Category: 575-03-1

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.575-03-1, name is 7-Hydroxy-4-(trifluoromethyl)coumarin, molecular formula is C10H5F3O3, molecular weight is 230.1401, as common compound, the synthetic route is as follows.Recommanded Product: 7-Hydroxy-4-(trifluoromethyl)coumarin

The synthetic steps of 4-trifluoromethyl-7-propylenecarbonyloxycoumarin are as follows:(1) To 10 mL of a solution containing 0.5 mmol of 4-trifluoromethyl-7-hydroxycoumarin and 0.625 mmol of triethylamine in a tetrahydrofuran solution, slowly add 0.6 mmol of acryloyl chloride chloride to the reaction flask within 30 min. Dissolved in 5 mL of tetrahydrofuran), the temperature is controlled at 0 ° C;(2) After stirring for 1 hour under ice bath conditions, the temperature of the solution was raised to room temperature and stirred overnight. ;(3) The reaction solution was subjected to a solvent under reduced pressure, and the residue was purified by silica gel chromatography eluting with ethyl acetate-hexane (1:3 v/v)

At the same time, in my other blogs, there are other synthetic methods of this type of compound,575-03-1, 7-Hydroxy-4-(trifluoromethyl)coumarin, and friends who are interested can also refer to it.

Reference:
Patent; Da Lianli Technology Changshu Institute Co., Ltd.; Cui Jingnan; Feng Lei; (12 pag.)CN103755672; (2016); B;,
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Related Products of 575-03-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 575-03-1, name is 7-Hydroxy-4-(trifluoromethyl)coumarin. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: The appropriate bromoketone (6a-o) (1.7 mmol) and triethylamine (1.6 mmol) were added to as olution of either7-hydroxy-4-methyl-2H-chromen-2-one 4 (1.4 mmol)or 7-hydroxy-4-(trifluoromethyl)-2H-chromen-2-one 5 (1.4 mmol) in THF (20 mL). The mixture was stirred at room temperature for 24h, filtered and the solvent was evaporated under reduced pressure.The solid residue was purified by column chromatography eluting with DCM/MeOH 9:1 to afford (7a-n) and (8a-o).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 575-03-1, 7-Hydroxy-4-(trifluoromethyl)coumarin.

Reference:
Article; Kandil, Sahar; Westwell, Andrew D.; Mcguigan, Christopher; Bioorganic and Medicinal Chemistry Letters; vol. 26; 8; (2016); p. 2000 – 2004;,
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Application of 575-03-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 575-03-1, name is 7-Hydroxy-4-(trifluoromethyl)coumarin. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: To a magnetically-stirred solution of 7-hydroxycoumarin derivatives (2 mmol), aromatic aldehydes (2 mmol) and NEt3 (2 mmol) in THF (8 mL) a mixture of dialkyl acetylenedicarboxylate (2 mmol) in THF (2 mL) was added in 15 min. The reaction mixture was then allowed to stand at room temperature for 0.5-10 h. After completion of the reaction as indicated by thin-layer chromatography (TLC) (n-hexane/EtOAc, 1:1), the solvent was removed under reduced pressure. The residue was purified by column chromatography on silica gel (Merck, 230-400 mesh) using a mixture of n-hexane/EtOAc (1:1) as eluent to afford the pure product as a light yellow powder.

According to the analysis of related databases, 575-03-1, the application of this compound in the production field has become more and more popular.

Reference:
Article; Asghari, Sakineh; Baharfar, Robabeh; Darabi, Samaneh Ahangar; Mohammadian, Reza; Journal of the Brazilian Chemical Society; vol. 26; 2; (2015); p. 218 – 223;,
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Synthetic Route of 575-03-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 575-03-1, name is 7-Hydroxy-4-(trifluoromethyl)coumarin. This compound has unique chemical properties. The synthetic route is as follows.

To a 100 mL reaction flask was added 2.8 g (0.01 mol) of dihydroartemisinin and 1.01 g (0.01 mol) of triethylamine,30 mL of dry methylene chloride was added, stirred to dissolve, cooled to -5 ° C, and 1.4 mL (0.01 mol) of trifluoroacetic acid Anhydride, and the reaction was continued at 0 ° C for 8 hours to obtain 10-trifluoroacetoxy dihydroartemisinin in dichloromethane, without Need to be processed, directly for the next step reaction. To the solution prepared above, 2.3 g of 7-hydroxy-4-trifluoromethylcoumarin was added (0.01 mol), and the reaction was continued for 14 hours at room temperature (TLC monitoring reaction end point). To the reaction solution was further added 30 mLDichloromethane, the organic layer was separated and washed 5 times (5 x 20 mL) with saturated sodium bicarbonate solution, dried over anhydrous sodium sulfate Phase, the desiccant was filtered off and the dichloromethane was distilled off under reduced pressure to give the crude product which was purified by column chromatography (200-300 mesh silica gel, petroleum ether: acetic acid Ethyl ester = 8: 1) to give 2.53 g of a white solid in 51percent yield.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 575-03-1, 7-Hydroxy-4-(trifluoromethyl)coumarin.

Reference:
Patent; Shenyang Pharmaceutical University; Guo, Chun; Tian, Ye; Hou, Zhuang; Guo, Mengbi; Li, Jianteng; Mou, Yanhua; Xia, Mingyu; (25 pag.)CN106188088; (2016); A;,
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Electric Literature of 575-03-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 575-03-1, name is 7-Hydroxy-4-(trifluoromethyl)coumarin, molecular formula is C10H5F3O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

[Syntheses of 6a and 6b] ; The compounds 6 and 6b were synthesized in the same manner. Firstly, triethylamine (1.1 eq) was added to a suspension of 7-hydroxy-4-(trifluoromethyl)coumarin (1.0 g) and 2,4-dinitrobenzenesulfon 1 chloride or, 2-nitro-4-(trifluoromethyl)benzenesulfonyl chloride (1.1 eq) in dichloromethane (20 mL) at 0°C. Next, the obtained mixed solution was stirred at room temperature for 1 hour. The reaction solution was diluted with dichloromethane (200 mL), was washed with 1M hydrochloric acid (200 mL) and saturated saline (200 mL), and was dried over magnesium sulfate. The residue obtained by evaporating the solvent under a reduced pressure was refined by silica gel column-chromatography (dichloromethane), thereby obtaining each objective compound. Yields and instrumental analytical values of these compounds will be described below. 6a: 1.9 g (95percent) as a white crystal. m.p. 123-124.5° C (from benzene). 1H-NMR(270 MHz, [D]6-DMSO, TMS): delta= 9.13 (d, 4JH,H=2.3 Hz, 1H; aromatic), 8.64 (dd, 3JH,H= 8.7 Hz, 4JH,H=2.3 Hz, 1H; aromatic), 8.35 (d, 3JH,H= 8.7 Hz, 1H; aromatic), 7.79 (dd, 3JH,H=8.9 Hz, 8JH,H=1.5 Hz, 1H; aromatic), 7.54 (d, 4JH,H=2.5 Hz, 1H, aromatic), 7.32 (dd, 3JH,H=8.9, 4JH,H= 2.5 Hz, 1H; aromatic), 7.15 (s, 1H; aromatic). FTIR (KBr): nu = 1751 (CO, s), 1558(NO2, s), 1542 (NO2, s)cm-1. Elemental analysis (percent) calcd for C16H7 F3N2O9S: C 41.75, H 1.53, N6.09; found: C 41.74, H 1.63, N 5,92. FAB HRMS calcd for C16H8F3N2O9S (MH+): 460.9903; found: 460.9888. 6b: 2.0 g (95percent) as a white crystal. m.p. 134.5-136°C (from AcOEt-hexane). 1H-NMR (270 MHz, [D]6-DMSO, TMS): delta = 5.82 (s, 1H; aromatic), 8.33 (d, 4JH,H = 1.5 Hz, 2H; aromatic), 7.83 (dd, 3JH,H= 8.9 Hz, 4JH,H= 1.8 Hz, 1H; aromatic), 7.57 (t, 4JH,H= 2.2 Hz, 1H; aromatic), 7.34 (dt, 3JH,H= 8.9 Hz, 4JH,H= 2.2 Hz, 1H, aromatic), 7.15 (s, 1H; aromatic). FTIR (KBr): nu = 1752 (CO, s), 1557 (NO2, s) cm-1. Elemental analysis (percent) calcd for C17H7F6NO7S: C 42.25, H 1.46, N 2.90; found: C 42.24, H 1.55, N 2.72. FAB HRMS calcd for C17H8F6NO7S (MH+): 483.9926; found: 483.9925.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 575-03-1, 7-Hydroxy-4-(trifluoromethyl)coumarin.

Reference:
Patent; Osaka Industrial Promotion Organization; EP1650200; (2006); A1;,
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Alcohols – Chemistry LibreTexts

Electric Literature of 575-03-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 575-03-1, name is 7-Hydroxy-4-(trifluoromethyl)coumarin, molecular formula is C10H5F3O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Commercially available 7-hydroxy-4-trifluoromethyl coumarin (0.069g, 0.30mmol) was dissolved in dry DMF (2.0mL) and then 60percent NaH in mineral oil (0.012g, 0.30mmol) was added while cooling at 0°C. The mixture was slowly warmed at room temperature, then 3-chlorobenzyl bromide (0.040mL, 0.30mmol) was added dropwise via syringe after 1h and stirring was continued for 24h at room temperature. After addition of crushed ice, the suspension was treated with 2.0N aq. solution of NaOH (5mL). The mixture was stirred for 1h and the resulting precipitate was filtered and washed with water, yielding compound 24. White crystals; yield: 84percent, mp: 118.8?120.3°C (ethanol). 1H NMR (300MHz, DMSO-d6) delta: 5.27 (s, 2H), 6.85 (s, 1H), 7.13 (dd, J1=2.4Hz, J2=8.9Hz, 1H), 7.23 (d, J=2.4Hz, 1H), 7.40?7.45 (m, 3H), 7.54 (s, 1H), 7.61?7.64 (m, 1H). Anal. (C17H10ClF3O3) C, H.

According to the analysis of related databases, 575-03-1, the application of this compound in the production field has become more and more popular.

Reference:
Article; Pisani, Leonardo; Catto, Marco; Nicolotti, Orazio; Grossi, Giancarlo; Di Braccio, Mario; Soto-Otero, Ramon; Mendez-Alvarez, Estefania; Stefanachi, Angela; Gadaleta, Domenico; Carotti, Angelo; European Journal of Medicinal Chemistry; vol. 70; (2013); p. 723 – 739;,
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Reference of 575-03-1, Adding some certain compound to certain chemical reactions, such as: 575-03-1, name is 7-Hydroxy-4-(trifluoromethyl)coumarin,molecular formula is C10H5F3O3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 575-03-1.

General procedure: The appropriate bromoketone (6a-o) (1.7 mmol) and triethylamine (1.6 mmol) were added to as olution of either7-hydroxy-4-methyl-2H-chromen-2-one 4 (1.4 mmol)or 7-hydroxy-4-(trifluoromethyl)-2H-chromen-2-one 5 (1.4 mmol) in THF (20 mL). The mixture was stirred at room temperature for 24h, filtered and the solvent was evaporated under reduced pressure.The solid residue was purified by column chromatography eluting with DCM/MeOH 9:1 to afford (7a-n) and (8a-o).

According to the analysis of related databases, 575-03-1, the application of this compound in the production field has become more and more popular.

Reference:
Article; Kandil, Sahar; Westwell, Andrew D.; Mcguigan, Christopher; Bioorganic and Medicinal Chemistry Letters; vol. 26; 8; (2016); p. 2000 – 2004;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Related Products of 575-03-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 575-03-1, name is 7-Hydroxy-4-(trifluoromethyl)coumarin, molecular formula is C10H5F3O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: The appropriate bromoketone (6a-o) (1.7 mmol) and triethylamine (1.6 mmol) were added to as olution of either7-hydroxy-4-methyl-2H-chromen-2-one 4 (1.4 mmol)or 7-hydroxy-4-(trifluoromethyl)-2H-chromen-2-one 5 (1.4 mmol) in THF (20 mL). The mixture was stirred at room temperature for 24h, filtered and the solvent was evaporated under reduced pressure.The solid residue was purified by column chromatography eluting with DCM/MeOH 9:1 to afford (7a-n) and (8a-o).

According to the analysis of related databases, 575-03-1, the application of this compound in the production field has become more and more popular.

Reference:
Article; Kandil, Sahar; Westwell, Andrew D.; Mcguigan, Christopher; Bioorganic and Medicinal Chemistry Letters; vol. 26; 8; (2016); p. 2000 – 2004;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Related Products of 575-03-1 ,Some common heterocyclic compound, 575-03-1, molecular formula is C10H5F3O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: The compounds 2a-e and 3a-e were synthesized according to the method from literature [26?28].To a solution of compound 1a-e (10.0 mmol) in acetone (30 mL), 1,2?dibromoethane or1,3-dibromopropane (30.0 mmol) and potassium carbonate (12.3 mmol) were added. The reactionmixture was stirred at 56¡ã C for 10 h, then poured into water, and extracted with ethyl acetate (30 mL x 3).The organic layer was dried over anhydrous Na2SO4 and concentrated under reduced pressure.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,575-03-1, its application will become more common.

Reference:
Article; Tian, Ye; Liang, Zhen; Xu, Hang; Mou, Yanhua; Guo, Chun; Molecules; vol. 21; 6; (2016);,
Alcohol – Wikipedia,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 575-03-1, name is 7-Hydroxy-4-(trifluoromethyl)coumarin. This compound has unique chemical properties. The synthetic route is as follows. Quality Control of 7-Hydroxy-4-(trifluoromethyl)coumarin

2) 4.6 g of the product of step 1), 6 g of anhydrous potassium carbonate, 50 ml of acetone and 8.4 g of 1,3-dibromopropane were heated under reflux for 4 hours, and then cooled to room temperature and filtrated. The solvent was removed by rotation to give yellowish oil, which was passed through a column to give 5.6 g of white solid. Melting point: 72-74¡ãC, yield: 80.1 percent.

With the rapid development of chemical substances, we look forward to future research findings about 575-03-1.

Reference:
Patent; Huazhong University of Science and Technology; NHWA Pharma. Corporation; ZHANG, Guisen; CHEN, Yin; XU, Xiangqing; LIU, Bifeng; LIU, Xin; ZHAO, Song; LIU, Shicheng; YU, Minquan; ZHANG, Heng; LIU, Xinghua; EP2698369; (2014); A1;,
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