Category: 53463-68-6

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 53463-68-6, name is 10-Bromodecanol, molecular formula is C10H21BrO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. HPLC of Formula: C10H21BrO

To 2.00 g of 10-bromo-1-decanol in 15 mL of chloroform (CHCl3) was added dropwise 16.9 mmol of 3,4-dihydro-2H-pyran (DHP) and catalytic amounts of p-toluenesulphonic acid (pTSA). The reaction mixture was stirred for 24 h at room temperature. The organic layer was washed with water (2 .x. 20 mL), NaHCO3 (2 .x. 20 mL), CHCl3 (1 .x. 20 mL), and dried over MgSO4, filtered, and evaporated in vacuo. The crude product was purified using silica gel column chromatography eluting with hexane/ether (9:1). The pure product 2 (Banaszak et al., 2009) was obtained as a colorless oil 2.35 g (7.32 mmol) for a 100percent yield.

With the rapid development of chemical substances, we look forward to future research findings about 53463-68-6.

Reference:
Article; Carballeira, Ne?stor M.; Montano, Nashbly; Cintro?n, Gabriel A.; Ma?rquez, Carmary; Rubio, Celia Ferna?ndez; Prada, Christopher Ferna?ndez; Balan?a-Fouce, Rafael; Chemistry and Physics of Lipids; vol. 164; 2; (2011); p. 113 – 117;,
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Reference of 53463-68-6, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.53463-68-6, name is 10-Bromodecanol, molecular formula is C10H21BrO, molecular weight is 237.18, as common compound, the synthetic route is as follows.

10-Bromodecanol (50 g, 210 mmol) was oxidized using pyridiniumchlorochromate (90.5 g, 420 mmol) in CH2Cl2 (800 mL) at room temperature for 3 h. The organic layerwas filtered, and the residual was washed with petroleum. Removal of the solvent from the combinedorganic layers in vacuo gave a dark oil. The dark-colored residue was chromatographed over SiO2,and elution with hexane/EtOAc (30:1, v/v) gave crude 10-bromodecanal. Triethyl orthoformate (44.5g, 300 mmol) and p-sulphonic acid monohydrate (0.57 g, 3 mmol)were added to a stirred and ice-cooled solution of the crude 10-bromodecanal in anhydrous ethanol(300 mL). After the exothermic reaction had subsided, the mixture was left at 0 C overnight. Water wasthen added, and the mixture was made basic by adding K2CO3 solution. The mixture was extractedwith diethyl ether, and then washed with brine and dried over MgSO4. The solvent was removedunder reduced pressure and the product was chromatographed on silica (hexane/EtOAc (25:1, v/v)),which gave crude 1,l-diethoxy-10-bromodecanal.This product was converted into the title iodide by being stirred for 4 h with sodium iodide(90 g, 600 mmol) in dry acetone (500 mL) under reflux. The solvent was removed under reducedpressure, the mixture was diluted with water (200 mL), and the product was extracted withpetroleum. The extracts were washed with water, 1% Na2S2O3 solution, and brine; dried overNa2SO4; and concentrated under reduced pressure. The resulting residue was chromatographed overSiO2. Elution with hexane/EtOAc (25:1, v/v) was conducted to yield 1,l-diethoxy-10-iododecan (5) as anoil (58.8 g, 78% yield based on 10-bromodecanol); 1H-NMR (500 MHz, CDCl3) delta 1.21 (6H, t, J = 7.0 Hz),1.29 (12 H, m), 1.60 (2 H, m), 1.82 (2H, m), 3.19 (2H, t, J = 7.0 Hz), 3.49 (2H, m), 3.64 (2H, m), 4.48 (1H, t,J = 6.0 Hz); 13C-NMR (125 MHz, CDCl3) delta 102.9, 60.8, 60.8, 33.6, 33.5, 30.5, 29.4, 29.4, 29.3, 28.5, 24.7,13.4, 15.4, 7.3.

Statistics shows that 53463-68-6 is playing an increasingly important role. we look forward to future research findings about 10-Bromodecanol.

Reference:
Article; Liu, Fu; Kong, Xiangbo; Zhang, Sufang; Zhang, Zhen; Molecules; vol. 24; 9; (2019);,
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Synthetic Route of 53463-68-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 53463-68-6, name is 10-Bromodecanol. This compound has unique chemical properties. The synthetic route is as follows.

(10-Bromo-decyloxy)-t-butyl-dimethyl-silane. To a stirred solution of 10-bromo- decanol (2.44 g, 10.3 mmol) in NMP (13 mL) at 0 C, TBSCI (1.66 g, 11.0 mmol) was added followed by imidazole (0,716 g, 10,5 mmol) portion wise (3 x 0,200 g & 1 x 0,116 g) in 15 min intervals. After the last portion of imidazole had been added, the reaction was stirred for an additional 2 h at 0 C and then it was poured into water (100 mL). The product was extracted into pentane (100 mL), the’organic phase-was concentrated/7 ? vacuo (20 mbar, 50 C) and the crude liquid was purified by filtration through a short silica gel column, using 1: 9 MTBE : petroleum benzene as eluent. The product was obtained as a colorless liquid (3.12 g, 8. 88 mmol, 86% yield based on 10-bromo-decan-1-ol). Reaction conditions were not optimized.

According to the analysis of related databases, 53463-68-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; DSM IP Assets B.V.; WO2005/47223; (2005); A1;,
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Reference of 53463-68-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 53463-68-6, name is 10-Bromodecanol, molecular formula is C10H21BrO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

10-Bromodecan-1-ol (0.24 g, 1.0 mmol) in dry THF (1mL) was mixed with 3,4-dihydro-2H-pyran (0.11 g, 1.25 mmol) and iodine (0,05 g, 0.2 mmol). The mixture was added to a 50 mL conical flask, and a small funnel was placed over it to reduce possible evaporation of solvent. The flask was irradiated in microwave oven at 600 MW power for 3min. On cooling, the reaction mixture was diluted with chloroform (30 mL) and washed with 10percent aq. sodium thiosulphate solution (2 x 5 mL), water (2 x 5 mL), brine and dried. Evaporation of the solvent under reduced pressure and purification by silica gel column chromatography (1:9 ethyl acetate: n-hexane) furnished 10-bromo-1-tetrahydropyranyloxydecane (0.30 g, 94percent) as a colourless oil.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 53463-68-6, 10-Bromodecanol.

Reference:
Article; Kaur, Jasamrit; Kaur, Irvinder; Jindal, Gitanjali; Manhas, Priya; Gupta, Neeru; Singh, Jasvinder; Journal of Chemical Research; vol. 39; 4; (2015); p. 230 – 232;,
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Reference of 53463-68-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 53463-68-6, name is 10-Bromodecanol, molecular formula is C10H21BrO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

10-Bromodecan-1-ol (0.24 g, 1.0 mmol) in dry THF (1mL) was mixed with 3,4-dihydro-2H-pyran (0.11 g, 1.25 mmol) and iodine (0,05 g, 0.2 mmol). The mixture was added to a 50 mL conical flask, and a small funnel was placed over it to reduce possible evaporation of solvent. The flask was irradiated in microwave oven at 600 MW power for 3min. On cooling, the reaction mixture was diluted with chloroform (30 mL) and washed with 10percent aq. sodium thiosulphate solution (2 x 5 mL), water (2 x 5 mL), brine and dried. Evaporation of the solvent under reduced pressure and purification by silica gel column chromatography (1:9 ethyl acetate: n-hexane) furnished 10-bromo-1-tetrahydropyranyloxydecane (0.30 g, 94percent) as a colourless oil.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 53463-68-6, 10-Bromodecanol.

Reference:
Article; Kaur, Jasamrit; Kaur, Irvinder; Jindal, Gitanjali; Manhas, Priya; Gupta, Neeru; Singh, Jasvinder; Journal of Chemical Research; vol. 39; 4; (2015); p. 230 – 232;,
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Adding a certain compound to certain chemical reactions, such as: 53463-68-6, 10-Bromodecanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 53463-68-6, blongs to alcohols-buliding-blocks compound. COA of Formula: C10H21BrO

DHP (6 mL, 65.82 mmol) and PPTS (127 mg, 0.50 mmol) were added to a solution of bromo-alcohol (12 g, 50.63 mmol) in 100 mL of CH2Cl2 and the mixture was stirred for 16 h. The reaction mixture was quenched with 2 M Na2CO3 solution and extracted with CH2Cl2. The organic layer was dried over Na2SO4, concentrated under reduced pressure. Purification by flash column (6percent EtOAc/hexanes) yielded 16 (14.9 g, 92percent) as a colorless oil. Rf=0.65 (10percent EtOAc/hexanes); 1H NMR (500 MHz, CDCl3): delta 4.54 (dd, J=3.9, 2.9 Hz, 1H), 3.83 (ddd, J=11.7, 8.7, 2.9 Hz, 1H), 3.69 (dt, J=9.7, 6.8 Hz, 1H), 3.47 (m, 1H), 3.36 (m, 3H), 1.81 (m, 3H), 1.67 (m, 1H), 1.53 (m, 6H), 1.39 (m, 2H), 1.28 (m, 10H); 13C NMR (75 MHz, CDCl3): delta 98.7, 67.5, 62.2, 33.9, 32.7, 30.6, 29.6, 29.3, 29.2, 28.6, 28.0, 26.1, 25.4, 19.5; IR (neat): numax 2924, 2855, 1454, 1354, 1126, 1072, 1028 cm?1; HRMS (ESI): calcd for C15H29O2NaBr [M+Na]+ 343.1248; found 343.1251.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,53463-68-6, its application will become more common.

Reference:
Article; Kadam, Vilas D.; Sudhakar, Gangarajula; Tetrahedron; vol. 71; 7; (2015); p. 1058 – 1067;,
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