Category: 58551-69-2

Zong, Fang published the artcileEfficacy of carboprost tromethamine combined with leonurus japonicus for prevention of postpartum hemorrhage in high-risk pregnant women: A protocol for systematic review and meta-analysis, Related Products of alcohols-buliding-blocks, the publication is Medicine (Philadelphia, PA, United States) (2021), 100(30), e26792, database is CAplus and MEDLINE.

No well-designed and systematic evaluation of the efficacy and safety of leonurus japonicus injection (LJI) in combination with carboprost tromethamine has been found. Therefore, we undertook a meta-anal. to assess the efficacy and safety of carboprost tromethamine combined with LJI for the prevention of postpartum hemorrhage in high-risk pregnant women to provide new evidence-based medical evidence for clin. treatment. This systematic review and meta-anal. would be performed according to Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines. The following databases including EMBASE, MEDICINE, Wanfang, China National Knowledge Infrastructure database, and Cochrane central controlled trial registries were searched by 2 reviewers from inception to July 2021. Mesh and keyword search terms were “motherwort,” “Yimucao,” “leonurus japonicas,””carboprost tromethamine,” and “postpartum hemorrhage”. Any cohort studies that assessed the efficacy and safety of carboprost tromethamine combined with LJI for the prevention of postpartum hemorrhage would be included. P05 was set as the level of significance. The review would add to the existing literature by showing compelling evidence and improved guidance in clinic settings.

Medicine (Philadelphia, PA, United States) published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C10H10N2, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ma, Li-hua published the artcileClinical observation of prophylaxis from uterine inertia postpartum hemorrhage by hemabate, Related Products of alcohols-buliding-blocks, the publication is Zhongguo Xueye Liubianxue Zazhi (2011), 21(4), 693-694, 769, database is CAplus.

The objective was to evaluate the effect of prophylaxis from uterine inertia postpartum hemorrhage by hemabate. 90 Cases of puerperal with the postpartum hemorrhage volume â‰?50mL, were divided randomly into the observation groups who were injected with hemabate 250μg in the uterus body immediately, and the control groups who were injected with oxytocin 20U in the uterus body and buccal sublingually misoprostol 400μ g, and the rate of postpartum hemorrhage and the hemorrhage volume of 2h postpartum or 2 to 24h postpartum were compared. Comparing with the control groups, the observation groups had a lower rate of postpartum hemorrhage, and the less hemorrhage volume of 2h postpartum and 2 to 24h postpartum, and the difference had a statistical significance. Hemabate is more effective than misoprostol to prevent postpartum hemorrhage, with the characteristics of high performance, quick effect, safety and convenience.

Zhongguo Xueye Liubianxue Zazhi published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C25H47NO8, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Drew, Kurt L. M. published the artcileSize estimation of chemical space: how big is it?, Product Details of C25H47NO8, the publication is Journal of Pharmacy and Pharmacology (2012), 64(4), 490-495, database is CAplus and MEDLINE.

To estimate the size of organic chem. space and its sub-regions, i.e. drug-like chem. space and known drug space (KDS), anal. of the growth of organic compounds as a function of their carbon atoms based on a power function (f(x) = A × B, C = x) and an exponential function (f(x) = AeBx) was carried out. Also, the statistical distribution of KDS and drug-like chem. space (drugs with good oral-bioavailability) based on their carbon atom count was used to deduce their size. Key findings The power function (f(x) = A × B, C = x) gives a superior fit to the growth of organic compounds leading to an estimate of 3.4 × 109 populating chem. space. KDS is predicted to be 2.0 × 106 mols. and drug-like chem. space is calculated to be 1.1 × 106 compounds The results showed that the values here are much smaller than previously reported. However, the numbers are large but not astronomical. A clear rationale on how we reach these numbers is given, which hopefully will lead to more refined predictions.

Journal of Pharmacy and Pharmacology published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C25H47NO8, Product Details of C25H47NO8.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts