Category: 56239-26-0

Related Products of 56239-26-0, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 56239-26-0 as follows.

90 mg (0.59 mmol) of cis 4-amino-cyclohexanol hydrochloride were dissolved in 10 ml dimethyl acetamide and 59.3 mg (1.48 mmol) of sodium hydride (60percent) were added. After stirring 30 minutes at room temperature, a solution of 200 mg (0.49 mmol) of 7- benzylsulfanyl-6-fluoro-2-(4-methoxy-benzyl)-2H-isoquinolin-1-one (126) in 20 ml of dimethyl acetamide was added and the mixture was stirred at 80 0C for 1 h, then at 130 0C for 3 h. Another 1.2 equivalents of cis 4-amino-cyclohexanol hydrochloride and 2.5 equivalents of sodium hydride were added and the temperature was increased to 160 0C. After 8h the solution is cooled down to room temperature and the solvent is removed under reduced pressure. The residue is dissolved in dichloromethane, washed with water and dried with magnesium sulfate. After evaporation of the solvent and purification by preparative HPLC, the title compound was isolated as trifluoroacetate. R1 = 1.18 min (Method C). Detected mass: 501.6 (M+H+).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,56239-26-0, its application will become more common.

Reference:
Patent; SANOFI-AVENTIS DEUTSCHLAND GMBH; WO2007/12422; (2007); A1;,
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Related Products of 56239-26-0, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 56239-26-0, name is cis-4-Aminocyclohexanol hydrochloride. This compound has unique chemical properties. The synthetic route is as follows.

Potassium carbonate (78 g, 565 mmol) was added to ethyl 2,4-dichloropyrimidine-5- carboxylate (50.0 g, 226 mmol) and cis-4-aminocyclohexanol hydrochloride (34.3 g, 226 mmol) in acetonitrile (700 mL) at rt under air. The reaction mixture was stirred at rt for 16 h. The mixture was filtered through a Celite pad. The filtrate was concentrated under reduced pressure. The precipitate was collected by filtration, washed with MeCN (100 mL) and dried under vacuum to afford the title compound (41.0 g, 61percent) as a white solid; 1H NMR (400 MHz, DMSO) 1.32 (3H, t), 1.42 – 1.58 (2H, m), 1.60 – 1.75 (6H, m), 3.66 (1H, d), 4.06 (1H, dd), 4.33 (2H, q), 4.57 (1H, d), 8.46 (1H, d), 8.63 (1H, s); m/z MH+ 300.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 56239-26-0, cis-4-Aminocyclohexanol hydrochloride.

Reference:
Patent; ASTRAZENECA AB; CANCER RESEARCH TECHNOLOGY LIMITED; FINLAY, Maurice, Raymond, Verschoyle; GOLDBERG, Frederick, Woolf; TING, Attilla, Kuan, Tsuei; (103 pag.)WO2018/114999; (2018); A1;,
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Reference of 56239-26-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 56239-26-0, name is cis-4-Aminocyclohexanol hydrochloride, molecular formula is C6H14ClNO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To tert-butyl 3-(5-chloro-2-fluoropyridin-4-yl)phenyl((tetrahydro-2H-pyran-4- yl)methyl)carbamate (440 mg, 1.045 mmol) was added DMSO (4 ml), TEA (0.729 ml, 5.23 mmol), and (ls,4s)-4-aminocyclohexanol hydrochloride (476 mg, 3.14 mmol) . The reaction was stirred at 95-100 °C for 40 hr. The reaction was followed by LCMS. The reaction was let cool, added 250 ml of ethyl acetate, washed with saturated sodium bicarbonate, water (2x), filtered and concentrated to constant mass. The crude was purified by silica gel chromatography using 12g column eluting with 30-85percent ethyl acetate with heptane. The desired fractions were concentrated to constant mass, giving 363 mg of the titled compound as free base used without further purification. LCMS (m/z): 516.2 (MH+), rt = 0.80 min.

According to the analysis of related databases, 56239-26-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; NOVARTIS AG; ANTONIOS-MCCREA, William R.; BARSANTI, Paul A.; HU, Cheng; JIN, Xianming; MARTIN, Eric J.; PAN, Yue; PFISTER, Keith B.; SENDZIK, Martin; SUTTON, James; WAN, Lifeng; WO2012/66065; (2012); A1;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 56239-26-0, name is cis-4-Aminocyclohexanol hydrochloride. This compound has unique chemical properties. The synthetic route is as follows. 56239-26-0

EXAMPLE 86[0124] Preparation of 4-((R)-Tetrahydrofuran-3-yloxy)-5-(2,3- dihydrobenzo[b][l,4]dioxin-6-yl)-N-((ls,4S)-4-methoxycyclohexyl)pyrimidin-2-amineJ.: Preparation of Starting Material 4-Methoxycyclohexanamine HydrochlorideReagents and Conditions: a) K2CO3 H2; b) KHMDS, MeI, and THF; c) NH2NH2, EtOH, then 4M HCI H2N HCIStep 1-1: Preparation of 2-((ls,4s)-4-Hydroxycyclohexyl)isoindoline-l,3-dione (2) [0125] To a stirred solution of cis-4-aminocyclohexanol HCl (107 mg, 0.71 mmol) in H2O(1.7 mL) at room temperature was added K2CO3 (174 mg, 1.25 mmol), followed by N- carboethoxyphthalimide (174 mg, 0.79 mmol). After stirring at room temperature for 30 min, the solid was filtered, washed with H2O, and dried in vacuo to provide the title compound (140 mg, 81percent) as a white solid. 1H NMR (300 MHz, CDCl3) delta 7.82 (m, IH), 7.79 (m, IH), 4.10 (m, IH), 2.64 (m, IH), 1.5-2.0 (set of m, 4H). MS (ESI) m/z: Found: 491 (2M+ + 1), CaIc. 245(M+).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 56239-26-0, cis-4-Aminocyclohexanol hydrochloride.

Reference:
Patent; CYSTIC FIBROSIS FOUNDATION THERAPEUTICS, INC.; CHIANG, Phoebe; GHOSH, Shomir; WO2010/68863; (2010); A2;,
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Adding some certain compound to certain chemical reactions, such as: 56239-26-0, name is cis-4-Aminocyclohexanol hydrochloride, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 56239-26-0. 56239-26-0

Cis-4-Aminocyclohexanol hydrochloride (Aldrich cat740365: 8.3 mg, 0.055 mmol) was added to a solution of 5-(3-phenylpiperidin-1-yl)pyridine-2-carbaldehyde (10 mg, 0.04 mmol) in N,N-dimethylformamide, followed by acetic acid (0.11 mmol). After 5 min, sodium cyanoborohydride (6.9 mg, 0.11 mmol) was added. The reaction mixture was stirred at room temperature overnight. The crude reaction mixture was purified by prep LCMS (pH 2, acetonitrile/water+TFA) to give the desired product as its TFA salt. LC-MS calculated for C23H32N3O (M+H)+: m/z 366.3; found: 366.3.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 56239-26-0.

Reference:
Patent; Incyte Corporation; Wu, Liangxing; Qian, Ding-Quan; Lu, Liang; Lajkiewicz, Neil; Konkol, Leah C.; Li, Zhenwu; Zhang, Fenglei; Li, Jingwei; Wang, Haisheng; Xu, Meizhong; Xiao, Kaijiong; Yao, Wenqing; (101 pag.)US2018/177784; (2018); A1;,
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