Category: 575-03-1

Reference of 575-03-1, Adding some certain compound to certain chemical reactions, such as: 575-03-1, name is 7-Hydroxy-4-(trifluoromethyl)coumarin,molecular formula is C10H5F3O3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 575-03-1.

Similarly, the reaction of 4-nitrophthalonitrile (1.00 g, 5.78 mM) with 7-hydroxy-4-trifluoromethylcoumarin(1.33 g, 5.78 mM) was initiated in 30 mL of DMF in the presence of K2CO3 (2.30 g, 16.6 mM). The reaction mixture was heated with stirring at 90 ¡ãC under an inert nitrogen atmosphere for 24 h. Thereafter, the reaction mixture was cooled to room temperature, poured into 60 mL water, and extracted with CH3CN. The combined organic extracts were dried over sodium sulfate and filtered. The solvent was evaporated under reduced pressure and the remaining residue was added to 30percent HCl to induce precipitation. The precipitate was then repeatedly washed with water and added to hot methanol (MeOH), filtered, and dried under P2O5. Yield: 41percent; m.p. (¡ãC): 180.0?181.8; FT-IR (numax/cm?1): nu(C=O) 1729, nu(C?N) 2235, nu(C?O?C) 990, 1129; 1H NMR (ppm): 7.06 (s, 1H, H1), 7.99 (s, 1H, H2), 7.64 (d, 1H, J = 8.73 Hz, H3), 8.19 (d, 1H, J = 8.74 Hz, H4), 7.43 (s, 1H,H5), 7.28 (d, 1H, J = 8.80 Hz, H6), 7.80 (d, 1H, J = 9.01 Hz, H7); 13C NMR (ppm): 159.78, 158.74, 158.42, 156.01, 146.85, 137.01, 127.37, 124.64, 124.38, 123.44, 117.57, 117.21, 116.26, 116.11, 115.69, 110.82, 110.40, 109.04; UV?Vis [DMF, lambdamax (epsilon, M?1 cm?1)]: 443 nm (90), 318 nm (29875), 307 nm (33370). Molecular mass (m/z): Calcd: 356.25. Found: 379.03 [M + Na]+. Anal. Calcd for C18H7F3N2O3 (percent): C, 60.68; H, 1.98;N, 7.86. Found: C, 60.48; H, 2.30; N, 7.86.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 575-03-1, 7-Hydroxy-4-(trifluoromethyl)coumarin, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Chohan, Sumayya; Booysen, Irvin Noel; Mambanda, Allen; Akerman, Matthew Piers; Journal of Coordination Chemistry; vol. 68; 10; (2015); p. 1829 – 1846;,
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Reference of 575-03-1, Adding some certain compound to certain chemical reactions, such as: 575-03-1, name is 7-Hydroxy-4-(trifluoromethyl)coumarin,molecular formula is C10H5F3O3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 575-03-1.

General procedure: The appropriate bromoketone (6a-o) (1.7 mmol) and triethylamine (1.6 mmol) were added to as olution of either7-hydroxy-4-methyl-2H-chromen-2-one 4 (1.4 mmol)or 7-hydroxy-4-(trifluoromethyl)-2H-chromen-2-one 5 (1.4 mmol) in THF (20 mL). The mixture was stirred at room temperature for 24h, filtered and the solvent was evaporated under reduced pressure.The solid residue was purified by column chromatography eluting with DCM/MeOH 9:1 to afford (7a-n) and (8a-o).

According to the analysis of related databases, 575-03-1, the application of this compound in the production field has become more and more popular.

Reference:
Article; Kandil, Sahar; Westwell, Andrew D.; Mcguigan, Christopher; Bioorganic and Medicinal Chemistry Letters; vol. 26; 8; (2016); p. 2000 – 2004;,
Alcohol – Wikipedia,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 575-03-1, name is 7-Hydroxy-4-(trifluoromethyl)coumarin. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 7-Hydroxy-4-(trifluoromethyl)coumarin

General procedure: Substituted coumarin (a-e) (0.001 mol), substituted DHA (I, II)(0.001 mol) and anhydrous potassium carbonate (0.0011 mol) were added in 15 mL DMF and stirred for 5 h. After the completion of reaction, the mixture was poured in the water and extracted with ethyl acetate (50 mLx3). The organic layer was dried over anhydrous sodium sulfate and evaporated to dryness. The product was purified through column chromatography.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 575-03-1, 7-Hydroxy-4-(trifluoromethyl)coumarin.

Reference:
Article; Yu, Haonan; Hou, Zhuang; Tian, Ye; Mou, Yanhua; Guo, Chun; European Journal of Medicinal Chemistry; vol. 151; (2018); p. 434 – 449;,
Alcohol – Wikipedia,
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Electric Literature of 575-03-1, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 575-03-1 as follows.

(1) to 10 ml containing 0.5mmol of 4 – trifluoromethyl -7 – hydroxy coumarin and 0.625mmol of triethylamine in tetrahydrofuran solution, slowly dropping 0.6mmol to methyl benzoyl chloride (dissolved in 5 ml of in tetrahydrofuran), to control the temperature 0 ¡ãC;(2) stirring ice 1h after, solution to return to room temperature, stirring overnight;(3) the reaction solution through the pressure reducing and removing the solvent, the solid residue is purified by silica gel chromatography, using ethyl acetate-hexane – (1:3 v/v) elute, shall be 131 mg white solid powdery pure product.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,575-03-1, its application will become more common.

Reference:
Patent; Da Lianli Technology Changshu Institute Co., Ltd.; Cui Jingnan; Feng Lei; (11 pag.)CN104592985; (2017); B;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 575-03-1 as follows., 575-03-1

General procedure: The corresponding coumarin derivatives (4.21mmol) 5a-k and potassium carbonate (0.872 g, 6.31 mmol) were suspended in dry acetone, and then the corresponding dibromoalkyl derivative (84.12 mmol) was added. The mixture was refluxed for 6 h. After cooling to room temperature, the solid was filtered and washed with acetone. The filtrate was concentrated under reduced pressure and purified by column chromatography using petroleum ether/ethy actate (5 : 1 to 8:1) as eluent to get the intermediates of 6a-n

The chemical industry reduces the impact on the environment during synthesis 575-03-1, I believe this compound will play a more active role in future production and life.

Reference:
Article; He, Qi; Liu, Jing; Lan, Jin-Shuai; Ding, Jiaoli; Sun, Yongbing; Fang, Yuanying; Jiang, Neng; Yang, Zunhua; Sun, Liyuan; Jin, Yi; Xie, Sai-Sai; Bioorganic Chemistry; vol. 81; (2018); p. 512 – 528;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding some certain compound to certain chemical reactions, such as: 575-03-1, name is 7-Hydroxy-4-(trifluoromethyl)coumarin, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 575-03-1. 575-03-1

General procedure: The appropriate bromoketone (6a-o) (1.7 mmol) and triethylamine (1.6 mmol) were added to as olution of either7-hydroxy-4-methyl-2H-chromen-2-one 4 (1.4 mmol)or 7-hydroxy-4-(trifluoromethyl)-2H-chromen-2-one 5 (1.4 mmol) in THF (20 mL). The mixture was stirred at room temperature for 24h, filtered and the solvent was evaporated under reduced pressure.The solid residue was purified by column chromatography eluting with DCM/MeOH 9:1 to afford (7a-n) and (8a-o).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 575-03-1.

Reference:
Article; Kandil, Sahar; Westwell, Andrew D.; Mcguigan, Christopher; Bioorganic and Medicinal Chemistry Letters; vol. 26; 8; (2016); p. 2000 – 2004;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

575-03-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 575-03-1, name is 7-Hydroxy-4-(trifluoromethyl)coumarin, molecular formula is C10H5F3O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: The appropriate bromoketone (6a-o) (1.7 mmol) and triethylamine (1.6 mmol) were added to as olution of either7-hydroxy-4-methyl-2H-chromen-2-one 4 (1.4 mmol)or 7-hydroxy-4-(trifluoromethyl)-2H-chromen-2-one 5 (1.4 mmol) in THF (20 mL). The mixture was stirred at room temperature for 24h, filtered and the solvent was evaporated under reduced pressure.The solid residue was purified by column chromatography eluting with DCM/MeOH 9:1 to afford (7a-n) and (8a-o).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 575-03-1, 7-Hydroxy-4-(trifluoromethyl)coumarin, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Kandil, Sahar; Westwell, Andrew D.; Mcguigan, Christopher; Bioorganic and Medicinal Chemistry Letters; vol. 26; 8; (2016); p. 2000 – 2004;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

575-03-1 , The common heterocyclic compound, 575-03-1, name is 7-Hydroxy-4-(trifluoromethyl)coumarin, molecular formula is C10H5F3O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

(1) to 10 ml containing 0.5mmol of 4 – trifluoromethyl -7 – hydroxy coumarin and 0.625mmol of triethylamine in tetrahydrofuran solution, slowly dropping 0.6mmol to the propyl benzoyl chloride (dissolved in 5 ml of in tetrahydrofuran), to control the temperature 0 ¡ãC;(2) stirring ice 1h after, solution to return to room temperature, stirring overnight;(3) the reaction solution through the pressure reducing and removing the solvent, the solid residue is purified by silica gel chromatography, using ethyl acetate-hexane – (1:3 v/v) elute, shall be 148 mg white solid powdery pure product.

According to the analysis of related databases, 575-03-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Da Lianli Technology Changshu Institute Co., Ltd.; Cui Jingnan; Feng Lei; (11 pag.)CN104592985; (2017); B;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

575-03-1, Adding a certain compound to certain chemical reactions, such as: 575-03-1, 7-Hydroxy-4-(trifluoromethyl)coumarin, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 575-03-1, blongs to alcohols-buliding-blocks compound.

(1) to 10 ml containing 0.5mmol of 4 – trifluoromethyl -7 – hydroxy coumarin and 0.625mmol of triethylamine in tetrahydrofuran solution, slowly dropping 0.6mmol to chloride (dissolved in 5 ml of in tetrahydrofuran), to control the temperature 0 ¡ãC;(2) stirring ice 1h after, solution to return to room temperature, stirring overnight;(3) the reaction solution through the pressure reducing and removing the solvent, the solid residue is purified by silica gel chromatography, using ethyl acetate-hexane – (1:3 v/v) elute, shall be 132 mg white solid powdery pure product.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,575-03-1, its application will become more common.

Reference:
Patent; Da Lianli Technology Changshu Institute Co., Ltd.; Cui Jingnan; Feng Lei; (11 pag.)CN104592985; (2017); B;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

575-03-1 , The common heterocyclic compound, 575-03-1, name is 7-Hydroxy-4-(trifluoromethyl)coumarin, molecular formula is C10H5F3O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: To a magnetically-stirred solution of 7-hydroxycoumarin derivatives (2 mmol), aromatic aldehydes (2 mmol) and NEt3 (2 mmol) in THF (8 mL) a mixture of dialkyl acetylenedicarboxylate (2 mmol) in THF (2 mL) was added in 15 min. The reaction mixture was then allowed to stand at room temperature for 0.5-10 h. After completion of the reaction as indicated by thin-layer chromatography (TLC) (n-hexane/EtOAc, 1:1), the solvent was removed under reduced pressure. The residue was purified by column chromatography on silica gel (Merck, 230-400 mesh) using a mixture of n-hexane/EtOAc (1:1) as eluent to afford the pure product as a light yellow powder.

The synthetic route of 575-03-1 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Asghari, Sakineh; Baharfar, Robabeh; Darabi, Samaneh Ahangar; Mohammadian, Reza; Journal of the Brazilian Chemical Society; vol. 26; 2; (2015); p. 218 – 223;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts