58551-69-2 Archives - Page 3 of 8 - Alcohols-buliding-blocks

Lin, Xing-zhe’s team published research in Zhongguo Fuyou Baojian in 31 | CAS: 58551-69-2

Zhongguo Fuyou Baojian published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C25H47NO8, Synthetic Route of 58551-69-2.

Lin, Xing-zhe published the artcileAnalysis on clinical effects and safeties of carboprost tromethamine of different administration modes in treatment of postpartum hemorrhage, Synthetic Route of 58551-69-2, the publication is Zhongguo Fuyou Baojian (2016), 31(22), 4660-4662, database is CAplus.

Objective To evaluate the clin. effects of i.m. and cervical injection of carboprost tromethamine in treatment of postpartum hemorrhage. Methods A total of 460 patients were randomly divided into control group (318 cases) and exptl. group (142 cases). The cases in control group were treated by i.m. injection of carboprost tromethamine (250 μg), while the cases in exptl. group were treated by cervical injection of carboprost tromethamine (250 μg). The amounts of endometrorrhagia and colporrhagia within 2 h after the end of the third stage of labor and the incidence rates of adverse reactions in the two groups were compared. Results The amounts of endometrorrhagia in exptl. group and control group were (71.43±13.96) ml and (50.56±10.78) ml, resp. (P<0.05); the amounts of colporrhagia in exptl. group and control group were (35.31±6.32) ml and (44.27±8.31) ml, resp. (P<0.05); the incidence rates of adverse reactions in exptl. group and control group were 16.12% and 11.66%, resp. (P>0.05). Conclusion It is recommended to treat uterine inertia patients by i.m. injection to prevent and treat postpartum hemorrhage; cervical injection should be selected to prevent postpartum hemorrhage among the patients with other causes.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Liao, Yan-ling’s team published research in Hainan Yixue in 25 | CAS: 58551-69-2

Hainan Yixue published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C25H47NO8, Product Details of C25H47NO8.

Liao, Yan-ling published the artcileClinical efficacy of midazolam and dezocine for hemabate-induced side effects during caesarean section, Product Details of C25H47NO8, the publication is Hainan Yixue (2014), 25(1), 35-37, database is CAplus.

The clin. efficacy of midazolam and dezocine for hemabate (carboprost tromethamine injection) induced side effects in the patients undergoing caesarean section was explored. Forty patients used hemabate during saesarean section were randomly divided into two groups, each with twenty cases. Before hemabate intrauterine injection, the patients in the control group were given normal saline 3 mL i.v., while those in the exptl. group were given midazolam 2 mg and dezocine 5 mg i.v. Respiratory function, circulatory function and side effects were observed before and after hemabate medication. The changes of MAP, HR, RR and SpO₂ in the exptl. group were fewer than those in the control group at any time point (P<0.05). The incidence of side effects in exptl. group was lower than that in the control group (P<0.05). Midazolam and dezocine could be used effectively and safely for bemabate-induced side effects during caesarean section.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wang, Zhi-mei’s team published research in Zhongguo Yaofang in 25 | CAS: 58551-69-2

Zhongguo Yaofang published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C9H8O4, Application of 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid.

Wang, Zhi-mei published the artcileEffect of carboprost tromethamine on amount of bleeding in cesarean section at different time points of high risk parturients, Application of 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, the publication is Zhongguo Yaofang (2014), 25(4), 336-338, database is CAplus.

The aim of this paper is to observe the effects of carboprost tromethamine on the amount of bleeding in cesarean section of high risk parturients at different time points. The clin. data of 180 high risk parturients with postpartum hemorrhage tendency in cesarean section were retrospectively analyzed and divided into treatment group and control group according to the duration of carboprost tromethamine treatment. Treatment group was given intrauterine injection of carboprost tromethamine 250 μg and i.v. dripping of oxytocin 10 u after the delivery of fetus; control group was given intrauterine injection of carboprost tromethamine 250 μg if the amount of bleeding increased because uterine inertia and uterine massage was invalid, following intrauterine injection of oxytocin 10 u i.v. after the delivery of fetus. Both groups were given carboprost tromethamine continuously, depending on the situation. The amounts of bleeding and adverse drug reactions were recorded in 2 groups. The incidence of postpartum hemorrhage in treatment group was 17.7%, which was significantly lower than in control group(28.7%); the amounts of bleeding in treatment group 2 h and 24 h after operation were significantly lower than in control group; there was statistical significance(P<0.05). Adverse drug reaction of 2 groups was slight and recovered spontaneously. The application of carboprost tromethamine in advance could effectively decrease postpartum hemorrhage in high risk parturients with postpartum hemorrhage tendency, and it’s safety.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Jiang, Biwei’s team published research in Zhongguo Jiceng Yiyao in 20 | CAS: 58551-69-2

Zhongguo Jiceng Yiyao published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C25H47NO8, Application of 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid.

Jiang, Biwei published the artcileApplication of carboprost tromethamine combined with modified patch suture in placenta previa postpartum hemorrhage, Application of 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, the publication is Zhongguo Jiceng Yiyao (2013), 20(4), 533-535, database is CAplus.

The effect of carboprost tromethamine (hemabate) combined with modified patch suture in placenta previa postpartum hemorrhage was observed Sixty-two patients with placenta previa were divided into the control group (30 cases) and treatment group (32 cases). The control group was treated with hemabate, and the treatment group was treated with hemabate combined with modified patch suture. The two groups of intraoperative, postpartum 2 h, 24 h postpartum were compared in bleeding volume and Hb changes. The intraoperative bleeding volume [(321.9±67.8) ml vs (435.9±83.3) ml] and 2h, 24h postpartum bleeding volume [(417.7±68.0) ml vs (539.6±70.4) ml and (485.3±68.5) ml vs (621.0±81.3) ml] of the treatment group were significant less than that of the control group (t=5.926, 6.938, 7.133, all P<0.05). Significant difference in changes of Hb level was also observed between the two groups, though postpartum level was not significantly reduced in the treatment group compared with the control group [(5.0±6.5) g/L vs (-4.0±6.8) g/L] (t=-3.662, P<0.05). Hemabate combined with modified patch suture can be more effective in the prevention of postpartum hemorrhage in placenta previa.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Dong, Li’s team published research in Zhongguo Fuyou Baojian in 31 | CAS: 58551-69-2

Dong, Li published the artcileStudy on the application timing of tromethamine in cesarean section of patients with central placenta previa, Computed Properties of 58551-69-2, the publication is Zhongguo Fuyou Baojian (2016), 31(18), 3701-3703, database is CAplus.

Objective To explore the application timing of tromethamine in cesarean section of patients with central placenta previa. Methods Sixty-four women underwent cesarean section in Department of Obstetrics and Gynecol. in the hospital from Jan. 2013 to Dec. 2014, then they were diagnosed as central placenta previa and divided into observation group and control group based on random number table according to the sequence of admission, 32 women in each group. The patients in observation group were treated by tromethamine immediately after delivery of fetus, while the patients in control group were treated by tromethamine after delivery of placenta. The numbers of automatic placental expulsion, the numbers of manual removal of placenta, operation time, and the amounts of blood loss during operation in the two groups were compared. Results The amounts of blood loss during operation and at two hours after operation in observation group were statistically significantly less than those in control group (P<0.01). There was no statistically significant difference in the amount of blood loss within 24 h after operation between the two groups (P>0.05). The rate of automatic placental expulsion in observation group was statistically significantly higher than that in control group, while the rate of manual removal of placenta in observation group was statistically significantly lower than that in control group (P<0.01). The operation time in observation group was statistically significantly shorter than that in control group (P<0.01). Six patients in observation group were treated by uterine gauze, while fourteen patients in control group were treated by uterine gauze, there was statistically significant difference between the two groups (P<0.01). The rates of intraoperative and postoperative blood transfusion in observation group and control group were 15.6% and 37.5%, resp., there was statistically significant difference between the two groups (P<0.01). There was no statistically significant difference in the incidence rate of adverse reactions between the two groups (P>0.05). Conclusion Uterine body injection of tromethamine immediately after delivery of fetus during cesarean section of patients with central placenta previa can quickly promote lower segment uterine contraction, improve placental delivery rate, reduce the amount of blood loss during operation, shorten operation time, the adverse reactions are few, but the price is expensive, so it can be used as obstetric emergency medication or preventive medication of high risk pregnant women.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Guo, Zhenzhen’s team published research in Jianyan Yixue Yu Linchuang in 13 | CAS: 58551-69-2

Jianyan Yixue Yu Linchuang published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C25H47NO8, Name: 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid.

Guo, Zhenzhen published the artcileEfficacy of carboprost trometamol vs. misoprostol in preventing hemorrhage after cesarean section, Name: 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, the publication is Jianyan Yixue Yu Linchuang (2016), 13(22), 3258-3260, database is CAplus.

Objective: To investigate the efficacy of carboprost trometamol vs. misoprostol in preventing hemorrhage after cesarean section. Methods: 114 cases of high-risk parturient women were divided into group A and group B, which received carboprost trometamol and misoprostol after cesarean section, resp. Results: There was no significant difference of postpartum hemorrhage rate between the two groups, but the 2 h hemorrhage and 24 h hemorrhage in group A were significantly lower than those in group B. Conclusion: Carboprost trometamol shows a better preventive effect on hemorrhage after cesarean section than misoprostol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ning, Ling-li’s team published research in Zhongguo Fuyou Baojian in 32 | CAS: 58551-69-2

Ning, Ling-li published the artcileAnalysis of curative effect of Hemabate combined with B-Lynch suture in treatment of postpartum hemorrhage caused by uterine asthenia, COA of Formula: C25H47NO8, the publication is Zhongguo Fuyou Baojian (2017), 32(18), 4595-4596, database is CAplus.

Purpose: The article explored the clin. effect of Hemabate combined with B-Lynch suture in the treatment of postpartum hemorrhage due to uterine asthenia. Methods: In the paper, 100 cases of postpartum hemorrhage due to uterine contraction and fatigue admitted to the Fuyang District Maternity and Child Health Hospital from March 2014 to March 2016 were selected as the research objects, and were divided into observation group and control group by random number method, with 50 cases in each group. The observation group was treated with Simabate combined with B-Lynch suture, and the control group was treated with traditional hemostasis. The clin. efficacy, operation time, intraoperative blood loss, 24 h postoperative blood loss, postoperative Hb level, hospital stay and postoperative complications were observed in the two groups. Results: The total effective rate of the observation group was 96.00%, and the control group was 80.00%. The difference between the two groups was statistically significant (P < 0.05); the operation time of the observation group was (49.98 ± 7.24) min, and the intraoperative blood loss was ( 514.43 ± 29.53) ml, 24 h postoperative blood loss was (125.97 ± 15.26) ml, hospitalization time was (7.92 ± 2.36) days, the control group was (71.41 ± 6.08) min, (720.16 ± 31.27) ml, (230.14 ± 21.91) ml, (10.04 ± 3.71)d, the difference between the two groups was statistically significant (P < 0.05). The Hb level of the observation group was higher than that of the control group, but the difference was not statistically significant (P > 0.05). The incidence of complications in the observation group was significantly lower than that in the control group, but the difference was not statistically significant (P > 0.05). Conclusion: The clin. effect of Simabate combined with B-Lynch suture in the treatment of postpartum hemorrhage due to uterine attenuation was definite and could shorten the operation time, to reduce intraoperative and postpartum hemorrhage, it was a fast, safe and easy way to stop bleeding, with fewer complications.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Li, Qihong’s team published research in Zhongguo Fuyou Baojian in 30 | CAS: 58551-69-2

Li, Qihong published the artcileObservation on the effect of dexmedetomidine on reduction of adverse reactions induced by carboprost tromethamine during cesarean section, Product Details of C25H47NO8, the publication is Zhongguo Fuyou Baojian (2015), 30(35), 6368-6370, database is CAplus.

Objective To evaluate the preventive effect of dexmedetomidine on adverse reactions induced by carboprost tromethamine during cesarean section. Methods The pregnant women preparing for low-segment cesarean section were randomly divided into group D (dexmedetomidine), group O (ondansetron), and group C (control group), 30 women in each group. Cesarean section was completed in all the cases under continual epidural anesthesia, then they were treated by i.v. transfusion of 20 U oxytocin after delivery and deltoideus triangularis injection of 250 μg carboprost tromethamine. The cases in group D were treated by i.v. transfusion of dexmedetomidine (load capacity 1 μg/kg, the duration time of i.v. transfusion was less than 10 min, the infusion speed was 0.4 μg·kg^-1·h^-1) before 10 min of carboprost tromethamine treatment. The cases in group C were treated by i.v. injection of ondansetron after delivery. The cases in group C were treated by normal saline at equal quantity. Mean arterial blood pressure (MAP), heart rate, and SpO₂ at 5 min after entering operation room (baseline, T0), 5 min after injection of carboprost tromethamine (T1), and the end of surgery (T2) were recorded. The incidence rates of nausea, vomiting, chest distress, and flushed face from usage of carboprost tromethamine to end of surgery were calculated Modified OAA/S scoring was conducted at T2 and after 2 h of surgery (T3). Results Compared with group D, MAP at T2 and T3 in group C and group O increased significantly, heart rates at T2 and T3 in group C and group O fastened significantly, SpO₂ at T2 and T3 in group C and group O decreased significantly, there were statistically significant differences (P<0.05). Compared with group C, the incidence rates of chest distress, flushed face, nausea, and vomiting in group D decreased significantly, the incidence rates of nausea and vomiting in group O decreased significantly, there were statistically significant differences (P<0.05). Compared with group C, OAA/S score in group D increased significantly (P<0.05). Conclusion I.v. transfusion of dexmedetomidine before carboprost tromethamine during cesarean section can prevent gastrointestinal and cardiovascular reactions caused by carboprost, the effect is superior to ondansetron.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Yan, Cui-hua’s team published research in Zhongguo Linchuang Yanjiu in 29 | CAS: 58551-69-2

Zhongguo Linchuang Yanjiu published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C37H30ClIrOP2, Computed Properties of 58551-69-2.

Yan, Cui-hua published the artcileEfficacy and safety of carboprost tromethamine combined with low B-Lynch suture in treatment of refractory placenta previa postpartum hemorrhage, Computed Properties of 58551-69-2, the publication is Zhongguo Linchuang Yanjiu (2016), 29(4), 541-543, database is CAplus.

Objective: To explore the clin. efficacy and safety of carboprost tromethamine combined with low B-Lynch suture in the treatment of refractory placenta previa and postpartum hemorrhage (PPH). Methods: Using retrospective research methods, 108 patients with refractory placental previa PPH admitted from May 2011 to May 2015 were divided into control group (n=53) and observation group (n=55) according to the treatment method. . Both groups were given cesarean section for delivery. The control group was given oxytocin, and the placenta was dissected with 8 intermittent suture. The observation group was treated with carboprost tromethamine combined with low B-Lynch suture. The clin. efficacy, intraoperative blood loss, vaginal bleeding 2h postoperatively, vaginal bleeding 24h postoperatively, and the incidence of adverse reactions were compared between the two groups. If the hemostasis is ineffective, the two groups of patients will be treated with catheter arterial embolization (TAE) to stop the bleeding. If the TAE fails to stop the bleeding, hysterectomy will be performed. Results: (1) After treatment, the number of markedly effective, effective and ineffective cases in the observation group were 34, 19 and 2 resp., and the total clin. effective rate was 96.36% (53/55), the number of markedly effective, effective and ineffective cases in the control group were resp. 15 cases, 24 cases and 14 cases, and the total clin. effective rate was 73.58% (39/53). The difference in efficacy between the two groups was statistically significant (P<0.05). (2) There was no statistically significant difference in intraoperative blood loss between the two groups (P>0.05), but the vaginal bleeding in the observation group was significantly less than that in the control group at 2h and 24h after surgery (P<0.01). (3) The incidence of adverse reactions after treatment in the control group was 22.64% (12/53), and the observation group was 7.27% (4/55). The difference in the incidence of adverse reactions between the two groups was statistically significant (P<0.01). Conclusion: Carboprost tromethamine combined with low B-Lynch suture in the treatment of refractory placenta previa postpartum hemorrhage has a significant clin. effect and a low incidence of postoperative adverse reactions.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Li, Wei’s team published research in Hebei Yixue in 22 | CAS: 58551-69-2

Hebei Yixue published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C25H47NO8, Related Products of alcohols-buliding-blocks.

Li, Wei published the artcileAnalysis of clinical efficacy of pituitrin combined with carboprost tromethamine in treatment of massive hemorrhage after placental abruption, Related Products of alcohols-buliding-blocks, the publication is Hebei Yixue (2016), 22(2), 221-223, database is CAplus.

Objective: To explore the clin. effect of pituitrin combined with carboprost tromethamine in the treatment of massive hemorrhage after placental abruption. Methods: A total of 116 patients with postpartum hemorrhage caused by premature abruption of placenta were selected and randomly divided into a control group and an observation group with 58 cases in each group. Both groups were treated with carboprost tromethamine, patients in the observation group were given pituitrin injection at the same time, and the time to hemostasis, total bleeding and the incidence of adverse events in the two groups were compared, and clin. summary and anal. were performed. Results: The observation group had bleeding volume 15min after delivery (224.7 ± 11.9) mL, bleeding volume 30min after delivery (254.8 ± 12.1) mL, bleeding volume 2h after delivery (275.2 ± 14.9) mL, bleeding volume 24h after delivery (291.7 ± 17.6) mL, postpartum hemostasis time (18.7 ± 5.9) min, hysterectomy rate 1.7%, neonatal asphyxia rate 6.9%, and no blood transfusion or death occurred, which were significantly better than the control group with statistical significance (P < 0.05). Conclusion: For patients with massive hemorrhage after premature abruption of placenta, the treatment of carboprost tromethamine combined with pituitrin can quickly inhibit the bleeding and improve the safety of mother and child.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts