Category: 585-88-6

On March 31, 2021, Holm, Tobias Palle; Meng-Lund, Helena; Rantanen, Jukka; Jorgensen, Lene; Grohganz, Holger published an article.Product Details of 585-88-6 The title of the article was Screening of novel excipients for freeze-dried protein formulations. And the article contained the following:

The typical excipients used as bulking agents and lyoprotectants for freeze-drying are usually limited to only a few selected substances, such as sucrose and mannitol. Considering the sheer diversity amongst proteins, it is doubtful that this limited choice should, in every case, provide the best possible option in order to achieve the most stable product. In this work, a screening of 12 proteins with 64 excipients was conducted in order to increase the knowledge space of potential excipients. Three critical quality attributes (CQAs) of the freeze-dried products, namely the solid state, the cake appearance and the protein integrity based on changes in tryptophan fluorescence were investigated by high throughput X-ray powder diffraction, image anal. and intrinsic fluorescence spectroscopy, resp. It was found, that in some cases the excipient had a dominating influence on the CQAs, while in other cases the CQAs were primarily protein dependent, or that the CQAs were dependent on the combination of both. In the course of this investigation, a general view of potentially relevant excipients, and their interplay with various proteins, was obtained, thereby furthermore paving the way for the use of novel freeze-drying excipients. The experimental process involved the reaction of SweetPearlR P300 DC Maltitol(cas: 585-88-6).Product Details of 585-88-6

The Article related to freeze dried protein formulation lyoprotectant stability, excipients, formulation development, freeze-drying, high throughput, image analysis, intrinsic fluorescence spectroscopy, protein stability, solid state analysis and other aspects.Product Details of 585-88-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On December 31, 2020, Ye, Xianfeng; Li, Zhoukun; Luo, Xue; Wang, Wenhui; Li, Yongkai; Li, Rui; Zhang, Bo; Qiao, Yan; Zhou, Jie; Fan, Jiaqin; Wang, Hui; Huang, Yan; Cao, Hui; Cui, Zhongli; Zhang, Ruifu published an article.Related Products of 585-88-6 The title of the article was A predatory myxobacterium controls cucumber Fusarium wilt by regulating the soil microbial community. And the article contained the following:

Myxobacteria are micropredators in the soil ecosystem with the capacity to move and feed cooperatively. Some myxobacterial strains have been used to control soil-borne fungal phytopathogens. However, interactions among myxobacteria, plant pathogens, and the soil microbiome are largely unexplored. In this study, we aimed to investigate the behaviors of the myxobacterium Corallococcus sp. strain EGB in the soil and its effect on the soil microbiome after inoculation for controlling cucumber Fusarium wilt caused by Fusarium oxysporum f. sp. cucumerinum (FOC). A greenhouse and a 2-yr field experiment demonstrated that the solid-state fermented strain EGB significantly reduced the cucumber Fusarium wilt by 79.6% (greenhouse), 66.0% (2015, field), and 53.9% (2016, field). Strain EGB adapted to the soil environment well and decreased the abundance of soil-borne FOC efficiently. Spatiotemporal anal. of the soil microbial community showed that strain EGB migrated towards the roots and root exudates of the cucumber plants via chemotaxis. Cooccurrence network anal. of the soil microbiome indicated a decreased modularity and community number but an increased connection number per node after the application of strain EGB. Several predatory bacteria, such as Lysobacter, Microvirga, and Cupriavidus, appearing as hubs or indicators, showed intensive connections with other bacteria. The predatory myxobacterium Corallococcus sp. strain EGB controlled cucumber Fusarium wilt by migrating to the plant root and regulating the soil microbial community. This strain has the potential to be developed as a novel biol. control agent of soil-borne Fusarium wilt. The experimental process involved the reaction of SweetPearlR P300 DC Maltitol(cas: 585-88-6).Related Products of 585-88-6

The Article related to corallococcus predatory myxobacterium fusarium wilt cucumber soil microbial community, cooccurrence network, corallococcus sp. egb, fusarium oxysporum f. sp. cucumerinum, micropredator, myxobacteria, root exudates, soil microbiome and other aspects.Related Products of 585-88-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On June 1, 2022, Ilhan, Zehra Esra; Brochard, Vincent; Lapaque, Nicolas; Auvin, Stephane; Lepage, Patricia published an article.Electric Literature of 585-88-6 The title of the article was Exposure to anti-seizure medications impact growth of gut bacterial species and subsequent host response. And the article contained the following:

Anti-seizure medications (ASMs) are the first line of treatment for seizure control in children with epilepsy. Cumulative evidence suggests an imbalanced gut microbiota in refractory epilepsy patients. We systematically investigated the differential antimicrobial impacts of nine ASM active ingredients, seven common excipients of ASMs, and four syrup formulations on core early-life gut microbiota strains. Addnl., we evaluated the toxicity and gene expression profiles of HT-29 colon epithelial cells when exposed to active ingredients with or without bacterial supernatants. The physicochem. structure of ASM active ingredients and bacterial phylogeny were found to be related to ASM toxicity. Carbamazepine, lamotrigine, and topiramate reduced the growth of more than ten strains along with syrup excipient propyl-paraben. Various artificial sweeteners present in ASM formulations stimulated the growth of gut bacterial strains. The active ingredients that were more toxic to bacterial strains also exhibited toxicity towards HT-29 cells, yet Bifidobacterium longum supernatant reduced cytotoxic effects of carbamazepine and lamotrigine. Akkermansia muciniphila or mixed community supernatants reduced the expression of drug resistance genes in HT-29 cell lines. In summary, our results indicate that several ASM active ingredients and their excipients regulate the growth of gut bacterial strains in a species-specific manner. Interactions between ASMs and gut epithelial cells might be modulated by gut microbial metabolites. The experimental process involved the reaction of SweetPearlR P300 DC Maltitol(cas: 585-88-6).Electric Literature of 585-88-6

The Article related to carbamazepine lamotrigine topiramate antiseizure agent gut bacteria epilepsy, anaerobic metabolism, antiepileptic drugs, drug formulations, epilepsy, intestinal epithelial cells, microbiome, parabens, pharmaco-resistance, seizures, toxicity and other aspects.Electric Literature of 585-88-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Beltra, Marta; Tomas, Hector; Lopez, Juan C.; Borras, Fernando; Ropero, Ana B. published an article in 2022, the title of the article was Nutritional Description of Foods with Low- and No-Calorie Sweeteners in Spain: The BADALI Project.HPLC of Formula: 585-88-6 And the article contains the following content:

The use of low- and no-calorie sweeteners (LNCS) in foods has increased in recent years in response to the neg. effects of free sugar on health. However, the health impact of LNCS is still unclear. Studies of the prevalence of LNCS in foods have been published previously, including in Spain. However, the use of health (HCs) and nutrition claims (NCs) to promote these foods and a full nutritional characterization are largely lacking. For this purpose, we used the BADALI database with 4218 foods present in the Spanish market. Our results show that 9.3% of foods have LNCS (including both intense and polyols). Sucralose and acesulfame K were the intense sweeteners most frequently used (52.4% and 48.2%, resp.), whereas maltitol was the preferred polyol (20.3%). Of all foods with LNCS, 30% also had added sugar. Many more foods with LNCS presented HCs and NCs than those without. Sugar was the nutrient most frequently claimed in NCs for LNCS-containing foods, whereas vitamins were for those without these sweeteners. NCs compliance with regulation was similar in both conditions (60.1% for foods without and 63.9% for foods with LNCS). As expected, foods with LNCS had less total sugar content and energy. Surprisingly, the nutrient profile of yogurts with LNCS changed completely: less total and saturated fat, whereas more proteins and sodium. Biscuits with LNCS contained more fiber. The results of our study reveal that the prevalence of LNCS is becoming high in some food types in Spain and that foods containing LNCS are more frequently promoted with HCs/NCs. In addition, it confirms the general reduction in energy and sugar content expected in foods with LNCS. Furthermore, it suggests a reformulation of products beyond sugar content. The experimental process involved the reaction of SweetPearlR P300 DC Maltitol(cas: 585-88-6).HPLC of Formula: 585-88-6

The Article related to food calorie sweetener nutritional characterization spain, added sugar, beverages, food products reformulation, health claims, intense sweeteners, no calorie sweeteners, non-nutritive sweeteners, nutrient composition, nutrition claims, polyols, regulation compliance and other aspects.HPLC of Formula: 585-88-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On June 8, 2022, Yang, Hua; Yan, Ruxue; Li, Yue; Lu, Zhaoxin; Bie, Xiaomei; Zhao, Haizhen; Lu, Fengxia; Chen, Meirong published an article.Computed Properties of 585-88-6 The title of the article was Structure-function analysis of a quinone-dependent dehydrogenase capable of deoxynivalenol detoxification. And the article contained the following:

The pyrroloquinoline quinone (PQQ)-dependent dehydrogenase DepA detoxifies deoxynivalenol (DON) by converting the C3-OH into a keto group. Herein, two crystal structures of DepA and its complex with PQQ were determined, together with biochem. evidence confirming the interactions of DepA with PQQ and DON and revealing a unique tyrosine residue important for substrate selection. Furthermore, four loops over the active site essential for DepA activity were identified, of which three loops were stabilized by PQQ, and the fourth loop invisible in both structures was considered important for binding DON, together constituting a lid for the active site. Preliminary engineering of the loop showed its potential for enzyme improvement. This study provides structural insights into how a PQQ-dependent dehydrogenase is equipped with the function of DON conversion and for the first time shows the necessity of a lid structure for PQQ-dependent dehydrogenase activity, laying foundation for structure-based design to enhance catalysis efficiency. The experimental process involved the reaction of SweetPearlR P300 DC Maltitol(cas: 585-88-6).Computed Properties of 585-88-6

The Article related to pyrroloquinoline quinone dependent dehydrogenase depa devosia structure deoxynivalenol detoxification, devosia pqq dependent dehydrogenase depa structure deoxynivalenol detoxification, crystal structure, deoxynivalenol, enzyme engineering, quinone-dependent dehydrogenase, substrate specificity and other aspects.Computed Properties of 585-88-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts