Category: 583-03-9

Synthetic Route of 583-03-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 583-03-9, name is 1-Phenylpentan-1-ol, molecular formula is C11H16O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

The typical reaction steps are as follows:1 mmol of the starting alcohol of the reactant column shown in Table 2,OH – Ni3In-LDH 14 mg,Mesitylene 5mL were added to the reactor,Into the oxygen,Atmospheric reaction,The reaction was stirred at 60 for a certain period of time.The solid catalyst was removed by filtration,Using gas chromatography internal standard method (chlorobenzene as internal standard) to analyze the content of liquid products,Calculate yield.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 583-03-9, 1-Phenylpentan-1-ol.

Reference:
Patent; Changzhou University; Zhou Weiyou; Dai Xuan; He Mingyang; Sun Fuan; Pan Jiugao; (8 pag.)CN107176898; (2017); A;,
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Reference of 583-03-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.583-03-9, name is 1-Phenylpentan-1-ol, molecular formula is C11H16O, molecular weight is 164.24, as common compound, the synthetic route is as follows.

At room temperature, in a 50 ml round-bottom flask is sequentially added in the 1 – benzene amyl alcohol (0.164 g, 1 mmol), benzoic acid (0.183g, 1.5 mmol), NBS (0.356g, 2 mmol) and 1, 4 – dioxane (2 ml). In the 60 C stirring 1 hour, then adding DBU (0.304 g, 2 mmol), continue to reaction 4 hours (TLC detection reaction). Then, stopping the reaction, concentrated under reduced pressure, to obtain crude product. Finally petroleum ether and ethyl acetate mixed eluent flushing, rapid column chromatography (silica gel column) to obtain the corresponding product alpha – acyloxy ketone compound (yellow liquid 0.260g, yield 92%).

The chemical industry reduces the impact on the environment during synthesis 583-03-9, I believe this compound will play a more active role in future production and life.

Reference:
Patent; Qufu Normal University; Wang, Hua; Wei, Wei; Zhu, Minghui; Cui, Huanhuan; (19 pag.)CN106518663; (2017); A;,
Alcohol – Wikipedia,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 583-03-9, name is 1-Phenylpentan-1-ol. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 583-03-9

In a typical reaction, acetic anhydride (500muL, 5.3mmol), pyridine (200muL) and triethylamine (4.0mmol) were added subsequently to a stirred solution of 1-phenylpentanol rac-4a (492mg, 3.0mmol) in dichloromethane (2mL) at room temperature. The reaction was stirred for 24h-52h at room temperature, monitored by TLC. Dichloromethane (10mL) was added and the mixture was quenched with an addition of 1M aq HCl (2mL). The aqueous layer was extracted with dichloromethane (2¡Á10mL). The combined organic extracts were neutralized and washed with saturated aq NaHCO3 (5mL) and brine (10mL), then dried over MgSO4 and filtered. The organic solvent was concentrated under reduced pressure and the residue was purified by silica gel column chromatography (hexane/ethyl acetate, 3:1) to give corresponding acetate rac-4b. The 1H NMR spectra of acetates 3b,24 4b,24 5b,24 6b,24 7b,26 8b,28 9b29 were all in agreement with those reported in the literature.

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Reference:
Article; Hoang, Hai Nam; Matsuda, Tomoko; Tetrahedron; vol. 72; 46; (2016); p. 7229 – 7234;,
Alcohol – Wikipedia,
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