Category: 57371-44-5

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 57371-44-5, name is 3-(4-(Benzyloxy)-3-methoxyphenyl)propan-1-ol. This compound has unique chemical properties. The synthetic route is as follows. Product Details of 57371-44-5

To a solution ofpyridinium chlorochromate (2.4 g, 11.03 mmol) in dichloromethane (20 mL), O-protectedalcohol 3 (3.0 g, 11.03 mmol) in dichloromethane (20 mL) was added dropwiseusing pressure equalizing additional funnel with constant stirring (magnetic spin bar).The reaction mixture was then heated at reflux. After the completion of the reaction (1 hr)as monitored by tlc for disappearance of O-protected alcohol 3 (eluent: petroleum ether60-80C and EtOAc in 6:4 ratio, Rf D 0.3), silica gel (5 g, 200-400 mesh) was added tothe mixture and dichloromethane was evaporated under vacuum to afford a crude productadsorbed on the gel. It was purified by column chromatography over silica gel (100-200 mesh) using petroleum ether (60-80C) and EtOAc mixtures (95:5 to 80:20) as eluent.The pure product (2.52 g, 85%) was obtained as a white powder, mp. 64-66C; lit.3664-65C; 1H NMR (500 MHz, CDCl3): d 9.84 (s, 1H), 7.45 (d, 2H, J D 7.5), 7.38 (t, 2H,J D 7.4), 7.31 (t, 2H, J D 7.3), 5.14 (s, 2H), 3.90 (s, 3H), 2.91 (t, 2H, J D 7.5), 2.77 (t,2H, J D 7.4); 13C NMR (125 MHz, CDCl3): d 201.4, 149.47, 146.44, 137.01, 133.31,128.20, 127.47, 126.96, 119.83, 114.17, 112.03, 70.93, 55.72, 45.12, 27.46; Mass (ESI) :[MCCNa] for C17H18O3Na, Calcd: 293.1154. Found: 293.0597.Anal. Calcd for C17H18O3: C, 75.53; H, 6.71. Found: C, 75.59; H, 6.72.

With the rapid development of chemical substances, we look forward to future research findings about 57371-44-5.

Reference:
Article; Kumar, N. Vijendra; Kumar, S. C. Santosh; Srinivas; Bettadaiah; Organic Preparations and Procedures International; vol. 47; 6; (2015); p. 443 – 448;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 57371-44-5, name is 3-(4-(Benzyloxy)-3-methoxyphenyl)propan-1-ol. A new synthetic method of this compound is introduced below., Formula: C17H20O3

General procedure: To an ice-cooled solution of 2-iodoxybenzoic acid (0.876 g, 3.129 mmol) in DMSO (1.11 mL, 15.64 mmol) was added a solution of alcohol 26a (0.59 g, 2.607 mmol) in dry CH2Cl2 (10 mL). The mixture was stirred at room temperature for 2 h and then filtered through a Celite pad and washed with ether. The combined organic filtrates were washed with water, brine, dried over anhydrous Na2SO4, and concentrated in vacuo. The residue was purified by silica gel column chromatography (EtOAc/pet-ether, 1:9) to afford the pure compound 27a (0.508 g, 87%) as a viscous liquid. The unstable aldehyde used immediately for the next reaction.

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Reference:
Article; Sabitha, Gowravaram; Srinivas, Chitti; Reddy, Teega Rammohan; Yadagiri, Kurra; Yadav, Jhillu Singh; Tetrahedron Asymmetry; vol. 22; 24; (2011); p. 2124 – 2133;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts