohols-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Benzene,Alcohol, name is 9-Phenyl-9H-xanthen-9-ol, and the molecular formula is C19H14O2, Product Details of C19H14O2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Luk’yanov, S. M. published the artcileConversion of 1,3-benzodioxans into xanthene derivatives, Recommanded Product: 9-Phenyl-9H-xanthen-9-ol, the publication is Zhurnal Organicheskoi Khimii (1978), 14(2), 399-401, database is CAplus.

Treatment of dioxanes I (R = Ph, Me) with Ph₃C⁺ClO^–₄ in HOAc gave 21-62.8% II, which was also prepared by reaction of o-HOC₆H₄CPh₂OH with Ph₃C⁺ClO₄^– or HClO₄. Treatment of II with BrCH₂CO₂Et and Zn gave 93% III (R¹ = CH₂CO₂Et) III (R¹ = p-H₂NC₆H₄, p-Me₂NC₆H₄, EtO) were also prepared

Zhurnal Organicheskoi Khimii published new progress about 596-38-3. 596-38-3 belongs to alcohols-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Benzene,Alcohol, name is 9-Phenyl-9H-xanthen-9-ol, and the molecular formula is C19H14O2, Recommanded Product: 9-Phenyl-9H-xanthen-9-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Hammad, M. published the artcileSynthesis of some new pyrazolones and benzimidazole acetonitriles derived from xanthene, Product Details of C19H14O2, the publication is Egyptian Journal of Chemistry (1987), 29(6), 617-22, database is CAplus.

Cyclizations of α-cyano xanthenyl hydrazides I [R = H, Me, PhCH₂, Ph, 4-MeC₆H₄; R¹ = CH(CN)CONHNH₂] gave xanthenylpyrazolones II. Condensation of xanthenol I (R same as above, R¹ = OH) with benzimidazol-2-ylacetonitrile gave benzimidazolylxanthenylacetonitriles III.

Egyptian Journal of Chemistry published new progress about 596-38-3. 596-38-3 belongs to alcohols-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Benzene,Alcohol, name is 9-Phenyl-9H-xanthen-9-ol, and the molecular formula is C19H14O2, Product Details of C19H14O2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Weber, Edwin published the artcileVersatile and convenient lattice hosts derived from singly bridged triarylmethane frameworks. X-ray crystal structures of three inclusion compounds, Computed Properties of 596-38-3, the publication is Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999) (1990), 2167-77, database is CAplus.

A new family of host mols., based on the singly bridged triarylmethanol and triarylacetic acid frameworks, is described. These hosts form crystalline inclusions with a variety of uncharged organic mols. ranging from protic dipolar to apolar compounds (130 different species). The formation and stoichiometry depend in a systematic manner on structural parameters of the host, such as the nature of the functional group and the substituents, and on the substituent positions. The crystal structures of three inclusion compounds [I (R = OH)·benzene (8:3), I (R = OH)·dioxane (4:3), and I (R = CO₂H)·EtOH (1:1)] have been studied by x-ray diffraction. They reveal the building principles of the new inclusion family. In the crystals of I (R = OH)·benzene (8:3), the benzene is interstitially entrapped by H-bonded tetramer clusters of I (R = OH). Crystals of I (R = OH)·dioxane (4:3) are built of H-bonded 2:1 host-guest complexes including interstitial mols. of dioxane. In the case of I (R = CO₂H)·EtOH (1:1), the building principle is formation of 2:2 host-guest clusters via a twelve-membered H-bonded ring.

Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999) published new progress about 596-38-3. 596-38-3 belongs to alcohols-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Benzene,Alcohol, name is 9-Phenyl-9H-xanthen-9-ol, and the molecular formula is C17H18N2O6, Computed Properties of 596-38-3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts