Category: 5344-90-1

Tan, Zhenda; Ci, Chenggang; Yang, Jian; Wu, Yang; Cao, Liang; Jiang, Huanfeng; Zhang, Min published the artcile< Catalytic Conversion of N-Heteroaromatics to Functionalized Arylamines by Merging Hydrogen Transfer and Selective Coupling>, HPLC of Formula: 5344-90-1, the main research area is azaarene alkyl bromide amino arylmethanol ruthenium hydrogen transfer coupling; alkylaminoaryl methylazaarene preparation chemoselective.

A ruthenium-catalyzed deconstruction of N-heteroaromatics to functionalized arylamines with 2-aminoaryl methanols via hydrogen transfer and selective coupling was reported. The reaction was achieved via sequential functionalization of the β and α-sites of the initially formed N-heteroarenium salts followed by a C-N cleavage, proceeding with the striking features of broad substrate scope, excellent functional groups tolerance, high chemoselectivity and atom-efficiency, and applicable for streamline synthesis of some biomedical mols. The strategy utilized will pave the avenues for further development of catalytic transformations of inert organo-systems to functional frameworks.

ACS Catalysis published new progress about Amino alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, HPLC of Formula: 5344-90-1.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 5344-90-1 ,Some common heterocyclic compound, 5344-90-1, molecular formula is C7H9NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

A. 2-Amino-5-bromobenzyl alcohol (1a): A solution of 12.316 g (0.1 mol) of 2-aminobenzyl alcohol in 300 mL of dry ether was treated at about 0° C. with 40.97 g (0.1 mol) of 2,4,4,6-tetrabromocyclohexa-2,5-dienone added in portions with vigorous stirring. Stirring was continued for about 1 hour at about 0° C., then the mixture was extracted twice with dilute HCl. The combined acid extracts were washed with ether and the ether was discarded. The acid solution was made alkaline with NaOH and extracted with fresh ether. The ether extracts were washed with water, brine, dried (Na2 SO4) and concentrated to afford 17.86 g (88percent) of 1a, mp 107-110° C. 1 H NMR (CDCl3): d=7.22-7.17 (m, 2 H); 6.57 (d, 1 H); 4.61 (s, 2 H). (MS (El): m/z=201, 203 (M+, Br isotopes).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,5344-90-1, its application will become more common.

Reference:
Patent; Pfizer Inc.; US5843972; (1998); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts