Category: 584-02-1

Guo, Jiami published the artcileAzobisisobutyronitrile-Initiated Oxidative C-H Functionalization of Simple Alcohols with Diaryl(arylethynyl)phosphine Oxides: A Metal-Free Approach toward Hydroxymethyl Benzo[b]phosphole Oxides and 6H-Indeno[2,1-b]phosphindole 5-Oxide Derivatives, Related Products of alcohols-buliding-blocks, the main research area is azobisisobutyronitrile oxidative radical addition cyclization alc diaryl arylethynyl phosphine; oxide one pot benzophosphole indenophosphindole regioselective mechanism mol structure.

The first metal-free and facile radical addition/cyclization of simple alcs. with diaryl(arylethynyl)phosphine oxides has been described with azobisisobutyronitrile as a radical initiator, affording an efficient and one-pot procedure to access a new class of hydroxymethyl benzo[b]phosphole oxides, e.g. I, and 6H-indeno[2,1-b]phosphindole 5-oxides, e.g. II, for potential application in organic materials via sequential C(sp3)-H/C(sp2)-H functionalization. The method employs easily accessible starting materials and is endowed with high regioselectivity and broad functional-group tolerance.

Journal of Organic Chemistry published new progress about Aliphatic alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 584-02-1 belongs to class alcohols-buliding-blocks, name is 3-Pentanol, and the molecular formula is C5H12O, Related Products of alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Jin, Lele published the artcileHigh performance of Mo-promoted Ir/SiO2 catalysts combined with HZSM-5 toward the conversion of cellulose to C5/C6 alkanes, Name: 3-Pentanol, the main research area is molybdenum promoted iridium silica catalyst cellulose conversion liquid alkane; Hydrogenolysis; Liquid fuel; Microcrystalline cellulose; Molybdenum.

In this study, the Mo-promoted Ir/SiO2 (Ir-MoOx/SiO2) catalysts combined with the zeolite HZSM-5 were used for the direct conversion of microcrystalline cellulose (MCC) to liquid fuel (C5/C6 alkanes) in n-dodecane/H2O system. A synergistic effect was formed between the partially reduced MoOx species and the Ir particles, which effectively promoted the catalytic activity of Ir/SiO2 catalyst. When the Mo/Ir molar ratio was 0.5, a high yield of C5/C6 alkanes (91.7%) was achieved at 210°C for 12 h. In addition, the main component of C5/C6 alkanes was n-hexane, which was proven to be obtained by the hydrogenolysis of the key intermediate, sorbitol, formed from the hydrolysis and hydrogenation of MCC.

Bioresource Technology published new progress about Cyclic ethers Role: SPN (Synthetic Preparation), PREP (Preparation). 584-02-1 belongs to class alcohols-buliding-blocks, name is 3-Pentanol, and the molecular formula is C5H12O, Name: 3-Pentanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ding, Zhengwei published the artcileCatalysis with Diboron(4)/Pyridine: Application to the Broad-Scope [3 + 2] Cycloaddition of Cyclopropanes and Alkenes, Recommanded Product: 3-Pentanol, the main research area is aryl cyclopropyl methanone ethene diboron pyridine catalyst cycloaddition; cyclopentyl aryl methanone preparation diastereoselective regioselective green chem.

In contrast to the extensive but non-recyclable use of tetraalkoxydiboron compounds as stoichiometric reagents in diverse reactions, this article reports an atom-economical reaction using a com. diboron as the catalyst. The key to success was designing a catalytic cycle for radical [3 + 2] cycloaddition involving a pyridine cocatalyst to generate from the diboron catalyst and reversibly mediate the transfer of boronyl radicals. In comparison with known [3 + 2] cycloaddition with transition metal-based catalysts, the current reaction features not only metal-free conditions, inexpensive and stable catalysts and simple operation but also remarkably broadened substrate scope. In particular, previously unusable cyclopropyl ketones without an activating group and/or alkenes with 1,2-disubstitution and 1,1,2-trisubstitution patterns were successfully used for the first time. Consequently, challenging cyclopentane compounds with various levels of substitution (65 examples, 57 new products, up to six substituents at all five ring atoms) were readily prepared in generally high to excellent yield and diastereoselectivity. The reaction was also successfully applied in concise formal synthesis of an anti-obesity drug and building natural product-like complex bridged or spirocyclic compounds Mechanistic experiments and computational investigation support the proposed radical relay catalysis featuring a pyridine-assisted boronyl radical catalyst. Overall, this work demonstrates the first approach to use tetraalkoxydiboron compounds as catalysts and may lead to the development of new, green, and efficient transition metal-like boron-catalyzed organic reactions.

Journal of the American Chemical Society published new progress about [3+2] Cycloaddition reaction catalysts (regio and stereoselective). 584-02-1 belongs to class alcohols-buliding-blocks, name is 3-Pentanol, and the molecular formula is C5H12O, Recommanded Product: 3-Pentanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kurandina, Daria published the artcileTransition-Metal- and Light-Free Directed Amination of Remote Unactivated C(sp3)-H Bonds of Alcohols, Product Details of C5H12O, the main research area is directed remote amination aliphatic alc diazonium salt.

Due to the great value of amino alcs., new methods for their synthesis are in high demand. Abundant aliphatic alcs. represent the ideal feedstock for the method development toward this important motif. To date, transition-metal-catalyzed approaches for the directed remote amination of alcs. have been well established. Yet, they have certain disadvantages such as the use of expensive catalysts and limited scope. Very recently, transition-metal-free visible-light-induced radical approaches have emerged as new powerful tools for directed remote amination of alcs. Relying on 1,5-HAT reactivity, these methods are limited to β- or δ-amination only. Herein, we report a novel transition-metal- and visible-light-free room-temperature radical approach for remote β-, γ-, and δ-C(sp3)-N bond formation in aliphatic alcs. using mild basic conditions and readily available diazonium salt reagents. Thus, e.g., reaction of silylmethyl iodide I with PhN2.BF4- afforded II (76%, GC-MS yield) in presence of HCO2Li.H2O as base and reducing agent in DMA/MeOH mixed solvent.

Journal of the American Chemical Society published new progress about Abstraction reaction (iodine abstraction from silylmethyl iodide). 584-02-1 belongs to class alcohols-buliding-blocks, name is 3-Pentanol, and the molecular formula is C5H12O, Product Details of C5H12O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Bai, Xishan published the artcileHydrogen-Borrowing Amination of Secondary Alcohols Promoted by a (Cyclopentadienone)iron Complex, Formula: C5H12O, the main research area is hydrogen borrowing amination secondary alc cyclopentadienone iron complex catalyst.

Thanks to a highly active catalyst, the scope of the (cyclopentadienone)iron complex-promoted ‘hydrogen-borrowing’ (HB) amination has been expanded to secondary alcs., which had previously been reported to react only in the presence of large amounts of co-catalysts [e.g., p-anisidine + 1-phenylethanol â†?N-(4-methoxyphenyl)-1-phenylethylamine (89% conversion) in presence of mol. sieves with amine:alc. stoichiometry of 4:1 at 150° in toluene]. A range of cyclic and acyclic secondary alcs. were reacted with aromatic and aliphatic amines giving fair to excellent yields of the substitution products. The catalyst was also able to promote the cyclization of diols bearing a secondary alc. group with primary amines to generate saturated N-heterocycles.

Synthesis published new progress about Aliphatic amines Role: RCT (Reactant), RACT (Reactant or Reagent). 584-02-1 belongs to class alcohols-buliding-blocks, name is 3-Pentanol, and the molecular formula is C5H12O, Formula: C5H12O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Jin, Lele published the artcileCatalytic conversion of cellulose to C5/C6 alkanes over Ir-VOx/SO2 combined with HZSM-5 in n-dodecane/water system, Application In Synthesis of 584-02-1, the main research area is catalytic conversion C5 C6 alkane liquid fuel.

The liquid fuel (made of C5/C6 alkanes) was obtained directly from the hydrogenolysis of microcrystalline cellulose (MCC) with Ir-VOx/SiO2 combined with HZSM-5 as the composite catalyst in a biphasic system (n-dodecane + H2O). The performance of the catalyst was investigated by carrying out a series of experiments using various V/Ir molar ratios, catalyst dosages, reaction temperatures, reaction time, hydrogen pressure and substrates. At the optimized conditions, the cellulose was almost completely converted, and at the same time, a high C5/C6 yield of 85.1% was obtained at 210° for 24 h and 6 MPa with the V/Ir molar ratio being 0.13. These results not only proved that Ir-VOx/SiO2 (V/Ir = 0.13) has excellent performance for the hydrogenolysis of MCC to liquid alkanes, but also indicated that vanadium is a good metal promoter for iridium. In addition, it was proven the C5/C6 alkanes were obtained via sorbitol through the combined effect of Ir-VOx/SiO2 and HZSM-5.

Fuel Processing Technology published new progress about Alkanes, C5 Role: SPN (Synthetic Preparation), PREP (Preparation). 584-02-1 belongs to class alcohols-buliding-blocks, name is 3-Pentanol, and the molecular formula is C5H12O, Application In Synthesis of 584-02-1.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Shinohara, Riku published the artcileSN2 Reaction of Diarylmethyl Anions at Secondary Alkyl and Cycloalkyl Carbons, Name: 3-Pentanol, the main research area is alkyl diphenyl phosphate diarylmethyl anion nucleophilic substitution reaction; diarylmethyl substituted alkane preparation.

The substitution reaction of the di-Et allylic and propargylic phosphates with Ar2CH anions was applied to sec-alkyl phosphates to compare reactivity and stereoselectivity. However, the substitution took place on the Et carbon of the di-Et phosphate group. We then found that the di-Ph phosphate leaving group ((PhO)2PO2) was suited for the substitution at the sec-alkyl carbon. Enantioenriched di-Ph sec-alkyl phosphates with different substituents (Me, Et, iPr) on the vicinal position underwent the substitution reaction with almost complete inversion (>99% enantiospecificity). The substitution reactions of cyclohexyl phosphates possessing cis or trans substituents (Me and/or tBu) at the C4, C3, and C2 positions of the cyclohexane ring were also studied to observe the difference in reactivity among the cis and trans isomers. A transition-state model with the phosphate leaving group ((PhO)2PO2) in the axial position was proposed to explain the difference. This model was supported by computational calculation of the virtual substitution reaction of the structurally simpler “”dimethyl”” cyclohexyl phosphates (leaving group = (MeO)2PO2) with MeLi. Furthermore, the calculation unexpectedly indicated higher propensity of (PhO)2PO2 as a leaving reactivity than alkyl phosphate groups such as (MeO)2PO2 and (iPrO)2PO2.

European Journal of Organic Chemistry published new progress about Alkanes Role: SPN (Synthetic Preparation), PREP (Preparation) (aryl). 584-02-1 belongs to class alcohols-buliding-blocks, name is 3-Pentanol, and the molecular formula is C5H12O, Name: 3-Pentanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Liu, Lujie published the artcileHydrodeoxygenation of C4-C6 sugar alcohols to diols or mono-alcohols with the retention of the carbon chain over a silica-supported tungsten oxide-modified platinum catalyst, Name: 3-Pentanol, the main research area is sugar hydrodeoxygenation alc diol silica tungsten oxide platinum catalyst.

The hydrodeoxygenation of erythritol, xylitol, and sorbitol was investigated over a Pt-WOx/SiO2 (4 wt% Pt, W/Pt = 0.25, molar ratio) catalyst. 1,4-Butanediol can be selectively produced with 51% yield (carbon based) by erythritol hydrodeoxygenation at 413 K, based on the selectivity over this catalyst toward the regioselective removal of the C-O bond in the -O-C-CH2OH structure. Because the catalyst is also active in the hydrodeoxygenation of other polyols to some extent but much less active in that of mono-alcs., at higher temperature (453 K), mono-alcs. can be produced from sugar alcs. A good total yield (59%) of pentanols can be obtained from xylitol, which is mainly converted to C2 + C3 products in the literature hydrogenolysis systems. It can be applied to the hydrodeoxygenation of other sugar alcs. to mono-alcs. with high yields as well, such as erythritol to butanols (74%) and sorbitol to hexanols (59%) with very small amounts of C-C bond cleavage products. The active site is suggested to be the Pt-WOx interfacial site, which is supported by the reaction and characterization results (TEM and XAFS). WOx/SiO2 selectively catalyzed the dehydration of xylitol to 1,4-anhydroxylitol, whereas Pt-WOx/SiO2 promoted the transformation of xylitol to pentanols with 1,3,5-pentanetriol as the main intermediate. Pre-calcination of the reused catalyst at 573 K is important to prevent coke formation and to improve the reusability.

Green Chemistry published new progress about Cyclic ethers Role: IMF (Industrial Manufacture), PREP (Preparation). 584-02-1 belongs to class alcohols-buliding-blocks, name is 3-Pentanol, and the molecular formula is C5H12O, Name: 3-Pentanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhang, Qing published the artcileNi-Catalyzed Enantioselective Allylic Alkylation of H-Phosphinates, SDS of cas: 584-02-1, the main research area is nickel catalyzed enantioselective allylic alkylation phosphinate allylic acetate; stereogenic allylic phenyl phosphinate preparation crystal structure; mol structure stereogenic allylic phenyl phosphinate.

The asym. synthesis of P-stereogenic phosphinates through allylic alkylation of H-phosphinates was developed. With H-phosphinates and allylic acetates as the starting materials, a variety of allylic P-chiral phosphinates were accessed in high enantioselectivities of up to 92% ee and generally high yields. A further study demonstrated the applicability of this protocol, including the scale-up synthesis and facile transformation of chiral products from phosphinates to phosphine oxides with organolithium reagents under mild reaction conditions.

Organic Letters published new progress about Acetates Role: RCT (Reactant), RACT (Reactant or Reagent) (allylic). 584-02-1 belongs to class alcohols-buliding-blocks, name is 3-Pentanol, and the molecular formula is C5H12O, SDS of cas: 584-02-1.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhong, Jian-Ji published the artcileEfficient acceptorless photo-dehydrogenation of alcohols and N-heterocycles with binuclear platinum(II) diphosphite complexes, Quality Control of 584-02-1, the main research area is binuclear platinum diphosphite complex preparation UV absorption; ketone aldehyde preparation; alc photodehydrogenation binuclear platinum diphosphite complex catalyst; indole quinoline isoquinoline benzothiazole pyrrole preparation; saturated heterocycle photodehydrogenation binuclear platinum diphosphite catalyst; quinazolinone preparation; anthranilamide alc tandem dehydrogenation coupling binuclear platinum diphosphite catalyst.

Binuclear platinum(II) diphosphite complexes as practical and efficient photocatalysts for oxidant-free and acceptorless dehydrogenation of alcs. and N-heterocycles in high yields even under substrate-limiting conditions was described. The reaction could be used for constructing quinazolin-4(3H)-ones from anthranilamide and alcs. This protocol offered the unique reactivity of binuclear platinum(II) diphosphite complexes, wide substrate scope, mild reaction conditions, scalability, utility and versatility of these photocatalysts with practical relevance. Regeneration of the photocatalyst by means of reductive elimination of dihydrogen from the in-situ formed platinum(III)-hydride species represented an alternative paradigm to the current approach in photoredox catalysis.

Chemical Science published new progress about Acetophenones Role: SPN (Synthetic Preparation), PREP (Preparation). 584-02-1 belongs to class alcohols-buliding-blocks, name is 3-Pentanol, and the molecular formula is C5H12O, Quality Control of 584-02-1.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts