Category: 5856-63-3

Chiral Arylated Amines via C-N Coupling of Chiral Amines with Aryl Bromides Promoted by Light was written by Song, Geyang;Yang, Liu;Li, Jing-Sheng;Tang, Wei-Jun;Zhang, Wei;Cao, Rui;Wang, Chao;Xiao, Jianliang;Xue, Dong. And the article was included in Angewandte Chemie, International Edition in 2021.Recommanded Product: (R)-2-Aminobutan-1-ol This article mentions the following:

A method based on mol. Ni catalysis driven by light, which enabled stereoretentive C-N coupling of optically active amines, amino alcs. and amino acid esters with aryl bromides, with no need for any external photosensitizer was reported. The method was effective for a wide variety of coupling partners, including those bearing functional groups sensitive to bases and nucleophiles, thus providing a viable alternative to accessing synthetically important chiral N-aryl amines, amino alcs. and amino acids esters. Its viability was demonstrated by 92 examples with up to 99% ee. In the experiment, the researchers used many compounds, for example, (R)-2-Aminobutan-1-ol (cas: 5856-63-3Recommanded Product: (R)-2-Aminobutan-1-ol).

(R)-2-Aminobutan-1-ol (cas: 5856-63-3) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Recommanded Product: (R)-2-Aminobutan-1-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chiral separation of aliphatic primary amino alcohols as o-phthaldialdehyde/mercaptoethanol derivatives on polysaccharide-based chiral stationary phases was written by Dousa, Michal. And the article was included in Chirality in 2019.Recommanded Product: 5856-63-3 This article mentions the following:

A sensitive chiral high performance liquid chromatog. (HPLC) method for the determination of aliphatic primary amino alc. isomers with o-phthaldialdehyde/mercaptoethanol precolumn derivatization has been developed and validated. Seven chiral columns were tested in a reversed phase mode. Excellent enantioseparation with the resolution more than 2.0 was achieved on Chiralcel OJ-3R. The effect of various chromatog. conditions including column temperature, acetonitrile content in the mobile phase, buffer pH, buffer concentration, and buffer type in the mobile phase on the retention and the selectivity was investigated. The final mobile phase consisted of binary mixture of 20mM ammonium formate solution with acetonitrile (75:25; volume/volume). The analyses were performed at mobile phase flow rate of 1.0 mL/min and the column temperature of 40°C. The fluorescence detection was performed at excitation wavelength of 345 nm and emission wavelength of 450 nm. The developed method was fully validated in terms of linearity, sensitivity, accuracy, precision, intermediate precision, and selectivity according to International Council for Harmonisation of Tech. Requirements for Pharmaceuticals for Human Use guidelines using internal normalization procedure. The proposed chiral method was proved to be highly sensitive, simple, and rapid and was successfully applied to the determination of D-Valinol content in com. available samples of L-Valinol. In the experiment, the researchers used many compounds, for example, (R)-2-Aminobutan-1-ol (cas: 5856-63-3Recommanded Product: 5856-63-3).

(R)-2-Aminobutan-1-ol (cas: 5856-63-3) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Recommanded Product: 5856-63-3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Specific cooperative effect for the enantiomeric separation of amino acids using aqueous two-phase systems with task-specific ionic liquids was written by Wu, Datong;Zhou, Ying;Cai, Pengfei;Shen, Shanshan;Pan, Yuanjiang. And the article was included in Journal of Chromatography A in 2015.COA of Formula: C4H11NO This article mentions the following:

Aqueous two-phase systems (ATPS) based on hydrophilic ionic liquid (IL) and inorganic salt solution were designed and prepared for the enantiomeric separation of racemic amino acids. Two different kinds of hydrophilic ionic liquids (I, IL-1 and II IL-2) containing functional groups were synthesized to sep. racemic amino acids. Preliminary experiments showed that D-enantiomer of amino acids cooperatively interacted with ILs, which pushed D-enantiomer to remain in the bottom IL-rich phase. By contrast, L-enantiomer was transferred into the top Na₂SO₄-rich phase. The enantioselectivity of IL-1 was better than that of IL-2 because of their different intermol. interactions. Various factors influencing separation efficiency were also systematically studied including extraction time, IL volume and temperature Also, the mechanism was studied by ¹H NMR and DFT calculations, which showed that the hydrogen bond between the carboxylate and amide groups and the resonance-assisted hydrogen bond between amino and hydroxyl groups conditioned the movement between the residues and ILs. Finally, IL-1 was validated with other general amino acids by the same procedures based on ATPS. In the experiment, the researchers used many compounds, for example, (R)-2-Aminobutan-1-ol (cas: 5856-63-3COA of Formula: C4H11NO).

(R)-2-Aminobutan-1-ol (cas: 5856-63-3) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.COA of Formula: C4H11NO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Enantioselective Fluorescent Recognition in the Fluorous Phase: Enhanced Reactivity and Expanded Chiral Recognition was written by Wang, Chao;Wu, Elaine;Wu, Xuedan;Xu, Xiangchuan;Zhang, Guoqing;Pu, Lin. And the article was included in Journal of the American Chemical Society in 2015.Safety of (R)-2-Aminobutan-1-ol This article mentions the following:

A novel perfluoroalkyl-BINOL-based chiral diketone is the 1st highly enantioselective fluorescent sensor in the fluorous phase. One enantiomer of a chiral amino alc. or diamine at a concentration >1 mM can cause an up to 1200-2000-fold fluorescent enhancement of the sensor (0.08 mM), while the other enantiomer gives only a 10-50-fold enhancement. The fluorous-phase-based sensor is found to enhance the reactivity of the previously reported fluorous insoluble sensor with amino alcs. and expand its chiral recognition ability. Dynamic light scattering studies show the formation of aggregates of very different particle sizes when two enantiomers of a substrate interact with the sensor in perfluorohexane (FC-12). This substantial difference enables easy discrimination of the enantiomers with UV-lamps or even the naked eye. NMR, IR, and mass spectroscopic studies indicate that the fluorescent enhancement and enantioselectivity should originate from the fluorous solvent-promoted nucleophilic addition of the amino alcs. to the carbonyl groups of the sensor. In the experiment, the researchers used many compounds, for example, (R)-2-Aminobutan-1-ol (cas: 5856-63-3Safety of (R)-2-Aminobutan-1-ol).

(R)-2-Aminobutan-1-ol (cas: 5856-63-3) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Safety of (R)-2-Aminobutan-1-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Stereoselective synthesis of functionalized α-amino acids isolated by filtration was written by Sivak, Ivan;Toberny, Michal;Kyselicova, Andrea;Caletkova, Ol’ga;Berkes, Dusan;Jakubec, Pavol;Kolarovic, Andrej. And the article was included in Journal of Organic Chemistry in 2018.Reference of 5856-63-3 This article mentions the following:

Crystallization-induced diastereomer transformation (CIDT) represents a highly appealing and convenient synthetic tool. Despite its numerous advantages, it remains rather rarely used due to its uncertain predictability to occur. Herein, we describe CIDT based on aza-Michael reactions of diversely functionalized (E)-3-acylacrylic acids. This method provides direct access to a broad variety of α-amino acid derivatives in excellent stereochem. purities. In the experiment, the researchers used many compounds, for example, (R)-2-Aminobutan-1-ol (cas: 5856-63-3Reference of 5856-63-3).

(R)-2-Aminobutan-1-ol (cas: 5856-63-3) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Reference of 5856-63-3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

3-Vinyl oxindole-chromone synthon as a skeletal reconstruction reactant for the synthesis of 2-hydroxy benzoyl pyridones was written by Zhang, Lei;Liu, Ren-Ming;Wang, Wei-Na;Liu, Xiong-Li;Dai, Yi-Feng;Yu, Zhang-Biao;Peng, Li-Jun. And the article was included in New Journal of Chemistry in 2022.Reference of 5856-63-3 This article mentions the following:

The first example of ring-opening and recyclization reaction of 3-vinyl oxindole-chromones I [R¹ = H, 4-F, 5-Br, etc.; R² = H, 5-F, 4-Cl, etc.] as versatile synthons, which can react with ammonia or primary aliphatic amines as binucleophiles was developed, serving as a fruitful strategy for the eco-friendly and atom-economic synthesis of a new family of skeletally diverse 2-hydroxy benzoyl pyridones II [R³ = H, CH₂CH₂OMe, CH₂CH₂CN, etc.] with high to excellent yields (70-92%). The advantages of this methodol., including the use of easily available raw materials and the catalyst-free, wide functional group tolerance, and gram-scale synthesis, make the developed methodol. a practical way to access important biol. active 2-hydroxy benzoyl pyridone mols. In the experiment, the researchers used many compounds, for example, (R)-2-Aminobutan-1-ol (cas: 5856-63-3Reference of 5856-63-3).

(R)-2-Aminobutan-1-ol (cas: 5856-63-3) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Reference of 5856-63-3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Diverse synthetic approaches towards C1′-branched acyclic nucleoside phosphonates was written by Kalcic, Filip;Dracinsky, Martin;Janeba, Zlatko. And the article was included in Organic & Biomolecular Chemistry in 2021.Reference of 5856-63-3 This article mentions the following:

Herein we describe and compare five convenient approaches leading to key synthetic 6-chloropurine acyclic nucleoside phosphonates (ANPs), e.g. I, bearing the 9-phosphonomethoxyethyl (PME) moiety branched at the C₁‘ position. These intermediates can be further vastly diversified into target C1′-branched ANPs bearing either natural or unnatural nucleobases. The importance of C1′-branched ANPs is emphasized by their analogy with C1’-substituted cyclic nucleotides (such as remdesivir, a broad-spectrum antiviral agent) and evaluation of their biol. activity (e.g. antiviral, antineoplastic, and antiprotozoal) will be a tempting subject of further research. In the experiment, the researchers used many compounds, for example, (R)-2-Aminobutan-1-ol (cas: 5856-63-3Reference of 5856-63-3).

(R)-2-Aminobutan-1-ol (cas: 5856-63-3) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Reference of 5856-63-3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Design, synthesis and anticonvulsant-analgesic activity of new N-[(phenoxy)alkyl]- and N-[(phenoxy)ethoxyethyl]aminoalkanols was written by Rapacz, Anna;Waszkielewicz, Anna M.;Panczyk, Katarzyna;Pytka, Karolina;Koczurkiewicz, Paulina;Piska, Kamil;Pekala, Elzbieta;Budziszewska, Boguslawa;Starek-Swiechowicz, Beata;Marona, Henryk. And the article was included in MedChemComm in 2017.Quality Control of (R)-2-Aminobutan-1-ol This article mentions the following:

New derivatives of N-[(phenoxy)alkyl]- and N-[(phenoxy)ethoxyethyl]aminoalkanols have been synthesized and evaluated for their anticonvulsant activity in maximal electroshock (MES), maximal electroshock seizure threshold (MEST), and pentylenetetrazol (PTZ) tests. Their neurotoxicity was evaluated via rotarod and chimney tests. The compounds exhibiting the most beneficial activity and protection indexes were evaluated for analgesic activity using the formalin test for neurogenic pain. They were also evaluated for their influence on cytotoxic activity using in vitro cellular models (HepG2 and CRL-2534 cell lines). Experiments performed using MTT and neutral red cytotoxicity assays showed that all evaluated compounds were safe for normal, glial cells (astrocytes) and did not induce hepatotoxic effects. Based on the results from the in vitro studies, the safety of the evaluated compounds was inferred. The most promising compound in this research was 1-{2-[2-(2,3-dimethylphenoxy)ethoxy]ethyl}piperidin-3-ol hydrochloride. Addnl., in silico metabolism prediction for the compound has been performed. In the experiment, the researchers used many compounds, for example, (R)-2-Aminobutan-1-ol (cas: 5856-63-3Quality Control of (R)-2-Aminobutan-1-ol).

(R)-2-Aminobutan-1-ol (cas: 5856-63-3) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Quality Control of (R)-2-Aminobutan-1-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Novel Inorganic Mesoporous Material with Chiral Nematic Structure Derived from Nanocrystalline Cellulose for High-Resolution Gas Chromatographic Separations was written by Zhang, Jun-Hui;Xie, Sheng-Ming;Zhang, Mei;Zi, Min;He, Pin-Gang;Yuan, Li-Ming. And the article was included in Analytical Chemistry (Washington, DC, United States) in 2014.Synthetic Route of C4H11NO This article mentions the following:

Chiral nematic mesoporous silica (CNMS) has attracted widespread attention due to some unique features, such as its nematic structure, chirality, large pore size, high temperature resistance, low cost, and ease of preparation The authors 1st reported the use of CNMS as a stationary phase for capillary gas chromatog. (GC). The CNMS-coated capillary column not only gives good selectivity for the separation of linear alkanes, aromatic hydrocarbons, polycyclic aromatic hydrocarbons (PAHs), and isomers but also offers excellent enantioselectivity for chiral compounds Compared with enantioseparations on com. β-DEX 120 and Chirasil-L-Val columns, a CNMS-coated capillary column offers excellent enantioselectivity, chiral recognition complementarity, and the separation of analytes within short elution times. It can also be potentially applied in high-temperature GC at >350°. CNMS could soon become very attractive for separations In the experiment, the researchers used many compounds, for example, (R)-2-Aminobutan-1-ol (cas: 5856-63-3Synthetic Route of C4H11NO).

(R)-2-Aminobutan-1-ol (cas: 5856-63-3) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Synthetic Route of C4H11NO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Co-Assembly of Chiral Amines and a Four-Armed Cyano-Substituted Luminophore through Hydrogen Bonds for Potential Development of Smart Chiroptical Materials was written by Liu, Yiping;Hao, Aiyou;Xing, Pengyao. And the article was included in Chemistry – A European Journal in 2022.Category: alcohols-buliding-blocks This article mentions the following:

Chirality transfer from chiral mols. to assemblies is of vital importance to the design of functional chiral materials. In this work, selective co-assembly behaviors between chiral mols. and an achiral luminophore, potentially driven by the intermol. salt-bridge type hydrogen bonds are reported. Cyano-substituted tetrakis(arylthio)benzene carboxylic acid (TA) served as the luminophore and hydrogen bond donors, which underwent co-assembly with different chiral amines. It was found that structures of chiral amines affect the chirality transfer and the properties of co-assemblies due to effects on hydrogen bonds and stacking pattern. Only in specific co-assemblies, the chiroptical properties occurred at both ground state and excited states based on the emerged Cotton effects and circularly polarized luminescence (CPL) signals, revealing that the chirality was successfully transferred from mol. level to supramol. level. In addition, accurate quant. examination of chiral amines was realized by CD spectra. This work demonstrates the characteristic chirality response and transfer through co-assembly, providing a potential method to develop smart chiroptical materials. In the experiment, the researchers used many compounds, for example, (R)-2-Aminobutan-1-ol (cas: 5856-63-3Category: alcohols-buliding-blocks).

(R)-2-Aminobutan-1-ol (cas: 5856-63-3) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts