Category: 55218-73-0

Category: alcohols-buliding-blocksOn November 20, 2020 ,《Photochemical C-H Silylation and Hydroxymethylation of Pyridines and Related Structures: Synthetic Scope and Mechanismsã€?appeared in ACS Catalysis. The author of the article were Rammal, Fatima; Gao, Di; Boujnah, Sondes; Hussein, Aqeel A.; Lalevee, Jacques; Gaumont, Annie-Claude; Morlet-Savary, Fabrice; Lakhdar, Sami. The article conveys some information:

Described herein is an efficient approach for C-H silylation and hydroxymethylation of pyridines and related heterocycles by the combination of silanes or methanol with readily available N-methoxypyridinium ions with a low catalyst loading (2 mol %) under blue light irradiation The synthetic importance of the developed reactions is demonstrated by the synthesis of biol. relevant compounds ESR spectroscopy, quantum yield measurements, and d.-functional theory calculations allowed to understand reaction mechanisms of both photocatalytic reactions. In the experiment, the researchers used many compounds, for example, (4-Phenylpyridin-2-yl)methanol(cas: 55218-73-0Category: alcohols-buliding-blocks)

(4-Phenylpyridin-2-yl)methanol(cas: 55218-73-0) belongs to hydroxy-containing compounds. Hydroxy-containing compounds engage in intermolecular hydrogen bonding increasing the electrostatic attraction between molecules and thus to higher boiling and melting points than found for compounds that lack this functional group.Category: alcohols-buliding-blocks Organic compounds, which are often poorly soluble in water, become water-soluble when they contain two or more hydroxy groups, as illustrated by sugars and amino acid.

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Sohar, Pal; Lazar, Janos; Bernath, Gabor published an article on February 28 ,1985. The article was titled 《Saturated heterocycles. 67. Isolation and structure elucidation of the by-product formed in the aminomethylation of α-methylstyreneã€? and you may find the article in Chemische Berichte.Product Details of 55218-73-0 The information in the text is summarized as follows:

Aminomethylation of α-methylstyrene gave pyridine derivative I (R = H) along with a significant amount of its hydroxymethyl derivative (I; R = CH2OH) (II). The structure of II was determined spectrally by conversion to its aromatic, acyl, and N-Me derivative In the part of experimental materials, we found many familiar compounds, such as (4-Phenylpyridin-2-yl)methanol(cas: 55218-73-0Product Details of 55218-73-0)

(4-Phenylpyridin-2-yl)methanol(cas: 55218-73-0) belongs to hydroxy-containing compounds. Hydroxy groups participate in the dehydration reactions that link simple biological molecules into long chains.Product Details of 55218-73-0 The joining of a fatty acid to glycerol to form a triacylglycerol removes the −OH from the carboxy end of the fatty acid.

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Deng, Lisheng; Diao, Jiasheng; Chen, Pinhong; Pujari, Venugopal; Yao, Yuan; Cheng, Gang; Crick, Dean C.; Prasad, B. V. Venkataram; Song, Yongcheng published an article in Journal of Medicinal Chemistry. The title of the article was 《Inhibition of 1-Deoxy-d-Xylulose-5-Phosphate Reductoisomerase by Lipophilic Phosphonates: SAR, QSAR, and Crystallographic Studies》.Application In Synthesis of (4-Phenylpyridin-2-yl)methanol The author mentioned the following in the article:

1-Deoxy-D-xylulose-5-phosphate reductoisomerase (DXR) is a novel target for developing new antibacterial (including antituberculosis) and antimalaria drugs. Forty-one lipophilic phosphonates, representing a new class of DXR inhibitors, were synthesized, among which 5-phenylpyridin-2-ylmethylphosphonic acid possesses the most activity against E. coli DXR (EcDXR) with a Ki of 420 nM. Structure-activity relationships (SAR) are discussed, which can be rationalized using our EcDXR:inhibitor structures, and a predictive quant. SAR (QSAR) model is also developed. Since inhibition studies of DXR from Mycobacterium tuberculosis (MtDXR) have not been performed well, 48 EcDXR inhibitors with a broad chem. diversity were found, however, to generally exhibit considerably reduced activity against MtDXR. The crystal structure of a MtDXR:inhibitor complex reveals the flexible loop containing the residues 198-208 has no strong interactions with the 3,4-dichlorophenyl group of the inhibitor, representing a structural basis for the reduced activity. Overall, these results provide implications in the future design and development of potent DXR inhibitors. The results came from multiple reactions, including the reaction of (4-Phenylpyridin-2-yl)methanol(cas: 55218-73-0Application In Synthesis of (4-Phenylpyridin-2-yl)methanol)

(4-Phenylpyridin-2-yl)methanol(cas: 55218-73-0) belongs to hydroxy-containing compounds. Hydroxy-containing compounds engage in intermolecular hydrogen bonding increasing the electrostatic attraction between molecules and thus to higher boiling and melting points than found for compounds that lack this functional group. Organic compounds, which are often poorly soluble in water, become water-soluble when they contain two or more hydroxy groups, as illustrated by sugars and amino acid.Application In Synthesis of (4-Phenylpyridin-2-yl)methanol

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The author of 《2-[(Phenylthio)methyl]pyridine derivatives: new antiinflammatory agents》 were Haviv, Fortuna; DeNet, Robert W.; Michaels, Raymond J.; Ratajczyk, James D.; Carter, George W.; Young, Patrick R.. And the article was published in Journal of Medicinal Chemistry in 1983. Application of 55218-73-0 The author mentioned the following in the article:

The title compounds I (R = H, Br, Cl, F, Me, NH2, OMe, etc., R1 = H, Cl, OH, Me, OMe, Ph, etc.) and related compounds as the HCl salts, prepared mostly by the reaction of 2-picolyl chloride [4377-33-7] or 2-(hydroxymethyl)pyridine  [586-98-1] with the appropriate mercaptol either in 48% HBr under reflux or in the presence of NaOEt in EtOH at room temperature, were investigated as inflammation inhibitors in rat. I (R = H, Br, Cl, F, or NO2 and R1 = H) were effective inhibitors of immune complex induced inflammation as represented by the rat reverse passive Arthus reaction. 2-[[(4-bromophenyl)thio]methyl]pyridine (I; R = Br, R1 = H) [83782-10-9] also inhibited both exudate formation and cellular accumulation in the more conventional carrageenin pleural test, whereas indomethacin inhibited only exudate volume in this model. Structure-activity relations are discussed. The results came from multiple reactions, including the reaction of (4-Phenylpyridin-2-yl)methanol(cas: 55218-73-0Application of 55218-73-0)

(4-Phenylpyridin-2-yl)methanol(cas: 55218-73-0) belongs to hydroxy-containing compounds. Hydroxy groups participate in the dehydration reactions that link simple biological molecules into long chains. The creation of a peptide bond to link two amino acids to make a protein removes the −OH from the carboxy group of one amino acid.Application of 55218-73-0

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The author of 《Potential antitumor agents. 12. 2-Formyl-4-aminophenylpyridine thiosemicarbazones》 were Agrawal, Krishna C.; Booth, Barbara A.; DeNuzzo, Suzanne M.; Sartorelli, Alan C.. And the article was published in Journal of Medicinal Chemistry in 1975. Application In Synthesis of (4-Phenylpyridin-2-yl)methanol The author mentioned the following in the article:

Title compounds 4-(o-aminophenyl)- [55218-89-8], 4-(p-aminophenyl)- [55218-90-1], and 4-(m-aminophenyl)-2-formylpyridine thiosemicarbazone (I) [52583-84-3] were prepared from 4-phenylpyridine [939-23-1] by methylation with MeLi, nitration, separation of isomers as HCl or HNO3 salts, N-oxidation, rearrangement with Ac2O, hydrolysis, and oxidation of the resulting carbinol of the nitro group and reaction with thiosemicarbazide. Of the title compounds, only I was active, increasing the life span of mice bearing Sarcoma 180 ascites cells by ∼20 days. 2-Formyl-4-phenylpyridine thiosemicarbazone [55218-79-6] was only marginally active in the mouse sarcoma test. Structure-activity relations are discussed. In addition to this study using (4-Phenylpyridin-2-yl)methanol, there are many other studies that have used (4-Phenylpyridin-2-yl)methanol(cas: 55218-73-0Application In Synthesis of (4-Phenylpyridin-2-yl)methanol) was used in this study.

(4-Phenylpyridin-2-yl)methanol(cas: 55218-73-0) belongs to hydroxy-containing compounds. Hydroxy groups participate in the dehydration reactions that link simple biological molecules into long chains. The creation of a peptide bond to link two amino acids to make a protein removes the −OH from the carboxy group of one amino acid.Application In Synthesis of (4-Phenylpyridin-2-yl)methanol

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Alcohol – Wikipedia,
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