Category: 58551-69-2

Wang, Rui-jiao published the artcileStudy on effect of oxytocin combined with carboprost tromethamine in preventing postpartum hemorrhage in high-risk women, Category: alcohols-buliding-blocks, the publication is Zhongguo Fuyou Baojian (2016), 31(15), 3033-3035, database is CAplus.

Objective: To analyze the preventive effect of the combination of carboprost tromethamine and oxytocin on postpartum hemorrhage in cesarean section of high-risk women, and observe the occurrence of adverse reactions after maternal medication. Methods: A total of 120 high-risk pregnant women who were scheduled for cesarean delivery at the Obstetrics Department of Liaobu Hospital in Dongguan City were collected, and randomly divided into 3 groups. 40 cases in group A, who were given oxytocin alone. 40 patients in group B were treated with oxytocin combined with carboprost methylate suppository. 40 patients in group C were given oxytocin combined with carboprost tromethamine. The intraoperative and postoperative bleeding volume, postpartum hemorrhage, treatment and adverse reactions of the three groups were compared. Results: The intraoperative and postoperative 2 h bleeding volume of group B and group C were significantly lower than that of group A (P < 0.05), among which the difference of group C was more significant. The bleeding volume in group C was significantly lower than that in group A and group B at 2-24 h after operation (P < 0.05). The incidence of postpartum hemorrhage, blood transfusion rate, and treatment rate of other hemostatic measures in group B and group C were significantly lower than those in group A (P < 0.05). Conclusion: The combination of carboprost tromethamine and oxytocin can effectively reduce the amount of postpartum hemorrhage and the incidence of postpartum hemorrhage in high-risk women, and it is safe and worthy of further promotion.

Zhongguo Fuyou Baojian published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C11H19N, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wu, Xia published the artcileApplication of urapidil in prevention and treatment of adverse reactions caused by carboprost tromethamine in cesarean section, Recommanded Product: 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, the publication is Nanjing Yike Daxue Xuebao, Ziran Kexueban (2015), 35(9), 1305-1307, database is CAplus.

The application effect of urapidil on prevention and treatment of adverse reactions caused by carboprost tromethamine in cesarean section was observed A total of 60 full-term pregnant patients who needed cesarean section of lower uterine segment were randomly divided into urapidil group (U group) and normal saline group (N group), 30 cases in each group. After fetal childbirth, based on injection of carboprost tromethamine 250 μg, urapidil of 12.5 mg was i.v. injected in U group, and 20 mL normal saline was injected in N group. The mean arterial blood pressure (MAP), heart rate (HR) and pulse oxygen saturation (SPO₂) were recorded in both groups before anesthesia (T₀), at fetal childbirth (T₁), 10 min after injection of carboprost tromethamine (T₂) and 30 min after injection of carboprost tromethamine (T₃). And the adverse reactions in both groups were observed There were no statistically significant differences in MAP, HR and SPO₂ at T₀ between both two groups (P>0.05). Compared with T₀, MAP and HR in N group were increased at T₂ (P<0.05), while SPO₂ was decreased (P<0.05). Compared with N group, MAP and HR in U group were decreased at T₂ (P<0.05), while SPO₂ was increased (P<0.05). The incidences of headache and chest tightness were higher in N group than in U group (P<0.05). Urapidil can be effectively used in the prevention and treatment of adverse reactions caused by carboprost tromethamine in cesarean section, which is conducive to the stability of circular breathing.

Nanjing Yike Daxue Xuebao, Ziran Kexueban published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C11H8O3, Recommanded Product: 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Habek, Jasna Čerkez published the artcileREFRACTORY BRADYCARDIA–A RARE COMPLICATION OF CARBOPROST TROMETHAMINE FOR INDUCTION OF ABORTION, COA of Formula: C25H47NO8, the publication is Acta clinica Croatica (2016), 55(2), 323-5, database is MEDLINE.

We report a first case of refractory several-hour sinus bradycardia, a rare but already described side effect of intramuscular administration of carboprost tromethamine to induce abortion for medical indication in a patient without cardiovascular and other diseases. After administration of atropine sulfate 3×0.5 mg intravenously without effect, the patient‘s sinus rhythm spontaneously normalized as carboprost was eliminated from the body (it has a 3-hour half-life). It is reasonable to believe that the specific prostaglandin underlay the etiology of bradycardia.

Acta clinica Croatica published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C25H47NO8, COA of Formula: C25H47NO8.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Bao, Zhi-hui published the artcileClinical analysis of carboprost tromethamine and misoprostol in the prevention of postpartum hemorrhage of high-risk pregnant women after cesarean section, Related Products of alcohols-buliding-blocks, the publication is Shiyong Yaowu Yu Linchuang (2014), 17(2), 243-245, database is CAplus.

Objective: To compare the value of carboprost tromethamine and misoprostol in the prevention and treatment of postpartum hemorrhage in high-risk pregnant women after cesarean section. Methods: 102 cases of high-risk pregnant women were randomly divided into 2 groups, 52 cases in group A were treated with carboprost tromethamine, while 52 cases in group B were treated with misoprostol. The postpartum hemorrhage rate and the amount of bleeding were compared between the two groups. Results: There was no significant difference in the postpartum hemorrhage rate between the 2 groups (P > 0.05). The amount of bleeding at postpartum 2 h and 24 h in group A were less than those of group B (P < 0.05). No significant difference was found in the incidence of adverse reactions between the 2 groups (P > 0.05). Conclusion: Carboprost tromethamine can prevent postpartum hemorrhage, and the effect is superior to that of misoprostol, it can improve the rate of contraction of the uterus, and reduce the rate of postpartum hemorrhage.

Shiyong Yaowu Yu Linchuang published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C25H47NO8, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhang, Meijie published the artcileEffect of hemabate combined with oxytocin on bleeding after cesarean section, Recommanded Product: 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, the publication is Xin Zhongyi (2015), 47(5), 185-186, database is CAplus.

Objective: To observe the effect of hemabate combined with oxytocin on bleeding after cesarean section. Methods: 116 cases of cesarean section women were randomly divided into a control group and an observation group. The control group received hemabate, while the observation group addnl. received oxytocin. Results: The total effective rate in the observation group was significantly higher than that in the control group. After treatment, the postpartum hemorrhage volume significantly decreased in both groups, and the observation group was significantly lower than that in the control group. There were no serious adverse reactions in both groups. Conclusion: Hemabate combined with oxytocin for maternal postoperative cesarean section can significantly reduce postpartum hemorrhage and improve clin. effect.

Xin Zhongyi published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C44H28ClFeN4, Recommanded Product: 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Li, Jie published the artcileOptimum target plasma concentration of propofol in preventing adverse effects of carboprost tromethamine in patients undergoing caesarean section, Safety of 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, the publication is Zhonghua Mazuixue Zazhi (2016), 36(3), 321-324, database is CAplus.

Objective To investigate the optimum target plasma concentration of propofol in preventing the adverse effects of carboprost tromethamine in the patients undergoing caesarean section. Methods One hundred and twenty-eight nulliparous parturients who were at full term with a singleton fetus, of American Society of Anesthesiologists phys. status I or II, aged 24-37 yr, weighing 54-78 kg, scheduled for elective caesarean section under combined spinal-epidural anesthesia, were randomly divided into 4 groups (n = 32 each) using a random number table: control group (group C) and different concentrations of propofol groups (P_1-3 groups). Carboprost tromethamine 250 μg was injected into the body of the uterus, and propofol with the target plasma concentrations of 0.8, 1.2 and 1.6 μg/mL was simultaneously given by target-controlled infusion in P₁, P₂ and P₃ groups, resp., and normal saline was infused at a rate of 0.5 mL·kg^-1·h^-1 in group C. The occurrence of cardiovascular events was recorded from the end of carboprost tromethamine administration until the end of surgery. The related adverse effects after carboprost tromethamine administration and Ramsay sedation score at 15 mm after carboprost tromethamine administration were recorded, and satisfactory sedation was defined as Ramsay sedation score of 2. The occurrence of complications associated with combined spinal-epidural anesthesia was recorded during the postoperative follow-up. Results Compared with group C, the incidence of carboprost tromethamine-related adverse effects was significantly decreased in P₂ and P₃ groups, the rate of satisfactory sedation was significantly increased in P₁ and P₂ groups, the incidence of hypotension and tachycardia was significantly decreased in group P₁ (P<0.05), and no significant change was found in the incidence of carboprost tromethamine-related adverse effects in group P₁ and in the rate of satisfactory sedation in group P₃ (P>0.05). Compared with group P₁, the incidence of carboprost tromethamine-related adverse effects was significantly decreased in P₂ and P₃ groups, the rate of satisfactory sedation was significantly increased in group P₂, and the rate of satisfactory sedation was significantly decreased in group P₃ (P<0.05). Compared with group P₂, the rate of satisfactory sedation was significantly decreased (P<0.05), and no significant change was found in the incidence of carboprost tromethamine-related adverse effects in group P₃ (P>0.05). No cardiovascular events were found in group P₂, and the incidence of hypotension was 9% in group P₃. Conclusion The optimum target plasma concentration of propofol in preventing the adverse effects of carboprost tromethamine is 1.2 μg/mL in the patients undergoing caesarean section.

Zhonghua Mazuixue Zazhi published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C25H47NO8, Safety of 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Cui, Wen-hua published the artcileApplication of carboprost tromethamine and improved B-Lynch suture in postnatal hemorrhage of cesarean section, Application of 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, the publication is Zhongguo Fuyou Baojian (2013), 28(22), 3710-3711, database is CAplus.

The objective of this paper is to investigate carboprost tromethamine and uterine Modified B-Lynch suture in the treatment of intractable postpartum hemorrhage in cesarean. Here, 36 patients treated by general application can not stop the bleeding maternal carboprost tromethamine and modified B-Lynch suture. The results shows, 30 cases of postpartum hemorrhage were stopped, the bleeding rate was 83.33%. Carboprost tromethamine and modified B-Lynch suture in the treatment of uterine cesarean intractable postpartum hemorrhage is certainly worthy of promotion.

Zhongguo Fuyou Baojian published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C25H47NO8, Application of 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Vaid, Arvind published the artcileA randomized controlled trial of prophylactic sublingual misoprostol versus intramuscular methyl-ergometrine versus intramuscular 15-methyl PGF2α in active management of third stage of labor, Related Products of alcohols-buliding-blocks, the publication is Archives of Gynecology and Obstetrics (2009), 280(6), 893-897, database is CAplus and MEDLINE.

Objective: To compare the efficacy and side effects of 0.2 mg methyl-ergometrine IM, 400 μg misoprostol sublingual and 125 μg 15 Me PGF2α IM in active management of third stage of labor. Method: Two hundred low risk pregnant women with induced or spontaneous labor were randomized to receive either 400 μg misoprostol sublingually or 0.2 mg methyl-ergometrine i.m. or 125 μg 15-Me PGF2α i.m., after the delivery of anterior shoulder of baby. The main outcome measures were: blood loss more than 500 mL, need for addnl. oxytoxic drug, change in Hb level and side effects due to drugs. Results: The median estimated blood loss, blood loss more than 500 mL, need for addnl. oxytocic drug and change in Hb levels were similar in all three groups. The significant side effects in the misoprostol group were shivering, pyrexia (temperature > 38°C) and vomiting, which were self-limiting. Diarrhea was significantly more in the 15 Me PGF2α group. Three women in methyl-ergometrine group underwent manual removal of placenta. One woman in misoprostol group received blood transfusion. Conclusion: Sublingual misoprostol appears to be as effective as i.m. methyl-ergometrine and i.m. 15-Me PGF2α in the prevention of postpartum hemorrhage. It can be a good alternative in resource poor setting.

Archives of Gynecology and Obstetrics published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C5H7BO2S, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Lin, Hanfeng published the artcileApplication of carboprost tromethamine in treatment of hypertension in pregnancy, Application In Synthesis of 58551-69-2, the publication is Fujian Yiyao Zazhi (2013), 35(5), 99-100, database is CAplus.

Objective: To investigate application of carboprost tromethamine in treatment of hypertension in pregnancy. Methods: 200 cases of patients with hypertension in pregnancy were selected as a treatment group, and 200 cases of normal pregnancy at the same period were selected as a control group. Two groups underwent lumbar epidural anesthesia for cesarean section surgery, the control group was instantly given oxytocin 20 IU injection for uterine wall after childbirth of fetus, the treatment group was one-time given carboprost tromethamine injection 250 μg after childbirth of fetus, and both groups were given 20 IU of oxytocin via continuous i.v. infusion for 6 h. The bleeding state, incidence of postpartum hemorrhage, Hb level, and blood pressure after childbirth were observed during surgery and after surgery within 2 h and 24 h. Results: Compared with the control group, the amount of bleeding within 2h, 24 h after surgery of the treatment group was lower, and incidence of postpartum hemorrhage was lower (P < 0.05). Blood pressure difference of the two groups was not statistically significant (P > 0.05) and the two groups had no significant adverse reactions. Conclusions: Carboprost tromethamine is an effective measure to prevent postpartum hemorrhage of hypertension in pregnancy.

Fujian Yiyao Zazhi published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C25H47NO8, Application In Synthesis of 58551-69-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Yuan, Mingfeng published the artcileDexmedetomidine prevented Hemabate adverse reactions in cesarean section, Related Products of alcohols-buliding-blocks, the publication is Jiangsu Yiyao (2015), 41(21), 2597-2598, database is CAplus.

Dexmedetomidine prevented Hemabate adverse reactions in cesarean section was studied. After Hemabate in cesarean section, D group treated dexmedetomidine and C group was control group. BP, HR, RR, SpO2 were recoreded at room (T0), before Hemabeta (T1), after drug 10 min (T2). At T2, BP and HR were higher than T0, SpO2 of group D change was small, SpO2 of group C decreased. Adverse reaction of group D was lower than group C. Dexmedetomidine reduced Hemabate adverse reactions in cesarean section.

Jiangsu Yiyao published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C9H13NO2, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts