Category: 59-23-4

Liu, Chang published the artcileExtraction, characterization of aloe polysaccharides and the in-depth analysis of its prebiotic effects on mice gut microbiota, Related Products of alcohols-buliding-blocks, the main research area is aloe polysaccharide galactose rhamnose gut microbiota; Aloe polysaccharides; Gut microbiota; In-depth bioinformatics analysis; Ultrasound extraction.

Despite the well-known health benefits of aloe polysaccharide (APs), little is known about how APs modulate the gut microbiota and the relationship between microbiota and SCFAs. Here, APs was extracted by ultrasound extraction FT-IR and glycosidic linkage type anal. showed that a major part of APs consisted of → 4 -β-Manp- 1 → residues with acetyl groups. APs supplementation to mice prominently boosted SCFAs-producing Bacteroides and Parabacteria in the feces. On the other hand, it decreased the abundance of Firmicutes and Clostridium. A pos. correlation between microbiota and SCFAs was revealed, with Parabacteria and Clostridium being the key microbiota to significantly promote SCFAs. APs promoted the fructose and mannose metabolism by upregulating the gene expression of 17 enzymes, containing fructose-bisphosphate aldolase [EC:4.1.2.13]. Our findings highlight SCFAs-producing Parabacteria were primary degrader of APs, and APs may have prebiotic effects on gut microbiota.

Carbohydrate Polymers published new progress about 16S rRNA Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Related Products of alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Deng, Wenwen published the artcileStructural characterization and hypolipidemic activities of purified stigma maydis polysaccharides, Application In Synthesis of 59-23-4, the main research area is stigma maydis polysaccharide hypolipidemic activity; bile acid‐binding; hyperlipidemia; poloxamer 407; stigma maydis polysaccharide.

This study aimed to investigate structural features and antihyperlipidemic effects of the stigma maydis polysaccharide, termed SMP-1. This polysaccharide was composed of D-mannose, L-rhamnose, D-glucose, D-galactose, L-arabinose, D-xylose, and D-galacturonic acid, with a molar ratio of 1.00:0.21:1.41:1.44:0.70:0.44:0.56. The SMP-1 was mainly bonded by (1 → 6) and (1 → 3) linkages, with various monosaccharides being evenly distributed in the main and side chains. Moreover, SMP-1 had neither triple-helical structure nor mol. aggregation. Importantly, the SMP-1 could effectively bind the bile acids in vitro and significantly lower the total cholesterol, triglyceride, low-d. lipoprotein cholesterol levels, and moderately increase the high-d. lipoprotein cholesterol level in poloxamer 407-induced hyperlipidemic mice. Moreover, pretreatment with SMP-1 (≥300 mg/kg) could remarkably reduce fat accumulation and restore hepatocyte morphol. in the liver of hyperlipidemic mice. Altogether, these findings indicated that SMP-1 could be developed as a safe and effective food supplement for preventing and treating hyperlipidemic disorders.

Food Science & Nutrition (Hoboken, NJ, United States) published new progress about Bile acids Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Application In Synthesis of 59-23-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Fu, Yuan published the artcilePhysicochemical characteristics and biological activities of polysaccharides from the leaves of different loquat (Eriobotrya japonica) cultivars, Synthetic Route of 59-23-4, the main research area is Eriobotrya leaf physicochem polysaccharide; Binding properties; Enzyme inhibition; Eriobotrya japonica; Loquat; Polysaccharides; Weight-average molecular weights.

In order to explore polysaccharides from loquat leaves (LLPs) as functional food ingredients for prevention and treatment of obesity and type 2 diabetes, the physicochem. characteristics, in vitro binding properties, and inhibitory effects on α-amylase and α-glucosidase of polysaccharides from the leaves of different loquat cultivars, including ‘Baiyu’, ‘Chuannong8’, ‘Yuanbao’, and ‘Dawuxing’, were investigated and compared. Results showed that the contents of total uronic acids and degree of esterification in LLPs ranged from (27.04 ± 1.76)% to (41.46 ± 1.91)%, and from (20.54 ± 0.11)% to (26.90 ± 0.10)%, resp. The weight-average mol. weights of LLPs ranged from 4.307 × 106 Da to 5.101 × 106 Da, and the major constituent monosaccharides of LLPs were rhamnose, galacturonic acid, arabinose, and galactose. Furthermore, LLPs exerted strong in vitro fat binding, cholesterol binding, and bile acid binding capacities, as well as remarkable inhibitory effects on α-amylase and α-glucosidase, which might be attributed to their mol. weights, mol. weight distributions, and degree of esterification. Results are helpful for better understanding of chem. structures and bioactivities of polysaccharides from loquat leaves, and LLPs had good potential to be explored as functional food ingredients for prevention and treatment of obesity and type 2 diabetes.

International Journal of Biological Macromolecules published new progress about Bile acids Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Synthetic Route of 59-23-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kassara, Stella published the artcilePectolytic enzyme reduces the concentration of colloidal particles in wine due to changes in polysaccharide structure and aggregation properties, Computed Properties of 59-23-4, the main research area is penzyme polysaccharide colloidal particle aggregation property.

To explore the effect of pectolytic enzyme application on polysaccharide size and colloidal interactions, rose wines were prepared from pressed Shiraz grape juice, and red wines were made from the same juice by the addition of skins and seeds from fresh pressings. A pectolytic enzyme preparation containing primarily polygalacturonase and side-activities of arabinase and pectin lyase was used. Enzyme treatment enhanced the contribution of high mol. weight (≈ 200 kDa) polysaccharides rich in mannose and glucose (mannoproteins) and removed arabinose-rich polysaccharides of intermediate (≈ 40 kDa) size. Enzyme application reduced the mol. weight average of a class of smaller polysaccharides of approx. 6 kDa (rhamnogalacturonan II). All wines had similar particle sizes, but enzyme treatment markedly reduced particle concentration in wines, particularly in rose wines. Wine polysaccharides were purified and when reconstituted in model wine, showed reduced particle concentration in response to enzyme treatment. Aggregation of polysaccharide in the presence of seed tannin was also markedly reduced by enzyme treatment. The results indicated that changes in structure introduced by the enzyme affected wine colloidal properties, potentially increasing polysaccharide solubility

International Journal of Biological Macromolecules published new progress about Anthocyanins Role: FFD (Food or Feed Use), BIOL (Biological Study), USES (Uses). 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Computed Properties of 59-23-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Motta, Marcus Vinicius Lisboa published the artcileStudy of the mechanical degradation mechanism of guar gum in turbulent flow by FTIR, Product Details of C6H12O6, the main research area is turbulent flow guar gum mech degradation mechanism; Degradation mechanism, FTIR; Drag reduction; Polymers.

Guar gum is used in low concentrations as a drag reducing agent in turbulent flows to significantly accelerate flow in oil pipelines, oil well operations and aqueous systems. Drag reduction also promotes a decrease in energy demand in pumping systems. However, the polymers undergo mech. degradation and lose the ability to promote drag reduction over time. In this paper, the drag reduction, the power required by the pumps and the degradation of the guar gum were evaluated during a turbulent flow of an aqueous solution containing the biopolymer. The results indicate the mechanism of degradation of guar gum by the hydrolysis of the bond α (1 → 6), liberating the galactose, which justice to the loss of efficiency throughout the process. An understanding of this mechanism should allow for the development of more mech. resistant polymers and the increase of drag reduction capacity over time.

International Journal of Biological Macromolecules published new progress about Biopolymers Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Product Details of C6H12O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Motta, Marcus Vinicius Lisboa published the artcileThermal and spectroscopic analyses of guar gum degradation submitted to turbulent flow, Synthetic Route of 59-23-4, the main research area is guar gum oxidative degradation turbulent flow thermal spectroscopy analysis; (13)C NMR; Drag reduction; Guar gum.

In this paper, a 400 ppm aqueous solution of guar gum polysaccharide was submitted to a turbulent flow regime in order to monitor mol. degradation and drag reduction Guar gum samples were isolated and analyzed by spectroscopic, thermoanal. and viscosimetric techniques. The drag reduction promoted by guar gum is compromised as the polysaccharide undergoes degradation Viscosimetric anal. of guar gum showed a reduction in viscous mol. mass. Mid-IR spectra and hydrogen NMR suggest that mech. degradation promotes hydrolysis of the glycosidic bond α(1→ 6) releasing (D)-galactose owing to the appearance of the carbonyl functional group. Thermal anal. revealed the reduction of the polysaccharide′s thermal stability by reduction of the polymer chain. A comprehensive anal. of these combined parameters affords a foundation for the development of more efficient biopolymers in the context of improved drag reduction

International Journal of Biological Macromolecules published new progress about Biopolymers Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Synthetic Route of 59-23-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Niu, Jinzhong published the artcileFunctional characterization of galectin-3 from Nile tilapia (Oreochromis niloticus) and its regulatory role on monocytes/macrophages, Name: (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, the main research area is Oreochromis galectin monocyte macrophage functional characterization; Galectin-3; Inflammation; Monocytes/macrophages; Nile tilapia; Phagocytosis.

Galectin-3 is a kind of β-galactoside-binding lectin involved in host defense against pathogen infection. However, the immune functions of fish galectin-3 remain poorly understood. In this study, the roles of a fish galectin-3 (OnGal-3) from Nile tilapia (Oreochromis niloticus) on the binding activity on bacterial pathogens or PAMPs, the agglutinating activity on bacterial pathogens and the regulatory effects on monocytes/macrophages activity were investigated. After in vitro challenge of Streptococcus agalactiae and Aeromonas hydrophila, OnGal-3 expressions were significantly up-regulated in monocytes/macrophages. In addition, recombinant OnGal-3(rOnGal-3) protein showed strong binding activity on bacterial pathogens or PAMPs. Also, rOnGal-3 agglutinated Gram-pos. and Gram-neg. bacteria. Moreover, rOnGal-3 could induce the inflammatory factors expressions in monocytes/macrophages and enhance phagocytosis and respiratory burst activity of monocytes/macrophages. These results suggest that fish galectin-3 participates in anti-bacterial immune response through recognizing pathogens and modulating monocytes/macrophages activity.

Fish & Shellfish Immunology published new progress about A zeolites Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Name: (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chen, Guangjing published the artcileComparison of different extraction methods for polysaccharides from bamboo shoots (Chimonobambusa quadrangularis) processing by-products, Name: (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, the main research area is Chimonobambusa shoot polysaccharide yield uronic acid antioxidant; Antioxidant activity; Chemical structure; Chimonobambusa quadrangularis polysaccharides; Extraction methods; Physicochemical property.

The aim of this study was to evaluate the influences of extraction methods on the yield, chem. structure and antioxidant activity of polysaccharides from bamboo shoots (Chimonobambusa quadrangularis) processing byproducts (CPS). CPSs were extracted by using five methods including hot water extraction (HWE), accelerated solvent extraction (ASE), ultrasonic-assisted extraction (UAE), microwave-assisted extraction (MAE) and enzyme-assisted extraction (EAE). The exptl. results showed that the uronic acid contents, monosaccharide contents, mol. weights and antioxidant activities of the five CPSs were significantly different. CPS extracted using ASE method (ASE-CPS) possessed the highest extraction yield (9.94%), the highest medium-high-mol.-weight value (136.07 kDa) and notable antioxidant ability. UAE-CPS had the highest uronic acid (9.42%) and the lowest medium-high-mol. weight value (117.49 kDa), and its antioxidant activity was the best. Based on the correlation anal., the higher uronic acid content, smaller mol. weight, and lower content of monosaccharide composition of glucose for the CPS-UAE might contribute to its higher antioxidant activity. From an industrial viewpoint, ASE technique could be a promising and alternative way to extract CPS due to its high yield, notable antioxidant activity, and convenient industrialization.

International Journal of Biological Macromolecules published new progress about Amino acids Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Name: (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chu, Lulu published the artcileChemical composition, antioxidant activities of polysaccharide from Pine needle (Pinus massoniana) and hypolipidemic effect in high-fat diet-induced mice, Synthetic Route of 59-23-4, the main research area is Pinus needle polysaccharide antioxidant hypolipidemic high fat diet; Antioxidant activities; Chemical composition; Hypolipidemic effect; Pine needle polysaccharide.

The aim of this study is to investigate hypolipidemic and antioxidant effects of Pine needle polysaccharide (PNP) from Pinus massoniana in high-fat diet (HFD)-induced mice. PNP could significantly improve the serum lipid levels (total cholesterol, triacylglycerols, high-d. lipoprotein cholesterol, low-d. lipoprotein cholesterol), enhance the antioxidant enzymes levels (total antioxidant capability, superoxide dismutase, glutathione peroxidase, catalase), and decrease malondialdehyde (MDA) content in HFD-induced mice. PNP exhibited distinct antioxidant ability on the superoxide anions, 1, 1-diphenyl-2-picrylhydrazyl (DPPH) and ferric ion reducing antioxidant power (FRAP) in vitro. The average mol. weight (Mw) of PNP was 6.17 × 105 Da, and mainly of fucose, arabinose, galactose, glucose, galacturonic acid. These results suggested that PNP might be used as functional foods and natural drugs in enhancing antioxidant ability and alleviating the hyperlipidemia.

International Journal of Biological Macromolecules published new progress about Blood lipids Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Synthetic Route of 59-23-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Gao, Chao published the artcileUnique Binding Specificities of Proteins toward Isomeric Asparagine-Linked Glycans, Synthetic Route of 59-23-4, the main research area is asparagine Nglycan Siglec protein structure influenza virus infection; N-glycan isomer; N-glycan-binding specificity; chemoenzymatic synthesis; glycan-binding proteins; glycosyltransferases; microarray.

The glycan ligands recognized by Siglecs, influenza viruses, and galectins, as well as many plant lectins, are not well defined. To explore their binding to asparagine (Asn)-linked N-glycans, we synthesized a library of isomeric multiantennary N-glycans that vary in terminal non-reducing sialic acid, galactose, and N-acetylglucosamine residues, as well as core fucose. We identified specific recognition of N-glycans by several plant lectins, human galectins, influenza viruses, and Siglecs, and explored the influence of sialic acid linkages and branching of the N-glycans. These results show the unique recognition of complex-type N-glycans by a wide variety of glycan-binding proteins and their abilities to distinguish isomeric structures, which provides new insights into the biol. roles of these proteins and the uses of lectins in biol. applications to identify glycans.

Cell Chemical Biology published new progress about Agglutinins Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Synthetic Route of 59-23-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts