Category: 579-43-1

Szostak, Michal;Spain, Malcolm;Procter, David J. published 《Ketyl-Type Radicals from Cyclic and Acyclic Esters are Stabilized by SmI₂(H₂O)_n: The Role of SmI₂(H₂O)_n in Post-Electron Transfer Steps》 in 2014. The article was appeared in 《Journal of the American Chemical Society》. They have made some progress in their research.Related Products of 579-43-1 The article mentions the following:

Mechanistic details pertaining to the SmI₂-H₂O-mediated reduction and reductive coupling of 6-membered lactones, the first class of simple unactivated carboxylic acid derivatives that had long been thought to lie outside the reducing range of SmI₂, were elucidated. Results provide new exptl. evidence that water enables the productive electron transfer from Sm(II) by stabilization of the radical anion intermediate rather than by solely promoting the first electron transfer as originally proposed. Notably, these studies suggest that all reactions involving the generation of ketyl-type radicals with SmI₂ occur under a unified mechanism based on the thermodn. control of the second electron transfer step, thus providing a blueprint for the development of a broad range of novel chemoselective transformations via open-shell electron pathways. To complete the study, the researchers used rel-(1R,2S)-1,2-Diphenylethane-1,2-diol (cas: 579-43-1) .

Desymmetrization of rel-(1R,2S)-1,2-Diphenylethane-1,2-diol(cas:579-43-1 Related Products of 579-43-1) using chiral phosphine catalyst has been reported. Conversion of meso-hydrobenzoin to trans-stillbene oxide by treatment with an aryl sulfonyl chloride and aqueous sodium hydroxide has been reported.

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Recommanded Product: 579-43-1In 2017, Mecozzi, Francesco;Dong, Jia Jia;Saisaha, Pattama;Browne, Wesley R. published 《Oxidation of Vicinal Diols to α-Hydroxy Ketones with H₂O₂ and a Simple Manganese Catalyst》. 《European Journal of Organic Chemistry》published the findings. The article contains the following contents:

α-Hydroxy ketones are valuable synthons in organic chem. Here we show that oxidation of vic-diols to α-hydroxy ketones with H₂O₂ can be achieved with an in situ prepared catalyst based on manganese salts and pyridine-2-carboxylic acid. Furthermore the same catalyst is effective in alkene epoxidation, and it is shown that alkene oxidation with the Mn^II catalyst and H₂O₂ followed by Lewis acid ring opening of the epoxide and subsequent oxidation of the alkene to α-hydroxy ketones can be achieved under mild (ambient) conditions. To complete the study, the researchers used rel-(1R,2S)-1,2-Diphenylethane-1,2-diol (cas: 579-43-1) .

Desymmetrization of rel-(1R,2S)-1,2-Diphenylethane-1,2-diol(cas:579-43-1 Recommanded Product: 579-43-1) using chiral phosphine catalyst has been reported. Conversion of meso-hydrobenzoin to trans-stillbene oxide by treatment with an aryl sulfonyl chloride and aqueous sodium hydroxide has been reported.

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Guo, Pengfei;Liao, Shengyun;Wang, Shun;Shi, Jing;Tong, Xinli published 《Highly efficient and selectivity-controllable aerobic oxidative cleavage of C-C bond over heterogeneous Fe-based catalysts》. The research results were published in《Journal of Catalysis》 in 2021.Synthetic Route of C14H14O2 The article conveys some information:

A base-free selectivity-controllable aerobic oxidative cleavage of C-C bond with heterogeneous Fe-based catalysts (Fe_xO_y-N@C₃N₄) was developed. In the presence of oxygen, 1,2-diols were selectively transformed to the corresponding aldehyde, while the Me esters were orientedly produced from 1,2-diones in methanol medium.rel-(1R,2S)-1,2-Diphenylethane-1,2-diol (cas: 579-43-1) were involved in the experimental procedure.

rel-(1R,2S)-1,2-Diphenylethane-1,2-diol(cas: 579-43-1 Synthetic Route of C14H14O2) has been used in the preparation of trans-methyl meso-hydrobenzoin phosphite.

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Martin, Teo;Salamone, Michela;Bietti, Massimo published 《Hydrogen atom transfer from 1,2- and 1,3-diols to the cumyloxyl radical. The role of structural effects on metal-ion induced C-H bond deactivation》. The research results were published in《Chemical Communications (Cambridge, United Kingdom)》 in 2019.Reference of rel-(1R,2S)-1,2-Diphenylethane-1,2-diol The article conveys some information:

Strong C-H bond deactivation toward HAT has been observed in the reactions of the cumyloxyl radical with 1,2- and 1,3-diols, following addition of Li⁺ and Ca²⁺. Weaker effects have been observed with Mg²⁺. The role of the substrate structure and of the metal ion in the formation of Lewis acid-base complexes is discussed. To complete the study, the researchers used rel-(1R,2S)-1,2-Diphenylethane-1,2-diol (cas: 579-43-1) .

Desymmetrization of rel-(1R,2S)-1,2-Diphenylethane-1,2-diol(cas:579-43-1 Reference of rel-(1R,2S)-1,2-Diphenylethane-1,2-diol) using chiral phosphine catalyst has been reported. Conversion of meso-hydrobenzoin to trans-stillbene oxide by treatment with an aryl sulfonyl chloride and aqueous sodium hydroxide has been reported.

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Yang, Lu;Wenzel, Thomas;Williamson, R. Thomas;Christensen, Melodie;Schafer, Wes;Welch, Christopher J. published 《Expedited Selection of NMR Chiral Solvating Agents for Determination of Enantiopurity》. The research results were published in《ACS Central Science》 in 2016.Related Products of 579-43-1 The article conveys some information:

The use of NMR chiral solvating agents (CSAs) for the anal. of enantiopurity was known for decades, but was supplanted in recent years by chromatog. enantioseparation technol. While chromatog. methods for the anal. of enantiopurity are now commonplace and easy to implement, there are still individual compounds and entire classes of analytes where enantioseparation can prove extremely difficult, notably, compounds that are chiral by virtue of very subtle differences such as isotopic substitution or small differences in alkyl chain length. NMR anal. using CSAs can often be useful for such problems, but the traditional approach to selection of an appropriate CSA and the development of an NMR-based anal. method often involves a trial-and-error approach that can be relatively slow and tedious. The authors describe a high-throughput experimentation approach to the selection of NMR CSAs that employs automation-enabled screening of prepared libraries of CSAs in a systematic fashion. This approach affords excellent results for a standard set of enantioenriched compounds, providing a valuable comparative data set for the effectiveness of CSAs for different classes of compounds The technique was successfully applied to challenging pharmaceutical development problems that are not amenable to chromatog. solutions Overall, this methodol. provides a rapid and powerful approach for studying enantiopurity that compliments and augments conventional chromatog. approaches.rel-(1R,2S)-1,2-Diphenylethane-1,2-diol (cas: 579-43-1) were involved in the experimental procedure.

rel-(1R,2S)-1,2-Diphenylethane-1,2-diol(cas: 579-43-1 Related Products of 579-43-1) has been used in the preparation of trans-methyl meso-hydrobenzoin phosphite.

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Name: rel-(1R,2S)-1,2-Diphenylethane-1,2-diolIn 2020, Luca, Lorena De;Mezzetti, Antonio published 《Chiral Benzoins via Asymmetric Transfer Hemihydrogenation of Benzils: The Detail that Matters》. 《Journal of Organic Chemistry》published the findings. The article contains the following contents:

The synthesis of enantiomerically pure benzoins by hydrogenation of readily available benzils was long thwarted by their base sensitivity. It was shown here that an iron(II) hydride complex catalyzes the asym. transfer hydrogenation of benzils from 2-propanol. When strictly base-free conditions are granted, excellent enantioselectivity was achieved even with o-substituted substrates, which are particularly challenging to prepare with other methods. Hence, under optimized reaction conditions, chiral benzoins were prepared in good yields (up to 83%) and excellent enantioselectivity (up to 98% ee) in short reaction times (30-75 min). Also, this work confirms that both enantiomers of the benzoin products can be accessed when a metal catalyst is used, which is a clear advantage over enzymic methods. To complete the study, the researchers used rel-(1R,2S)-1,2-Diphenylethane-1,2-diol (cas: 579-43-1) .

Desymmetrization of rel-(1R,2S)-1,2-Diphenylethane-1,2-diol(cas:579-43-1 Name: rel-(1R,2S)-1,2-Diphenylethane-1,2-diol) using chiral phosphine catalyst has been reported. Conversion of meso-hydrobenzoin to trans-stillbene oxide by treatment with an aryl sulfonyl chloride and aqueous sodium hydroxide has been reported.

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Name: rel-(1R,2S)-1,2-Diphenylethane-1,2-diolIn 2016, Archelas, Alain;Zhao, Wei;Faure, Bruno;Iacazio, Gilles;Kotik, Michael published 《Epoxide hydrolase-catalyzed enantioselective conversion of trans-stilbene oxide: Insights into the reaction mechanism from steady-state and pre-steady-state enzyme kinetics》. 《Archives of Biochemistry and Biophysics》published the findings. The article contains the following contents:

A detailed kinetic study based on steady-state and pre-steady-state measurements is described for the highly enantioselective epoxide hydrolase Kau2. The enzyme, which is a member of the α/β-hydrolase fold family, preferentially reacts with the (S,S)-enantiomer of trans-stilbene oxide (TSO) with an E value of ∼200. The enzyme follows a classical two-step catalytic mechanism with formation of an alkyl-enzyme intermediate in the first step and hydrolysis of this intermediate in a rate-limiting second step. Tryptophan fluorescence quenching during TSO conversion appears to correlate with alkylation of the enzyme. The steady-state data are consistent with (S,S) and (R,R)-TSO being two competing substrates with marked differences in k_cat and K_m values. The high enantiopreference of the epoxide hydrolase is best explained by pronounced differences in the second-order alkylation rate constant (k₂/K_S) and the alkyl-enzyme hydrolysis rate k₃ between the (S,S) and (R,R)-enantiomers of TSO. Our data suggest that during conversion of (S,S)-TSO the two active site tyrosines, Tyr¹⁵⁷ and Tyr²⁵⁹, serve mainly as electrophilic catalysts in the alkylation half-reaction, polarizing the oxirane oxygen of the bound epoxide through hydrogen bond formation, however, without fully donating their hydrogens to the forming alkyl-enzyme intermediate.rel-(1R,2S)-1,2-Diphenylethane-1,2-diol (cas: 579-43-1) were involved in the experimental procedure.

Desymmetrization of rel-(1R,2S)-1,2-Diphenylethane-1,2-diol(cas:579-43-1 Name: rel-(1R,2S)-1,2-Diphenylethane-1,2-diol) using chiral phosphine catalyst has been reported. Conversion of meso-hydrobenzoin to trans-stillbene oxide by treatment with an aryl sulfonyl chloride and aqueous sodium hydroxide has been reported.

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COA of Formula: C14H14O2《Amine Catalysis for the Organocatalytic Diboration of Challenging Alkenes》 was published in 2016. The authors were Farre, Albert;Soares, Kaline;Briggs, Rachel A.;Balanta, Angelica;Benoit, David M.;Bonet, Amadeu, and the article was included in《Chemistry – A European Journal》. The author mentioned the following in the article:

The generation of in situ sp²-sp³ diboron adducts has revolutionized the synthesis of organoboranes. Organocatalytic diboration reactions have represented a milestone in terms of unpredictable reactivity of these adducts. However, current methodologies have limitations in terms of substrate scope, selectivity and functional group tolerance. Here a new methodol. based on the use of simple amines as catalyst is reported. This methodol. provides a completely selective transformation overcoming current substrate scope and functional/protecting group limitations. Mechanistic studies have been included in this report. To complete the study, the researchers used rel-(1R,2S)-1,2-Diphenylethane-1,2-diol (cas: 579-43-1) .

rel-(1R,2S)-1,2-Diphenylethane-1,2-diol(cas: 579-43-1 COA of Formula: C14H14O2) has been used in the preparation of trans-methyl meso-hydrobenzoin phosphite.

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Sotto, Nicolas;Billamboz, Muriel;Chevrin-Villette, Carole;Len, Christophe published 《Selective Pinacol Coupling on Regeneratable Supported Acids in Sole Water》. The research results were published in《Journal of Organic Chemistry》 in 2015.Synthetic Route of C14H14O2 The article conveys some information:

Efficient pinacol coupling was developed in water, using a reusable heterogeneous supported acid source and zinc as cheap available metal source. This medium can be easily regenerated up to 10-fold without loss of activity. Moreover, supported acids enhance the selectivity of the pinacol coupling reaction compared with homogeneous acids. Thus, e.g., pinacol coupling of 4-bromobenzaldehyde in water using Zn as electron donor and Amberlyst 15 as proton source afforded 1,2-bis(4-bromophenyl)-1,2-ethanediol (82%, DL/meso = 29/71) + 4-bromobenzyl alc. (11%). To complete the study, the researchers used rel-(1R,2S)-1,2-Diphenylethane-1,2-diol (cas: 579-43-1) .

rel-(1R,2S)-1,2-Diphenylethane-1,2-diol(cas: 579-43-1 Synthetic Route of C14H14O2) has been used in the preparation of trans-methyl meso-hydrobenzoin phosphite.

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Product Details of 579-43-1《Microbial synthesis of (S)- and (R)-benzoin in enantioselective desymmetrization and deracemization catalyzed by Aureobasidium pullulans included in the blossom protect agent》 was published in 2021. The authors were Kolodziejska, Renata;Studzinska, Renata;Tafelska-Kaczmarek, Agnieszka;Pawluk, Hanna;Mlicka, Dominika;Wozniak, Alina, and the article was included in《Molecules》. The author mentioned the following in the article:

Aureobasidium pullulans strains DSM 14940 and DSM 14941 included in the Blossom Protect agent to be used in the bioreduction reaction of a sym. dicarbonyl compound Both chiral 2-hydroxy-1,2-diphenylethanone antipodes were obtained with a high enantiomeric purity. Mild conditions (phosphate buffer [pH 7.0, 7.2], 30°C) were successfully employed in the synthesis of (S)-benzoin using two different methodologies: benzyl desymmetrization and rac-benzoin deracemization. Bioreduction carried out with higher reagent concentrations, lower pH values and prolonged reaction time, and in the presence of additives, enabled enrichment of the reaction mixture with (R)-benzoin. The described procedure was a potentially useful tool in the synthesis of chiral building blocks with a defined configuration in a simple and economical process with a lower environmental impact, enabling one-pot biotransformation. To complete the study, the researchers used rel-(1R,2S)-1,2-Diphenylethane-1,2-diol (cas: 579-43-1) .

Desymmetrization of rel-(1R,2S)-1,2-Diphenylethane-1,2-diol(cas:579-43-1 Product Details of 579-43-1) using chiral phosphine catalyst has been reported. Conversion of meso-hydrobenzoin to trans-stillbene oxide by treatment with an aryl sulfonyl chloride and aqueous sodium hydroxide has been reported.

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