Category: 585-88-6

Saraiva, Ariana; Carrascosa, Conrado; Raheem, Dele; Ramos, Fernando; Raposo, Ant Onio published an article in 2020, the title of the article was Maltitol: analytical determination methods, applications in the food industry, metabolism and health impacts.Computed Properties of 585-88-6 And the article contains the following content:

A review. Bulk sweetener maltitol belongs to the polyols family and there have been several dietary applications in the past few years, during which the food industry has used it in many food products: bakery and dairy products, chocolate, sweets. This review paper addresses and discusses in detail the most relevant aspects concerning the anal. methods employed to determine maltitol’s food safety and industry applications, its metabolism and its impacts on human health. According to our main research outcome, we can assume that maltitol at lower doses poses little risk to humans and is a good alternative to using sucrose. However, it causes diarrhoea and foetus complications at high doses. Regarding its determination, high-performance liquid chromatog. proved the primary method in various food matrixes. The future role of maltitol in the food industry is likely to become more relevant as processors seek alternative sweeteners in product formulation without compromising health. The experimental process involved the reaction of SweetPearlR P300 DC Maltitol(cas: 585-88-6).Computed Properties of 585-88-6

The Article related to review analytical determination food industry metabolism health impact maltitol, food additives, food industry, food safety, health impacts, maltitol, metabolism, sweeteners and other aspects.Computed Properties of 585-88-6

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Haewpetch, Patinya; Rudeekulthamrong, Prakarn; Kaulpiboon, Jarunee published an article in 2022, the title of the article was Enzymatic Synthesis of Maltitol and Its Inhibitory Effect on the Growth of Streptococcus mutans DMST 18777.Product Details of 585-88-6 And the article contains the following content:

This study aimed to synthesize maltitol using recombinant CGTase from Bacillus circulans A11 with β-cyclodextrin (β-CD) and sorbitol as a glucosyl donor and acceptor, resp., and assess its antibacterial activity. Optimal conditions for producing the highest yield, 25.0% (weight/weight), were incubation of 1% (w/v) β-CD and sorbitol with 400 U/mL of CGTase in 20 mM phosphate buffer at pH 6.0 and 50°C for 72 h. Subsequently, maltitol underwent large-scale production and was purified by HPLC. By mass spectrometry, the mol. weight of the synthesized maltitol was 379.08 daltons, corresponding exactly to that of standard maltitol. The relative sweetness of synthesized and standard maltitol was ~90% of that of sucrose. Spot assay on the agar plate showed that maltitol inhibited the growth of Streptococcus mutans DMST 18777 cells. In addition, the MIC and MBC values of synthesized and standard maltitol against S. mutans were also determined as 20 and 40 mg/mL, resp. These results show that the synthesized maltitol can be produced at high yields and has the potential to be used as an anticariogenic agent in products such as toothpaste. The experimental process involved the reaction of SweetPearlR P300 DC Maltitol(cas: 585-88-6).Product Details of 585-88-6

The Article related to streptococcus mutan maltitol growth inhibitory effect, streptococcus mutans, antibacterial activity, anticariogenic activity, cyclodextrin glycosyltransferase (cgtase), maltitol and other aspects.Product Details of 585-88-6

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Billy, Yin Sing O.; Coyle, Daisy H.; Dunford, Elizabeth K.; Wu, Jason H. Y.; Louie, Jimmy Chun Yu published an article in 2021, the title of the article was The use of non-nutritive and low-calorie sweeteners in 19,915 local and imported pre-packaged foods in Hong Kong.Product Details of 585-88-6 And the article contains the following content:

This study aims to examine the use of non-nutritive (NNSs) and low-calorie sweeteners (LCSs) in pre-packaged foods in Hong Kong and the differences in the number of NNSs/LCSs used between products from different regions. In a cross-sectional audit, the types of NNSs/LCSs used in 19,915 pre-packaged foods in Hong Kong were examined by searching the ingredients list of the included products for keywords related to 20 common NNSs/LCSs and their resp. E-numbers Prevalence of use of NNSs and LCSs, the co-presence of NNSs/LCSs and free sugar ingredients (FSI), and the number of NNSs/LCSs used in the included foods were computed. Pearson’s χ2 test was used to compare the total number of NNSs and/or LCSs used in food items from different regions. Sucralose (E955) was the most commonly used NNS (1.9%), followed by acesulfame K (E950, 1.6%). Sorbitol was the most commonly used LCS (2.9%). Overall, the use of LCSs was less common compared with NNSs (3.7% vs. 4.5%). The use of different types of NNSs varied substantially between food types. Notably, 20.2% of potato crisps and 15.2% of other crisps or extruded snacks contained at least one NNS and/or LCS. Co-presence of FSIs and NNSs/LCSs were most common in confectionery (15.7%) and snack foods (15.5%). Asian prepackaged foods were more likely to contain NNSs/LCSs (10.1%) compared with those from other regions. To conclude, NNSs/LCSs were used in a wide range of non-diet pre-packaged products which could be a public health concern due to their higher consumption frequencies than “diet” products. The experimental process involved the reaction of SweetPearlR P300 DC Maltitol(cas: 585-88-6).Product Details of 585-88-6

The Article related to nonnutritive lowcalorie sweetener prepackaged food hong kong, hong kong, intense sweeteners, low-calorie sweeteners, non-nutritive sweeteners, pre-packaged foods, sugar substitutes and other aspects.Product Details of 585-88-6

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On October 25, 2021, Macho, Oliver; Gabrisova, Ludmila; Brokesova, Jana; Svacinova, Petra; Muzikova, Jitka; Galbava, Paulina; Blasko, Jaroslav; Sklubalova, Zdenka published an article.Application of 585-88-6 The title of the article was Systematic study of paracetamol powder mixtures and granules tabletability: Key role of rheological properties and dynamic image analysis. And the article contained the following:

The aim of this systematic study was to analyze the granulometric and rheol. behavior of tableting mixtures in relation to tabletability by single tablet and lab-scale batch compression with an eccentric tablet machine. Three mixtures containing 33, 50, and 66% of the cohesive drug paracetamol were prepared The high compressibility of the powder mixtures caused problems with overcompaction or lamination in the single tablet compression method; due to jamming of the material during the filling of the die, the lab-scale batch compression was impossible. Using high shear granulation, the flow properties and tabletability were adjusted. A linear relationship between the span of granules and the specific energy measured by FT4 powder rheometer was detected. In parallel, a linear relationship between conditioned bulk d. and the tensile strength of the tablets at lab-scale batch tableting was noted. The combination of dynamic image anal. and powder rheometry was useful for predicting the tabletability of pharmaceutical mixtures during the single tablet (design) compression and the lab-scale batch compression. The experimental process involved the reaction of SweetPearlR P300 DC Maltitol(cas: 585-88-6).Application of 585-88-6

The Article related to paracetamol powder mixture granule tabletability dynamic image analysis, dynamic image analysis, heckel analysis, high shear granulation, paracetamol, powder rheology, tabletability and other aspects.Application of 585-88-6

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On September 30, 2022, Li, Junnan; Li, Yannan; Duan, Wenzhe; Zhao, Zhonghui; Yang, Lixuan; Wei, Wei; Li, Jingchun; Li, Yang; Yu, Yao; Dai, Baoan; Guo, Rongjuan published an article.Category: alcohols-buliding-blocks The title of the article was Shugan granule contributes to the improvement of depression-like behaviors in chronic restraint stress-stimulated rats by altering gut microbiota. And the article contained the following:

The investigation aims to evaluate the potential effect of Shugan Granule (SGKL) on the gut, brain, and behaviors in rats exposed to chronic restraint stress (CRS). The fecal microbiota and metabolite changes were studied in rats exposed to CRS and treated with SGKL (0.1 mg/kg/day). Depressive behaviors of these rats were determined through an open-field experiment, forced swimming test, sucrose preference, and weighing. Moreover, LPS-stimulated microglia and CRS-stimulated rats were treated with SGKL to investigate the regulation between SGKL and the PI3K/Akt/pathway, which is inhibited by LY294002, a PI3K inhibitor. (I) SGKL improved the altered behaviors in CRS-stimulated rats; (ii) SGKL ameliorated the CRS-induced neuronal degeneration and tangled nerve fiber and also contributed to the recovery of intestinal barrier injury in these rats; (iii) SGKL inhibited the hippocampus elevations of TNF-α, IL-1β, and IL-6 in response to CRS modeling; (iv) based on the principal coordinates anal. (PCoA), SGKL altered α-diversity indexes and shifted β-diversity in CRS-stimulated rats; (v) at the genus level, SGKL decreased the CRS-enhanced abundance of Bacteroides; (vi) Butyricimonas and Candidatus Arthromitus were enriched in SGKL-treated rats; (vii) altered gut microbiota and metabolites were correlated with behaviors, inflammation, and PI3K/Akt/mTOR pathway; (viii) SGKL increased the LPS-decreased phosphorylation of the PI3K/Akt/mTOR pathway in microglia and inhibited the LPS-induced microglial activation; (ix) PI3K/Akt/mTOR pathway inactivation reversed the SGKL effects in CRS rats. SGKL targets the PI3K/Akt/mTOR pathway by altering gut microbiota and metabolites, which ameliorates altered behavior and inflammation in the hippocampus. The experimental process involved the reaction of SweetPearlR P300 DC Maltitol(cas: 585-88-6).Category: alcohols-buliding-blocks

The Article related to shugan granule antidepressant gut microbiota depression chronic restraint stress, shugan granule, chronic restraint stress, depression-like behaviors, gut metabolome, gut microbiota and other aspects.Category: alcohols-buliding-blocks

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On February 29, 2020, Gatidou, Georgia; Vazaiou, Niki; Thomaidis, Nikolaos S.; Stasinakis, Athanasios S. published an article.Synthetic Route of 585-88-6 The title of the article was Biodegradability assessment of food additives using OECD 301F respirometric test. And the article contained the following:

The ready biodegradability of twenty food additives, belonging to the classes of artificial sweeteners, natural sweeteners, preservatives and colorings, was investigated using activated sludge as inoculum and OECD 301F respirometric test. According to the results, saccharin, aspartame, sodium cyclamate, xylitol, erythritol, maltitol, potassium sorbate, benzoic acid and sodium ascorbate are characterized as readily biodegradable compounds, partial biodegradation (<60% during the test) was noticed for steviol, inulin, alitame, curcumin, ponceau 4R and tartrazine, while no biodegradation was observed for the other five compounds The duration of lag phase before the start of biodegradation varied between the target compounds, while their ultimate biodegradation half-life values ranged between 0.7 ± 0.1 days (benzoic acid) and 24.6 ± 1.0 days (curcumin). The expected removal of target compounds due to ultimate biodegradation mechanism was estimated for a biol. wastewater treatment system operated at a retention time of one day and percentages higher than 40% were calculated for sodium cyclamate, potassium sorbate and benzoic acid. Higher removal percentages are expected in full-scale Sewage Treatment Plants (STPs) due to the contribution of other mechanisms such as sorption to suspended solids, (bio)transformation and co-metabolic phenomena. Further biodegradation experiments should be conducted under different exptl. conditions for the food additives that did not fulfill the requirements of the applied protocol. Future studies should also focus on the occurrence and fate of food colorants and natural sweeteners in full-scale STPs. The experimental process involved the reaction of SweetPearlR P300 DC Maltitol(cas: 585-88-6).Synthetic Route of 585-88-6

The Article related to food additive biodegradability artificial sweetener preservative coloring, micropollutants, oecd protocol, ready biodegradability, sweeteners, ultimate biodegradation kinetics, wastewater and other aspects.Synthetic Route of 585-88-6

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Dimitrokalli, Evangelia; Fertaki, Stefani; Lykouras, Michail; Kokkinos, Petros; Orkoula, Malvina; Kontoyannis, Christos published an article in 2021, the title of the article was Warfarin Sodium Stability in Oral Formulations.Product Details of 585-88-6 And the article contains the following content:

Warfarin sodium is a low-dose pharmaceutical blood thinner that exists in two forms: the clathrate form and the amorphous form. In com. available warfarin sodium oral suspension, the active pharmaceutical ingredient (API) is added in the amorphous state. This study investigates the apparent instability of the com. available warfarin liquid oral formulation using Raman and IR spectroscopy, X-ray diffraction, differential scanning calorimetry, UV spectroscopy, and optical microscopy. Warfarin, not its sodium salt, was identified as the undissolved solid existing in the suspension. This was found to be due to the dissociation of sodium salt and the protonation of the warfarin ion in the liquid phase, which triggered the crystallization of the sparingly soluble unsalted form. The coexistence of protonated and unprotonated warfarin ions in the supernatant, as detected by Raman and UV spectroscopy, confirmed this assumption. Study of the dissolution of warfarin sodium amorphous salt and crystalline sodium clathrate in the placebo and pure water verified the results. The effect of pH and temperature on warfarin precipitation was also explored. The experimental process involved the reaction of SweetPearlR P300 DC Maltitol(cas: 585-88-6).Product Details of 585-88-6

The Article related to warfarin sodium stability oral formulation, dsc, ir, raman spectroscopy, x-ray powder diffraction, crystallization, oral suspension, warfarin, warfarin clathrate, warfarin sodium amorphous and other aspects.Product Details of 585-88-6

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Alcohol – Wikipedia,
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Malecki, Jan; Terpilowski, Konrad; Nastaj, Maciej; Solowiej, Bartosz G. published an article in 2022, the title of the article was Physicochemical, Nutritional, Microstructural, Surface and Sensory Properties of a Model High-Protein Bars Intended for Athletes Depending on the Type of Protein and Syrup Used.Application of 585-88-6 And the article contains the following content:

The main objective of this study was to investigate the possibility of using a combination of vegetable proteins from soybean (SOY), rice (RPC), and pea (PEA) with liquid syrups: tapioca fiber (TF), oligofructose (OF), and maltitol (ML) in the application of high-protein bars to determine the ability of these ingredients to modify the textural, physicochem., nutritional, surface properties, microstructure, sensory parameters, and technol. suitability. Ten variants of the samples were made, including the control sample made of whey protein concentrate (WPC) in combination with glucose syrup (GS). All combinations used had a pos. effect on the hardness reduction of the bars after the storage period. Microstructure and the contact angle showed a large influence on the proteins and syrups used on the features of the manufactured products, primarily on the increased hydrophobicity of the surface of samples made of RPC + ML, SOY + OF, and RPC + TF. The combination of proteins and syrups used significantly reduced the sugar content of the product. Water activity (<0.7), dynamic viscosity (<27 mPas•g/cm3), and sensory anal. (the highest final ratings) showed that bars made of RPC + OF, SOY + OF, and SOY + ML are characterized by a high potential for use in this type of products. The experimental process involved the reaction of SweetPearlR P300 DC Maltitol(cas: 585-88-6).Application of 585-88-6

The Article related to protein bar athlete syrup physicochem nutritional microstructure sensory property, contact angle, industrial application, liquid fiber, nutritional value, optical microscopy, plant protein and other aspects.Application of 585-88-6

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Usai-Satta, Paolo; Oppia, Francesco; Lai, Mariantonia; Cabras, Francesco published an article in 2021, the title of the article was Hydrogen breath tests: are they really useful in the nutritional management of digestive disease?.Application of 585-88-6 And the article contains the following content:

Carbohydrate malabsorption is a frequent digestive problem associated with abdominal pain, bloating and diarrhea. Hydrogen breath testing (BT) represents the most reliable and validated diagnostic technique. The aim of this manuscript was to clarify the usefulness of BTs in the nutritional management of these disorders. A literature search for BT related to carbohydrate malabsorption was carried out using the online databases of Pubmed, Medline and Cochrane. Lactose BT showed good sensitivity and optimal specificity for lactose malabsorption. However, an accurate diagnosis of lactose intolerance should require blind lactose challenge although this method is difficult to utilize in clin. practice. Regarding dose-depending fructose and sorbitol malabsorption, BTs could not add diagnostic advantage compared with a direct dietary intervention. In addition, carbohydrates are fundamental components of fermentable oligo-, di- and monosaccharides and polyols (FODMAPs). Before starting a low FODMAP diet, lactose BT should be suggested in a population with low prevalence of hypolactasia. BTs represent a valid and noninvasive technique in many digestive conditions. Regarding the management of carbohydrate intolerance, lactose BT can be recommended with some limitations. No sufficient evidence is available about the usefulness of BTs for other sugars in clin. practice. The experimental process involved the reaction of SweetPearlR P300 DC Maltitol(cas: 585-88-6).Application of 585-88-6

The Article related to hydrogen breath test nutrition management digestive disease, fodmap, fructose and sorbitol malabsorption, hydrogen breath testing, lactose malabsorption and intolerance, nutritional management and other aspects.Application of 585-88-6

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On August 1, 2021, Lin, Jieye; Oliver, Allen G.; Meredith, Reagan J.; Carmichael, Ian; Serianni, Anthony S. published an article.Related Products of 585-88-6 The title of the article was Isopropyl 3-deoxy-α-D-ribo-hexopyranoside (isopropyl 3-deoxy-α-D-glucopyranoside): evaluating trends in structural parameters. And the article contained the following:

Iso-Pr 3-deoxy-α-D-ribo-hexopyranoside (iso-Pr 3-deoxy-α-D-glucopyranoside), C9H18O5, (I), crystallizes from a methanol-Et acetate solvent mixture at room temperature in a 4C1 chair conformation that is slightly distorted towards the C5SC1 twist-boat form. A comparison of the structural parameters in (I), Me α-D-glucopyranoside, (II), α-D-glucopyranosyl-(1→4)-D-glucitol (maltitol), (III), and 3-deoxy-α-D-ribo-hexopyranose (3-deoxy-α-D-glucopyranose), (IV), shows that most endocyclic and exocyclic bond lengths, valence bond angles and torsion angles in the aldohexopyranosyl rings are more affected by anomeric configuration, aglycon structure and/or the conformation of exocyclic substituents, such as hydroxymethyl groups, than by monodeoxygenation at C3. The structural effects observed in the crystal structures of (I)-(IV) were confirmed though d. functional theory (DFT) calculations in computed structures (I)c-(IV)c. Exocyclic hydroxymethyl groups adopt the gauche-gauche (gg) conformation (H5 anti to O6) in (I) and (III), and the gauche-trans (gt) conformation (C4 anti to O6) in (II) and (IV). The O-glycoside linkage conformations in (I) and (III) resemble those observed in disaccharides containing β-(1→4) linkages. The experimental process involved the reaction of SweetPearlR P300 DC Maltitol(cas: 585-88-6).Related Products of 585-88-6

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