Category: 5344-90-1

Semeniuchenko, Volodymyr; Sharif, Sepideh; Day, Jonathan; Chandrasoma, Nalin; Pietro, William J.; Manthorpe, Jeffrey; Braje, Wilfried M.; Organ, Michael G. published the artcile< (DiMeIHeptCl)Pd: A Low-Load Catalyst for Solvent-Free (Melt) Amination>, Electric Literature of 5344-90-1, the main research area is halobenzene amine palladium catalyst aryl amination; phenyl amine preparation.

(DiMeIHeptCl)Pd, a hyper-branched N-aryl Pd NHC catalyst, was shown to be efficient at performing amine arylation reactions in solvent-free (“”melt””) conditions. The highly lipophilic environment of the alkyl chains flanking the Pd center served as lubricant to allow the complex to navigate through the paste-like environment of these mixtures The protocol was used on a multi-gram scale to make a variety of aniline derivatives, including substrates containing alc. moieties.

Journal of Organic Chemistry published new progress about Amination. 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Electric Literature of 5344-90-1.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Balamurugan, Gunasekaran; Balaji, Sundarraman; Ramesh, Rengan; Bhuvanesh, Nattamai S. P. published the artcile< Synthesis and Structures of Arene Ruthenium (II)-NHC Complexes: Efficient Catalytic α-alkylation of ketones via Hydrogen Auto Transfer Reaction>, Formula: C7H9NO, the main research area is arene ruthenium heterocyclic compound complex preparation; aryl alkyl ketone alkanol ruthenium catalyst chemoselective alkylation; alkyl aryl ketone preparation; hydroxymethyl aniline ketone ruthenium catalyst heterocyclization; quinoline preparation.

A panel of six new arene Ru (II)-NHC complexes (NHC = 1,3-diethyl-(5,6-dimethyl)benzimidazolin-2-ylidene, 1,3-dicyclohexylmethyl-(5,6-dimethyl)benzimidazolin-2-ylidene and 1,3-dibenzyl-(5,6-dimethyl)benzimidazolin-2-ylidene) were synthesized from the transmetallation reaction of Ag-NHC with [(η6-arene)RuCl2]2 and characterized. The ruthenium (II)-NHC complexes were developed as effective catalysts for α-alkylation of ketones and synthesis of bioactive quinoline using primary/amino alcs. as coupling partners resp. The reactions were performed with 0.5 mol% catalyst load in 8 h under aerobic condition and the maximum yield was up to 96%. Besides, the different alkyl wingtips on NHC and arene moieties were studied to differentiate the catalytic robustness of the complexes in the transformations.

Applied Organometallic Chemistry published new progress about Alkylation catalysts, regioselective. 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Formula: C7H9NO.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Qian, Heng-Yu published the artcile< Synthesis, crystal structures, and antibacterial activity of new tetranuclear zinc(II) complexes with schiff base ligands>, Formula: C7H9NO, the main research area is zinc complex Schiff base ligand crystal structure antibacterial activity.

Two new tetranuclear zinc(II) complexes, [Zn4(L1)2(μ2-η1:η1-CH3COO)4(μ1,1-N3)2] (1) and [Zn4(L2)4(CH3CH2OH) (H2O)] (2), where L1 and L2 are the deprotonated forms of 4-fluoro-2-((pyridin-2-ylmethylimino)methyl)phenol (HL1) and 4-fluoro-2-((2-(hydroxymethyl)phenylimino)methyl)phenol (H2L2), have been synthesized and characterized by elemental anal., IR and UV-vis spectroscopy, and single crystal X-ray diffraction. X-ray crystal structural study indicated that the distances between the adjacent Zn atoms are 3.160(1)-3.353(1) Å in 1 and 3.005(1)-3.168(1) Å in 2. All zinc atoms in 1 are pentacoordinated in trigonal bipyramidal geometry, and those in 2 are in square pyramidal and octahedral geometry. The complexes and the Schiff bases were assayed for antibacterial activities against three Gram-pos. bacterial strains (B. subtilis, S. aureus, and St. faecalis) and three Gram-neg. bacterial strains (E. coli, P. aeruginosa, and E. cloacae) by MTT method.

Acta Chimica Slovenica published new progress about Antibacterial agents. 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Formula: C7H9NO.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhong, Yuanhai; Zhou, Taigang; Zhang, Zhuohua; Chang, Ruiqing published the artcile< Copper-Catalyzed Transfer Hydrogenation of N-Heteroaromatics with an Oxazaborolidine Complex>, Category: alcohols-buliding-blocks, the main research area is quinoline hydrogenation oxaborolidine borane complex copper catalyst; tetrahydroquinoline preparation transfer hydrogenation quinoline oxaborolidine borane complex.

Quinolines, quinoxalines, acridine and 1,10-phenanthroline were hydrogenated at the heterocyclic ring by borane-oxaborolidine complex, prepared in situ from ethanolamine and BH3·THF, giving tetrahydro-derivatives; the reaction is catalyzed by copper(II) and copper(I) salts. The first time use of the oxazaborolidine complex in transfer hydrogenation, was accomplished. A general and efficient method for copper-catalyzed transfer hydrogenation of a variety N-heteroaromatics with oxazaborolidine-BH3 complex under mild reaction conditions afforded the corresponding hydrogenated products in up to 96% yields. Mechanistic studies indicate that the hydrogen source originated from water and borane that coordinate with the nitrogen atom of oxazaborolidine. Accordingly, a plausible mechanism for this reaction was proposed. This method was successfully used in the key step synthesis of natural products (±)-Angustureine and (±)-Galipinine in three steps.

ACS Omega published new progress about Amino alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ansari, Arshad J.; Yadav, Ayushi; Mukherjee, Anirban; Sathish, Elagandhula; Nagesh, Kommu; Singh, Ritesh published the artcile< Metal free amination of congested and functionalized alkyl bromides at room temperature>, SDS of cas: 5344-90-1, the main research area is aryl amine preparation; bromoamide aromatic heteroaromatic amine amination; benzodiazepine preparation.

The authors report a highly facile and unprecedented approach to synthesize congested N-(hetero)aryl amines, e.g., 4-NCC6H4NNHCMe2CONHOBn, en route to α-amino acid amides using α-bromoamides as alkylating agents under mild reaction conditions (room temperature). The involvement of aza-oxyallyl cations as alkylating agents is the hallmark of this reaction. This method was readily adapted for the rapid synthesis of coveted 1,4-benzodiazepine-3,5-diones I [R = R1 = H, MeO, R2 = OBn; R = R1 = R2 = H; R = R1 = MeO, R2 = H; R = H, R1 = Cl, R2 = OBn].

Chemical Communications (Cambridge, United Kingdom) published new progress about Amides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, SDS of cas: 5344-90-1.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Tan, Zhenda; Ci, Chenggang; Yang, Jian; Wu, Yang; Cao, Liang; Jiang, Huanfeng; Zhang, Min published the artcile< Catalytic Conversion of N-Heteroaromatics to Functionalized Arylamines by Merging Hydrogen Transfer and Selective Coupling>, HPLC of Formula: 5344-90-1, the main research area is azaarene alkyl bromide amino arylmethanol ruthenium hydrogen transfer coupling; alkylaminoaryl methylazaarene preparation chemoselective.

A ruthenium-catalyzed deconstruction of N-heteroaromatics to functionalized arylamines with 2-aminoaryl methanols via hydrogen transfer and selective coupling was reported. The reaction was achieved via sequential functionalization of the β and α-sites of the initially formed N-heteroarenium salts followed by a C-N cleavage, proceeding with the striking features of broad substrate scope, excellent functional groups tolerance, high chemoselectivity and atom-efficiency, and applicable for streamline synthesis of some biomedical mols. The strategy utilized will pave the avenues for further development of catalytic transformations of inert organo-systems to functional frameworks.

ACS Catalysis published new progress about Amino alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, HPLC of Formula: 5344-90-1.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Tavakoli, Ghazal; Prechtl, Martin H. G. published the artcile< The reductive deaminative conversion of nitriles to alcohols using para-formaldehyde in aqueous solution>, Recommanded Product: (2-Aminophenyl)methanol, the main research area is benzylic alkyl primary alc chemoselective preparation; ruthenium catalyst chemoselective reduction nitrile paraformaldehyde water; mechanism reductive deamination nitrile paraformaldehyde water ruthenium catalyst.

In the presence of [Ru(p-cymene)Cl2]2, paraformaldehyde in H2O/toluene acted as a reductant for the chemoselective reductive deamination of alkyl and aryl nitriles to yield alkyl or benzylic primary alcs. The mechanism of the reaction is studied using the characterization of reaction intermediates by mass spectrometry; dimeric ruthenium complexes are necessary to generate reduced ruthenium complexes from paraformaldehyde, while nitrile coordination generates monomeric complexes of ruthenium which reduce the nitriles to alcs.

Catalysis Science & Technology published new progress about Aralkyl alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Recommanded Product: (2-Aminophenyl)methanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yun, Xue-Jing; Zhu, Jing-Wei; Jin, Yan; Deng, Wei; Yao, Zi-Jian published the artcile< Half-Sandwich Ruthenium Complexes for One-Pot Synthesis of Quinolines and Tetrahydroquinolines: Diverse Catalytic Activity in the Coupled Cyclization and Hydrogenation Process>, Application In Synthesis of 5344-90-1, the main research area is ruthenium half sandwich cyclometalated complex preparation hydrogenation catalyst; amine ketone hydrogenation catalyst ruthenium half sandwich cyclometalated complex.

Four types of half-sandwich ruthenium complexes with an N,O-coordinate mode based on hydroxyindanone-imine ligands have been prepared in good yields. These stable ruthenium complexes exhibited high activity in the catalytic synthesis of quinolines from the reactions of amino alcs. with different types of ketones or secondary alcs. under very mild conditions. Moreover, the methodol. for the direct one-pot synthesis of tetrahydroquinoline derivatives from amino alcs. and ketones has been also developed on the basis of the continuous catalytic activity of this ruthenium catalyst in the selective hydrogenation of the obtained quinoline derivatives with a low catalyst loading. The corresponding products, quinolines and tetrahydroquinoline derivatives, were afforded in good to excellent yields. The efficient and diverse catalytic activity of these ruthenium complexes suggested their potential large-scale application. All of the ruthenium complexes were characterized by various spectroscopies to confirm their structures. Half-sandwich ruthenium complexes based on hydroxyindanone-imine ligands exhibited high activity in the catalytic synthesis of quinoline derivatives starting from amino alcs. and ketones as well as secondary alcs. under very mild conditions. One-pot synthesis of tetrahydroquinoline has been also developed on the basis of the continuous catalytic activity of these ruthenium catalysts in selective hydrogenation.

Inorganic Chemistry published new progress about Aralkyl amines Role: RCT (Reactant), RACT (Reactant or Reagent). 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Application In Synthesis of 5344-90-1.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Cai, Wei; Zhou, Yiming; He, Yanlin; Huang, You published the artcile< DABCO catalyzed [4+2] annulations of Morita-Baylis-Hillman carbonates with isocyanates>, COA of Formula: C7H9NO, the main research area is alkoxy oxopropenyl dihydroquinazoline carboxylate preparation; MBH carbonate preparation isocyanate DABCO catalyst chemoselective cycloaddition.

A highly concise method for 1,4-diazabicyclo[2.2.2]octane (DABCO) catalyzed [4+2] annulations of o-amino-acylation of aryl Morita-Baylis-Hillman (MBH) carbonates with isocyanates was developed. For the first time, MBH carbonates served as 1,4-dipoles, providing functionalized 3,4-dihydroquinazolinones in mild conditions with good to excellent yields. The d. functional theory calculations of the mechanism supports this hypothesis.

Chemical Communications (Cambridge, United Kingdom) published new progress about [4+2] Cycloaddition reaction (chemoselective). 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, COA of Formula: C7H9NO.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wu, Tun-Hui; Su, Zih-Syuan; Sung, Robert; Sung, Kuangsen published the artcile< Aza-ortho-Quinone Methide and Its Conjugated Acid: Reactivity, Stability and Acidity>, Quality Control of 5344-90-1, the main research area is quinone methide laser flash photolysis kinetics reactivity chem stability; acidity; aza-o-quinone methide; cycloaddition; drug metabolite; reactivity.

Aza-o-quinone methides and their conjugated acids are reactive drug metabolites that might react with nucleophilic sites of DNAs and proteins to cause cancer or immune responses, and their reactivity with water is the key information to judge if these metabolites are harmful in living systems. For the first time, aza-o-quinone methide (1) and its conjugated acid (2) are observed by laser flash photolysis, and their reactivity, stability and acidity in water are determined

ChemPhysChem published new progress about Absorption spectra. 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Quality Control of 5344-90-1.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts