Category: 55743-13-0

On March 15, 2006, Bharate, Sandip B.; Bhutani, Kamlesh K.; Khan, Shabana I.; Tekwani, Babu L.; Jacob, Melissa R.; Khan, Ikhlas A.; Singh, Inder Pal published an article.Recommanded Product: 55743-13-0 The title of the article was Biomimetic synthesis, antimicrobial, antileishmanial and antimalarial activities of euglobals and their analogues. And the article contained the following:

In the present communication, naturally occurring phloroglucinol-monoterpene adducts, euglobals G1-G4 (3b/a and 4a/b) and 16 new analogs (13a/b-18a/b and 19-22) were synthesized by biomimetic approach. These synthetic compounds differ from natural euglobals in the nature of monoterpene and acyl functionality. All of these compounds were evaluated for their antibacterial, antifungal, antileishmanial and antimalarial activities. Analog 17b possessed good antibacterial activity against methicillin-resistant Staphylococcus aureus, while analogs 19-22 possessed potent antifungal activity against Candida glabrata with IC50s ranging from 1.5 to 2.5 μg/mL. Euglobals along with all synthesized analogs exhibited antileishmanial activity. Amongst these, euglobal G2 (3a), G3 (4a) and analogs 13a and 14a showed potent antileishmanial activity with IC50s ranging from 2.8 to 3.9 μg/mL. Analog 16a possessed antimalarial activity against chloroquine sensitive D6 clone of Plasmodium falciparum. None of the compounds showed toxicity against mammalian kidney fibroblasts (vero cells) up to the concentration of 4.76 μg/mL. The experimental process involved the reaction of 2,4,6-Trihydroxy-3-methylbenzaldehyde(cas: 55743-13-0).Recommanded Product: 55743-13-0

The Article related to antimicrobial antileishmanial antimalarial euglobal analog, Microbial, Algal, and Fungal Biochemistry: Other and other aspects.Recommanded Product: 55743-13-0

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Teng, Xingxing; Wang, Yuanyuan; Gu, Jinhua; Shi, Peiqi; Shen, Zhibin; Ye, Lianbao published an article in 2018, the title of the article was Antifungal agents: design, synthesis, antifungal activity and molecular docking of phloroglucinol derivatives.Recommanded Product: 55743-13-0 And the article contains the following content:

Pseudoaspidinol is a phloroglucinol derivative with Antifungal activity and is a major active component of Dryopteris fragrans. In our previous work, we studied the total synthesis of pseudoaspidinol belonging to a phloroglucinol derivative and investigated its antifungal activity as well as its intermediates. However, the results showed these compounds have low antifungal activity. In this study, in order to increase antifungal activities of phloroglucinol derivatives, we introduced antifungal pharmacophore allylamine into the methylphloroglucinol. Meanwhile, we remained C1-C4 acyl group in C-6 position of methylphloroglucinol using pseudoaspidinol as the lead compound to obtain novel phloroglucinol derivatives, synthesized 17 compounds, and evaluated antifungal activities on Trichophyton rubrum and Trichophyton mentagrophytes in vitro. Mol. docking verified their ability to combine the protein binding site. The results indicated that most of the compounds had strong antifungal activity, in which compound 17 were found to be the most active on Trichophyton rubrum with Min. Inhibitory Concentration (MIC) of 3.05 μg/mL and of Trichophyton mentagrophytes with MIC of 5.13 μg/mL. Docking results showed that compounds had a nice combination with the protein binding site. These researches could lay the foundation for developing antifungal agents of clin. value. The experimental process involved the reaction of 2,4,6-Trihydroxy-3-methylbenzaldehyde(cas: 55743-13-0).Recommanded Product: 55743-13-0

The Article related to trichophyton phloroglucinol derivative antifungal mol docking, allylamine, antifungal activity, molecular docking, phloroglucinol derivatives, squalene epoxidase, Pharmacology: Effects Of Antimicrobials and Parasiticides and other aspects.Recommanded Product: 55743-13-0

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Joshi, B. S.; Gawad, D. H. published an article in 1974, the title of the article was Flavanones from the stem of Unona lawii. Isolation of lawinal, desmethoxymatteucinol, desmethoxymatteucinol-7-methyl ether, and a synthesis of lawinal.Name: 2,4,6-Trihydroxy-3-methylbenzaldehyde And the article contains the following content:

From the hexane extract of the stem Unona lawii three flavanones were isolated and two of these identified as demethoxymatteucinol (I) and demethoxymatteucinol 7-methyl ether (II). On the basis of spectral and synthetic evidence, a new flavanone designated as lawinal is 5,7-dihydroxy-6-formyl-8-methylflavanone (III). The three isomeric compounds C25H20O5 (M+ 400) obtained in the reaction of methylphloroglucinol and cinnamoyl chloride were characterized as IV, V and VI. The experimental process involved the reaction of 2,4,6-Trihydroxy-3-methylbenzaldehyde(cas: 55743-13-0).Name: 2,4,6-Trihydroxy-3-methylbenzaldehyde

The Article related to unona lawii flavanone, lawinal unona lawii, matteucinol demethoxy unona lawii, phloroglucinol reaction cinnamoyl chloride, Heterocyclic Compounds (One Hetero Atom): Flavones and Isoflavones and other aspects.Name: 2,4,6-Trihydroxy-3-methylbenzaldehyde

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Joshi, B. S.; Gawad, Dilip H. published an article in 1976, the title of the article was Isolation and structure of some new flavones and dibenzoylmethanes from Unona lawii Hook. f. and Thoms..Product Details of 55743-13-0 And the article contains the following content:

In addition to the flavanones reported earlier by B. S. Joshi and D. H. Gawad (1974) from the stem of Unona lawii Hook. f. & Thoms. 5 new compounds designated as unonal (I, R = H), unonal-7-methyl ether (I, R = Me), isounonal (II), 3-formyl-2,4,6-trihydroxy-5-methyldibenzoylmethane, and 3-formyl-2,6-dihydroxy-4-methoxy-5-methyldibenzoylmethane were isolated. The structures of these compounds are derived from spectral and synthetic evidences. The experimental process involved the reaction of 2,4,6-Trihydroxy-3-methylbenzaldehyde(cas: 55743-13-0).Product Details of 55743-13-0

The Article related to unona flavone dibenzoylmethane, unonal, isounonal, Heterocyclic Compounds (One Hetero Atom): Flavones and Isoflavones and other aspects.Product Details of 55743-13-0

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On December 9, 2021, Blagg, Julian; Roffey, Jon; Drysdale, Martin; Winship, Paul; Clark, David published a patent.Reference of 2,4,6-Trihydroxy-3-methylbenzaldehyde The title of the patent was Heterocyclic benzamide compounds as MLH1 and/or PMS2 proteins inhibitors and their preparation, pharmaceutical compositions and use in the treatment of cancer. And the patent contained the following:

The invention relates to heterocyclic benzamide compounds of formula I that target the MLH1 and/or PMS2 proteins that are components of the DNA Mismatch Repair (MMR) process. The invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which MLH1 and/or PMS2 activity is implicated. Compounds of formula I wherein R1 and R3 are independently H,OH, halo, C1-4 alkoxy; provided that as least one of the R1 and R3 is OH; R2 is H, F; R4 is H, halo, C1-6 alkyl, (un)substituted C3-6 cycloalkyl, (un)substituted C3-6 cycloalkyl-C1-2 alkyl, etc.; R6 is C1-6 alkyl, C3-8 cycloalkyl, C3-8 cycloalkyl-C1-2 alkyl, 4- to 7-membered cyclic ring, etc.; R10 is NR11R12; R11 and R12 are taken together with the nitrogen atom attached to form (un)substituted 5- to 7-membered heterocyclic ring fused with 5- to 6-membered monocyclic heteroaryl or with Ph to form 8- to 11-membered bicyclic heteroaryl; and their pharmaceutically acceptable salts, hydrates or solvates as MLH1 and/or PMS2 proteins inhibitors in the treatment of cancer thereof, are claimed. Example compound II was prepared by using amidation and desulfonylation as the key steps. All the invention compounds were evaluated for their MLH1 and/or PMS2 proteins inhibitory activity. The experimental process involved the reaction of 2,4,6-Trihydroxy-3-methylbenzaldehyde(cas: 55743-13-0).Reference of 2,4,6-Trihydroxy-3-methylbenzaldehyde

The Article related to heterocyclic benzamide preparation mlh1 pms2 protein inhibitor treatment cancer, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Reference of 2,4,6-Trihydroxy-3-methylbenzaldehyde

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On May 25, 2016, Chen, Congxi; Tian, Yongjian; Liang, Qiuyan; Bao, Xiaowei published a patent.COA of Formula: C8H8O4 The title of the patent was Preparation method of dracorhodin and its hydrochloride and perchlorate, intermediates. And the patent contained the following:

The title preparation method includes (1) performing Vilsmeier formylation reaction of 1,3,5-trimethoxybenzene (formula SM) and formylating agent (N,N-dimethylformamide or N-methyl-N-phenylformamide) to obtain 2,4,6-trimethoxybenzaldehyde (I); (2) performing Huangminglong reduction reaction with 50-85 wt% hydrazine hydrate and sodium hydroxide or potassium hydroxide in solvent B (ethylene glycol or glycerol monomethyl ether) to obtain 1,3,5-trimethoxy-2-methylbenzene (II); (3) performing Vilsmeier formylation reaction with the formylating agent to obtain 2,4,6-trimethoxy-3-methylbenzaldehyde (III); (4) cracking methoxy of the compound III with demethylation reagent (boron halide, aluminum halide, etc.) in solvent D (1,2-dichloroethane, dichloromethane, etc.) to obtain 2,4,6-trihydroxy-3-methylbenzaldehyde (IV); (5) performing substitution reaction with benzyl halide in solvent E (acetone, DMF, etc.) in presence of alkali E (potassium carbonate, sodium carbonate, etc.) to obtain 4,6-bis(benzyloxy)-2-hydroxy-3-methylbenzaldehyde (formula V); (6) performing substitution reaction with methylation agent (di-Me carbonate or iodomethane) in solvent F (acetone, DMF, etc.) to obtain 4,6-bis(benzyloxy)-2-methoxy-3-methylbenzaldehyde (VI); (7) performing benzyl protecting group removal reaction with hydrogen gas in solvent G (ethanol, methanol, etc.) in presence of noble metal catalyst (5-10 wt% palladium/carbon or palladium hydroxide/carbon) under protection of nitrogen gas to obtain 4,6-dihydroxy-2-methoxy-3-methylbenzaldehyde (VII); (8) performing condensation reaction with acetophenone in presence of acetic acid and hydrogen chloride to obtain dracorhodin hydrochloride (VIII); (9) dissolving in methanol, adding saturated sodium acetate solution, and crystallizing to obtain dracorhodin (X); or (10) reacting dracorhodin hydrochloride with perchloric acid to obtain dracorhodin perchlorate (IX). The preparation method has short process route, readily available raw materials, high product yield, low cost, good process reproducibility, and environment friendliness. The experimental process involved the reaction of 2,4,6-Trihydroxy-3-methylbenzaldehyde(cas: 55743-13-0).COA of Formula: C8H8O4

The Article related to dracorhodin perchlorate preparation, Heterocyclic Compounds (One Hetero Atom): Benzopyrans (Including Coumarins, Isocoumarins, Chromones, Benzopyrones, Dibenzopyrans, and Other Arenopyrans) and other aspects.COA of Formula: C8H8O4

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On July 12, 2019, Wu, Jie; Mu, Ran; Sun, Mingna; Zhao, Nan; Pan, Miaomiao; Li, Hongshuang; Dong, Yi; Sun, Zhaogang; Bai, Jie; Hu, Minwan; Nathan, Carl F.; Javid, Babak; Liu, Gang published an article.Recommanded Product: 2,4,6-Trihydroxy-3-methylbenzaldehyde The title of the article was Derivatives of Natural Product Agrimophol as Disruptors of Intrabacterial pH Homeostasis in Mycobacterium tuberculosis. And the article contained the following:

This article reports the rational medicinal chem. of a natural product, agrimophol (1), as a new disruptor of intrabacterial pH (pHIB) homeostasis in Mycobacterium tuberculosis (Mtb). Through the systematic investigation of the structure-activity relationship of 1, scaffold-hopping of the diphenylmethane scaffold, pharmacophore displacement strategies, and studies of the structure-metabolism relationship, a new derivative 5a was achieved. Compound 5a showed 100-fold increased potency in the ability to reduce pHIB to pH 6.0 and similarly improved mycobactericidal activity compared with 1 against both Mycobacterium bovis-BCG and Mtb. Compound 5a possessed improved metabolic stability in human liver microsomes and hepatocytes, lower cytotoxicity, higher selectivity index, and similar pKa value to natural 1. This study introduces a novel scaffold to an old drug, resulting in improved mycobactericidal activity through decreasing pHIB, and may contribute to the critical search for new agents to overcome drug resistance and persistence in the treatment of tuberculosis. The experimental process involved the reaction of 2,4,6-Trihydroxy-3-methylbenzaldehyde(cas: 55743-13-0).Recommanded Product: 2,4,6-Trihydroxy-3-methylbenzaldehyde

The Article related to agrimophol derivative antitubercular disruption ph homeostasis mycobacterium tuberculosis, agrimophol, coumarin, diphenylmethane scaffold, intrabacterial ph homeostasis, pharmacophores and other aspects.Recommanded Product: 2,4,6-Trihydroxy-3-methylbenzaldehyde

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On August 21, 2015, Dong, Yi; Du, Nana; Li, Xueyuan; Zheng, Litao; Liu, Gang published an article.Category: alcohols-buliding-blocks The title of the article was Tandem Chloropalladation/Cyclization and Dearomative Cyclization toward Functionalized Tricyclic Bridged [3.2.1] Skeleton Compounds. And the article contained the following:

In the presence of PdCl2(MeCN)2 and CuCl2, o-alkenylphenylalkynyl carbonyl compounds such as allyloxyphenylpropynamide I underwent aerobic chemoselective dearomative cyclization reactions to yield fused tricyclic dienones such as II (R = MeO, BuO, EtO, PhCH2O, Me). The structure of II (R = PhCH2O) was determined by X-ray crystallog. The experimental process involved the reaction of 2,4,6-Trihydroxy-3-methylbenzaldehyde(cas: 55743-13-0).Category: alcohols-buliding-blocks

The Article related to fused tricyclic dienone chemoselective preparation, palladium copper catalyst aerobic dearomative cyclization alkenylphenylalkynyl carbonyl compound, tandem aerobic chloropalladation dearomative cyclization alkenylphenylalkynyl carbonyl compound, oxatricyclododecanecarboxamide mol crystal structure and other aspects.Category: alcohols-buliding-blocks

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Sib, Anna; Gulder, Tobias A. M. published an article in 2018, the title of the article was Chemo-enzymatic Total Synthesis of Oxosorbicillinol, Sorrentanone, Rezishanones B and C, Sorbicatechol A, Bisvertinolone, and (+)-Epoxysorbicillinol.Product Details of 55743-13-0 And the article contains the following content:

The sorbicillinoids are a large family of fungal natural products, many of which possess highly challenging mol. architectures. Depending on their individual structures they exhibit strong biol. activities ranging from radical scavenging and anti-infective properties to cytotoxicity. Despite the resulting strong biomedical potential of these natural products and the interest of synthetic chemists owing to their fascinating structures, many sorbicillinoids are currently not synthetically accessible, thus hampering in-depth biol. characterization and structural diversification. By using recombinant oxidoreductase SorbC and readily accessible sorbicillin-type synthetic precursors, we have developed enantioselective, one-pot chemo-enzymic routes to a broad range of sorbicillinoids, thereby establishing total syntheses of oxosorbicillinol, sorrentanone, rezishanones B and C, sorbicatechol A, bisvertinolone, and (+)-epoxysorbicillinol. The experimental process involved the reaction of 2,4,6-Trihydroxy-3-methylbenzaldehyde(cas: 55743-13-0).Product Details of 55743-13-0

The Article related to sorbicillinoid chemoenzymic preparation, oxosorbicillinol chemoenzymic synthesis, sorrentanone chemoenzymic synthesis, rezishanone chemoenzymic synthesis, sorbicatechol a chemoenzymic synthesis, bisvertinolone chemoenzymic synthesis, epoxysorbicillinol chemoenzymic synthesis, biocatalysis, enzyme catalysis, natural products, sorbicillinoids, total synthesis and other aspects.Product Details of 55743-13-0

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