Category: 55357-38-5

Reference of 55357-38-5, Adding some certain compound to certain chemical reactions, such as: 55357-38-5, name is 2-Hydroxy-N,N,N-trimethylethanaminium 4-methylbenzenesulfonate,molecular formula is C12H21NO4S, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 55357-38-5.

P1-(cytidin-5′-yl)-P2-(trimethylammoniumethyl)-methylenebis(phosphonate) is an analog of cytidyl diphosphocholine (citicholine), an important intermediate in lipid metabolism and a drug under development for treatment for ischemic stroke. The analog may be prepared by the reaction of the appropriate BTA with a p-toluenosulfonate salt of choline. Thus, a mixture of the BTA prepared from N4-acetylcytidin-5′-ylphosphonomethylenephosphonic acid (1 mmol in 10 ml of dry pyridine) and p-toluenosulfonate salt of choline (412 mg, 1.5 mmol) is kept at 55C for 4 hours. The mixture is processed as described in Example 3. P1-(N4-acetyl-2′,3′-O-isopropylidenecytidin-5′-yl)-P2-(trimethylammoniumethyl)-methylenebisphosphonate is obtained, and deprotected with Dowex 50WX8/H+ to give the desired compound.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 55357-38-5, 2-Hydroxy-N,N,N-trimethylethanaminium 4-methylbenzenesulfonate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Pharmasset, Ltd.; EP1469003; (2004); A2;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Electric Literature of 55357-38-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 55357-38-5, name is 2-Hydroxy-N,N,N-trimethylethanaminium 4-methylbenzenesulfonate, molecular formula is C12H21NO4S, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

EXAMPLE 1 A solution of 48.7 g of cholest-5-en-3beta-yl 2-hydroxyethylcarbonate and 10 ml of quinoline in 500 ml of methylene chloride is added dropwise at room temperature to a solution of 12.5 ml of phosphorus oxychloride. The solution is treated at room temperature while stirring with 60 ml of pyridine and 77 g of choline tosylate in 500 ml of methylene chloride, whereupon the reaction mixture is stirred at room temperature overnight. The mixture is treated with 125 ml of water and 34 g of sodium bicarbonate and then with 3000 ml of acetone. The precipitated product is filtered off under suction, dissolved in 1000 ml of chloroform-methanol 1:1 and stirred with 500 g of ion exchanger (Amberlite MB-3). The latter is filtered off under suction and the solution is evaporated. The resulting residue is recrystallized in a mixture of methylene chloride-methanol 1:1 and dioxan. There are obtained 39 g of O-[[2-[[(cholest-5-en-3beta-yloxy)carbonyl]oxy]ethoxy]hydroxyphosphinyl]choline hydroxide internal salt of melting point 224 C., MS: 640 (M+H)+.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 55357-38-5, 2-Hydroxy-N,N,N-trimethylethanaminium 4-methylbenzenesulfonate.

Reference:
Patent; Hoffmann-La Roche Inc.; US5215972; (1993); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 55357-38-5, name is 2-Hydroxy-N,N,N-trimethylethanaminium 4-methylbenzenesulfonate. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 2-Hydroxy-N,N,N-trimethylethanaminium 4-methylbenzenesulfonate

Fig. 2. Synthesis of the novel phospholipid analogs 1-O-DPPC and 1-O-DPPG’ with the phosphate in the C-2 position from (S)-O-benzyl glycidol. (a) C16H33OH,NaH, DMF/THF (71%); (b) i. POCl3, Et3N, DCM, ii. Pyridine, Choline tosylate EPO (65%); (c) H2, Pd/C, MeOH (99%); (d) C15H31COOH, DMAP, Et3N, DCM (83%); (e) (1-Pr)2NP(OMe)Cl, TMP, DCM; (f) i. (R)-isopropylidene glycerol, Phenyl- IH- tetrazole, DCM, ii. t-BuOOH (67% over 2 steps); (g) H2, Pd/C, MeOH (99%); (h) Palmitic acid, DMAP, DCC, DCM (92%); (i) i. CH3CN, isopropanol, Me3N, DCM, ii. HCl, MeOH, DCM, H2O, iii. NaHCO3, DCM (70%).; The unnatural PC and PG phospholipids (1-O-DPPC, 1-O-DPPG’) with the phos- phocholine and phosphoglycerol head groups linked to the C-2 position of the glyc¬ erol moiety were synthesized utilizing (S)-O-benzyl glycidol as a versatile starting material [27,28] as shown in Fig. 2. Opening of the epoxide 1 under basic condi¬ tions, using THF/DMF (1:1) as a solvent system that minimizes dimerization gave 2 in 71% yield after purification by column chromatography. The phosphorylation was performed using phosphorous oxychloride in CH2Cl2 [27], which gave 3 in 65% yield. Debenzylation under H2 atmosphere with Pd/C as catalyst followed by a sim¬ ple acylation using palmitoyl chloride gave the target 1-O-DPPC lipid. The synthe¬ sis of 1-O-DPPG’ was carried out from 2 using (1-Pr)2NPClOMe [31] as the phos- phorylation reagent. The phosphorylation using TMP as base in the lipid coupling followed by (R)-isopropylidene glycerol with 5-phenyl-lH-tetrazole as a weak pro¬ ton donor gave the protected phospholipid 4 in 67% yield after oxidation. Debenzy¬ lation followed by acylation using DCC gave 5 in 92% yield. Deprotection of lipid 5 was carried out with Me3N to remove the methyl protection group, followed by stir- ring in CH2Cl2/MeOH/0.5M HCl (65:25:4) resulting in removal of the isopro- pylidene group. Finally, the proton on the phosphate was exchanged with sodium us- EPO ing NaHCO3, which gave the desired 1-O-DPPG’ in 70% yield after purification by column chromatography. AEL-43 and AEL-44 were obtained by simple deprotec- tion. Debenzylation of 3 under H2 with Pd/C as catalyst gave AEL-43 in quantitative yield. Deprotection of 4 was carried out using Me3N, CH2Cl2/MeOH/0.5M HCl (65:25:4) as described above followed by debenzylation using H2-PdZC which gave AEL-44 in 71% yield.

With the rapid development of chemical substances, we look forward to future research findings about 55357-38-5.

Reference:
Patent; LIPLASOME PHARMA A/S; WO2006/48017; (2006); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 55357-38-5, 2-Hydroxy-N,N,N-trimethylethanaminium 4-methylbenzenesulfonate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Formula: C12H21NO4S, blongs to alcohols-buliding-blocks compound. Formula: C12H21NO4S

(R) -1,2-glyceryl distearate-glycerol-3-phosphatidic acid (0.2 g, 0.28 mmol)Was added to 60 mL of dry pyridine,It was heated at 50 0.5h,Then, choline p-toluenesulfonate (0.84 g, 3 mmol)And trichloroacetonitrile 5mL,The reaction was continued at 50 36h,Concentration under reduced pressure crude,Flash column chromatography (developing solvent CHCl3-CH3OH-H2O, 15: 5: 1) gave a white gel, 0.13 g, 59% yield.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,55357-38-5, 2-Hydroxy-N,N,N-trimethylethanaminium 4-methylbenzenesulfonate, and friends who are interested can also refer to it.

Reference:
Patent; Ji, Min; Cai, Jin; Gu, Ning; Li, Rui; (7 pag.)CN103408588; (2016); B;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Electric Literature of 55357-38-5 ,Some common heterocyclic compound, 55357-38-5, molecular formula is C12H21NO4S, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a solution comprising compound la prepared starting from 7.4 gr. of compound 2a a solution of 12.7 gr. of choline tosylate in dry acetonitrile was added. A solution of 5.9 ml. of triethylamine in 4 ml. DCM was added thereto. The reaction mixture was stirred overnight. The reaction mixture was then concentrated, 250 ml. of hexane was added and evaporated to dryness. The residue was redissolved in 390 ml. of THF and precipitated choline tosylate was filtered. Concentrated HCl (1. 7ml) was added and the reaction mixture was stirred for 1 hour. The reaction mixture was dried over magnesium sulfate, filtered, and the pH was basified with triethylamine. The precipitation was filtered, the filtrate was evaporated to dryness and then redissolved in a solvent mixture consisting of chloroform, methanol and water (8: 4: 3). The lower phase was separated and washed 4 times with the same upper phase and evaporated. The crude product was dissolved in 45 ml. of 1M tetrabutylammonium fluoride in THF and the reaction mixture was stirred at 45C for 2 hours. The resulting solution was evaporated and the crude product was purified by silicagel chromatographic column. (Eluent: gradual mounting concentration of methanol in chloroform). The relevant fractions were evaporated and the resulting product was then co-evaporated with acetonitrile. 1.49 of pure product was obtained (23% yield). 1H NMR 300 MHz (8 ppm, CD30D) : 0.92 (t, 3H), 1.31 (bm, 20H), 1.44 (m, 2H), 2.10 (q, 2H), 2.92 (m, 1H), 3. 33 (m, 1H), 3.67 (m, 2H), 3.92 (m, 1H), 4.04 (m, 2H), 4.30 (m, 2H), 5.55 (dd, 1H), 5. 78 (dt, 1H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,55357-38-5, its application will become more common.

Reference:
Patent; BIOLAB LTD.; WO2005/68480; (2005); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 55357-38-5, name is 2-Hydroxy-N,N,N-trimethylethanaminium 4-methylbenzenesulfonate. A new synthetic method of this compound is introduced below., SDS of cas: 55357-38-5

40 mg of {2-[(4′-Hexyl-biphenyl-4-carbonyl)-amino]-benzyl}-phosphonic acid (compound of preparation example 3) are dissolved in 10 ml of pyridine and 111 mg of dry choline p- toluolsulfonate salt and 2 ml trichloroacetonitrile are added. The mixture obtained is stirred at 500C for 76 hours. From the mixture obtained solvent is evaporated and the evaporation residue is subjected to RP-18 chromatography (0,1% TFA-water/methanol gradient). [2-({2- [(4′-Hexyl-biphenyl-4-carbonyl)-amino]-be?zyl}-hydroxy-phosphinoyloxy)-ethyl]-trimethyl- ammonium, inner salt is obtained.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 55357-38-5, 2-Hydroxy-N,N,N-trimethylethanaminium 4-methylbenzenesulfonate.

Reference:
Patent; NOVARTIS AG; WO2008/22771; (2008); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 55357-38-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.55357-38-5, name is 2-Hydroxy-N,N,N-trimethylethanaminium 4-methylbenzenesulfonate, molecular formula is C12H21NO4S, molecular weight is 275.3644, as common compound, the synthetic route is as follows.

EXAMPLE 9 A solution of 2.22 g of (E)-stigmasta-5,22-dien-3beta-yl (2-hydroxyethyl)carbonate and 1.1 ml of pyridine in 10 ml of chloroform is added dropwise to a solution, cooled to 0 C., of 0.75 g of phosphorus oxychloride in 3 ml of chloroform. The mixture is reacted at room temperature for 1 hour. Then, 1.6 g of choline tosylate in 15 ml of pyridine are added. The mixture is stirred overnight, then a solution of 2 g of potassium bicarbonate is added. The mixture is evaporated to dryness and the residue is taken up in 100 ml of THF/methanol/chloroform (1/1/1). The solids are filtered off. The solution remaining behind is percolated over an ion exchanger (Amberlite MB-3). After chromatography on silica gel with chloroform/methanol/water (60/35/5 vol) and crystallization from methylene chloride/acetone there are obtained 1.6 g of O-[hydroxy-[2-[[[(E)-stigmasta-5,22-dien-3beta-yloxy]carbonyl]oxy]ethoxy]phosphinyl]choline hydroxide internal salt, MS: 666 (M+H+).

The chemical industry reduces the impact on the environment during synthesis 55357-38-5, I believe this compound will play a more active role in future production and life.

Reference:
Patent; Hoffmann-La Roche Inc.; US5215972; (1993); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts