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03/9/2021 News Application of 55414-72-7

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 55414-72-7, (2-Amino-5-methoxyphenyl)methanol.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 55414-72-7, name is (2-Amino-5-methoxyphenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows. COA of Formula: C8H11NO2

General procedure: The product S1 was dissolved in CHCl3. Then pyridine (1.2 equiv) and 4-toluenesulfonyl chloride (1.2 equiv) were added to the solution. The mixture was stirred at room temperature for 2 hours. After the reaction was completed, the reaction mixture was quenched with saturated ammonium chloride, and the mixture was extracted with ethyl acetate and dried over Na2SO4. After removal off the solvent, the crude product S2 was used directly without further purification.

Reference:
Article; Sun, Bing-Bing; Hu, Qing-Xian; Hu, Jia-Ming; Yu, Jie-Qiang; Jia, Jun; Wang, Xing-Wang; Tetrahedron Letters; vol. 60; 30; (2019); p. 1967 – 1970;,
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Brief introduction of (2-Amino-5-methoxyphenyl)methanol

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 55414-72-7, (2-Amino-5-methoxyphenyl)methanol, other downstream synthetic routes, hurry up and to see.

Reference of 55414-72-7, Adding some certain compound to certain chemical reactions, such as: 55414-72-7, name is (2-Amino-5-methoxyphenyl)methanol,molecular formula is C8H11NO2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 55414-72-7.

The product of preparation 3 (300mg, 2.0mmol) in tetrahydrofuran (3mL) was added dropwise to a suspension of sodium hydride (60% dispersion in mineral oil, 54mg, 2.3mmol) in tetrahydrofuran (2mL). The mixture was stirred for 45 minutes and the temperature was maintained at -10C. The product of preparation 5 (357mg, 1.3mmol) in tetrahydrofuran (3mL) was added dropwise and the mixture was stirred for a further hour. The temperature was then allowed to increase to 25C and the reaction was quenched with sodium hydrogen carbonate solution (5mL), and diluted with ethyl acetate (20mL) and water (10mL). The organic phase was separated, washed with brine (10mL), dried over magnesium sulfate and concentrated in vacuo to give an oily residue. Purification of the oil by column chromatography on silica gel, eluting with dichloromethane: methanol, 100: 0 to 97: 3, afforded the title compound in 59% yield, 300mg. MS APCI+ m/z 390,392 [MH]+

Reference:
Patent; PFIZER LIMITED; PFIZER INC.; WO2005/121152; (2005); A1;,
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Sources of common compounds: 55414-72-7

The synthetic route of 55414-72-7 has been constantly updated, and we look forward to future research findings.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 55414-72-7, name is (2-Amino-5-methoxyphenyl)methanol, the common compound, a new synthetic route is introduced below. Formula: C8H11NO2

Compound 4 (216 mg, 1.41 mmol) and MnO2 (900 mg,10.4 mmol) were dissolved in dry THF (20 mL). The reaction mixture was stirred under nitrogen atmosphere at room temperature for 4 h. After that time another portion of MnO2 (900 mg,10.35 mmol) was added, followed by a third portion of MnO2 (900 mg, 10.35 mmol) after the same time interval. The reaction mixture was stirred under N2 atmosphere at room temperature for a total of 24 h. The mixture was filtered through a layer of celiteand washed with small amount of THF. The filtrate was evaporated under reduced pressure to produce the title compound as a brown oil (225 mg, 99%); 1H NMR (400 MHz, CDCl3) d 9.85 (d, J = 0.3 Hz,CHO), 7.01 (dd, J = 8.8, 2.9 Hz, ArH4), 6.96 (d, J = 2.9 Hz, ArH6),6.63 (d, J = 8.8 Hz, ArH3), 5.83 (s, 2H, NH2), 3.79 (s, 3H, OCH3),13C{1H} NMR (101 MHz, CDCl3) d 193.7, 150.9, 144.9, 124.8,118.6, 117.9, 116.9, 56.0. This compound is unstable at room temperature and must be kept in a vial filled with nitrogen gas at 20C; for this reason it was not fully characterised.

The synthetic route of 55414-72-7 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Lizarme, Yuvixza; Wangsahardja, Jonatan; Marcolin, Gabriella M.; Morris, Jonathan C.; Jones, Nicole M.; Hunter, Luke; Bioorganic and Medicinal Chemistry; vol. 24; 7; (2016); p. 1480 – 1487;,
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The origin of a common compound about 55414-72-7

With the rapid development of chemical substances, we look forward to future research findings about 55414-72-7.

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 55414-72-7, name is (2-Amino-5-methoxyphenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 55414-72-7

A mixture of compound 6 (0.081 g, 0.35 mmol) and thionyl chloride (1.12 mL, 15.4 mmol) was stirred at reflux for 5 h. The excess thionyl chloride was removed and the residue was cooled to 0 C. Aqueous saturated sodium bicarbonate solution (10 mL) and a solution of compound 4 (0.046 g, 0.30 mmol) in methanol (2 mL) were added slowly with rapid stirring. The mixture was stirred at room temperature overnight and the resultant pink-orange solid was collected and washed with aqueous HCl (1 M, 5 mL), water (5 mL), diethyl ether (5 mL) and hexane (5 mL). The solid was dried to obtain the title compound as a sticky orange powder (0.063 g, 58%); 1H NMR (300 MHz, CDCl3): delta 3.81 (s, 3H), 3.82 (s, 3H), 4.71 (s, 2H), 6.82-6.93 (m, 3H), 7.17 (d, J = 3.1 Hz, 1H), 7.49 (d, J = 8.8 Hz, 1H), 7.91 (d, J = 8.8 Hz, 1H), 8.57 (br s, 1H); this material was carried forward to the next step without further purification.

With the rapid development of chemical substances, we look forward to future research findings about 55414-72-7.

New learning discoveries about 55414-72-7

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,55414-72-7, its application will become more common.

Adding a certain compound to certain chemical reactions, such as: 55414-72-7, (2-Amino-5-methoxyphenyl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 55414-72-7, blongs to alcohols-buliding-blocks compound. Recommanded Product: 55414-72-7

In a 50 mL round bottom flask, 2 mmol of 2-amino-5-methoxybenzyl alcohol (Formula (1-3)), 2 mmol of benzaldehyde (Formula (2-1)), 0.2 mmol of ABNO, 0.6 was added. The KOH of mmol and the toluene of 4mL replace the air in the bottle with oxygen, seal the bottle mouth with a rubber stopper and insert an oxygen balloon.The reaction flask was placed in a pre-heated oil bath and heated to 80C for 5 hours.The solvent was distilled off under reduced pressure and then subjected to column chromatography. The mixture of ethyl acetate/petroleum ether having a volume ratio of 1:50 was used as an eluent to collect the eluent containing the target compound, and the solvent was distilled off to obtain the product 6- Methoxy-2-phenyl-4H-3,1-benzoxazine with isolated yield of 94%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,55414-72-7, its application will become more common.

Reference:
Patent; Zhejiang University of Technology; Shen Zhenlu; Li Meichao; Ma Jiaqi; Hu Xinquan; Hu Baoxiang; (13 pag.)CN106831632; (2017); A;,
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Analyzing the synthesis route of (2-Amino-5-methoxyphenyl)methanol

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 55414-72-7, (2-Amino-5-methoxyphenyl)methanol.

Related Products of 55414-72-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 55414-72-7, name is (2-Amino-5-methoxyphenyl)methanol, molecular formula is C8H11NO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A solution of compound 8 (240 mg, 1.22 mmol) and EDC·HCl (277 mg, 1.44 mmol) in DMF (2 mL) was stirred at room temperature for 5 min, then cooled to 0 C. To this solution was added successively 1-hydroxybenzotriazole (195 mg, 1.44 mmol), a solution of compound 4 (207 mg, 1.35 mmol) in DMF (2 mL), and triethylamine (0.25 mL, 1.80 mmol). The mixture was warmed to room temperature and stirred under N2 atmosphere for 6 h. The solvent was removed under reduced pressure and the crude product was partitioned between aqueous HCl (10 mL, 1 N) and ethyl acetate (20 mL). The aqueous layer was extracted with ethyl acetate (4 * 20 mL). The organic layers were combined and washed with water (10 * 20 mL), then dried with MgSO4 and concentrated onto silica under reduced pressure. The residue was subjected to flash chromatography eluting with 1:9?3:7 ethyl acetate/dichloromethane, to afford the title compound as a pale yellow solid (238 mg, 59%); mp 168-170 C; IR (neat) numax (cm-1): 3375, 3257, 3067, 3021, 2946, 2840, 2656, 2321, 2085, 2008, 1926, 1790, 1647, 1578, 1538, 1505; 1H NMR (400 MHz, CD3CN) delta 8.64 (s, 1H, NH), 8.14 (d, J = 9.1 Hz, ArH3), 7.66 (d, J = 8.7 Hz, ArH6′), 7.20 (d, J = 2.8 Hz, ArH6), 7.15 (dd, J = 9.1, 2.8 Hz, ArH4), 6.98 (d, J = 3.0 Hz, ArH3′), 6.92 (dd, J = 8.7, 3.0 Hz, ArH5′), 4.63 (s, 2H, CH2), 3.94 (s, 3H, OCH3), 3.77 (s, 3H, OCH3), 3.45 (s, 1H, OH); 13C{1H} NMR (101 MHz, CD3CN) delta 165.8 (C=O), 164.9 (C5), 158.6 (C4′), 140.2 (C1), 137.1 (C1′), 136.6 (C2), 129.1 (C2′), 128.2 (C3), 126.7 (C6′), 115.9 (C4), 115.1 (C6), 114.4 (C3′), 113.7 (C5′), 62.5 (CH2), 57.2 (OCH3), 56.1 (OCH3); HRMS (ESI,+ve) C16H16N2O6Na+ [MNa+] requires m/z 355.0901, found 355.0894.

The origin of a common compound about (2-Amino-5-methoxyphenyl)methanol

Application of 55414-72-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 55414-72-7, name is (2-Amino-5-methoxyphenyl)methanol, molecular formula is C8H11NO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Compound 21 (120 mg, 0.72 mmol) and EDC.HCl (165 mg, 0.86 mmol) were dissolved in DMF(2 mL) and stirred for 5 minutes. To this mixture at 0 C was added a solution of 1-hydroxybenzotriazole (116 mg, 0.86 mmol) and compound 4 (132 mg, 0.86 mmol) in DMF (1mL),followed by DIPEA (0.18 mL, 1.08 mmol). The reaction mixture was stirred under N2 atmosphere atroom temperature for 24 h. The solvent was evaporated under reduced pressure. The crude product was dissolved in HCl (5 mL, 1N) and ethyl acetate (10 mL). After partitioning of the two layers, the aqueous layer was extracted with ethyl acetate (4 x 15 mL). All organic layers were combined and washed with water (10 x 20 mL). Finally the organic layer was dried with MgSO4 and evaporated onto silica. The crude product was purified by column chromatography, eluting with 1:4 ethylacetate/dichloromethane, to produce the title compound as a moist white solid (118 mg, 55%) and 23 asa yellow solid (50 mg, 27%). Data for 22: m.p. 144-146 C; IR (neat) vmax (cm-1) 3232, 3071, 2918,2864, 2712, 2450, 2284, 2111, 2069, 1647, 1580, 1521; 1H NMR (400 MHz, CDCl3) delta 8.56 (s, 1H,NH), 8.11 (d, J = 8.1 Hz, ArH3), 7.97 (d, J = 8.7 Hz, ArH6), 7.68 (m, 3H, ArH4, ArH6, ArH5), 6.93(d, J = 8.7 Hz, ArH5), 6.81 (s, 1H, ArH3), 4.74 (s, 2H, CH2), 3.82 (s, 3H, OCH3) 3.96 (s, H, OH);13C{1H} NMR (101 MHz, CDCl3) delta 164.9 (C=O), 157.2 (C4), 146.8 (C2), 134.0 (C4), 133.2 (C1),132.7 (C1), 130.9 (C6), 129.5 (C2), 128.9 (C5), 125.3 (C6), 124.9 (C3), 113.8 (C5), 64.5 (CH2), 55.7(OCH3); HRMS (ESI, +ve) C15H14N2O5Na+ [MNa+] requires m/z 325.0795, found 325.0772. Data for 23: m.p. 135-137 C; IR (neat) vmax (cm-1) 3235, 3069, 2646, 2321, 2103, 1920, 1729, 1655,1523; 1H NMR (400 MHz, CDCl3) delta 8.30 (s, 1H, NH), 8.14 (d, J = 8.2 Hz, ArH), 7.84-7.81 (m, 2H,ArH), 7.75-7.61 (m, 6H, ArH), 7.03-6.98 (m, 2H, ArH), 5.36 (s, 2H, CH2), 3.83 (s, 3H, OCH3);13C{1H} NMR (101 MHz, CDCl3) delta 166.0, 165.7, 157.9, 148.0, 146.5, 134.1, 133.3, 133.0, 132.3, 130.8, 130.3, 129.1, 129.0, 128.8, 127.5, 127.0, 124.8, 124.0, 116.8, 115.9, 65.7, 55.7; HRMS (ESI,+ve) C22H17N3O8Na+ [MNa+] requires m/z 474.0928, found 474.0882.

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Potassium tert-butoxide (49.3 mg, 0.439 mmol) was dissolved in technical-grade THF(1.7 mL, containing ~0.2% H2O), and the solution was stirred at room temperature in air for 1 min.A solution of amide 6 (51.2 mg, 0.245 mmol) and 2-amino-5-methoxybenzyl alcohol (43.3 mg,0.283 mmol) in THF (0.8 mL) was added, and the mixture was stirred at room temperature in air for3 h. Water (20 mL) was added, and the mixture was extracted with ethyl acetate (20 mL). Theorganic layer was washed with 1M aqueous HCl solution (3 ¡Á 20 mL). The organic layer was driedover MgSO4, filtered, and concentrated in vacuo. The crude product was purified by flashchromatography using 1:2 ethyl acetate / dichloromethane as eluent to give the title compound as awhite solid (13 mg, 17%).

Reference:
Article; Wangsahardja, Jonatan; Marcolin, Gabriella M.; Lizarme, Yuvixza; Morris, Jonathan C.; Hunter, Luke; Synlett; vol. 27; 8; (2016); p. 1237 – 1240;,
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