Category: 589-98-0

Reference of 589-98-0, Adding some certain compound to certain chemical reactions, such as: 589-98-0, name is 3-Octanol,molecular formula is C8H18O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 589-98-0.

General procedure: Compound 5 was dissolved in alcohol (13±16 equiv) and heated to 100C for 3 h in the presence of a catalytic amount of H2SO4 (0.1 equiv). Complete dissolution occurred while heating. The reaction was quenched by adding a saturated solution of NaHCO3 in water and the mixture was extracted with EtOAc. The organic layers were combined, and the solvent was evaporated under reducedpressure at 40C. The residual alcohol was removed by vacuum distillation. The crude residue was purified by flash column chromatography with appropriate eluents and a gradient. Diheptyl 2-[(4-methoxyphenoxy)methyl]pyrimidine-4,6-dicarboxylate (6a). Generalprocedure I was followed. Compound 5 (73 mg, 0.20 mmol), 1-heptanol (0.50 mL, 3.2 mmol,16 equiv), H2SO4 (1 muL, 0.03 mmol, 0.1 equiv). Flash chromatography eluents: n-hexane (A),Et2O (B); gradient: 8%66% B×10 CV. Compound 6a was isolated as a dark yellow oil (81mg, 0.16 mmol, 80% yield).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 589-98-0, 3-Octanol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Provenzani, Riccardo; Tarvainen, Ilari; Brandoli, Giulia; Lempinen, Antti; Artes, Sanna; Turku, Ainoleena; Jaentti, Maria Helena; Talman, Virpi; Yli-Kauhaluoma, Jari; Tuominen, Raimo K.; Boije af Gennaes, Gustav; PLoS ONE; vol. 13; 4; (2018);,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 589-98-0, name is 3-Octanol. This compound has unique chemical properties. The synthetic route is as follows. name: 3-Octanol

1.31 g (10.1 mmol) of 3-octanol,0.170 g (0.50 mmol) of tetrabutylammonium hydrogensulfate and 0.0155 g (0.10 mmol) of TEMPO were dissolved in 30 mL of dichloromethane and charged into the reaction vessel. After the liquid temperature in the reaction vessel was cooled to 5 DEG C, 1.98 g (12.0 mmol) of the crystals of sodium hypochlorite pentahydrate was added with stirring, and then the liquid temperatureThe mixture was kept at 5 DEG C and stirredOxidation reaction was carried out. After 1 hour from the start of the oxidation reaction, internal standard analysis was carried out by GC in the same manner as in Example 1 to find that 3-octanone was produced at a yield of 97%.

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Reference:
Patent; NIPPON LIGHT METAL COMPANY, LIMITED; TOMOHIDE, OKADA; TOMOTAKE, ASAWA; YUKIHIRO, SUGIYAMA; (9 pag.)KR2015/26729; (2015); A;,
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Synthetic Route of 589-98-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 589-98-0, name is 3-Octanol, molecular formula is C8H18O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Step 3a: Synthesis of Example 54 [0268] Thionyl chloride (0.29 mL, 4 mmol) was added to a suspension of Intermediate H (0.71 G, 1.0 mmol) and benzotriazole (0.24 G, 2 mmol) in toluene/dichloromethane (1:1, 20 mL), and the obtained mixture was heated under argon at 40 C. for 1 hour. 2-Ethylhexanol was then added, and the mixture was stirred at room temperature for 3 days. The reaction mixture was poured into water (100 mL), neutralized with saturated sodium bicarbonate, stirred for 30 minutes and extracted with dichloromethane (2¡Á100 mL). The extract was dried over magnesium sulfate, the volatiles were removed under reduced pressure and the residue was chromatographed (silica gel, hexane/dichloromethane 1:2). The fractions containing a fluorescent material were combined, the solvent was evaporated and the residue was dried in a vacuum oven to provide chromophore Example 54 (661, mg, 71% yield) as an orange glassy foam. 1H NMR (400 MHz, CDCl3): delta 7.93 (d, 4H, J=8.8 Hz), 7.90 (d, 4H, J=8.8 Hz), 7.78 (s, 2H), 7.35 (dd, 4H, J=7.3 and 8.4 Hz), 7.28 (d, 4H, J=8.5 Hz), 7.22 (dd, 4H, J=1.5 and 8.8 Hz), 7.16 (tt, 2H, J=7.4 and 1.1 Hz), 7.12 (d, 4H, J=8.5 Hz), 4.20 (m, 4H), 1.69 (m, 2H), 1.44-1.30 (m, 16H), 0.94 (t, 6H, J=7.3 Hz), 0.89 (t, 6H, J=7.3 Hz). UV-vis spectrum: lambdamax=442 nm (dichloromethane), 446 nm (PVB film). Fluorimetry: lambdamax=606 nm (dichloromethane), 558 nm (PVB film).

According to the analysis of related databases, 589-98-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; NITTO DENKO CORPORATION; RACHWAL, STANISLAW; WANG, PENG; RACHWAL, BOGUMILA; ZHANG, HONGXI; YAMAMOTO, MICHIHARU; US2013/74927; (2013); A1;,
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