Category: 5505-63-5

Soares da Costa, Diana; Sousa, Joao C.; Da Mesquita, Sandro; Petkova-Yankova, Nevena I.; Marques, Fernanda; Reis, Rui L.; Sousa, Nuno; Pashkuleva, Iva published the artcile< Bioorthogonal labeling reveals different expression of glycans in mouse hippocampal neuron cultures during their development>, Related Products of 5505-63-5, the main research area is glycan hippocampus neuron cell maturation glucose metabolism; glycosylation, biorthogonal chemistry, neuronal development, imaging..

The expression of different glycans at the cell surface dictates cell interactions with their environment and other cells, being crucial for the cell fate. The development of the central nervous system is associated with tremendous changes in the cell glycome that is tightly regulated. Herein, we have employed bioorthogonal Cu-free click chem. to image temporal distribution of different glycans in live mouse hippocampal neurons during their maturation in vitro. We show development-dependent glycan patterns with increased fucose and decreased mannose expression at the end of the maturation process. We also demonstrate that this approach is biocompatible and does not affect glycan transport although it relies on an administration of modified glycans. The applicability of this strategy to tissue sections unlocks new opportunities to study the glycan dynamics under more complex physiol. conditions.

Molecules published new progress about Carbohydrate transporters Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 5505-63-5 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H14ClNO5, Related Products of 5505-63-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Weldu, Welday Desta; Wang, Cheng-Chung published the artcile< Selective Acetylation of Non-anomeric Groups of per-O-Trimethylsilylated Sugars>, Application In Synthesis of 5505-63-5, the main research area is TMSOTf catalyzed protecting group aminoglycoside preparation regioselective acetylation.

Selective modification of the hydroxyl groups of sugars has been a long-standing challenge due to their proximate relative reactivity. Herein, we report a TMSOTf-catalyzed selective acetylation of the non-anomeric hydroxyl groups of several per-O-TMS-protected sugar substrates while leaving their anomeric group unaffected. In addition to standing versatile by itself, the anomeric O-TMS group left intact can be functionalized to afford key sugar precursors such as imidate donors, which could otherwise be synthesized via a stepwise anomeric deprotection-functionalization procedure.

Journal of Organic Chemistry published new progress about Acetylation catalysts. 5505-63-5 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H14ClNO5, Application In Synthesis of 5505-63-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Schafer, Rebecca J. B.; Monaco, Mattia R.; Li, Mao; Tirla, Alina; Rivera-Fuentes, Pablo; Wennemers, Helma published the artcile< The Bioorthogonal Isonitrile-Chlorooxime Ligation>, Product Details of C6H14ClNO5, the main research area is bioorthogonal isonitrile chlorooxime ligation.

Bioorthogonal reactions are valuable tools for the selective labeling and imaging of natural products and proteins. Here, we present the reaction between isonitriles and chlorooximes as a ligation that proceeds quickly (k ≈ 1 M-1 s-1) and with high chemoselectivity in an aqueous environment. Imaging of metabolically labeled cell surface glycans underlined the tolerance of the ligation to common functional groups in cellular systems. Live-cell dual-labeling experiments revealed that the isonitrile-chlorooxime ligation is orthogonal to the strain-promoted azide-alkyne cycloaddition

Journal of the American Chemical Society published new progress about Azide-alkyne 1,3-dipolar cycloaddition reaction (strain-promoted (SPAAC)). 5505-63-5 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H14ClNO5, Product Details of C6H14ClNO5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Soares da Costa, Diana; Sousa, Joao C.; Da Mesquita, Sandro; Petkova-Yankova, Nevena I.; Marques, Fernanda; Reis, Rui L.; Sousa, Nuno; Pashkuleva, Iva published the artcile< Bioorthogonal labeling reveals different expression of glycans in mouse hippocampal neuron cultures during their development>, Related Products of 5505-63-5, the main research area is glycan hippocampus neuron cell maturation glucose metabolism; glycosylation, biorthogonal chemistry, neuronal development, imaging..

The expression of different glycans at the cell surface dictates cell interactions with their environment and other cells, being crucial for the cell fate. The development of the central nervous system is associated with tremendous changes in the cell glycome that is tightly regulated. Herein, we have employed bioorthogonal Cu-free click chem. to image temporal distribution of different glycans in live mouse hippocampal neurons during their maturation in vitro. We show development-dependent glycan patterns with increased fucose and decreased mannose expression at the end of the maturation process. We also demonstrate that this approach is biocompatible and does not affect glycan transport although it relies on an administration of modified glycans. The applicability of this strategy to tissue sections unlocks new opportunities to study the glycan dynamics under more complex physiol. conditions.

Molecules published new progress about Carbohydrate transporters Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 5505-63-5 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H14ClNO5, Related Products of 5505-63-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts