Category: 59101-28-9

Adding a certain compound to certain chemical reactions, such as: 59101-28-9, 16-Bromohexadecan-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, HPLC of Formula: C16H33BrO, blongs to alcohols-buliding-blocks compound. HPLC of Formula: C16H33BrO

11.1 Diethyl 2-[(tert-butoxycarbonyl)amino] -2-(1 6-hydroxyhexadecyl)malonate10461] Diethyl 2-(tert-butoxycarbonyl)amidomalonate 2 (1.18 g, 3.80 mmol, purity: 89% (GC), 1.1 eq.) obtained as in example 1.2, bromide 15 (1.11 g, 3.40 mmol) obtained as in example 4.2 and caesium carbonate (2.35 g, 7.20 mmol, 2.1 eq.) were suspended in acetonitrile (20 mE) and heated to reflux for 6 h. After cooling to tt. the mixture was adsorbed on silica gel (3 g) and the product was purified by column chromatography (21 x3 cm, cyclohexane/ethyl acetate, 4:1 – 100% ethyl acetate) and isolated as white solid. Yield:577 mg (33%).10462] M.p. 450 C.10463] ?H-NMR (300 MHz, CDC13) oe [ppm]: 1.22-1.32(m, 30H, 6-CR2 to 17-CR2, 21-CR3, 23-CR3), 1.43 (s, 9R,26-CR3, 27-CR3, 28-CR3), 1.49-1.60 (m, 4R, 5-CR2,18-CR2), 1.95 (brs, 1R, 19-OR), 2.25 (m, 2H, 4-CR2), 3.63(t, 3JHH=6.7 Hz, 2H, 19-CR2), 4.23 (m, 4H, 20-CR2,22-CR2), 5.95 (br s, 1R, 2-NH).10464] ?3C-NMR (75 MHz, CDC13) oe [ppm]: 14.1 (q, C-2 1,C-23), 23.3 (t, C-5), 25.8 (t, C-17), 28.3 (q, C-26, C-27,C-28), 29.3, 29.5, 29.7 (t, C-6 to C-16, C-18), 32.8 (t, C-4),62.3 (t, C-20, C-22), 63.0 (t, C-19), 66.6 (s, C-2), 80.1 (s,C-25), 153.8 (s, C-24), 168.4 (s, C-i, C-3).10465] Exact Mass (ESI): C28R53NO7+R: calcd. 516.3895, found 516.3879; C28R53NO7+Na: calcd. 538.3714,found 538.3713.

The synthetic route of 59101-28-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER; Haufe, Guenter; Levkau, Bodo; Schaefers, Michael; Schilson, Stefani Silke; Keul, Petra; US2014/170067; (2014); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Related Products of 59101-28-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 59101-28-9, name is 16-Bromohexadecan-1-ol, molecular formula is C16H33BrO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

4.3 Diethyl2-acetamido-2-(i 6-hydroxyhexadecyl)malonate10221] The bromide 15(0.967 g, 2.70 mmol), diethyl 2-ac- etamidomalonate 1 (0.640 g, 2.8 mmol, 1.0 eq.) (obtained as in example 1.1 above) and caesium carbonate (1.680 g, 5.17 mmol, 1.9 eq.) were suspended in acetonitrile (20 mE) and refluxed for 5 h. The mixture was adsorbed at silica gel (1-2 g) and purified by colunm chromatography (silica gel, 1 6.5×4 cm, cyclohexane/ethyl acetate, 4:i)to give a yellowish solid. Yield: 0.912 g (74%).10222] M.p.: 48 C.10223] ?R-NMR (300 MHz, CDC13) oe [ppm]: 1.23-1.63(m, 34R, 5-CR2 to 18-CR2, 23-CR3, 25-CR3), 2.04 (m, 4R,21-CR3, 19-OR), 2.30 (m, 2R, 4-CR2), 3.63 (t, 3J,y=6.6 Rz,2R, 19-CR2), 4.20 (m, 4R, 22-CR2, 24-CR2), 6.84 (s, 1R,2-NR).10224] ?3C-NMR (75 MRz, CDC13) oe [ppm]: 14.0 (q, C-23,C-25), 23.1 (q, C-21), 23.6 (t, C-5), 25.8 (t, C-17), 28.4,29.3,29.7 (t, C-6 to C-16), 32.1 (t, C-18), 32.8 (t, C-4), 62.5 (t,C-22, C-24), 63.0 (t, C-19), 66.6 (s, C-2), 168.3 (s, C-i, C-3),169.0 (s, C-20).10225] Exact mass (ESI): C25R47NO5+Na: calcd. 480.3296, found 480.3300; (C25R47NO5)2+Na: calcd. 937.6699,found 937.6713.

According to the analysis of related databases, 59101-28-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER; Haufe, Guenter; Levkau, Bodo; Schaefers, Michael; Schilson, Stefani Silke; Keul, Petra; US2014/170067; (2014); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 59101-28-9, name is 16-Bromohexadecan-1-ol. A new synthetic method of this compound is introduced below., SDS of cas: 59101-28-9

To a solution of 16-bromohexadecarboxylic acid (10.00 g, 30.0 mmol) in 80 ml THF was added BH3 (70 ml, 70mmol, 1 M in THF) slowly at 0 C. After addition, the reaction mixture was stirred at room temperature for 60-90 minute.The mixture was cooled to 0 C and 80 mL water was added. The aqueous layer was extracted with hexanes (2x100mL). The combined organic layer was washed by 100 mL water, dried with sodium sulfate and concentrated to give awhite solid. The solid was dissolved into). To a solution of this while solid in 100 mL DMF was added potassium thioacetateat room temperature. After stirring at room temperature for 60 -90 minutes, 150 mL ethyl acetate was added to thereaction mixture, followed by 450 mL hexanes and 50 mL water. After being washed by three portions of water, theorganic layer was dried over sodium sulfate and concentrated.. After column chromatography on silica gel (silica gel:(200 g; eluting solvents: 5% ethyl acetate in hexanes; 15% ethyl acetate in hexanes; 25% ethyl acetate in hexanes),K133 was obtained as a white solid. 1H NMR (300 MHz, DMSO-d6) delta 4.31 (t, J=5.1Hz, 1 H, OH),3.37 (t, J=5.1Hz, 2H,CH2OH), 2.81 (t, J=6.9Hz, 2H, SCH2), 2.31 (s, 3H, CH3COS), 1.50 (m, 2H, CH2CH2OH), 1.40 (m, 2H, CH2CH2S), 1.23(br s, 24H, CH2).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 59101-28-9, 16-Bromohexadecan-1-ol.

Reference:
Patent; Clinical Micro Sensors, Inc.; CHUNLIN, Tao; EP2220102; (2014); B1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts