Category: 5344-90-1

Mondal, Rajarshi; Herbert, David E. published the artcile< Synthesis of Pyridines, Quinolines, and Pyrimidines via Acceptorless Dehydrogenative Coupling Catalyzed by a Simple Bidentate P^N Ligand Supported Ru Complex>, Related Products of 5344-90-1, the main research area is ruthenium catalyst dehydrogenative coupling multicomponent alc mol structure mechanism; pyridine quinoline pyrimidine preparation aldehyde adduct.

A ruthenium hydrido chloride complex supported by a simple, heteroleptic bidentate PN̂ ligand (I) containing a diarylphosphine and a benzannulated phenanthridine donor arm is reported. In the presence of base, the complex catalyzes multicomponent reactions using alc. precursors to produce structurally diverse mols. including pyridines, quinolines and pyrimidines via acceptorless dehydrogenative coupling pathways. Notably, I does not bear readily (de)protonated Bronsted acidic or basic groups common to transition metal catalysts capable of these sorts of transformations, suggesting metal-ligand cooperativity does not play a significant role in the catalytic reactivity of the complex. A rare example of an η2-aldehyde adduct of ruthenium was isolated and structurally characterized, and its role in acceptorless dehydrogenative coupling reactions is discussed.

Organometallics published new progress about Amino alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Related Products of 5344-90-1.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Azizi, Kobra; Akrami, Sedigheh; Madsen, Robert published the artcile< Manganese(III) Porphyrin-Catalyzed Dehydrogenation of Alcohols to form Imines, Tertiary Amines and Quinolines>, Application of C7H9NO, the main research area is manganese porphyrin chloride catalyst dehydrogenative coupling alcs amine; imine synthesis; tertiary amine synthesis; quinoline synthesis; alcohols; dehydrogenation; homogeneous catalysis; manganese; synthetic methods.

Manganese(III) porphyrin chloride complexes have been developed for the first time as catalysts for the acceptorless dehydrogenative coupling of alcs. and amines. The reaction has been applied to the direct synthesis of imines, tertiary amines and quinolines where only hydrogen gas and/or water are formed as the byproduct(s). The mechanism is believed to involve the formation of a manganese(III) alkoxide complex which degrades into the aldehyde and a manganese(III) hydride species. The latter reacts with the alc. to form hydrogen gas and thereby regenerates the alkoxide complex.

Chemistry – A European Journal published new progress about Aliphatic alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Application of C7H9NO.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Singh, Vivek Kumar; Donthireddy, S. N. R.; Pandey, Vipin K.; Rit, Arnab published the artcile< RuII-Complexes of heteroditopic chelating NHC ligands: effective catalysts for the β-alkylation of secondary alcohols and the synthesis of 2-alkylaminoquinoline derivatives following the dehydrogenative protocol>, Application In Synthesis of 5344-90-1, the main research area is ruthenium NHC imidazolylidene triazolylidene cymene complex preparation coupling catalyst; coupling primary secondary alc preparation aralkyl alc ruthenium catalyst; quinoline amine preparation cyclization amino alc nitrile ruthenium catalyst.

RuII-Complexes of chelating heteroditopic N-heterocyclic carbene ligands I·BF4 (1a-c; R = 2,4,6-Me3, 4-OMe, 4-CF3) featuring imidazol-2-ylidene (ImNHC) and 1,2,3-triazol-5-ylidene (tzNHC) donors connected via a CH2 spacer, were found to be very effective catalysts for the cross-coupling of secondary alcs. ArCH(OH)Me and primary alcs. RCH2OH with the elimination of H2O, yielding aralkyl alcs. ArCH(OH)CH2CH2R (Ar = substituted Ph, 2-naphthyl, 2-thienyl; R = aryl, hetaryl, C5H11). Diverse β-alkylated secondary alcs. were thus obtained by following this method in excellent yields of up to 95% by employing a very low catalyst 1a loading of 0.01-0.001 mol% along with the inexpensive base KOH. Mechanistically, the present protocol follows the borrowing hydrogen strategy which was established by various control experiments including deuterium labeling experiments and importantly, 1H NMR and ESI-MS analyses validated the participation of a Ru-H species in the catalytic cycle. Remarkably, the present system displayed the highest Ru-based TON of 396 000 for the β-benzylation of 1-phenylethanol with a catalyst loading of 1 ppm (0.0001 mol%). Addnl., diverse 2-alkylaminoquinoline derivatives were synthesized in a one-pot manner from 2-aminobenzyl alc., 2-arylacetonitrile, and various primary alcs.

Organic & Biomolecular Chemistry published new progress about Alkylation. 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Application In Synthesis of 5344-90-1.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Xu, Jing-xiu; Pan, Nan-lian; Chen, Jia-xi; Zhao, Jin-wu published the artcile< Visible-light-mediated oxidative cyclization of 2-aminobenzyl alcohols and secondary alcohols enabled by an organic photocatalyst>, Computed Properties of 5344-90-1, the main research area is photocatalysis photocyclization benzyl alc quinoline.

This paper describes a visible-light-mediated oxidative cyclization of 2-aminobenzyl alcs. and secondary alcs. to produce quinolines at room temperature This photocatalytic method employed anthraquinone as an organic small-mol. catalyst and DMSO as an oxidant. According to this present procedure, a series of quinolines were prepared in satisfactory yields.

Journal of Organic Chemistry published new progress about Aralkyl alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Computed Properties of 5344-90-1.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Abdullah, Fuad Othman; Behrouzi, Leila; Kaboudin, Babak published the artcile< A novel synthesis of highly stable palladium nanoparticles and their application in the reduction of nitroaromatic compounds>, Synthetic Route of 5344-90-1, the main research area is aristolochia olivieri extract stabilized palladium nanoparticle catalyst preparation; nitroarom compound palladium catalyst reduction; aromatic amine preparation green chem.

A mild and efficient method for synthesis of highly stable palladium nanoparticles (PdNPs) on Aristolochia Olivieri (AO) extract as a support and reducing agent was described. Investigation of catalytically activity of obtained catalyst (AO@PdNPs) was performed for the reduction of nitroarom. compounds Of note were the functional group tolerance, fast rate, and the ability to apply a scope of nitro compounds (up to 30). The synthesized catalyst was characterized with UV-visible spectra, FE-SEM, EDS, XRD, AAS, FT-IR, and TEM techniques. The corresponding amine product was obtained excellent to high yields. The catalytic activity of AO@PdNPs for the hydrogenation of 4-methyl-2-nitroaniline and 4-methoxy-2-nitroaniline was pursued by UV-visible spectroscopy which presented excellent activity of catalyst.

Materials Research Express published new progress about Aromatic amines Role: SPN (Synthetic Preparation), PREP (Preparation). 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Synthetic Route of 5344-90-1.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Tang, Shi; Ding, Shumin; Li, Dan; Li, Lianjie; Zhao, Haixia; Chai, Minxue; Wang, Jian published the artcile< Palladium-catalysed imidoylative spirocyclization of 3-(2-isocyanoethyl)indoles>, Recommanded Product: (2-Aminophenyl)methanol, the main research area is isocyanoalkyl indole organoiodide palladium catalyst tandem dearomative imidolylative spirocyclization; spiroindole azaarene preparation.

A palladium-catalyzed construction of spiroindolines through dearomative spirocyclization of 3-(2-isocyanoethyl)indoles was developed. 2′-Aryl-, vinyl-, and alkyl-substituted spiroindolines were accessed under mild conditions with excellent functional group tolerance. C1-tethered oxindole- and indole-spiroindoline bisheterocycles were generated in high yields via alkene/allene insertion and an imidoylative spirocyclization cascade. Addnl., a tandem dearomatization of two different indoles was realized with N-(2-bromobenzoyl)indoles as the electrophilic coupling partner of 3-(2-isocyanoethyl)indoles, affording polyindoline – spiroindoline bisheterocyclic scaffolds conveniently. Under the catalysis of Pd(OAc)2 and a spinol-derived phosphoramidite ligand, chiral spiroindolines were successfully accessed with up to 95% yield and 85% ee.

Chemical Communications (Cambridge, United Kingdom) published new progress about Aromatic amines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Recommanded Product: (2-Aminophenyl)methanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Li, Ling; Zhang, Shiqi; Deng, Xiongfei; Li, Guangxun; Tang, Zhuo; Zhao, Gang published the artcile< Preparation and Application of α-Imino Ketones through One-Pot Tandem Reactions Based on Heyns Rearrangement>, Related Products of 5344-90-1, the main research area is amine hydroxyketone regioselective diastereoselective tandem Heyns rearrangement oxidation; imino ketone preparation; hydroxyketone aminoalc regioselective diastereoselective tandem Heyns rearrangement oxidation; ketal preparation.

A metal-free and operationally simple strategy was developed to generate α-imino ketones with high regioselectivity. Meanwhile, the method allowed for the preparation of various N,O-ketals with high regioselectivities and diastereoselectivities through cascade reactions in one pot.

Organic Letters published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Related Products of 5344-90-1.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chakraborty, Gargi; Sikari, Rina; Das, Siuli; Mondal, Rakesh; Sinha, Suman; Banerjee, Seemika; Paul, Nanda D. published the artcile< Dehydrogenative Synthesis of Quinolines, 2-Aminoquinolines, and Quinazolines Using Singlet Diradical Ni(II)-Catalysts>, Application of C7H9NO, the main research area is quinoline biomimetic synthesis; aminoquinoline biomimetic synthesis; quinazoline biomimetic synthesis; nickel complex diamine singlet diradical oxidative condensation coupling catalyst.

Simple, straightforward, and atom economic methods for the synthesis of quinolines, 2-aminoquinolines, and quinazolines via biomimetic dehydrogenative condensation/coupling reactions, catalyzed by well-defined inexpensive and easy to prepare singlet diradical Ni(II)-catalysts featuring two antiferromagnetically coupled singlet diradical diamine type ligands are described. Various polysubstituted quinolines, 2-aminoquinolines, and quinazolines were synthesized in moderate to good yields from different low-cost and readily accessible starting materials. Several control experiments were carried out to get insight into the reaction mechanism which shows that the nickel and the coordinated diamine ligands participate in a synergistic way during the dehydrogenation of alcs.

Journal of Organic Chemistry published new progress about Acetonitriles Role: RCT (Reactant), RACT (Reactant or Reagent) (phenylacetonitriles). 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Application of C7H9NO.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yadav, Anamika; Ambule, Mayur D.; Kant, Ruchir; Srivastava, Ajay K. published the artcile< Silver/Palladium Relay Catalyzed Cross-Coupling of N'-Acetyl-8-quinolinesulfonylhydrazide with Alcohols: An Easy Access to 8-Quinolinesulfinate Esters>, Application In Synthesis of 5344-90-1, the main research area is silver palladium catalyzed cross coupling quinolinesulfonyl hydrazide alc; quinolinesulfinate ester preparation.

An efficient strategy for the synthesis of unexplored 8-quinolinesulfinate esters has been reported. The method involves in situ generation of quinoline sulfinate from N’-acetylquinoline-8-sulfonohydrazide via silver mediated cleavage followed by palladium-catalyzed cross-coupling with 1° and 2° alcs. to yield sulfinate esters. A variety of substituted alcs. were successfully employed in the reaction. Control experiments performed to understand the mechanism, revealed that the transformation follows a radical pathway and the alc. oxygen get incorporated in the resulting sulfinate esters. Two of the chirally pure alcs. were also used in the transformation to study the diastereoselectivity in the reaction. In order to demonstrate the synthetic utility, a representative allyl quinoline-8-sulfinate (I) was successfully converted into the 8-(allylsulfonyl)quinoline (II) via palladium(II) acetate mediated isomerization.

European Journal of Organic Chemistry published new progress about Hydrazides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Application In Synthesis of 5344-90-1.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Verma, Ashutosh; Hazra, Susanta; Dolui, Pritam; Elias, Anil J. published the artcile< Ruthenium-Catalyzed Synthesis of α-Alkylated Ketones and Quinolines in an Aqueous Medium via a Hydrogen-Borrowing Strategy Using Ketones and Alcohols>, Category: alcohols-buliding-blocks, the main research area is ruthenium catalyst preparation; aryl ketone alc ruthenium catalyst green alkylation; phenyl arylpropanone preparation; arylquinoline preparation.

A simple, efficient, and sustainable method for the synthesis of α-alkylated ketones and quin50556012Aolines using a hydrogen-borrowing strategy was reported, which has emerged as a greener alternative in organic transformation reactions. Synthesis of a range of α-alkylated ketones and quinoline derivatives was achieved by using the water-soluble [Ru(8-AQ)Cl(p-cym.)]+Cl- [Ru]-1 (AQ=aminoquinoline) catalyst with water as the reaction medium. By adopting this strategy, α-alkylated ketones and quinolines was synthesized using ketones or secondary alcs. as starting materials and the primary alc. as a green and naturally abundant alkylating agent.

Asian Journal of Organic Chemistry published new progress about Alkylation. 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts