Category: 59-23-4

Zhang, Tao published the artcilePurification, chemical analysis and antioxidative activity of polysaccharides from pH-modified citrus pectin after dialyzation, HPLC of Formula: 59-23-4, the main research area is modified citrus pectin polysaccharide purification chem analysis antioxidative activity.

Oxidative stress is a major risk factor implicated in the pathogenesis of many human diseases ranged from inflammation to cancer. Modified citrus pectin (MCP) is a com. available dietary supplement produced from citrus pectin. However, the antioxidative activity of MCP is currently unknown. In this study, MCP was fractionated by a combination of DEAE-cellulose and Sephadex G-75 chromatogs. into one neutral fraction (MCPN) and four acidic fractions (MCP02a, MCP02b, MCP04a, and MCP04b). Among these fractions, MCP02b and MCP04a exhibited good DPPH·-scavenging effect with a concentration-dependent manner. Structural anal. results showed that MCP02b mainly contained the HG domain as well as some RG-I domains with β-(1 → 4)-galactan side chains and 4-O-Me-β-GlcA attached to the nonreducing terminals of the side chains. These findings could extend the applications of MCP as an antioxidant agent for functional foods or food additives.

LWT–Food Science and Technology published new progress about Citrus. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, HPLC of Formula: 59-23-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Dhull, Sanju Bala published the artcileFunctional, thermal and rheological behavior of fenugreek (Trigonella foenum-graecum L.) gums from different cultivars: A comparative study, Category: alcohols-buliding-blocks, the main research area is Trigonella gum thermal rheol behavior; FTIR, rheology; Fenugreek gum; Shear thinning; Thermal properties.

Fenugreek gum (FG) was isolated from six different Indian fenugreek cultivars and studied for their functional, structural, thermal and rheol. attributes. The highest yield (13.5%) was observed for cultivar RMT-365. All galactomannans depicted good water and oil holding capacities ranging from 2009 ± 5.5 to 2099.9 ± 2.5% and 523.5 ± 3.5 to 553.0 ± 2.0%, resp. DSC thermograms of FG revealed the presence of one endothermic and one exothermic peak. For endothermic transition of gums from different cultivars, enthalpy change (Δ Ha) ranged from 234.2 to 351.8 J/g while for exothermic transition, Δ Ha values ranged from 72.0 to 102.1 J/g, much lower as compared with endothermic peak. The effect of variable shear rate on viscosity of 1% FG solutions showed their shear thinning behaviors for all the cultivars, whereby the viscosity decreased with increasing shear rate. Frequency sweep tests indicated typical viscoelastic fluid behavior for all the gum solutions Increase in the magnitude of G’ and G” of FG solutions was observed with an increase in frequency. A detailed understanding of different chem., functional and thermal properties of FG could surely enlarge the radius of its application and eventually aid in its utilization in different food, pharma and cosmetic products.

International Journal of Biological Macromolecules published new progress about Density. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wang, Qing published the artcileStructural characterization of a novel polysaccharide from Pleurotus citrinopileatus and its antitumor activity on H22 tumor-bearing mice, Formula: C6H12O6, the main research area is polysaccharide antitumor agent arabinose liver cancer inflammation anemia; Antitumor activity; Pleurotus citrinopileatus; Polysaccharide; Structural characterization.

In this research, a novel polysaccharide (PCP) was extracted from Pleurotus citrinopileatus and purified by Sephadex G-150 gel column, and its antitumor activity was investigated using the model H22 tumor-bearing mice. PCP was found to be composed of arabinose, galactose, glucose, xylose, mannose and glucuronic acid in a proportion of 0.66: 14.59: 10.77: 1: 0.69: 0.23 with average mol. weight of 7.30 x 105 Da. Further anal. suggested that PCP was a pyranose with α-type and β-type glycosidic residues. The antitumor assays in vivo indicated that PCP could effectively suppress H22 solid tumor growth, protect immune organs and improve inflammation and anemia. Besides, Annexin V-FITC/PI double staining and JC-1 staining demonstrated that PCP could induce apoptosis of H22 hepatoma cells. The PI staining assay revealed that PCP induced H22 hepatoma cells apoptosis by arresting cell cycle in S phase. These results suggest that the polysaccharide from Pleurotus citrinopileatus possesses potential value in the treatment of liver cancer.

International Journal of Biological Macromolecules published new progress about Anemia. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Formula: C6H12O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Eriksen, Peter Lykke published the artcileNon-alcoholic fatty liver disease causes dissociated changes in metabolic liver functions, Synthetic Route of 59-23-4, the main research area is metabolism non alc fatty liver disease; Aminopyrine; Hepatic elimination; Indocyanine green; Liver function tests; Non-alcoholic steatohepatitis; Urea cycle.

Background: Non-alc. fatty liver disease (NAFLD) is a major health concern affecting 25% of the world’s population. It is generally held that a fatty liver does not influence liver function, but quant. measurements of metabolic liver functions have not been systematically performed. We aimed to study selected hepatocellular metabolic functions in patients with different stages of NAFLD. Methods: Twenty-five non-diabetic, biopsy-proven NAFLD patients [12 with simple steatosis; 13 with non-alc. steatohepatitis (NASH)] and ten healthy controls were included in a cross-sectional study. Hepatocyte cytosolic function was assessed by the galactose elimination capacity (GEC), mitochondrial-cytosolic metabolic capacity by the functional hepatic nitrogen clearance (FHNC), microsomal function by the aminopyrine breath test, and excretory liver function by indocyanine green (ICG) elimination. Results: GEC was 20% higher in NAFLD than in controls [3.15 mmol/min (2.9-3.41) vs. 2.62 (2.32-2.93); P = 0.02]. FHNC was 30% lower in NAFLD [23.3 L/h (18.7-28.9) vs. 33.1 (28.9-37.9); P = 0.04], more so in simple steatosis [19.1 L/h (13.9-26.2); P = 0.003] and non-significantly in NASH [27.9 L/h (20.6-37.8); P = 0.19]. Aminopyrine metabolism was 25% lower in simple steatosis [8.9% (7.0-10.7)] and 50% lower in NASH [6.0% (4.5-7.5)] than in controls [11.9% (9.3-12.8)] (P < 0.001). ICG elimination was intact. Conclusions: The hepatocellular metabolic functions were altered in a manner that was dissociated both by different effects on different liver functions and by different effects of different stages of NAFLD. Thus, NAFLD has widespread consequences for metabolic liver function, even in simple steatosis. Clinics and Research in Hepatology and Gastroenterology published new progress about Cytosol. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Synthetic Route of 59-23-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Roman-Carrasco, Patricia published the artcileOnly α-Gal bound to lipids, but not to proteins, is transported across enterocytes as an IgE-reactive molecule that can induce effector cell activation, Computed Properties of 59-23-4, the main research area is galactose protein lipid intestinal epithelial cell allergenic activity; chylomicron; delayed allergic reaction; glycolipid; glycoprotein; red meat allergy; α-Gal.

To better understand the delayed onset of allergic symptoms and investigate whether protein-bound or lipid-bound α-Gal causes these symptoms, we analyzed the capacity of α-Gal conjugated proteins and lipids to cross a monolayer of intestinal cells. Extracts of proteins and lipids from beef were prepared, subjected to in vitro digestions, and added to Caco-2 cells grown on permeable supports. The presence of α-Gal in the basolateral medium was investigated by immunoblotting, thin-layer chromatog. with immunostaining and ELISA, and its allergenic activity was analyzed in a basophil activation test. After addition of beef proteins to the apical side of Caco-2 cells, α-Gal containing peptides were not detected in the basolateral medium. Those peptides that crossed the Caco-2 monolayer did not activate basophils from an α-Gal allergic patient. Instead, when Caco-2 cells were incubated with lipids extracted from beef, α-Gal was detected in the basolateral medium. Furthermore, these α-Gal lipids were able to activate the basophils of an α-Gal allergic patient in a dose-dependent manner. Only α-Gal bound to lipids, but not to proteins, is able to cross the intestinal monolayer and trigger an allergic reaction. This suggests that the slower digestion and absorption of lipids might be responsible for the unusual delayed allergic reactions in α-Gal allergic patients and identifies glycolipids as potential allergenic mols.

Allergy (Oxford, United Kingdom) published new progress about Allergy. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Computed Properties of 59-23-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Hui, Heping published the artcileStructural characterization, antioxidant and antibacterial activities of two heteropolysaccharides purified from the bulbs of Lilium davidii var. unicolor Cotton, Recommanded Product: (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, the main research area is Lilium bulb heteropolysaccharide antioxidant antibacterial; Antioxidant and antibacterial activity; Heteropolysaccharides; Lilium davidii var. unicolor Cotton; Structural characterization.

Two heteropolysaccharides, BHP-1 and BHP-2, were separated and purified from the edible bulbs of Lilium davidii var. unicolor Cotton by anion-exchange and gel-permeation chromatog. The primary structural characteristics of BHP-1 and BHP-2 were investigated by Congo red test, X-ray diffractometry (XRD) anal., IR, GC and NMR. The results showed that the weight-average mol. weight (MW) and number-average mol. weight (Mn) of BHP-1 and BHP-2 were nearly 1.93 × 105 g/moL, 8.86 × 104 g/moL and 3.52 × 104 g/moL, 2.95 × 104 g/moL, resp. Glucose and mannose comprised BHP-1 in a relative molar ratio of 5.9:2.0, and BHP-2 was consisted of glucose, galactose, mannose and arabinose with approx. molar ratios of 8.3:1.5:1.0:1.1. Their backbone mainly contained α-(1 → 4)-linked D-glucopyranosyl. In addition, the C-6 of the glucose and C-2 of mannose residue of BHP-1 and BHP-2 were substituted. The two polysaccharides were semi-crystalline substance with multi-branching structure and triple helix conformation. Bioassays showed that BHP-1 and BHP-2 had effective antioxidant activities evaluated by DPPH, scavenging superoxide radical and OH radical in a dose-dependent manner. The two heteropolysaccharides also displayed distinct and selective antibacterial activity against B. cereus, P. putida, M. luteus and K. pneumonia with inhibition zones of 13 mm, 16 mm, 17 mm, 23 mm and 12 mm, 17 mm, 19 mm, 20 mm, resp. These findings provided a reference for potential applications of the polysaccharides from L. davidii as natural antioxidants and antibacterial agents in food and pharmaceuticals.

International Journal of Biological Macromolecules published new progress about Anomers. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Recommanded Product: (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Bakhshy, Ehsan published the artcileIsolation, qualitative and quantitative evaluation of galactomannan during germination of Trigonella persica (Fabaceae) seed, Product Details of C6H12O6, the main research area is Trigonella endosperm seed germination galactomannan; Galactomannan; Physicochemical properties; Seed germination.

Galactomannan extracted from Trigonella persica endosperm like to other galactomannans is useful in the medicine and pharmaceutical industry such as drug delivery due to its unique physicochem. properties. As soon as germination takes place, the hydrolysis of galactomannan begins and its structure changes. Evaluation of galactomannan content extracted from the germinating seeds (GEGS) and the non-germinated seeds (GENGS) showed that the amount of galactomannan was highest at 24 h after imbibition and was completely consumed approx. 48 h after imbibition. It seems that galactomannan is used for storage reserve synthesis in the cotyledon during germination. Based on the quant. assessment, FT-IR, macroscopic and microscopic observations, galactomannan of T. persica seeds have high an M/G ratio (approx. 5:1) and this ratio does not alter during germination. Therefore, changes in galactomannan structure (functional group and band) caused that GEGS have different physicochem. properties than GENGS. Based on the results, GENGS with a high M/G ratio may be suitable for drug delivery system due to some properties such as high viscosity and gelling.

International Journal of Biological Macromolecules published new progress about Aleuron. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Product Details of C6H12O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Gao, Pinyi published the artcileStructural features, selenization modification, antioxidant and anti-tumor effects of polysaccharides from alfalfa roots, Name: (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, the main research area is Medicago root polysaccharide antioxidant selenization antitumor; Alfalfa polysaccharides; Anti-tumor activities; Antioxidant activities; Chemical structures; Selenization.

Hot water extraction and chromatog. purification methods were used to extract and purify two polysaccharides (RAPS-1 and RAPS-2) from the roots of alfalfa. Subsequently, RAPS-2 was modified using the HNO3/Na2SeO3 method to obtain Se-RAPS-2. The structural features, antioxidant and in vitro anti-tumor activities of the three polysaccharides were evaluated. The structural anal. revealed that RAPS-1 (Mw = 10.0 kDa) was composed of rhamnose, xylose, arabinose, galacturonic acid, mannose and glucose, whereas RAPS-2 (Mw = 15.8 kDa) consisted of rhamnose, xylose, galacturonic acid, mannose, glucose and galactose. RAPS-1 contained 1 → 2, 1 → 4, 1 → 3, and 1 → 6 or 1 → glycosidic bonds; however, while RAPS-2 lacked 1 → 4 glycosidic linkages. The mol. weight of Se-RAPS-2 was 11.0 kDa less than that of RAPS-2. The results of activities demonstrated that Se-RAPS-2 displayed superior antioxidant activity and inhibitory effect in HepG2 cells than RAPS-1 and RAPS-2.

International Journal of Biological Macromolecules published new progress about Alfalfa. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Name: (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Shang, Hongmei published the artcileEffects of different extraction methods on the properties and activities of polysaccharides from Medicago sativa L. and extraction condition optimization using response surface methodology, Recommanded Product: (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, the main research area is Medicago polysaccharide extraction response surface methodol.

Polysaccharides from alfalfa (Medicago sativa L., MSPs) were extracted by four different methods: hot-water extraction (HWE), ultrasonic-assisted extraction (UAE), enzyme-assisted extraction (EAE) and ultrasonic-enzyme-assisted extraction (UEAE). The exptl. results showed that the monosaccharide compositions of the four MSPs extracted by the different extraction methods were the same, but the monosaccharide proportions were different. MSPs extracted by the UEAE method possessed the largest extraction yield, the highest uronic acid content and the best antioxidant activities among the four MSPs analyzed. Addnl., the Plackett-Burman design (PBD) and response surface methodol. (RSM) were used to determine the optimum UEAE conditions for extracting MSPs, revealing optimal conditions at a pH of 5.7, a 58 min enzymolysis time, a 40 °C enzymolysis temperature and a 41 °C ultrasonic temperature; an MSPs yield of 12.95% was obtained under these extraction conditions.

Process Biochemistry (Oxford, United Kingdom) published new progress about Alfalfa. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Recommanded Product: (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wu, Hongyan published the artcileExtraction optimization, physicochemical properties and antioxidant and hypoglycemic activities of polysaccharides from roxburgh rose (Rosa roxburghii Tratt.) leaves, Formula: C6H12O6, the main research area is Rosa polysaccharide antioxidant physicochem property hypoglycemia; Biological activity; Extraction and purification; Polysaccharides from Rosa roxburghii Tratt. leaves.

The optimum extraction conditions of polysaccharides from roxburgh rose (Rosa roxburghii Tratt.) leaves (RLP) were obtained by response surface methodol. (RSM), which were a liquid to solid ratio of 21.16 mL/g, an extraction temperature of 81.32°C, and an extraction time of 90.49 min. An RLP yield of 11.04% was obtained under these conditions. DEAE-52 cellulose and Sepharose CL-6B columns were used to purify the RLP, and the purified polysaccharide components RLP-1.2 and RLP-2.1 were obtained. Both RLP-1.2 and RLP-2.1 were composed of galacturonic acid (GalA), glucose (Glc), galactose (Gal), and arabinose (Ara). However, the molar ratios of GalA, Glc, Gal, and Ara in RLP-1.2 and RLP-2.1 were different. At a concentration of 10 mg/mL, the α-amylase inhibitory activities of RLP-1.2 and RLP-2.1 reached 80.74% and 89.85% that of acarbose, resp., and the α-glucosidase inhibitory activity of RLP-1.2 reached 87.91% that of acarbose. In addition, both RLP-1.2 and RLP-2.1 showed good antioxidant activity. These results suggested that RLP-1.2 and RLP-2.1 possess potential as natural hypoglycemic agents or natural antioxidants.

International Journal of Biological Macromolecules published new progress about Alfalfa. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Formula: C6H12O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts