Category: 58551-69-2

Cao, Shengyan published the artcileComparison of application effect of ergometrine and carboprost tromethamine in patients with bleeding during cesarean section with placenta previa, Recommanded Product: 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, the publication is Guizhou Yiyao (2021), 45(5), 784-785, database is CAplus.

The efficacy of carboprost tromethamine and ergometrine in the treatment of bleeding patients with placenta previa during cesarean section was investigated. In the hemostatic treatment of patients with bleeding during cesarean section of placenta previa, the overall effect of ergometrine and carboprost tromethamine is equivalent, but considering the low cost of ergometrine, clin. prevention and treatment of puerperium is recommended. Ergometrine should be used for middle and postpartum hemorrhage.

Guizhou Yiyao published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C25H47NO8, Recommanded Product: 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Song, Xiao-xia published the artcileComparison of the preventive and therapeutic effects of ergometrine maleate, carbetocin and carboprost tromethamine on postpartum hemorrhage caused by uterine asthenia, Application In Synthesis of 58551-69-2, the publication is Guangdong Yixue (2017), 38(18), 2850-2852, 2855, database is CAplus.

This paper discusses the safety and effectiveness of ergometrine maleate, carbetocin and carboprost aminobutyric triol in the prevention and treatment of postpartum hemorrhage caused by uterine asthenia during vaginal delivery. These three drugs are safe and effective when postpartum uterine atony occurs in patients with vaginal delivery. Carbetocin can be used as the first choice for oxytocin combination, but due to their different clin. characteristics, the drug selection should take into account the principle of individualization.

Guangdong Yixue published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C12H9NO, Application In Synthesis of 58551-69-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wu, Lian-fang published the artcileClinical study on prevention of postpartum hemorrhage of cesarean section using hemabatein high risk pregnant women, COA of Formula: C25H47NO8, the publication is Zhonghua Fuchanke Zazhi (2007), 42(9), 577-581, database is CAplus.

Objective: To observe the effect and safety of hemabat (H) on prevention of postpartum hemorrhage in cesarean section and after cesarean section in high risk pregnant women. Methods: Four hundred and sixty-nine pregnant women with high hemorrhagic risk factors including twin pregnancy, polyhydramnios, fetal macrosomia, placenta previa were planned cesarean section. A total of 457 pregnant women were divided into 3 groups by operation indications. There were 239 cases of fetal macrosomia, 145 cases of twin pregnancy and polyhydramnios, and 73 cases of placenta previa. Three kinds of hysterotonics were used randomly in each group. Group oxytocin (O): 20 U oxytocin injected into the uterine plus 20 U oxytocin intravascularly, 152 women; Group oxytocin + hemabate (O + H): 20 U oxytocin and 250 μg hemabat injected into the uterine, 192 women; group H: 250 μg hemabat, injected into the uterine, 125 women. The amount of bleeding during the operation and within 2-h after delivery were measured. The side effect of each group was observed Results: The amount of bleeding during cesarean section in group O was (445 ± 262) ml, in group 0 + H (332 ± 218) ml, and in group H (375 ± 265) ml. There was an extremely significant difference between group O and group O + H (P < 0.01). The amount of bleeding within 2 h after delivery in group O was (176 ± 193) ml, in group O + H was (110 ± 114) ml, and in group H was (124 ± 103) ml. There was a significant difference between groups O, O + H and H. Among the 469 women, 31 had total amount of bleeding more than 1000 mL during operation and within 2 h after delivery, 48% (15 women) were in group O, 23% in group O + H and 29% in group H. The total amount of bleeding in group O was much more than group O + H and group H in the group of fetal macrosomia (P < 0.01, P < 0.01). Similar results were found in the group of twin pregnancy and polyhydramnios (P < 0.01, P < 0.01). The total amount bleeding in group O + H was much less than group O in the group of placenta previa (P < 0.05). There were 5% (12) pregnant women whose total amount of bleeding was ≥ 1000 mL in the group of fetal macrosomia, 8% (11) in the group of twin pregnancy, 11% (8) in the group of placenta previa. No hysterectomy was done among the women. The incidence of side effects in the three groups was 2.6%, 11.5% and 7.0% resp. Vomiting was frequently seen in the latter two groups, but recovered soon without treatment. Conclusion: Hemabat can significantly reduce the amount of bleeding during the cesarean section in pregnant women with high hemorrhagic risk factors and can be used with oxytocin as firstline medicine to prevent hemorrhage during and after delivery.

Zhonghua Fuchanke Zazhi published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C15H23BO2, COA of Formula: C25H47NO8.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhang, Li published the artcileEvaluation of drug treatment for postpartum hemorrhage, Formula: C25H47NO8, the publication is Zhongguo Shiyong Fuke Yu Chanke Zazhi (2009), 25(2), 98-102, database is CAplus.

A review. Management options for postpartum hemorrhage (PPH) include pharmacol., surgical and radiol. interventions. In recent years, there are great progress in its pharmacol. treatment. Oxytocin and ergometrine remain first-line options, and there are many other new drugs such as carbetocin, hemabate, vasopressin and recombinant activated blood-coagulation factor VII a. This review summarizes the effectiveness, safety and the best drug combinations for the treatment of primary PPH, and highlights recent advances and developments.

Zhongguo Shiyong Fuke Yu Chanke Zazhi published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C3H6BrNaO3S, Formula: C25H47NO8.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wang, Hui-min published the artcileClinical analysis of carbetocin combined with romethamine for preventing high-risk postpartum hemorrhage after caesarean section, Synthetic Route of 58551-69-2, the publication is Xiandai Zhongxiyi Jiehe Zazhi (2013), 22(26), 2916-2917, database is CAplus.

This paper aims to explore the clin. anal. of carbetocin combined with romethamine for preventing high-risk postpartum hemorrhage after caesarean section. 76 Cases of high-risk factor caesarean section puerpera were divided into control group and treatment group(n=38). In control group, the puerpera were injected with oxytocin 20 IU right after delivery, and i.v. infused with carbetocin 100 μg. Based on the treatment of control group, the treatment group was injected with romethamine 250 μg. The hemorrhage amount, side effect of drug and exhaust time in both groups were observed during operation, 2 h and 24 h after operation. The hemorrhage amounts during operation, 2 h and 24 h after operation in treatment group were significantly less than those of control group(all P<0.05). The exhaust time of treatment group was shorten than that of control group(P<0.05). There were no significant differences in drug side effects between two groups. Carbetocin combined with romethamine has definite effect and less side effect for preventing high-risk postpartum hemorrhage after caesarean section.

Xiandai Zhongxiyi Jiehe Zazhi published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C8H13ClN2O, Synthetic Route of 58551-69-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Tang, Weikun published the artcileClinical effect evaluation of carboprost tromethamine in preventing postpartum hemorrhage due to placenta previa, Synthetic Route of 58551-69-2, the publication is Zhongguo Fuyou Baojian (2015), 30(28), 4908-4909, database is CAplus.

OBJECTIVE: The paper explored the clin. efficacy of intraoperative injection of carboprost tromethamine to prevent postpartum hemorrhage in cesarean sections with placenta previa. Methods: The paper selected 54 cases of cesarean delivery with placenta previa who were treated in the hospital from March 2013 to March 2015 as the research subjects, and were randomly divided into observation group and control group, 27 cases in each group. The mothers in the observation group were injected with carboprost tromethamine in the uterine body after the newborn was delivered, while the women in the control group were given oral misoprostol. The paper observed and recorded the occurrence of bleeding and adverse reactions in the two groups during and after operation, within 2 h and within 24 h. Results: The intraoperative blood loss of patients in the postpartum observation group, and within 2 h and 24 h after the operation were lower than those in the control group, and the difference was statistically significant (P < 0.05); the incidence of maternal adverse reactions was significantly lower in the observation group than in the control group. The difference was statistically significant (P < 0.05). Conclusion: Intraoperative injection of carboprost tromethamine during cesarean delivery with placenta previa could effectively prevent postpartum hemorrhage, reduce the amount of intraoperative and postoperative bleeding, and improve the quality of life of the woman.

Zhongguo Fuyou Baojian published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C9H6BrNO, Synthetic Route of 58551-69-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wang, Yan-jiao published the artcileEffect of oxytocin combined with carboprost tromethamine on postoperative hemorrhage, recovery of gastrointestinal function, and the first average urination time after cesarean section in full-term delivery, Category: alcohols-buliding-blocks, the publication is Zhongguo Fuyou Baojian (2017), 32(20), 4923-4925, database is CAplus.

Objective To explore the effect of oxytocin combined with carboprost tromethamine on postoperative hemorrhage, recovery of gastrointestinal function, and the first average urination time after cesarean section in full-term delivery. Methods A total of 130 women after full-term delivery were chosen from the hospital from Oct. 2014 to Oct. 2016, then they were divided into control group and observation group according to random number table, 65 women in each group. The women in observation group were treated by oxytocin combined with carboprost tromethamine. The amounts of postoperative hemorrhage at 2 and 24 h after operation, the time of gastrointestinal function recovery, the first average urination time, and the incidence rates of adverse effects in the two groups were compared. Results The amounts of postoperative hemorrhage at 2 and 24 h after operation in observation group were statistically significantly less than those in control group (t = 3.14, 3.30, P<0.05). The time of gastrointestinal function recovery in observation group was statistically significantly shorter than that in control group (t = 2.74, P<0.05). The first average urination time in observation group was statistically significantly better than that in control group (F = 3.78, P<0.05). There was no statistically significant difference in the incidence rates of adverse effects between the two groups (χ² = 0.97, P>0.05). Conclusion Oxytocin combined with carboprost tromethamine used for full-term delivery after cesarean section can effectively reduce the amount of postoperative hemorrhage, promote recovery of gastrointestinal function and urination as soon as possible, and it doesn′t increase the incidence rates of adverse effects, the value is superior to oxytocin.

Zhongguo Fuyou Baojian published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C12H19BrS, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Yang, Cai-hong published the artcileAnalysis of clinical efficacy and safety of carboprost tromethamine combined with Barkri balloon in treatment of postpartum hemorrhage, Application In Synthesis of 58551-69-2, the publication is Xiandai Zhenduan Yu Zhiliao (2017), 28(16), 3003-3005, database is CAplus.

To explore the clin. efficacy and safety of carboprost tromethamine combined with Barkri balloon in the treatment of postpartum hemorrhage. A total of 90 patients with postpartum hemorrhage admitted to our hospital from Jan. 2015 to Dec. 2016 were selected and randomly divided into a control group and an observation group with 45 cases each. In the control group, a Bakri balloon was injected from the vagina or uterine incision during cesarean section, and 300mL of normal saline was injected. Patients in the observation group were injected with carboprost tromethamine for combination therapy on the basis of the control group. Both groups of patients were treated for 24 h. The clin. efficacy of the two groups of patients was compared, systolic blood pressure (SBP), diastolic blood pressure (DBP) and blood oxygen saturation (SaO₂), blood loss and adverse reactions were compared for safety evaluation of the combination. Results: After treatment, the total effective rates of the observation group and the control group were 93.33% and 80.00%, resp., and there was a statistical difference between the two groups (P < 0.05). There was no statistical difference in the amount of bleeding before treatment between the two groups of patients with postpartum hemorrhage (P > 0.05). After 2h and 24h of hemostatic treatment, the bleeding volume of the observation group was significantly less than that of the control group (P < 0.05). There was no significant difference in SBP, DBP and SaO₂ between the two groups of patients with postpartum hemorrhage before and after treatment (P > 0.05). There was no significant difference in the occurrence of adverse reactions between the two groups (P > 0.05). There was no statistically significant difference in the incidence of adverse reactions between the two groups. Carprost tromethamine combined with Bakri balloon has good clin. efficacy and high safety in the treatment of postpartum hemorrhage, and it is worthy of clin. application.

Xiandai Zhenduan Yu Zhiliao published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C26H41N5O7S, Application In Synthesis of 58551-69-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Liao, Jin-hua published the artcileClinical observation of midazolam for prevention of adverse reactions in cesarean section induced by carboprost tromethamine, Application In Synthesis of 58551-69-2, the publication is Linchuang Mazuixue Zazhi (2014), 30(8), 812-813, database is CAplus.

Role of midazolam and ondansetron for prevention of adverse reactions in cesarean section women induced by carboprost tromethamine was compared. Totally 90 cesarean section women were involved and randomly divided into normal saline (N) group, ondansetron (O) group and midazolam (M) group. SBP, DBP, HR and SpO₂ were observed before, 0 and 5 min after carboprost tromethamine injection (T0, T1 and T2, resp.). SBP and DBP were significantly higher, HR was faster and SpO₂ was lower at T2 compared with those at T1 in 3 groups (P<0.05). SBP and DBP was lower, HR was slower and SpO₂ was higher in M group than those in N group (P<0.05). Midazolam prevents adverse reactions in cesarean section women induced by carboprost tromethamine, and the effect is better than ondansetron.

Linchuang Mazuixue Zazhi published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C25H47NO8, Application In Synthesis of 58551-69-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Lu, Jian-ping published the artcileClinical effect of hemabate in prevention and treatment of postpartum hemorrhage and adverse events among high risk pregnant women receiving cesarean section, Category: alcohols-buliding-blocks, the publication is Zhongguo Fuyou Baojian (2016), 31(18), 3717-3719, database is CAplus.

Objective To explore the clin. effect of hemabate in prevention and treatment of postpartum hemorrhage and adverse events among high risk pregnant women receiving cesarean section, accumulate experience for clin. optimization strategy among the population. Methods From June 2010 to Oct. 2013, 78 pregnant women underwent cesarean section in Department of Obstetrics and Gynecol. in the hospital were selected, then they were divided into study group and control group according to random number table, 39 cases in each group. The cases in control group were treated by oxytocin combined with carboprost methylate suppositories, while the cases in study group were treated by hemabate. The amounts of blood loss and urine volumes during operation and at 2 and 24 h after operation in the two groups were recorded, the incidence rates of adverse events in the two groups were compared. Results The amount of blood loss during operation and at 2 and 24 h after operation in study group were statistically significantly lower than those in control group (P<0.05). Urine volumes during operation and at 2 and 24 h after operation in study group were statistically significantly higher than those in control group (P<0.05). The incidence rate of adverse reactions in study group was statistically significantly lower than that in control group (P<0.05). Conclusion For the high-risk pregnant women receiving cesarean section, the clin. efficacy and safety of hemabate in prevention and treatment of postpartum hemorrhage are better than those of oxytocin combined with carboprost methylate suppositories, which is worthy of further promotion and application in clin. practice.

Zhongguo Fuyou Baojian published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C25H47NO8, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts