Category: 5344-90-1

Liu, Jiawei; Wang, Chuan published the artcile< Zinc-Catalyzed Hydroxyl-Directed Regioselective Ring Opening of Aziridines in SN2 Reaction Pathway>, Name: (2-Aminophenyl)methanol, the main research area is zinc catalyzed regioselective ring opening aziridinyl alc amine thiophenol.

In this protocol, a zinc-catalyzed catalytic regioselective ring opening of electronically and sterically unbiased 2,3-aziridinyl alcs. has been accomplished. The directing effect of the hydroxyl moiety enables the selective nucleophilic attack to the C-3 position of 2,3-aziridinyl alcs. with various aromatic amines and thiophenols as nucleophiles. This operationally simple reaction provides convenient access to a variety of amino alcs. and hydroxyl sulfides in excellent regiocontrol. Moreover, simple derivatization of the ring opening product establishes a general strategy to approach internal vicinal diamines in regioselective and diastereomerically pure form.

ACS Catalysis published new progress about Alcohols Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (aziridine). 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Name: (2-Aminophenyl)methanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Balaji, Sundarraman; Balamurugan, Gunasekaran; Ramesh, Rengan; Semeril, David published the artcile< Palladium(II) N^O Chelating Complexes Catalyzed One-Pot Approach for Synthesis of Quinazolin-4(3H)-ones via Acceptorless Dehydrogenative Coupling of Benzyl Alcohols and 2-Aminobenzamide>, HPLC of Formula: 5344-90-1, the main research area is palladium benzoylhydrazone chelating complex preparation catalyst dehydrogenative coupling aminobenzamide; crystal structure palladium benzoylhydrazone chelating palladacycle complex; mol structure palladium benzoylhydrazone chelating palladacycle complex; quinazolinone preparation; benzyl alc dehydrogenative coupling reaction aminobenzamide palladium benzoylhydrazone catalyst.

A convenient protocol for the 1-pot synthesis of quinazolin-4(3H)-ones using Pd(II) complexes via dehydrogenative coupling of readily available benzyl alcs. and 2-aminobenzamide was described. New structurally related Pd(II) N^O chelating complexes of general configuration [Pd(L)Cl(PPh3)] (L = dimethylamino benzoylhydrazone ligands) were designed and synthesized. The formation of the complexes was recognized by anal. and spectral methods (FTIR, NMR, HR-MS). The presence of a square-planar geometry around the Pd(II) ion was confirmed by single crystal x-ray diffraction study. A wide range of substituted quinazolinones were successfully achieved from a diverse range of benzyl alcs. in good to excellent yields using 1.0 mol % of catalyst loading under aerobic conditions. Also, control experiments reveal that the dehydrogenative coupling reaction involves initially the formation of an aldehyde intermediate and subsequent formation of a cyclic aminal intermediate.

Organometallics published new progress about Aralkyl alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, HPLC of Formula: 5344-90-1.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Li, Bai; Mei, Huihui; Chang, Yongxin; Xu, Kuoxi; Yang, Li published the artcile< A novel near-infrared turn-on fluorescent probe for the detection of Fe3+ and Al3+ and its applications in living cells imaging>, Quality Control of 5344-90-1, the main research area is fluorescent probe detection iron aluminum cell imaging; Cells imaging; Fe(3+) and Al(3+); Fluorescent detection.

A new hemicyanidine-based colorimetric-fluorescent probe L (I) has been synthesized and characterized by x-ray single crystal diffraction, NMR, HRMS and other technologies. The probe L serves as a “”turn-on”” probe for the detection of Fe3+ and Al3+ ions in DMF-HEPES system with a high sensitivity and an excellent selectivity. The probe L manifesting the color of the solution containing L turns red on the addition of Fe3+, and turns pink on the addition of Al3+. The fluorescence turn-on detection of Fe3+ and Al3+ ions is attributed to the photo-induced electron transfer (PET) process and the exertion of the chelation-enhanced fluorescence effect (CHEF) mechanism. The results of thin layer silica gel plate coloration experiments also present the same characteristics. Addnl., further the probe L exhibit good cell permeability and could be employed to monitor Fe3+ and Al3+ ions in the living cells.

Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy published new progress about Colorimetry. 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Quality Control of 5344-90-1.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Li, Bai; Mei, Huihui; Chang, Yongxin; Xu, Kuoxi; Yang, Li published the artcile< A novel near-infrared turn-on fluorescent probe for the detection of Fe3+ and Al3+ and its applications in living cells imaging>, Quality Control of 5344-90-1, the main research area is fluorescent probe detection iron aluminum cell imaging; Cells imaging; Fe(3+) and Al(3+); Fluorescent detection.

A new hemicyanidine-based colorimetric-fluorescent probe L (I) has been synthesized and characterized by x-ray single crystal diffraction, NMR, HRMS and other technologies. The probe L serves as a “”turn-on”” probe for the detection of Fe3+ and Al3+ ions in DMF-HEPES system with a high sensitivity and an excellent selectivity. The probe L manifesting the color of the solution containing L turns red on the addition of Fe3+, and turns pink on the addition of Al3+. The fluorescence turn-on detection of Fe3+ and Al3+ ions is attributed to the photo-induced electron transfer (PET) process and the exertion of the chelation-enhanced fluorescence effect (CHEF) mechanism. The results of thin layer silica gel plate coloration experiments also present the same characteristics. Addnl., further the probe L exhibit good cell permeability and could be employed to monitor Fe3+ and Al3+ ions in the living cells.

Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy published new progress about Colorimetry. 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Quality Control of 5344-90-1.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Das, Kalicharan; Mondal, Avijit; Pal, Debjyoti; Srimani, Dipankar published the artcile< Sustainable Synthesis of Quinazoline and 2-Aminoquinoline via Dehydrogenative Coupling of 2-Aminobenzyl Alcohol and Nitrile Catalyzed by Phosphine-Free Manganese Pincer Complex>, Recommanded Product: (2-Aminophenyl)methanol, the main research area is sustainable synthesis quinazoline aminoquinoline dehydrogenative annulation; phosphine free manganese pincer complex catalyzed dehydrogenative coupling; dehydrogenative coupling aminobenzyl alc nitrile one pot reaction.

A sustainable synthesis of quinazoline and 2-aminoquinoline via acceptorless dehydrogenative annulation is presented. The reaction is catalyzed by earth-abundant well-defined manganese complexes bearing NNS ligands. Furthermore, a one-pot synthetic strategy for the synthesis of 2-alkylaminoquinolines through sequential dehydrogenative annulation and N-alkylation reaction has also been demonstrated.

Organic Letters published new progress about Aminoquinolines Role: SPN (Synthetic Preparation), PREP (Preparation). 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Recommanded Product: (2-Aminophenyl)methanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Gholinejad, Mohammad; Rasouli, Zahra; Najera, Carmen; Sansano, Jose M. published the artcile< Palladium Nanoparticles on a Creatine-Modified Bentonite Support: An Efficient and Sustainable Catalyst for Nitroarene Reduction>, COA of Formula: C7H9NO, the main research area is creatine modified bentonite support palladium nanoparticle preparation thermal stability; nitroarene palladium catalyst chemoselective reduction green chem; aryl amine preparation; Amino acids; clays; heterogeneous catalysis; nitro reduction; palladium.

Creatine as the nitrogen-rich, green and cheap compound is used for modification of natural bentonite and the resulting material is employed for the stabilization of palladium nanoparticles having an average diameter of 3 nm. This new material bento-crt@Pd was characterized using different techniques such as X-ray diffraction (XRD), Fourier-transform IR spectroscopy (FTIR), solid state UV-vis, SEM (SEM), transmission electron microscopy (TEM), XPS, thermogravimetric anal. (TGA) and energy-dispersive X-ray spectroscopy (EDX). This green catalyst promoted efficient reduction of aromatic nitro compounds in aqueous media. By using this catalyst nitroarenes having electron donating as well as electron withdrawing groups were reduced efficiently to their corresponding amines at room temperature The catalyst can be recycled seven times and the reused catalyst was characterized by TEM and XPS.

ChemPlusChem published new progress about Aromatic amines Role: SPN (Synthetic Preparation), PREP (Preparation). 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, COA of Formula: C7H9NO.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Arcadi, Antonio; Calcaterra, Andrea; Fabrizi, Giancarlo; Fochetti, Andrea; Goggiamani, Antonella; Iazzetti, Antonia; Marrone, Federico; Mazzoccanti, Giulia; Serraiocco, Andrea published the artcile< One-pot synthesis of dihydroquinolones by sequential reactions of o-aminobenzyl alcohol derivatives with Meldrum's acids>, Synthetic Route of 5344-90-1, the main research area is quinolinone dihydro preparation; aminobenzyl alc heterocyclization Meldrum acid.

The functionalized 3,4-dihydroquinolin-2-ones I (R1 = Me, 4-MeOC6H4CH2, 4-BrC6H4CH2, 4-MeSC6H4CH2, 2-furylmethyl; R2 = H, Cl; R3 = H, Me, MeO; R4 = H, CF3) have been assembled in good to high yields through the sequential reaction of readily available N-Ts-o-aminobenzyl alcs. II with 5-R1-substituted Meldrum’s acids under mild basic conditions. Highly diastereoselective synthesis of trans-3-R1-4-phenyl-1-tosyl-3,4-dihydroquinolin-2(1H)-ones was accomplished from 2-(tosylamino)-α-phenylbenzenemethanol under the same reaction conditions. Regarding the reaction mechanism, the formation of dihydroquinolones proceeds through the in situ generation of aza-o-QMs followed by conjugate addition of enolate/cyclization/elimination of acetone and CO2.

Organic & Biomolecular Chemistry published new progress about Amino alcohols Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Synthetic Route of 5344-90-1.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Donthireddy, S. N. R.; Pandey, Vipin K.; Rit, Arnab published the artcile< [(PPh3)2NiCl2]-Catalyzed C-N Bond Formation Reaction via Borrowing Hydrogen Strategy: Access to Diverse Secondary Amines and Quinolines>, Category: alcohols-buliding-blocks, the main research area is aryl amine methanol nickel catalyst alkylation reaction; arylmethylamine preparation; aminobenzyl alc ethanone nickel catalyst dehydrogenation heterocyclization; quinoline preparation.

Com. available [(PPh3)2NiCl2] was found to be an efficient catalyst for the mono-N-alkylation of (hetero)aromatic amines, employing alcs. to deliver diverse secondary amines, including the drug intermediates chloropyramine and mepyramine in excellent yields (up to 97%) via the borrowing hydrogen strategy. This method shows a superior activity (TON up to 10000) with a broad substrate scope at a low catalyst loading of 1 mol % and a short reaction time. Further, this strategy was also successful in accessing various quinoline derivatives following the acceptorless dehydrogenation pathway.

Journal of Organic Chemistry published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kaur, Mandeep; U Din Reshi, Noor; Patra, Kamaless; Bhattacherya, Arindom; Kunnikuruvan, Sooraj; Bera, Jitendra K. published the artcile< A Proton-Responsive Pyridyl(benzamide)-Functionalized NHC Ligand on Ir Complex for Alkylation of Ketones and Secondary Alcohols>, Electric Literature of 5344-90-1, the main research area is pyridylbenzamidecarbene iridium complex preparation catalyst alkylation ketone alc; crystal structure pyridylbenzamidecarbene iridium complex; mol structure pyridylbenzamidecarbene iridium complex; Borrowing-Hydrogen; Homogeneous Catalysis; Hydrogen transfer; Metal-Ligand Cooperation; Proton-Responsive Ligand; Reaction Mechanism.

A Cp*Ir(III) complex (1) of a newly designed ligand L1 featuring a proton-responsive pyridyl(benzamide) appended on N-heterocyclic carbene (NHC) was synthesized. The mol. structure of 1 reveals a dearomatized form of the ligand. The protonation of 1 with HBF4 in THF gives the corresponding aromatized complex [Cp*Ir(L1H)Cl]BF4 (2). Both compounds were characterized spectroscopically and by x-ray crystallog. The protonation of 1 with acid was examined by 1H NMR and UV-visible spectra. The proton-responsive character of 1 is exploited for catalyzing α-alkylation of ketones and β-alkylation of secondary alcs. using primary alcs. as alkylating agents through H-borrowing methodol. Compound 1 is an effective catalyst for these reactions and exhibits a superior activity in comparison to a structurally similar Ir complex [Cp*Ir(L2)Cl]PF6 (3) lacking a proton-responsive pendant amide moiety. The catalytic alkylation was characterized by a wide substrate scope, low catalyst and base loadings, and a short reaction time. The catalytic efficacy of 1 is also demonstrated for the syntheses of quinoline and lactone derivatives via acceptorless dehydrogenation, and selective alkylation of two steroids, pregnenolone and testosterone. Detailed mechanistic studies and DFT calculations substantiate the role of the proton-responsive ligand in the H-borrowing process.

Chemistry – A European Journal published new progress about Alkylating agents (pyridyl(benzamide) Ir complexes). 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Electric Literature of 5344-90-1.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Nguyen, Thao T.; Nguyen, Khang X.; Pham, Phuc H.; Ly, Duc; Nguyen, Duyen K.; Nguyen, Khoa D.; Nguyen, Tung T.; Phan, Nam T. S. published the artcile< Copper-catalyzed synthesis of pyrido-fused quinazolinones from 2-aminoarylmethanols and isoquinolines or tetrahydroisoquinolines>, Computed Properties of 5344-90-1, the main research area is aminoarylmethanol isoquinoline copper catalyst amination annulation cascade reacation; isoquinolino quinazolinone preparation; tetrahydroisoquinoline aminoarylmethanol copper catalyst amination annulation cascade reacation; dihydroisoquinolino quinazolinone preparation.

Pyrido-fused quinazolinones were synthesized via copper-catalyzed cascade C(sp2)-H amination and annulation of 2-aminoarylmethanols with isoquinolines or pyridines. The transformation proceeded readily in the presence of a com. available CuCl2 catalyst with mol. oxygen as a green oxidant. Moreover, the dehydrogenative cross-coupling of 2-aminoarylmethanols with tetrahydroisoquinolines were explored, in which CuBr exhibited higher catalytic activity than CuCl2. Broad substrate scope with good tolerance of functionalities were observed under the optimized reaction conditions. The bioactive naturally occurring alkaloid rutaecarpine was obtained by this strategy. The remarkable feature of this protocol was that complicated heterocyclic structures were readily achieved in a single synthetic step from easily accessible reactants and catalysts. The pathway to pyrido-fused quinazolinones would be complementary to existing protocols.

Organic & Biomolecular Chemistry published new progress about Amination. 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Computed Properties of 5344-90-1.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts