Wang, Qiong-lin’s team published research in Xiandai Zhongxiyi Jiehe Zazhi in 22 | CAS: 58551-69-2

Xiandai Zhongxiyi Jiehe Zazhi published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C4H3Cl2NS, Name: 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid.

Wang, Qiong-lin published the artcilePreventive efficacy of carboprost tromethamine on delivery woman having risk factors of postpartum hemorrhage, Name: 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, the publication is Xiandai Zhongxiyi Jiehe Zazhi (2013), 22(23), 2538-2540, database is CAplus.

The purpose is to investigate clin. efficacy and safety of carboprost tromethamine in prevention of postpartum hemorrhage after high-risk pregnancy cesarean section. 200 Cases of delivery primiparous mothers underwent cesarean section were selected, and randomly divided into observation group and control group, n=100. Patients in the observation group after the babies were delivered were immediately injected with oxytocin 20IU in uterine body, then were injected with carboprost tromethamine 250 μg in uterine body, patients in the control group after the babies were delivered were immediately injected with oxytocin 20IU in uterine body, meanwhile i.v. injected with oxytocin 10 IU. Operative time, bleeding in operation, postpartum hemorrhage, postpartum hemorrhage incidence, postpartum lochia duration time, postpartum anemia incidence and other conditions of delivery women in two groups were observed There were effective 95 cases and ineffective 5 cases in the observation group, the total effective rate was 95%; there were effective 89 cases and ineffective 13 cases in the control group, the total efficiency was 87%; there was a significant difference in clin. efficacy of two groups (P<0.05). The average operation time and average bleeding amount of the observation group were 37.86 min, and 300.35 mL; the average operation time and average bleeding amount of the control group were 48.19min and 415.66mL; and there were significant differences between two groups (P<0.05). The postpartum hemorrhage amount of delivery woman in the observation group was 368.41 mL, the incidence of postpartum hemorrhage was 5%, the postpartum lochia duration time was (17.32±5.01) d, the incidence of postpartum anemia was 6%; the postpartum hemorrhage amount of delivery woman in the control group was 473.55 mL, the incidence of postpartum hemorrhage was 13%, the postpartum lochia duration time was (23.29±7.91) d, the incidence of postpartum anemia was 15%; and there were significant differences between two groups (P<0.05). Carboprost tromethamine for prevention of postpartum hemorrhage in high-risk pregnancy cesarean section women, is safe and effective, has mild adverse reactions, and is worthy of clin. application.

Xiandai Zhongxiyi Jiehe Zazhi published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C4H3Cl2NS, Name: 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Yin, Yue’s team published research in Xiandai Zhenduan Yu Zhiliao in 28 | CAS: 58551-69-2

Xiandai Zhenduan Yu Zhiliao published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C10H10CoF6P, Name: 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid.

Yin, Yue published the artcileClinical analysis of Hemabate combined with oxytocin for prevention of postpartum hemorrhage after cesarean section in high-risk parturients, Name: 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, the publication is Xiandai Zhenduan Yu Zhiliao (2017), 28(8), 1407-1408, database is CAplus.

To observe the prevention and safety effect and safety of Hemabate combined with oxytocin on postpartum hemorrhage of cesarean women with high risk factors of postpartum hemorrhage. The 240 pregnant women undergoing cesarean section with high risk factors of postpartum hemorrhage, such as uterine weakness, placenta previa, twin pregnancy, giant fetus, polyhydramnios, scarred uterus, etc., were selected as the research subjects, and they were randomly divided into observation group and 120 cases in each control group. In the control group, oxytocin 20U was injected i.v. after the fetus was delivered to prevent postpartum hemorrhage, and the observation group was combined with the control group with 250 μg deep i.m. injection of Hemabate. We observed and compared the bleeding volume and the incidence of postpartum hemorrhage and adverse reactions during cesarean section, 2h postpartum and 24h postpartum between the two groups. In the observation group, the average blood loss at 2h and 24h after delivery was significantly lower than that in the control group (P < 0.05). The incidence of postpartum hemorrhage in the observation group was 1.67% significantly lower than 11.67% in the control group (P < 0.05). There were 16 cases of postpartum adverse reactions in the observation group, the symptoms were mild and alleviated spontaneously. For pregnant women undergoing cesarean section with high risk factors for postpartum hemorrhage. The preventive use of Hemabate significantly reduces the amount of intraoperative and postpartum hemorrhage, reduces the incidence of postpartum hemorrhage, and the medication is safe, convenient and effective.

Xiandai Zhenduan Yu Zhiliao published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C10H10CoF6P, Name: 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Bojinova, S’s team published research in Akusherstvo i ginekologiia in 52 | CAS: 58551-69-2

Akusherstvo i ginekologiia published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C25H47NO8, Safety of 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid.

Bojinova, S published the artcile[The use of prostaglandin F2alpha (Prostin 15M) for terminationof second trimester pregnancy]., Safety of 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, the publication is Akusherstvo i ginekologiia (2013), 52(2), 53-5, database is MEDLINE.

The authors describe a case of terminating a second trimester pregnancy in 21 gestational weeks with use of Prostin 15 M. The patient come to the clinic in 21 gestational week with spontaneous rupture of the liquid amnii 72 hours ago, without any contractions and cervical dilatation. The foetus has breech presentation. From the ultrasound investment the fetal weight is measured to be around 380 grams and it has been confirmed that the liquid is less than normal. The woman refuse the use of Foley catheter. We induce the delivery with 10 E Oxytocin intravenously and with Cytotec by vaginal and per oral way (3 tablets equal to 600 micrograms) but there was no effect. There were no changes at the cervix and no contractions. Then we use 4 ampules of Prostin 15 M intramuscular through three hours and the pregnancy was successfully terminated.

Akusherstvo i ginekologiia published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C25H47NO8, Safety of 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Pan, Haijuan’s team published research in Guizhou Yiyao in 45 | CAS: 58551-69-2

Guizhou Yiyao published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C25H47NO8, Quality Control of 58551-69-2.

Pan, Haijuan published the artcileObservation on effect of carboprost tromethamine in prevention of postoperative bleeding during cesarean section with placenta previa, Quality Control of 58551-69-2, the publication is Guizhou Yiyao (2021), 45(7), 1064-1065, database is CAplus.

Objective: To investigate the effect of carboprost tromethamine in the prevention of postoperative bleeding during cesarean section with placenta previa. Methods: A controlled study was conducted on 88 puerperae with placenta previa who underwent cesarean section in our hospital from 2017.5 to 2019.5, and they were divided into observation group (carboprost tromethamine) and control group (oxytocin) 44 cases in each group, and the grouping method was random number table method to explore the effect of different treatments on postpartum hemorrhage and adverse reactions of puerperae. Results: The research objects in this paper were compared in terms of intraoperative blood loss, postoperative 12-h blood loss and postoperative 24-h blood loss. The observation group was significantly lower than the control group, and the difference was statistically significant (P < 0.05). Compared with the total effective rate, the observation group (97.73%) was significantly higher than the control group (86.36%), and the difference was statistically significant (P < 0.05). The observation group (2.27%, 9.09%) was significantly lower than the control group (15.91%, 27.27%), and the difference was statistically significant (P < 0.05). CONCLUSION: The application of carboprost tromethamine to pregnant women undergoing cesarean section with placenta previa could significantly reduce intraoperative and postoperative blood loss, with definite curative effect, less adverse reactions and high safety. This method was worthy of application and promotion.

Guizhou Yiyao published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C25H47NO8, Quality Control of 58551-69-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wang, Xin-ni’s team published research in Guangdong Yixue in 33 | CAS: 58551-69-2

Guangdong Yixue published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C8H10BNO3, SDS of cas: 58551-69-2.

Wang, Xin-ni published the artcileEfficacy of preventive intrauterine injection of carboprost tromethamine in cesarean section of pregnant women with critical risk of postpartum hemorrhage, SDS of cas: 58551-69-2, the publication is Guangdong Yixue (2012), 33(5), 696-697, database is CAplus.

Objective: To observe the clin. efficacy of preventive intrauterine injection of carboprost tromethamine in cesarean section of pregnant women with critical risk of postpartum hemorrhage. Methods: Ninety-eight critical pregnant women receiving cesarean section with probability of postpartum hemorrhage were divided into an observation group (n=50) and a control group (n=48). The patients in the observation group were given conventional intrauterine injection of oxytocin and carboprost tromethamine for prevention of postpartum hemorrhage after parturition, and the patients in the control group were given oxytocin, misoprostol, pituitrin and calcium gluconate. The indexes of 2, 24 h hemorrhage volume, incidence of postpartum hemorrhage, hemostasis time, transfusion rate and complications in long or short term were compared between the two groups after parturition. Results: The 2, 24 h hemorrhage volume, incidence of postpartum hemorrhage, hemostasis time, transfusion rate and uterectomy rate in the observation group were significantly lower compared with the control group (P<0.05). Conclusion: Preventive intrauterine injection of carboprost tromethamine in cesarean section reduces hemorrhage volume, decreases the incidence of postpartum hemorrhage, transfusion rate and complications in long and short term for pregnant women with critical risk of postpartum hemorrhage, and the earlier of time selection, the better of the efficacy, which is valuable to popularize in basis hospitals.

Guangdong Yixue published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C8H10BNO3, SDS of cas: 58551-69-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Huang, Qiu-hong’s team published research in Linchuang Yixue in 36 | CAS: 58551-69-2

Linchuang Yixue published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C25H47NO8, Name: 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid.

Huang, Qiu-hong published the artcileClinical effect of the combined application of carboprost tromethamine injection and gauze on patients with previa placenta underwent cesarean section, Name: 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, the publication is Linchuang Yixue (2016), 36(2), 24-25, database is CAplus.

The aim of this paper is to investigate the clin. effects of combined application of Carboprost tromethamine injection and gauze on patients with previa placenta underwent cesarean section. From March 2013 to March 2015, forty-two patients with previa placenta underwent cesarean section were selected in the sixth people’s hospital of Nanhai district, all patients were randomly divided into observation group and control group. The patients in observation group were given Carboprost tromethamine injection and gauze to stop bleeding, while the patients in control group were managed with gauze only. The operation situations(bleeding volume, operation time, transfusion rate, and uterus resection rate), the bleeding volume after operation(2 h, 4 h, 8 h, 12 h), and adverse effects after operation of the two groups were observed The bleeding volume in operation of observation group and control group was resp.(361.3±69.9) ml vs. (552.0±59.6) ml, and there was significant difference(P<0.05). No significant difference was observed in operation time, transfusion rate, uterus resection rate or adverse effects after operation between the two groups(P>0.05). The effects of hemostasis of the combined application of carboprost tromethamine injection and gauze are better than gauze only on patients with previa placenta underwent cesarean section.

Linchuang Yixue published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C25H47NO8, Name: 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wang, Chunfang’s team published research in Hebei Yixue in 23 | CAS: 58551-69-2

Hebei Yixue published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C8H11BO2, Safety of 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid.

Wang, Chunfang published the artcileTo explore the best time of hemabate in prevention and treatment of postpartum hemorrhage, Safety of 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, the publication is Hebei Yixue (2017), 23(1), 52-54, database is CAplus.

Objective: To study the best time of hemabate in prevention and treatment of postpartum hemorrhage, to provide basis for clin. diagnosis and treatment. Methods: 114 cases of cesarean section with bleeding tendency from Feb. 2014 to Feb. 2016 in our hospital were selected, the patients were randomly divided into group I, group II and group III, 38 cases in each group, group I injection of oxytocin and hemabate immediately after fetal delivery, group II injection of the oxytocin immediately after fetal delivery, application of hemabate when uterine atony, group III injection of oxytocin immediately after fetal delivery, not using hemabate, the bleeding intraoperative, back to the ward to postoperative 2H and 2H to postpartum 24 h were compared between the three groups. Results: The bleeding during operation of group I significantly lower than II group and III group (P<0.05), there were no significant amount of intraoperative blood loss in group II and group III (P>0.05); back to the ward to postoperative 2H bleeding of group I and group II were significantly lower than those in the group III (P<0.05), group I and group II were not statistically significant (P>0.05), 2H to postpartum 24h bleeding of group I and group II were significantly lower than those in the group III (P<0.05), group I and group II were not statistically significant (P>0.05). Conclusion: Fetal delivery immediately injection of oxytocin and hemabate could effectively reduce the amount of postpartum hemorrhage, it is the best time to prevent postpartum hemorrhage.

Hebei Yixue published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C8H11BO2, Safety of 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

van Laarhoven, Twan’s team published research in Bioinformatics in 27 | CAS: 58551-69-2

Bioinformatics published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C17H16O2, Name: 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid.

van Laarhoven, Twan published the artcileGaussian interaction profile kernels for predicting drug-target interaction, Name: 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, the publication is Bioinformatics (2011), 27(21), 3036-3043, database is CAplus and MEDLINE.

The in silico prediction of potential interactions between drugs and target proteins is of core importance for the identification of new drugs or novel targets for existing drugs. However, only a tiny portion of all drug-target pairs in current datasets are exptl. validated interactions. This motivates the need for developing computational methods that predict true interaction pairs with high accuracy. We show that a simple machine learning method that uses the drug-target network as the only source of information is capable of predicting true interaction pairs with high accuracy. Specifically, we introduce interaction profiles of drugs (and of targets) in a network, which are binary vectors specifying the presence or absence of interaction with every target (drug) in that network. We define a kernel on these profiles, called the Gaussian Interaction Profile (GIP) kernel, and use a simple classifier, (kernel) Regularized Least Squares (RLS), for prediction drug-target interactions. We test comparatively the effectiveness of RLS with the GIP kernel on 4 drug-target interaction networks used in previous studies. The proposed algorithm achieves area under the precision-recall curve (AUPR) up to 92.7, significantly improving over results of state-of-the-art methods. Moreover, we show that using also kernels based on chem. and genomic information further increases accuracy, with a neat improvement on small datasets. These results substantiate the relevance of the network topol. (in the form of interaction profiles) as source of information for predicting drug-target interactions.

Bioinformatics published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C17H16O2, Name: 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Govindappagari, Shravya’s team published research in Obstetrics & Gynecology (Philadelphia, PA, United States) in 135 | CAS: 58551-69-2

Obstetrics & Gynecology (Philadelphia, PA, United States) published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C25H47NO8, Computed Properties of 58551-69-2.

Govindappagari, Shravya published the artcileMild Thrombocytopenia and Postpartum Hemorrhage in Nulliparous Women With Term, Singleton, Vertex Deliveries, Computed Properties of 58551-69-2, the publication is Obstetrics & Gynecology (Philadelphia, PA, United States) (2020), 135(6), 1338-1344, database is CAplus and MEDLINE.

Objective: To assess whether mild thrombocytopenia (platelet count 100-149 k/μL) is associated with an increased risk of postpartum hemorrhage. Methods: Nulliparous women with term, singleton, vertex pregnancies undergoing labor at our institution between August 2016 and Sept. 2017 were included. The primary exposure was mild thrombocytopenia, defined as platelet count 100-149 k/μL, and the comparator was normal platelet count (150 k/μL or greater). Those with severe thrombocytopenia (platelet count less than 100 k/μL) were excluded from anal. The primary outcome was postpartum hemorrhage, determined by International Classification of Diseases, Tenth Revision codes and the hospital discharge problem list. Secondary outcomes included use of uterotonic agents (methylergonovine maleate or carboprost tromethamine), total blood loss 1,000 mL or greater, and blood transfusion. Data were analyzed by t test, χ or Fisher exact test, and multivariable logistic regression, with significance at α <0.05. Results: We evaluated 2,845 eligible women, of whom 2,579 (90.2%) had normal platelet count 150 k/μL or greater, 266 (9.3%) had platelet count 100-149 k/μL (mild thrombocytopenia), and 13 (0.5%) had platelet count less than 100 k/μL (severe thrombocytopenia). Compared with women with normal platelet count, those with mild thrombocytopenia had a higher rate of postpartum hemorrhage (16.9% vs 8.5%, P<.001) and were more likely to have total blood loss 1,000 mL or greater (4.5% vs 1.7%, P=.002) and receive methylergonovine maleate (10.5% vs 5.9%, P=.003) or carboprost tromethamine (6.0% vs 1.6%, P<.001) or both (3.8% vs 1.0%, P<.001), but rates of blood transfusion were no different (1.9% vs 1.5%, P=.59). The association between mild thrombocytopenia and postpartum hemorrhage persisted after multivariable adjustment for potential confounders (adjusted odds ratio 2.2, 95% CI 1.5-3.2, P<.001). Conclusion: Among nulliparous women with term, singleton, vertex pregnancies undergoing labor, those with mild thrombocytopenia (platelet count 100-149 k/μL) had a twofold greater likelihood of postpartum hemorrhage compared with those with normal platelet count.

Obstetrics & Gynecology (Philadelphia, PA, United States) published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C25H47NO8, Computed Properties of 58551-69-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Marinov, B’s team published research in Akusherstvo i ginekologiia in 46 Suppl 2 | CAS: 58551-69-2

Akusherstvo i ginekologiia published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C25H47NO8, Recommanded Product: 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid.

Marinov, B published the artcile[Some possibilities for application of “Pfizer” medicines–Prostin 15m, Prostin E2, Prepidil gel, Dostinex, Synarel–in the obstetrician practice]., Recommanded Product: 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, the publication is Akusherstvo i ginekologiia (2007), 57-60, database is MEDLINE.

The authors make a clinical and pharmacological overview of the possibilities of application in the obstetrician practice of part of the medicines of the company Pfiser. Some of these medicines have no analogue in Bulgaria–i.e. Prostin 15M. The authors outline the advantages of the Pfiser medicines in comparison with other medicines with similar action.

Akusherstvo i ginekologiia published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C25H47NO8, Recommanded Product: 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts