Category: 584-02-1

Ramesh, Madhan published the artcileHalf-Sandwich η6-p-Cymene) Ruthenium(II) complexes bearing 5-Amino-1-Methyl-3-Phenylpyrazole Schiff base ligands: Synthesis, structure and catalytic transfer hydrogenation of ketones, Related Products of alcohols-buliding-blocks, the main research area is ruthenium Schiff base complex preparation; alc preparation; ketone transfer hydrogenation ruthenium catalyst.

New (η6-p-cymene)ruthenium(II) complexes containing Schiff base ligands of the general composition [RuCl(η-p-cymene)(L)] were synthesized and screened for their efficiency as catalysts in the transfer hydrogenation of various ketones to alcs. RCH(OH)R1 [R = Et, Ph, 4-ClC6H4, etc.; R1 = Me, Et, Ph; RR1 = (CH2)4, (CH2)5] showing excellent conversion up to 99%. The complexes were characterized by anal. and spectral (FT-IR, UV-Vis, 1H NMR and 13C NMR) methods and the mol. structure of complex I was determined by single crystal X-ray diffraction studies, revealing a pseudo-octahedral piano stool geometry around ruthenium(II) ion. Under the optimized conditions, the influence of base, reaction temperature and substrate scope was also reported.

Journal of Organometallic Chemistry published new progress about Alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 584-02-1 belongs to class alcohols-buliding-blocks, name is 3-Pentanol, and the molecular formula is C5H12O, Related Products of alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Weber, Stefan published the artcileRethinking Basic Concepts-Hydrogenation of Alkenes Catalyzed by Bench-Stable Alkyl Mn(I) Complexes, Recommanded Product: 3-Pentanol, the main research area is alkene hydrogenation alkyl manganese complex catalyst.

An efficient additive-free manganese-catalyzed hydrogenation of alkenes to alkanes with mol. hydrogen is described. This reaction is atom economic, implementing an inexpensive, earth-abundant nonprecious metal catalyst. The most efficient precatalyst is the bench-stable alkyl bisphosphine Mn(I) complex fac-[Mn(dippe)(CO)3CH2CH2CH3Pr]. The catalytic process is initiated by migratory insertion of a CO ligand into the Mn-alkyl bond to yield an acyl intermediate which undergoes rapid hydrogenolysis to form the active 16e Mn(I) hydride catalyst [Mn(dippe)(CO)2(H)]. A range of mono- and disubstituted alkenes were efficiently converted into alkanes in good to excellent yields. The hydrogenation of 1-alkenes and 1,1-disubstituted alkenes proceeds at 25°, while 1,2-disubstituted alkenes require a reaction temperature of 60°. In all cases, a catalyst loading of 2 mol % and a hydrogen pressure of 50 bar were applied. A mechanism based on DFT calculations is presented, which is supported by preliminary exptl. studies.

ACS Catalysis published new progress about Alkanes Role: SPN (Synthetic Preparation), PREP (Preparation). 584-02-1 belongs to class alcohols-buliding-blocks, name is 3-Pentanol, and the molecular formula is C5H12O, Recommanded Product: 3-Pentanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Karakas, Duygu Elma published the artcileKetone transfer hydrogenation reactions catalyzed by catalysts based on a phosphinite ligand, COA of Formula: C5H12O, the main research area is furanylethyldiphenylphosphinite preparation ruthenium iridium complexation; ketone transfer hydrogenation catalyzed furanylethyldiphenylphosphinite ruthenium iridium complex.

Reaction of (±)-1-(2-furyl)ethanol with an equivalent Ph2PCl in the presence of Et3N proceeds in dry toluene under an argon atm. to give 1-(furan-2-yl)ethyldiphenylphosphinite (1) in good yield. Mononuclear complexes [dichloro(η6-p-cymene)(1-furan-2-ylethyldiphenylphosphinite)ruthenium(II)] (2), [dichloro(η6-benzene)(1-furan-2-ylethyldiphenylphosphinite)ruthenium(II)] (3), [chloro(η4-1,5-cyclooctadiene)(1-furan-2-ylethyldiphenylphosphinite)rhodium(I)] (4) and [dichloro(η5-pentamethylcyclopentadienyl)(1-furan-2-ylethyldiphenylphosphinite)iridium(III)] (5) were synthesized and characterized by microanal., IR, MS, and NMR spectroscopies. The complexes are employed as catalysts in transfer hydrogenation of aromatic ketones. The complexes catalyzed reduction of a variety of aromatic ketone substrates bearing electron-withdrawing or donating substituents with very high conversion rates (up to 99%); 5 was the most efficient catalyst for the transfer hydrogenation of ketones.

Journal of Coordination Chemistry published new progress about Aryl ketones Role: RCT (Reactant), RACT (Reactant or Reagent). 584-02-1 belongs to class alcohols-buliding-blocks, name is 3-Pentanol, and the molecular formula is C5H12O, COA of Formula: C5H12O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yan, Linjie published the artcileDesign, synthesis and evaluation of 2′-acetylene-7-deaza-adenosine phosphoamidate derivatives as anti-EV71 and anti-EV-D68 agents, Recommanded Product: 3-Pentanol, the main research area is alkylaminopyrrolopyrimidinylethynyl tetrahydrofuranylmethoxyphenoxyphosphorylaminopropanoate preparation diastereoselective antiviral SAR pharmacokinetic; Antiviral; Enterovirus; NITD008; Nucleoside/nucleotide inhibitor.

A series of phosphoamidate derivatives I [R1 = Me, iso-Bu, cyclohexyl etc.; R2 = H, Me, benzyl etc.] (NITD008) were synthesized and evaluated for their in-vitro antiviral activities against the enteroviruses EV71 and EV-D68. The phosphoamidate containing I [R1 = n-hexyl; R2 = Me] a hexyl ester of L-alanine exhibited the most promising activity against EV71 (IC50 = 0.13 ± 0.08 μM) and were 4-times more potent than NITD008. Meanwhile, the derivative containing a cyclohexyl ester of L-alanine I [R1 = cyclohexyl; R2 = Me] exhibited the most potent activity with high selectivity index against both EV71 (IC50 = 0.19 ± 0.27 μM, SI = 117.00) and EV-D68 (IC50 = 0.17 ± 0.16 μM, SI = 130.76), which were both higher than that of NITD008. The results indicated that the phosphoamidate I [R1 = cyclohexyl; R2 = Me] were the most promising candidate for further development as antiviral agents for the treatment of both EV71 and EV-D68 infection.

European Journal of Medicinal Chemistry published new progress about Amino acids Role: RCT (Reactant), RACT (Reactant or Reagent). 584-02-1 belongs to class alcohols-buliding-blocks, name is 3-Pentanol, and the molecular formula is C5H12O, Recommanded Product: 3-Pentanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yang, Ji published the artcileDirect synthesis of adipic acid esters via palladium-catalyzed carbonylation of 1,3-dienes, Recommanded Product: 3-Pentanol, the main research area is palladium pyridyl bidentate phosphine ligand catalyzed carbonylation diene alc; adipic acid ester green preparation carbonylation diene alc.

The direct carbonylation of 1,3-butadiene offers the potential for a more cost-efficient and environmentally benign route to industrially important adipic acid derivatives However, owing to the complex reaction network of regioisomeric carbonylation and isomerization pathways, a selective practical catalyst for this process has thus far proven elusive. Here, we report the design of a pyridyl-substituted bidentate phosphine ligand (HeMaRaphos) that, upon coordination to palladium, catalyzes adipate diester formation from 1,3-butadiene, carbon monoxide, and butanol with 97% selectivity and 100% atom-economy under industrially viable and scalable conditions (turnover number > 60,000). This catalyst system also affords access to a variety of other di- and triesters from 1,2- and 1,3-dienes.

Science (Washington, DC, United States) published new progress about 1,3-Alkadienes Role: RCT (Reactant), RACT (Reactant or Reagent). 584-02-1 belongs to class alcohols-buliding-blocks, name is 3-Pentanol, and the molecular formula is C5H12O, Recommanded Product: 3-Pentanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wang, Man published the artcileMerging N-Hydroxyphthalimide into Metal-Organic Frameworks for Highly Efficient and Environmentally Benign Aerobic Oxidation, Safety of 3-Pentanol, the main research area is hydroxyphthalimide metal organic framework green oxidation catalyst; N-hydroxyphthalimide; aerobic oxidation; heterogeneous catalysis; metal-organic frameworks; nitroxyl radicals.

Two highly efficient metal-organic framework catalysts TJU-68-NHPI and TJU-68-NDHPI have been successfully synthesized through solvothermal reactions of which the frameworks are merged with N-hydroxyphthalimide (NHPI) units, resulting in the decoration of pore surfaces with highly active nitroxyl catalytic sites. When t-Bu nitrite (TBN) is used as co-catalyst, the as-synthesized MOFs are demonstrated to be highly efficient and recyclable catalysts for a novel three-phase heterogeneous oxidation of activated C-H bond of primary and secondary alcs., and benzyl compounds under mild conditions. Based on the high efficiency and selectivity, an environmentally benign system with good sustainability, mild conditions, simple work-up procedure has been established for practical oxidation of a wide range of substrates.

Chemistry – A European Journal published new progress about Aldehydes Role: SPN (Synthetic Preparation), PREP (Preparation). 584-02-1 belongs to class alcohols-buliding-blocks, name is 3-Pentanol, and the molecular formula is C5H12O, Safety of 3-Pentanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Panda, Surajit published the artcileEfficient α-Alkylation of Arylacetonitriles with Secondary Alcohols Catalyzed by a Phosphine-Free Air-Stable Iridium(III) Complex, Category: alcohols-buliding-blocks, the main research area is iridium complex catalyzed alkylation arylacetonitrile secondary alc.

A well-defined and readily available air-stable dimeric iridium(III) complex catalyzed α-alkylation of arylacetonitriles using secondary alcs. with the liberation of water as the only byproduct is reported. The α-alkylations were efficiently performed at 120°C under solvent-free conditions with very low (0.1-0.01 mol %) catalyst loading. Various secondary alcs. including cyclic and acyclic alcs. and a wide variety of arylacetonitriles bearing different functional groups were converted into the corresponding α-alkylated products in good yields. Mechanistic study revealed that the reaction proceeds via alc. activation by metal-ligand cooperation with the formation of reactive iridium-hydride species.

Journal of Organic Chemistry published new progress about Acetonitriles Role: RCT (Reactant), RACT (Reactant or Reagent). 584-02-1 belongs to class alcohols-buliding-blocks, name is 3-Pentanol, and the molecular formula is C5H12O, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Bettoni, Leo published the artcileIron-Catalyzed α-Alkylation of Ketones with Secondary Alcohols: Access to β-Disubstituted Carbonyl Compounds, Recommanded Product: 3-Pentanol, the main research area is iron catalyzed alkylation ketone secondary alc borrowing hydrogen.

An iron-catalyzed borrowing hydrogen strategy has been applied in the synthesis of β-branched carbonyl compounds Various secondary benzylic and aliphatic alcs. have been used as alkylating reagents under mild reaction conditions. The ketones have been isolated in good to excellent yield. Deuterium labeling experiments provide evidence that the alc. is the hydride source in this reaction and that no reversible step or hydrogen/deuterium scrambling takes place during the process.

Organic Letters published new progress about Acetophenones Role: RCT (Reactant), RACT (Reactant or Reagent). 584-02-1 belongs to class alcohols-buliding-blocks, name is 3-Pentanol, and the molecular formula is C5H12O, Recommanded Product: 3-Pentanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ghosh, Rahul published the artcileTransfer Hydrogenation of Aldehydes and Ketones in Air with Methanol and Ethanol by an Air-Stable Ruthenium-Triazole Complex, Name: 3-Pentanol, the main research area is alc preparation chemoselective green chem; aldehyde ketone methanol ethanol transfer hydrogenation ruthenium triazole catalyst; ruthenium triazole catalyst preparation.

Coordination of 1,4-disubstituted 1,2,3-triazoles with [(p-cymene)RuCl2]2 followed by dehydrochlorination in the presence of a base resulted in the formation of ruthenium complexes, resp. Both were tested for the transfer hydrogenation of aldehydes and ketones in air using ecol. benign and cheap ethanol as the hydrogen source in the presence of a catalytic amount of a base. Air-stable ruthenium complex was proved to be an active catalyst for the transfer hydrogenation of a wide variety of aromatic and aliphatic aldehydes and ketones bearing various functionalities. Catalyst ruthenium complex was also effective for the transfer hydrogenation of carbonyls using the simplest primary alc., methanol, under aerobic conditions. Under the present catalytic protocol, labile or reducible functionalities such as nitro, cyano, and ester groups were tolerated. Good selectivity was also observed for acyclic α,β-unsaturated carbonyls. However, this catalytic protocol was not selective for 2-cyclohexen-1-one as both alkene and keto moieties were reduced. The transfer hydrogenations are believed to proceed via a ruthenium-hydride intermediate. Finally, transfer hydrogenation of acetophenone using isopropanol as a commonly used hydrogen source was also performed and the sustainable and green credentials of these catalytic protocols utilizing methanol, ethanol, and isopropanol were compared with the help of the CHEM21 green metrics toolkit.

ACS Sustainable Chemistry & Engineering published new progress about Alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 584-02-1 belongs to class alcohols-buliding-blocks, name is 3-Pentanol, and the molecular formula is C5H12O, Name: 3-Pentanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Onisuru, Oluwatayo Racheal published the artcileTransfer hydrogenation of ketone; an in situ approach toward an eco-friendly reduction, SDS of cas: 584-02-1, the main research area is silica supported palladium particle preparation; ketone transfer hydrogenation green chem.

The use of water as a solvent in chem. reactions has recently been brought to public attention, especially in the exploration of eco-friendly procedures. It is readily available, abundantly accessible, non-toxic, non-flammable, and at a low cost. As opposed to the previous limitation of reactant solubilities associated with aqueous media, a hydrogel such as a hydroxypropyl methylcellulose (HPMC) solution can significantly improve the reactant solubility This investigation employed water and HPMC as the reaction solvent, and the reaction medium viscosity was impressively enhanced. Silica-supported Pd particles (Pd@SiO2) were synthesized and effectively catalyzed the reduction of acetophenone in the presence of sodium borohydride (NaBH4) as the hydrogen source. The conversion of acetophenone to 1-Ph ethanol remained at a very high value of >99.34% with 100% selectivity towards 1-Ph ethanol.

RSC Advances published new progress about Alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 584-02-1 belongs to class alcohols-buliding-blocks, name is 3-Pentanol, and the molecular formula is C5H12O, SDS of cas: 584-02-1.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts