Category: 59-23-4

Uddin Pk, Moyen Md. published the artcileOptimization of extraction of antioxidant polysaccharide from Pleurotus ostreatus (Jacq.) P. Kumm and its cytotoxic activity against murine lymphoid cancer cell line, Recommanded Product: (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, the main research area is Pleurotus polysaccharide antioxidant cytotoxicity lymphoid cancer cell.

The purpose of this study was to optimize the extraction method for polysaccharide from the fruiting bodies of Pleurotus ostreatus (Jacq.) P.Kumm and to assess the antioxidant and cytotoxic potentials of polysaccharide. In this investigation, polysaccharides from Pleurotus ostreatus (Jacq.) P.Kumm were extricated by utilizing the hot water. One-single factor and response surface methodol. was established to optimize the extraction conditions for polysaccharide from Pleurotus ostreatus (Jacq.) P.Kumm. Examination of antioxidant activity of Pleurotus ostreatus polysaccharide (POP) was directed by utilizing 2, 2-diphenyl-1-picrylhydrazyl (DPPH) and 2, 2-azino-bis-3-ethyl-benzothiazoline-6-sulfonic acid (ABTS) techniques. Cytotoxicity of POP was evaluated using an MTT assay. The exptl. data were fitted to a quadratic equation utilizing multiple regression investigations, and the ideal conditions were as per the following: water/crude material proportion, 26.04 mL/g; an extraction time of 62.08 min; and an extraction temperature 70.5°C. Under such conditions, the polysaccharide yield was 5.32 ± 0.12% with the anticipated yield. POP showed good scavenging activity against DPPH radical (p<0.001, EC50 = 1036.38 μg/mL, R2 = 0.8313) and ABTS radicals (p<0.001, EC50 = 824.37 μg/mL, R2 = 0.8223), with a dose (p<0.001)-and-time (p<0.001) dependent cytotoxic potential on Ehrlich ascites carcinoma cell line in vitro. This demonstrated that polysaccharides (POP) had certain cancer prevention agent exercises. In this manner, these examinations give reference to addnl. research and reasonable improvement of Pleurotus ostreatus (Jacq.) P. Kumm polysaccharide and POP may prove a useful therapeutic agent, due to its robust antioxidant and cytotoxic activity. PLoS One published new progress about Carbohydrates Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Recommanded Product: (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yu, Yongyi published the artcileChemistry and immunostimulatory activity of a polysaccharide from Undaria pinnatifida, Related Products of alcohols-buliding-blocks, the main research area is Undaria UPP2 monosaccharide cytokine cell proliferation immunostimulatory; Immunomodulatory activity; Polysaccharide; RAW264.7 cell; Structure; Undaria pinnatifida.

An immunol. active polysaccharide named as UPP-2 (1035.52 kDa) was isolated from Undaria pinnatifida using traditional water extraction followed by DEAE Sepharose fast flow chromatog. UPP-2 was proven to be a low sulfated polysaccharide with relatively abundant uronic acid (13.08 ± 0.67%). UPP-2 mainly consisted of xylose (64.55%), glucose (23.81%), arabinose (5.90%) and mannose (4.26%), and its main glycosidic linkage types included →2-α-D-Xylp-(1→, →4)-α-D-Glcp-1→, α-D-Xylp-(1→ and →2,4)-β-D-Xylp-1→. Results indicated that UPP-2 significantly promoted the proliferation and pinocytic capacity of RAW264.7 cells, and upregulated the mRNA expressions of iNOS, TNF-α, IL-6, and IL-1β at 100-600μg/mL with a maximum of 195, 42, 768, and 539 times those of the neg. control, resp. Moreover, UPP-2 significantly increased the secretions of nitric oxide, TNF-α and IL-6 at 100-600μg/mL (8.0, 73.1, and 188.7 times compared to those of the neg. control, resp.), as well as promoted the production of IL-1β obviously at 600μg/mL. Overall, UPP-2 could be served as a potential dietary supplement or functional food based on its immunostimulatory activity.

Food and Chemical Toxicology published new progress about Carbohydrates Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Related Products of alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Liu, Yantao published the artcilePhysicochemical characterization of galactomannans extracted from seeds of Gleditsia sinensis Lam and fenugreek. Comparison with commercial guar gum, Product Details of C6H12O6, the main research area is Gleditsia seed guar gum galactomannan galactose physicochem property; Galactomannan; Intermolecular entanglement; Intrinsic viscosity; Rheological behavior; Solubility.

Gleditsia sinensis, fenugreek and guar galactomannans (referred to as GSG, FG, and GG) were extracted from their gums and investigated using various techniques. Mannose to galactose ratios were 3.55, 1.11, and 1.65, resp. The intrinsic viscosity of GSG was very close to that of GG, while that of FG was the lowest one. This was attributed to the influence of high galactose substitution of FG on the mannan backbone, which induced a lower chain dimension due to intermol. entanglement. High degrees of substitution and high temperatures contributed to improving the solubility of galactomannan. Rheol. behavior indicated that GG had the highest apparent viscosity, yet the power-law model could well-fitted the flow curves of GSG and FG, but not GG. Through morphol. observations, the extracted galactomannans exhibited rod-like structure in deionized water and showed fibrous filament network structure after dehydration by freeze-drying. The thermal behavior was greatly influenced by the degree of side groups and Mw of galactomannans.

International Journal of Biological Macromolecules published new progress about Carbohydrates Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Product Details of C6H12O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Lv, Qing-Qing published the artcileStructural characterization, α-amylase and α-glucosidase inhibitory activities of polysaccharides from wheat bran, Category: alcohols-buliding-blocks, the main research area is alphaamylase alphaglucosidase glucose galactose arabinose wheat bran; Polysaccharide; Structural characterization; Wheat bran; α-Amylase; α-Glucosidase.

In this study, two polysaccharide fractions were isolated from wheat bran by sequential extraction with water and alk. solution, DEAE Cellulose-52 chromatog. and Sephacryl S-400 gel permeation chromatog., they were named as WXA-1 and AXA-1, resp. Structural analyses indicated that both polysaccharide fractions were heteropolysaccharides, their average mol. weights were 193 kDa and 107 kDa, resp. The backbone of WXA-1 was → 4-β-D-Xylp-1→, which was substituted at O-3 positions by arabinose, glucose and galactose residues, while the backbone of AXA-1 was → 4-β-D-Xylp-1→, which was mainly substituted at O-3 positions by arabinose. AXA-1 exerted a stronger inhibitory effect on the activities of α-amylase and α-glucosidase compared with WXA-1. Moreover, AXA-1 exhibited a competitive inhibition of α-amylase and a mixed-type noncompetitive inhibition of α-glucosidase. These results suggest that AXA-1 can be used as α-amylase and α-glucosidase inhibitors.

Food Chemistry published new progress about Polysaccharides Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chiroma, Samaila Musa published the artcileCentella asiatica protects D-galactose/AlCl3 mediated Alzheimer’s disease-like rats via PP2A/GSK-3β signaling pathway in their hippocampus, COA of Formula: C6H12O6, the main research area is Centella asiatica galactose aluminum chloride alzheimers disease PPA GSK; Alzheimer’s disease; B-cell lymphoma 2; Centella asiatica; glycogen synthase kinase 3; hippocampus; protein poshophatase 2.

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder more prevalent among the elderly population. AD is characterised clin. by a progressive decline in cognitive functions and pathol. by the presence of neurofibrillary tangles (NFTs), deposition of beta-amyloid (Aβ) plaque and synaptic dysfunction in the brain. Centella asiatica (CA) is a valuable herb being used widely in African, Ayurvedic, and Chinese traditional medicine to reverse cognitive impairment and to enhance cognitive functions. This study aimed to evaluate the effectiveness of CA in preventing D-galactose/aluminum chloride (D-gal/AlCl3) induced AD-like pathologies and the underlying mechanisms of action were further investigated for the first time. Results showed that co-administration of CA to D-gal/AlCl3 induced AD-like rat models significantly increased the levels of protein phosphatase 2 (PP2A) and decreased the levels of glycogen synthase kinase-3 beta (GSK-3β). It was further observed that, CA increased the expression of mRNA of Bcl-2, while there was minimal effect on the expression of caspase 3 mRNA. The results also showed that, CA prevented morphol. aberrations in the connus ammonis 3 (CA 3) sub-region of the rat’s hippocampus. The results clearly demonstrated for the first time that CA could alleviate d-gal/AlCl3 induced AD-like pathologies in rats via inhibition of hyperphosphorylated tau (P-tau) bio-synthetic proteins, anti-apoptosis and maintenance of cytoarchitecture.

International Journal of Molecular Sciences published new progress about Bcl-2 proteins Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, COA of Formula: C6H12O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Sran, Kulwinder Singh published the artcileProduction, characterization and bio-emulsifying activity of a novel thermostable exopolysaccharide produced by a marine strain of Rhodobacter johrii CDR-SL 7Cii, Safety of (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, the main research area is exopolysaccharide Rhodobacter johrii fermentation; Bio-emulsifier; Exopolysaccharide; Rhodobacter johrii; Structural characterization.

An exopolysaccharide (EPS) producing bacterial strain was isolated from the surface of marine macroalgae (Padina sp.). Based on polyphasic taxonomy, the strain CDR-SL 7Cii was assigned to the genus Rhodobacter and found to be the closest relative of the species Rhodobacter johrii. The strain was able to produce 6.2 g/l of EPS upon fermentation using R2A medium enriched with 2.5% glucose. FT-IR anal. revealed the presence of hydroxyl, carboxyl and diacyl-ester functional groups in the purified EPS. Further Chromatog. study revealed that R. johrii synthesized a high mol. weight anionic exopolysaccharide composed of glucose, glucuronic acid, rhamnose and galactose in a molar ratio of 3:1.5:0.25:0.25. The 1D and 2D NMR spectroscopy (COSY/HSQC) anal. revealed the presence of 1,6 linked-α-D-Glcp, 1,4 linked-β-D-Glcp, 1,3 linked-β-D-GlcA, 1,3 linked-β-D-Galp, 1,6 linked-β-D-Galf and 3-α-L-Rhmp residues. Moreover, the purified EPS has shown stability towards elevated temperature and also acted as a bio-emulsifier to create a high pH and temperature stable emulsion of hydrocarbon/water indicating its industrial potential. This is the first report of EPS production by a strain of Rhodobacter johrii.

International Journal of Biological Macromolecules published new progress about Exopolysaccharides Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Safety of (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Liu, Tao published the artcilePurification and characterization of an exopolysaccharide produced by Lactobacillus plantarum HY isolated from home-made Sichuan Pickle, Recommanded Product: (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, the main research area is Lactobacillus exopolysaccharide purification characterization; Characteristics; Exopolysaccharide; Lactobacillus plantarum; Purification.

In the present study, the exopolysaccharide (EPS) producing strain HY was isolated from home-made Sichuan Pickle and identified as Lactobacillus plantarum. The EPS was purified by ethanol precipitation, and fractionation by column chromatog., and the yield of purified HY EPS was 1.423 g/L. The mol. weight of the purified HY EPS was 9.549 × 104 Da and composed of mannose, galactose, glucuronic acid and glucose in a mass percentage of 72.99%, 17.27%, 6.99% and 2.75%, resp. FT-IR spectrum exhibited the existence of carboxyl and hydroxyl group. Partial sugar residues and glycosidic bond present in HY EPS could be identified by NMR spectroscopy, i.e. α-D-glucose and α-D-mannose residues. The degradation temperature (320 °C) and m.p. (122.78 °C) of the HY EPS were determined by thermogravimetric anal. (TGA) and differential scanning calorimeter anal. (DSC). A highly porous structure of EPS was observed by SEM, and the AFM anal. of the EPS revealed presence of spherical lumps. Meanwhile, the in vitro biol. activity assays of HY EPS showed considerable antioxidant and α-amylase inhibitory activities, suggesting its promising potential to be applied in the food and pharmaceuticals industry.

International Journal of Biological Macromolecules published new progress about Exopolysaccharides Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Recommanded Product: (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wang, Yueming published the artcileOligosaccharide attenuates aging-related liver dysfunction by activating Nrf2 antioxidant signaling, Safety of (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, the main research area is liver dysfunction chitosan oligosaccharide antioxidant; D‐galactose; Nrf2 pathway; anti‐aging; chitosan oligosaccharide; liver.

Chitosan oligosaccharide (COS) is the depolymerized product of chitosan possessing various biol. activities and protective effects against inflammation and oxidative injury. The aim of the present study was to investigate the antioxidant effects of COS supplements on aging-related liver dysfunction. We found that COS treatment significantly attenuated elevated liver function biomarkers and oxidative stress biomarkers and decreased antioxidative enzyme activities in liver tissues in D-galactose (D-gal)-treated mice. Furthermore, COS treatment significantly upregulated the expression of Nrf2 and its downstream target genes HO-1, NQO1, and CAT. Moreover, in vitro experiments showed that COS treatment played a vital role in protecting H2O2-exposed L02 cells against oxidative stress by activating Nrf2 antioxidant signaling. These data indicate that COS could protect against D-gal-induced hepatic aging by activating Nrf2 antioxidant signaling, which may provide novel applications for the prevention and treatment of aging-related hepatic dysfunction.

Food Science & Nutrition (Hoboken, NJ, United States) published new progress about Animal gene Role: BSU (Biological Study, Unclassified), BIOL (Biological Study) (CAT). 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Safety of (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Liu, Jing-Yu published the artcileIsolation and structural characterization of a novel polysaccharide from Hericium erinaceus fruiting bodies and its arrest of cell cycle at S-phage in colon cancer cells, Synthetic Route of 59-23-4, the main research area is Hericium fruit body polysaccharide anticancer agent phase colon cancer; Anti-tumor activity; Hericium erinaceus polysaccharides; Structural characterization.

The fruiting body of Hericium erinaceus has been used to treat digestive system disorder-related diseases for over 2000 years in China. A novel polysaccharide, HEFP-2b, was obtained from H. erinaceus fruiting bodies. Phys. and chem. anal. showed that HEFP-2b consisted of fucose, galactose, glucose, and mannose in molar ratio of 11.81:22.82:44.28:21.09, and that its mol. weight was 3.252 × 104 Da. The backbone of HEFP-2b consisted of (→6)-linked-α-D-Glcp-(1→ and →4)-β-D-Galp-(1→and →3,6)-α-D-Manp linkage, with two side-branching units of (1→ and →6)-β-D-Galp and (1→ and →4)-α-D-Manp, terminated by Glc and Fuc. The results of the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and cell cycle arrest experiments revealed that HEFP-2b considerably inhibited the growth of colon cancer cells (HCT-116) in vitro. The growth inhibitory effects of HEFP-2b correlated with their ability to arrest the cell cycle at the S-phase. Our results will provide valuable information for future studies on HEFP-2b as a novel health-promoting functional food ingredient that can be used for treating colon cancer.

International Journal of Biological Macromolecules published new progress about Animal gene, cdk2 Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Synthetic Route of 59-23-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Park, Hae-Bin published the artcileDendritic cell-mediated cancer immunotherapy with Ecklonia cava fucoidan, HPLC of Formula: 59-23-4, the main research area is dendritic cell Ecklonia immunotherapy colorectal carcinoma; Anti-cancer; Dendritic cell; Ecklonia cava Fucoidan.

Fucoidan is known to exert immunomodulatory effects in animals and humans. Here, we extracted fucoidan from Ecklonia cava (ECF) and evaluated its immunostimulatory and anticancer activities in mice. Treatment with ECF resulted in the activation of bone marrow-derived dendritic cells (BMDCs) in vitro and splenic DCs in vivo. Moreover, the combination of ECF and ovalbumin (OVA) promoted OVA-specific T cell proliferation and cytokine production, which consequently suppressed B16-OVA tumor growth in vivo. The combination treatment with ECF and carcinoma self-antigen resulted in the inhibition of the growth of CT-26 carcinoma in mice through carcinoma antigen-specific immunity. Thus, ECF could function as an adjuvant for the induction of anticancer immunity.

International Journal of Biological Macromolecules published new progress about Animal gene, TNFA Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, HPLC of Formula: 59-23-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts