Category: 534-03-2

《Self-Assembled Polyurethane Capsules with Selective Antimicrobial Activity against Gram-Negative E. coli》 was published in ACS Biomaterials Science & Engineering in 2020. These research results belong to Barman, Ranajit; Mondal, Tathagata; Sarkar, Jayita; Sikder, Amrita; Ghosh, Suhrit. SDS of cas: 534-03-2 The article mentions the following:

This article reports the antimicrobial activity of two segmented amphiphilic polyurethanes, PU-1 and PU-2, containing a primary or secondary amine group, resp. In acidic water, intrachain H-bonding among the urethanes followed by hierarchical assembly resulted in the formation of capsules (Dh = 120 ± 20 and 100 ± 17 nm for PU-1 and PU-2, resp.) with a highly pos. surface charge. They showed selective interactions with bacterial cell mimicking liposomes over mammalian cell mimicking liposomes with favorable enthalpy and entropy contributions, which was attributed to the electrostatic interaction and hydrophobic effect. Antimicrobial studies with Escherichia coli revealed very low min. inhibitory concentration (MIC) values of 7.8 and 15.6μg/mL for PU-1 and PU-2, resp., indicating their ability to efficiently kill Gram-neg. bacteria. Killing of Gram-pos. Staphylococcus aureus was noticed only at C = 500μg/mL, indicating unprecedented selectivity for E. coli, which was further confirmed by SEM (SEM) studies. Hemolysis assay revealed HC50 values of 453 and 847μg/mL for PU-1 and PU-2, resp., which were >50 times higher than their resp. MIC values, thus making them attractive antimicrobial materials. Ortho-nitrophenyl-β-galactoside (ONPG) assay and live-dead fluorescence assay confirmed that for both the polymers, a membrane disruption pathway was operative for wrapping of the bacterial membrane, similar to what was proposed for antimicrobial peptides. SEM images of polymer-treated E. coli bacteria helped in visualization of the pore formation and the disrupted membrane structure. In the experiment, the researchers used many compounds, for example, 2-Aminopropane-1,3-diol(cas: 534-03-2SDS of cas: 534-03-2)

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Primary amines having a tertiary alkyl group (R3CNH2) are difficult to prepare with most methods but are made industrially by the Ritter reaction. In this method a tertiary alcohol reacts with hydrogen cyanide (HCN) in the presence of a concentrated strong acid; a formamide, RNH―CHO, is formed first, which then undergoes hydrolysis.SDS of cas: 534-03-2

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《The synthesis of trifluoromethylated N-nitroaryl-2-amino-1,3-dichloropropane derivatives and their evaluation as potential anti-cancer agents》 was written by Chappel, Lucy; Wong, Lai Chun; Leong, Chee-Onn; Mai, Chun-Wai; Meikle, Ian T.; Stanforth, Stephen P.; Truong, Thang V.. Product Details of 534-03-2This research focused ontrifluoromethylated nitroarylaminodichloropropane derivative preparation antitumor agent; Anti-cancer agents; Nitroaromatic drugs; Nitrogen mustards; Trifluoromethylated drugs. The article conveys some information:

Six N-nitroaryl-2-amino-1,3-dichloropropane derivatives were prepared and evaluated against 18 cancer cell lines and two non-cancerous cell lines. Anal. of cell viability data and IC50 values indicated that the presence of a trifluoromethyl group in the nitroaryl moiety is an important structural feature associated with the compounds’ cytotoxicities. After reading the article, we found that the author used 2-Aminopropane-1,3-diol(cas: 534-03-2Product Details of 534-03-2)

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Nitrous acid converts secondary amines (aliphatic or aromatic) to N-nitroso compounds (nitrosamines): R2NH + HNO2 → R2N―NO. Some nitrosamines are potent cancer-inducing substances, and their possible formation is a serious consideration when nitrites, which are salts of nitrous acid, are present in foods or pharmaceutical preparations. Tertiary amines give rise to nitrosamines more slowly; an alkyl group is eliminated as an aldehyde or ketone, along with nitrous oxide, N2O.Product Details of 534-03-2

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Safety of 2-Aminopropane-1,3-diolIn 2019 ,《Supramolecular Gels Derived from Simple Organic Salts of Flufenamic Acid: Design, Synthesis, Structures, and Plausible Biomedical Application》 was published in ACS Biomaterials Science & Engineering. The article was written by Parveen, Rumana; Jayamma, Bandi; Dastidar, Parthasarathi. The article contains the following contents:

Following supramol. synthon rationale in the context of crystal engineering, a non-steroidal-anti-inflammatory-drug (NSAID) namely Flufenamic acid (FA) and its β-alanine monopeptide derivative (FM) were converted to a series of primary ammonium monocarboxylate (PAM) salts. Majority of the PAM salts (∼90 %) showed gelation with various solvents including water and Me salicylate (important solvents in topical gel formulation). Structure-property correlation studies based on single crystal X-ray diffraction (SXRD) and powder X-ray diffraction (PXRD) data provided intriguing insights into the structure of the gel network. Furthermore, one of the gelator salts (S7) displayed anti-cancer activity on a highly aggressive human breast cancer cell line (MDA-MB-231) as revealed by MTT, PEG2 and cell migration assays. In the part of experimental materials, we found many familiar compounds, such as 2-Aminopropane-1,3-diol(cas: 534-03-2Safety of 2-Aminopropane-1,3-diol)

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Amine, any member of a family of nitrogen-containing organic compounds that is derived, either in principle or in practice, from ammonia (NH3). Naturally occurring amines include the alkaloids, which are present in certain plants; the catecholamine neurotransmitters (i.e., dopamine, epinephrine, and norepinephrine); and a local chemical mediator, histamine, that occurs in most animal tissues.Safety of 2-Aminopropane-1,3-diol

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《Design and validation of linkers for site-specific preparation of antibody-drug conjugates carrying multiple drug copies per cysteine conjugation site》 was published in International Journal of Molecular Sciences in 2020. These research results belong to Kumar, Amit; Mao, Shenlan; Dimasi, Nazzareno; Gao, Changshou. Quality Control of 2-Aminopropane-1,3-diol The article mentions the following:

First-generation cysteine-based site-specific antibody-drug conjugates (ADCs) are limited to one drug per cysteine. However, certain applications require a high drug to antibody ratio (DAR), such as when low-potency payloads are used. Higher drug load can be achieved using classical cysteine conjugation methods, but these result in heterogeneity, suboptimal efficacy and pharmacokinetics. Here, we describe the design, synthesis and validation of heterobifunctional linkers that can be used for the preparation of ADCs with a DAR of two, three and four in a site-specific manner per single cysteine conjugation site, resulting in site-specific ADCs with a DAR of four, six and eight. The designed linkers carry a sulfhydryl-specific iodoacetyl reactive group, and multiple cyclic diene moieties which can efficiently react with maleimide-carrying payloads through the Diels-Alder reaction. As a proof of concept, we synthesized site-specific DAR four, six and eight ADCs carrying tubulysin (AZ13601508) using engineered antibodies with a cysteine inserted after position 239 in the antibody CH2 domain. We evaluated and compared the in vitro cytotoxicity of ADCs obtained via the site-specific platform described herein, with ADCs prepared using classical cysteine conjugation. Our data validated a novel cysteine-based conjugation platform for the preparation of site-specific ADCs with high drug load for therapeutic applications. The experimental process involved the reaction of 2-Aminopropane-1,3-diol(cas: 534-03-2Quality Control of 2-Aminopropane-1,3-diol)

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Acylation is one of the most important reactions of primary and secondary amines; a hydrogen atom is replaced by an acyl group (a group derived from an acid, such as RCOOH or RSO3H, by removal of ―OH, such as RC(=O)―, RS(O)2―, and so on). Reagents may be acid chlorides (RCOC1, RSO2C1), anhydrides ((RCO)2O), or even esters (RCOOR′); the products are amides of the corresponding acids.Quality Control of 2-Aminopropane-1,3-diol

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《Antimicrobial Hyperbranched Polymer-Usnic Acid Complexes through a Combined ROP-RAFT Strategy》 was published in Macromolecular Rapid Communications in 2020. These research results belong to Rauschenbach, Moritz; Lawrenson, Stefan B.; Taresco, Vincenzo; Pearce, Amanda K.; O′Reilly, Rachel K.. Computed Properties of C3H9NO2 The article mentions the following:

Polymer-drug conjugates have received considerable attention over the last decades due to their potential for improving the clin. outcomes for a range of diseases. It is of importance to develop methods for their preparation that have simple synthesis and purification requirements but maintain high therapeutic efficacy and utilize macromols. that can be cleared via natural excretory pathways upon breakdown. Herein, the combination of ring-opening polymerization (ROP) and reversible addition-fragmentation chain-transfer (RAFT) polymerization is described for the straightforward synthesis of amphiphilic, stimuli-responsive, biodegradable, and highly functionalizable hyperbranched polymers. These unimol. nanoparticles demonstrate a versatile platform for the synthesis of polymer-drug conjugates owing to the inclusion of a Boc-protected polycarbonate moiety in either a block or random copolymer formation. A proof-of-concept study on the complexation of the poorly water-soluble antimicrobial drug usnic acid results in polymer-drug complexes with powerful antimicrobial properties against gram-pos. bacteria. Therefore, this work highlights the potential of amphiphilic and biodegradable hyperbranched polymers for antimicrobial applications. The experimental process involved the reaction of 2-Aminopropane-1,3-diol(cas: 534-03-2Computed Properties of C3H9NO2)

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Primary amines having a tertiary alkyl group (R3CNH2) are difficult to prepare with most methods but are made industrially by the Ritter reaction. In this method a tertiary alcohol reacts with hydrogen cyanide (HCN) in the presence of a concentrated strong acid; a formamide, RNH―CHO, is formed first, which then undergoes hydrolysis.Computed Properties of C3H9NO2

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The author of 《Fast and stable optical pH sensor materials for oceanographic applications》 were Staudinger, Christoph; Strobl, Martin; Breininger, Johanna; Klimant, Ingo; Borisov, Sergey M.. And the article was published in Sensors and Actuators, B: Chemical in 2019. Safety of 2-Aminopropane-1,3-diol The author mentioned the following in the article:

The study reports preparation and detailed comparison of four new pH sensor materials for seawater measurements. The composition of the sensors is optimized in several iterations to ensure optimal dynamic range, fast response time at low temperatures, low cross-sensitivities to temperature (dpKa/dT ∼ -0.013 pH units/K) and negligible cross sensitivity to ionic strength above salinity 15 PSU. The first generation (material “”pH-1′′) utilizes a pH indicator which is phys. entrapped into a polyurethane hydrogel. This material shows satisfactory performance only at comparably high temperatures with response times being extremely long at low temperatures (t95 > 2 h at 5 °C). The three other materials utilize cross-linked hydrophilic polymers based on poly(acryloylmorpholine) with indicator dye covalently coupled to the polymer. Moreover, the last two generations (“”pH-3′′ and “”pH-4′′) showed no drift over 54 days at 10 °C and only a drift of 0.003 pH units/day at 25 °C. The material of the fourth generation “”pH-4′′ explores a novel approach of covalent coupling via B-O linkage and is characterized by low synthetic effort and the pKa value optimal for seawater measurements (8.05 at 20 °C). Importantly, all new sensor materials are spectrally compatible to a recently presented seawater optode system for combined pH, pO2 and pCO2 measurements which facilitates their application in marine environment. In the experiment, the researchers used 2-Aminopropane-1,3-diol(cas: 534-03-2Safety of 2-Aminopropane-1,3-diol)

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Many important products require amines as part of their syntheses. Methylamine is utilized in the production of the analgesic meperidine (trade name Demerol) and the photographic developer Metol (trademark), and dimethylamine is used in the synthesis of the antihistamine diphenhydramine (trade name Benadryl), the solvent dimethylformamide (DMF), and the rocket propellant 1,1-dimethylhydrazine. The synthesis of the insect repellent N,N-diethyl-m-toluamide (DEET) incorporates diethylamine while that of the synthetic fibre Kevlar requires aromatic amines.Safety of 2-Aminopropane-1,3-diol

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Lisovskaya, Alexandra; Shadyro, Oleg; Schiemann, Olav; Carmichael, Ian published an article in 2021. The article was titled 《OH radical reactions with the hydrophilic component of sphingolipids》, and you may find the article in Physical Chemistry Chemical Physics.Safety of 2-Aminopropane-1,3-diol The information in the text is summarized as follows:

In this work, using the example of model compounds, we studied the reactions resulting from the interaction of OH radicals with the hydrophilic part of sphingolipids. We compared the stopped-flow EPR spectroscopy and pulse radiolysis with optical detection methods to characterize radical intermediates formed in the reaction of OH radicals with glycerol, serinol and N-boc-serinol. Quantum chem. calculations were also performed to help interpret the observed exptl. data. It was shown that H-abstraction from the terminal carbon atom is the main process that is realized for all the studied compounds The presence of the unsubstituted amino group (-NH2) is seen to completely change the reaction properties of serinol in comparison with those observed in glycerol and N-boc serinol. The results came from multiple reactions, including the reaction of 2-Aminopropane-1,3-diol(cas: 534-03-2Safety of 2-Aminopropane-1,3-diol)

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Amines have a free lone pair with which they can coordinate to metal centers. Amine–metal bonds are weaker because amines are incapable of backbonding, but they are still important for sensing applications.While stronger than hydrogen bonds, amine–metal bonds are still weaker than both covalent and ionic bonds.Safety of 2-Aminopropane-1,3-diol

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《Rhizobium rhizogenes mediated hairy root transformation and analysis of secondary metabolites in Phlogacanthus thyrsiflorus nees hairy roots using GC-MS》 was written by Singh, Shweta; Banerjee, Madhuparna; Kumar, Manish. Quality Control of 2-Aminopropane-1,3-diol And the article was included in Journal of Scientific & Industrial Research in 2020. The article conveys some information:

An efficient transformation system was developed for Phlogacanthus thyrsiflorus, a medicinal plant of northeast India, using Rhizobium rhizogenes strains A4 for infecting shoot tip, nodes and leaf explants derived from aseptically raised plants. The transformation frequency was found dependent on the explants as well as the co-culture periods. Highest transformation frequency of 95.69% was obtained from shoot tip explants co-cultured for 4 h. An average of 6.37 hairy roots per explant were obtained from shoot tip explants within three weeks of infection. Whereas, transformation frequency along with number of transformed roots were fewer in node and leaf explants. The presence of TL DNA of R. rhizogenes strains A4 in the hairy root genome of P. thyrsiflorus was confirmed through PCR based cloning and sequencing in which the sequencing results of the PCR amplicon confirmed the presence of rol b and rol c genes in the host genome. Sequence results for rol genes were found to be 97 percent and 99 percent similar with rol b and rol c gene present in NCBI database. GC-MS anal. of methanolic extract of the hairy roots reveals the presence of a few medicinally important secondary metabolites. In addition to this study using 2-Aminopropane-1,3-diol, there are many other studies that have used 2-Aminopropane-1,3-diol(cas: 534-03-2Quality Control of 2-Aminopropane-1,3-diol) was used in this study.

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. The methylamines occur in small amounts in some plants. Many polyfunctional amines (i.e., those having other functional groups in the molecule) occur as alkaloids in plants—for example, mescaline, 2-(3,4,5-trimethoxyphenyl)ethylamine; the cyclic amines nicotine, atropine, morphine, and cocaine; and the quaternary salt choline, N-(2-hydroxyethyl)trimethylammonium chloride, which is present in nerve synapses and in plant and animal cells.Quality Control of 2-Aminopropane-1,3-diol

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In 2022,Mukherjee, Anurag; Barman, Shubhankar; Ghosh, Anupam; Datta, Ayan; Datta, Anuja; Ghosh, Suhrit published an article in Angewandte Chemie, International Edition. The title of the article was 《A Hierarchical (Macro)molecular Assembly Assisted by Donor-Acceptor Charge-Transfer Interactions Exhibiting Room-Temperature Ferroelectricity》.Related Products of 534-03-2 The author mentioned the following in the article:

This communication reveals co-assembly of an electron-deficient naphthalene-diimide (NDI)-appended polyurethane (P1) and electron-rich pyrene (Py), forming an organogel with prominent room-temperature ferroelectricity. In a non-polar medium, intra-chain hydrogen-bonding among the urethane groups of P1 produces a folded structure with an array of the NDIs in the periphery, which intercalate Py by charge-transfer (CT)-interaction. Such CT-complexation enables slow crystallization of the peripheral hydrocarbons, causing gelation with nanotubular morphol., in which the wall consists of the alternating NDI-Py stack. Such D-A assembly exhibits ferroelectricity (saturation polarization Ps≈0.8μC cm-2 and coercive field Ec≈8 kV cm-1 at 500 V and 10 Hz frequency) with Curie temperature (Tc) of ≈350 K, which can be related to the disassembly of the CT-complex. In the absence of Py, P1 forms spherical aggregates, showing dielec. behavior. In the experiment, the researchers used many compounds, for example, 2-Aminopropane-1,3-diol(cas: 534-03-2Related Products of 534-03-2)

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Milder oxidation, using reagents such as NaOCl, can remove four hydrogen atoms from primary amines of the type RCH2NH2 to form nitriles (R―C≡N), and oxidation with reagents such as MnO2 can remove two hydrogen atoms from secondary amines (R2CH―NHR′) to form imines (R2C=NR′). Tertiary amines can be oxidized to enamines (R2C=CHNR2) by a variety of reagents.Related Products of 534-03-2

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Shin, Kyong-Oh; Kim, Sungeun; Park, Byeong Deog; Uchida, Yoshikazu; Park, Kyungho published an article in 2021. The article was titled 《N-Palmitoyl Serinol Stimulates Ceramide Production through a CB1-Dependent Mechanism in In Vitro Model of Skin Inflammation》, and you may find the article in International Journal of Molecular Sciences.Related Products of 534-03-2 The information in the text is summarized as follows:

Ceramides, a class of sphingolipids containing a backbone of sphingoid base, are the most important and effective structural component for the formation of the epidermal permeability barrier. While ceramides comprise approx. 50% of the epidermal lipid content by mass, the content is substantially decreased in certain inflammatory skin diseases, such as atopic dermatitis (AD), causing improper barrier function. It is widely accepted that the endocannabinoid system (ECS) can modulate a number of biol. responses in the central nerve system, prior studies revealed that activation of endocannabinoid receptor CB1, a key component of ECS, triggers the generation of ceramides that mediate neuronal cell fate. However, as the impact of ECS on the production of epidermal ceramide has not been studied, we here investigated whether the ECS stimulates the generation of epidermal ceramides in an IL-4-treated in vitro model of skin inflammation using N-palmitoyl serinol (PS), an analog of the endocannabinoid N-palmitoyl ethanolamine. Accordingly, an IL-4-mediated decrease in cellular ceramide levels was significantly stimulated in human epidermal keratinocytes (KC) following PS treatment through both de novo ceramide synthesis- and sphingomyelin hydrolysis-pathways. Importantly, PS selectively increases ceramides with long-chain fatty acids (FAs) (C22-C24), which mainly account for the formation of the epidermal barrier, through activation of ceramide synthase (CerS) 2 and Cer3 in IL-4-mediated inflamed KC. Furthermore, blockade of cannabinoid receptor CB1 activation by AM-251 failed to stimulate the production of total ceramide as well as long-chain ceramides in response to PS. These studies demonstrate that an analog of endocannabinoid, PS, stimulates the generation of specific ceramide species as well as the total amount of ceramides via the endocannabinoid receptor CB1-dependent mechanism, thereby resulting in the enhancement of epidermal permeability barrier function. The experimental part of the paper was very detailed, including the reaction process of 2-Aminopropane-1,3-diol(cas: 534-03-2Related Products of 534-03-2)

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Amines characteristically form salts with acids; a hydrogen ion, H+, adds to the nitrogen. With the strong mineral acids (e.g., H2SO4, HNO3, and HCl), the reaction is vigorous. Salt formation is instantly reversed by strong bases such as NaOH. Neutral electrophiles (compounds attracted to regions of negative charge) also react with amines; alkyl halides (R′X) and analogous alkylating agents are important examples of electrophilic reagents.Related Products of 534-03-2

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