Category: 58966-31-7

On January 11, 2017, Zheng, Hao published a patent.Quality Control of 1-(5-Chloro-2-methylphenyl)ethanol The title of the patent was A nose mask for sleeping. And the patent contained the following:

The invention discloses a nose mask for sleeping, belonging to medical instruments field. The nose mask for sleeping of the present invention, consists support. The two ends of the support are resp. fixedly connected with rhinarium. The rhinarium is provided with breather pipe, and the breather pipe surface is covered with filter membrane. The filter membrane is composed of polyallylacrylamide sodium 22, activated carbon 8, ethylparaben 3 and anhydrous calcium chloride 23 weight parts. The middle of the support is provided with connecting through hole which is connected with gas pipe. The gas pipe is disposed on the upper surface of the support, and is connected with gasket via the connecting through hole. The gasket is made from flexible material, and comprises adsorption layer, sustained-release layer and air-permeable layer from top to bottom. The adsorption layer is composed of nano indium oxide 27, polyoxypropylene diol 13, butenoate-grafted starch 41 and sodium dodecyl benzene sulfonate 16 weight parts. The sustained-release layer is composed of ephedrine derivative 6, Camellia oleifera extract 12, wood fiber 8, 2-acrylamide-2-methylpropanesulfonic acid 19, guar gum-g-poly(alginic acid-co-styrene) 21, Artemisia argyi leaf extract 4 and Abrus cantoniensis extract 8 weight parts. The air-permeable layer is composed of polyimide 30, Polycaprolactone 5, polylactic acid 19, sodium o-formylbenzene sulfonate isonicotinylhydrazone 22 and lignin fiber 13 weight parts. The inside of the rhinarium and support is hollow. The breather pipe is connected with rhinarium and support inside. The support is made up of flexible material, and the inside of the support is provided with iron wire for setting shape. The nose mask for sleeping of the present invention has the features of novel structure, reducing the mask size to a large extent, while ensuring the good ventilation of mouth and nasal airflow of the patient; it can achieve comfortable sleep, simultaneously ensures the mask not displace because of rolling in bed etc. . The experimental process involved the reaction of 1-(5-Chloro-2-methylphenyl)ethanol(cas: 58966-31-7).Quality Control of 1-(5-Chloro-2-methylphenyl)ethanol

The Article related to sleeping nose mask natural pharmaceutical, Pharmaceuticals: Prosthetics and Medical Goods and other aspects.Quality Control of 1-(5-Chloro-2-methylphenyl)ethanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Campbell, Stewart John; Darwish, David published an article in 1976, the title of the article was Asymmetric induction in the Sommelet rearrangement of chiral benzylsulfonium salts.Synthetic Route of 58966-31-7 And the article contains the following content:

The Sommelet rearrangement of (+)-ethylmethyl-p-nitrobenzylsulfonium perchlorate (I) and (+)-ethylmethyl-p-chlorobenzylsulfonium perchlorate (II) are described. Elution of I through a hydroxide exchange resin generated ethylmethylsulfonium p-nitrobenzylide [(+)-III] which decomposed in methanol at room temperature to Et 2-methyl-5-nitrobenzyl sulfide and (+)-Me α-(2-methyl-5-nitrophenyl)ethyl sulfide with 18 to 20.3% asymmetric induction. Decomposition of II in NaOMe solution at 70° produced Et 2-methyl-5-chlorobenzyl sulfide and (+)-Me α-(2-methyl-5-chlorophenyl)ethyl sulfide with 21 to 25.5% asymmetric induction. The lower estimates of asymmetric induction for each sulfide were made by comparison with sp. rotations of authentic samples obtained by synthesis and resolution The higher estimates were obtained by the use of a chiral lanthanide shift reagent Eu(hfbc)3 with the sulfone derivatives of these chiral sulfides. The ylide (+)-III reacted with aldehydes to produce oxiranes with no induction of asymmetry. The experimental process involved the reaction of 1-(5-Chloro-2-methylphenyl)ethanol(cas: 58966-31-7).Synthetic Route of 58966-31-7

The Article related to asym sommelet rearrangement benzylsulfonium, sulfonium asym sommelet rearrangement, Physical Organic Chemistry: Rearrangements, Including Isomerization and Tautomerization and other aspects.Synthetic Route of 58966-31-7

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On February 27, 2014, Nakajima, Tatsuo; Goi, Takashi; Kawata, Atsushi; Sugahara, Masakatsu; Yamakoshi, Shuhei published a patent.Name: 1-(5-Chloro-2-methylphenyl)ethanol The title of the patent was Preparation of 1-(7-hydroxy-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-1H-pyrazole-4-carboxylic acid derivatives as hypoxia-inducible factor-prolyl hydroxylase inhibitors. And the patent contained the following:

There are provided pyrazolopyrimidine compounds represented by formula [I; the 7-hydroxypyrazolo[4,3-d]pyrimidine-5-yl group is optionally substituted; X = a simple bond or an optionally substituted straight-chain alkylene; Z = H, R, RO, NRR1; R, R1 = independently each optionally substituted aryl, heteroaryl, alicyclic hydrocarbyl, or non-aromatic heterocyclyl] or pharmaceutically acceptable salts. These compounds have an hypoxia-inducible factor-prolyl hydroxylase (HIF-PDH) inhibitors (HIF-PHD) inhibitory effect, and are useful as stimulating agents for the production of erythropoietin in kidney (erythropoiesis stimulating agents) for the prevention and/or treatment of renal anemia. Thus, benzylation of 1-(7-methoxy-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-1H-pyrazole-4-carboxylic acid Et ester by 4-bromomethyl-1,2-dichlorobenzene in the presence of K2CO3 in MeCN with stirring at 80° for 2 h gave 47% 1-[1-(3,4-dichlorobenzyl)-7-methoxy-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-1H-pyrazole-4-carboxylic acid Et ester (II; R2 = Et, R3 = Me) and 35% 1-[2-(3,4-dichlorobenzyl)-7-methoxy-2H-pyrazolo[4,3-d]pyrimidin-5-yl]-1H-pyrazole-4-carboxylic acid Et ester (III). Saponification of II (R2 = Et, R3 = Me) with a mixture of 2 M aqueous NaOH solution and THF at 60° for 1.5 h followed by concentration and acidification with water and 1 M aqueous HCl solution gave 97% II (R2 = = R3 H). II (R2 = R3 = H) and 1-[1-[2-(6-ethylnaphthalen-3-yl)ethyl]-7-hydroxy-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-1H-pyrazole-4-carboxylic acid (IV) showed IC50 of 0.021 and 0.012 μM, resp., against human HIF-PHD2 and 0.16 and 0.18 μM, resp., against human HIF-PHD3. II (R2 = R3 = H) and IV at 3 μM promoted the production of erythropoietin in Hep38 cells by 4.6 and 168-fold, resp. The experimental process involved the reaction of 1-(5-Chloro-2-methylphenyl)ethanol(cas: 58966-31-7).Name: 1-(5-Chloro-2-methylphenyl)ethanol

The Article related to erythropoiesis (stimulating agents), homo sapiens, human, hypoxia-inducible factors role: bsu (biological study, unclassified), biol (biological study), pyrazoles role: pac (pharmacological activity), spn (synthetic preparation), thu (therapeutic use), biol (biological study), prep (preparation), uses (uses), pyrimidines role: pac (pharmacological activity), spn (synthetic preparation), thu (therapeutic use), biol (biological study), prep (preparation), uses (uses), renal anemia and other aspects.Name: 1-(5-Chloro-2-methylphenyl)ethanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts