Category: 534-03-2

Electric Literature of C3H9NO2In 2021 ,《Influence of the active layer structure on the photovoltaic performance of water-soluble polythiophene-based solar cells》 appeared in Polymers (Basel, Switzerland). The author of the article were Lanzi, Massimiliano; Quadretti, Debora; Marinelli, Martina; Ziai, Yasamin; Salatelli, Elisabetta; Pierini, Filippo. The article conveys some information:

A new side-chain C60-fullerene functionalized thiophene copolymer bearing tributylphosphine-substituted hexylic lateral groups was successfully synthesized by means of a fast and effective post-polymerization reaction on a regioregular ω-alkylbrominated polymeric precursor. The growth of the polymeric intermediate was followed by NMR spectrometry in order to determine the most convenient reaction time. The obtained copolymer was soluble in water and polar solvents and was used as a photoactive layer in single-material organic photovoltaic (OPV) solar cells. The copolymer photovoltaic efficiency was compared with that of an OPV cell containing a water-soluble polythiophenic homopolymer, functionalized with the same tributylphosphine-substituted hexylic side chains, in a blend with a water-soluble C60-fullerene derivative The use of a water-soluble double-cable copolymer made it possible to enhance the control on the nanomorphol. of the active blend, thus reducing phase-segregation phenomena, as well as the macroscale separation between the electron acceptor and donor components. Indeed, the power conversion efficiency of OPV cells based on a single material was higher than that obtained with the classical architecture, involving the presence of two distinct ED and EA materials (PCE: 3.11% vs. 2.29%, resp.). Moreover, the synthetic procedure adopted to obtain single material-based cells is more straightforward and easier than that used for the preparation of the homopolymer-based BHJ solar cell, thus making it possible to completely avoid the long synthetic pathway which is required to prepare water-soluble fullerene derivatives In the part of experimental materials, we found many familiar compounds, such as 2-Aminopropane-1,3-diol(cas: 534-03-2Electric Literature of C3H9NO2)

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Hydrogen peroxide (H2O2) and peroxy acids generally add an oxygen atom to the nitrogen of amines. With primary amines, this step is normally followed by further oxidation, leading to nitroso compounds, RNO, or nitro compounds, RNO2. Secondary amines are converted to hydroxylamines, R2NOH, and tertiary amines to amine oxides, R3NO.Electric Literature of C3H9NO2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Formula: C3H9NO2In 2020 ,《PH-responsive artesunate polymer prodrugs with enhanced ablation effect on rodent xenograft colon cancer》 was published in International Journal of Nanomedicine. The article was written by Hao, Dan-Li; Xie, Ran; De, Ge-Jing; Yi, Hong; Zang, Chen; Yang, Mi-Yi; Liu, Li; Ma, Hai; Cai, Wei-Yan; Zhao, Qing-He; Sui, Feng; Chen, Yan-Jun. The article contains the following contents:

Purpose: In this study, pH-sensitive poly(2-ethyl-2-oxazoline)-poly(lactic acid)-poly(β-amino ester) (PEOz-PLA-PBAE) triblock copolymers were synthesized and were conjugated with an antimalaria drug artesunate (ART), for inhibition of a colon cancer xenograft model. The as-prepared polymer prodrugs are tended to self-assemble into polymeric micelles in aqueous milieu, with PEOz segment as hydrophilic shell and PLA-PBAE segment as hydrophobic core. The pH sensitivity of the as-prepared copolymers was confirmed by acid-base titration with pKb values around 6.5. The drug-conjugated polymer micelles showed high stability for at least 96 h in PBS and 37°C, resp. The as-preparation copolymer prodrugs showed high drug loading content, with 9.57% ±1.24% of drug loading for PEOz-PLA-PBAE-ART4. The conjugated ART could be released in a sustained and pH-dependent manner, with 92% of released drug at pH 6.0 and 57% of drug released at pH 7.4, resp. In addition, in vitro experiments showed higher inhibitory effect of the prodrugs on rodent CT-26 cells than that of free ART. Animal studies also demonstrated the enhanced inhibitory efficacy of PEOz-PLA-PBAE-ART2 micelles on the growth of rodent xenograft tumor. The pH-responsive artesunate polymer prodrugs are promising candidates for colon cancer adjuvant therapy. The results came from multiple reactions, including the reaction of 2-Aminopropane-1,3-diol(cas: 534-03-2Formula: C3H9NO2)

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Examples of direct uses of amines and their salts are as corrosion inhibitors in boilers and in lubricating oils (morpholine), as antioxidants for rubber and roofing asphalt (diarylamines), as stabilizers for cellulose nitrate explosives (diphenylamine), as protectants against damage from gamma radiation (diarylamines), as developers in photography (aromatic diamines), as flotation agents in mining, as anticling and waterproofing agents for textiles, as fabric softeners, in paper coating, and for solubilizing herbicides.Formula: C3H9NO2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The author of 《Light-responsive serinol-based polyurethane nanocarrier for controlled drug release》 were Sun, Jingjiang; Rust, Tarik; Kuckling, Dirk. And the article was published in Macromolecular Rapid Communications in 2019. Recommanded Product: 534-03-2 The author mentioned the following in the article:

In the present work, a new and facile strategy for the synthesis of light-responsive polyurethanes (LrPUs) based on serinol with o-nitrobenzyl pendent groups is developed. Stable monodisperse nanoparticles from these LrPUs can be formulated reproducibly in a simple manner, which is shown by dynamic light scattering (DLS) measurements. Upon irradiation with UV light, both polymers and nanoparticles undergo rapid degradation, which is investigated by DLS, SEM, size exclusion chromatog., and UV-vis spectroscopy. The nanoparticles are also employed for the encapsulation of the model drug Nile Red, and by exposure to UV light, a burst release of the payload is detected via fluorescence spectroscopy. This strategy can be easily applied to the straightforward synthesis of various new serinol-based monomers with different stimuli-responsive properties and therefore expand the family of biodegradable polymers. The experimental part of the paper was very detailed, including the reaction process of 2-Aminopropane-1,3-diol(cas: 534-03-2Recommanded Product: 534-03-2)

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Nitrous acid converts secondary amines (aliphatic or aromatic) to N-nitroso compounds (nitrosamines): R2NH + HNO2 → R2N―NO. Some nitrosamines are potent cancer-inducing substances, and their possible formation is a serious consideration when nitrites, which are salts of nitrous acid, are present in foods or pharmaceutical preparations. Tertiary amines give rise to nitrosamines more slowly; an alkyl group is eliminated as an aldehyde or ketone, along with nitrous oxide, N2O.Recommanded Product: 534-03-2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yang, Yang; Wang, Ke; Chen, Hao; Feng, Zhiqiang published an article in 2021. The article was titled 《Design, synthesis, evaluation, and SAR of 4-phenylindoline derivatives, a novel class of small-molecule inhibitors of the programmed cell death-1/ programmed cell death-ligand 1 (PD-1/PD-L1) interaction》, and you may find the article in European Journal of Medicinal Chemistry.Safety of 2-Aminopropane-1,3-diol The information in the text is summarized as follows:

The blockade of the PD-1/PD-L1 immune checkpoint pathway with small mols. is an emerging immunotherapeutic approach. A novel series of 4-phenylindoline derivatives were synthesized, and their inhibitory activity against the PD-1/PD-L1 protein-protein interaction (PPI) was evaluated through a homogenous time-resolved fluorescence (HTRF) assay. Among them, I and II exhibited potent activity with IC50 values of 17 nM and 12 nM, resp. Furthermore, I showed the promising inhibitory activity against the PD-1/PD-L1 interaction with the EC50 value of 0.43μM in a co-culture model of PD-L1/TCR Activator-expressing CHO cells and PD-1-expressing Jurkat cells. Besides, the structure-activity relationships (SAR) of the novel synthesized 4-phenylindoline derivatives was concluded, and the binding mode of II with the PD-L1 dimer was analyzed by mol. simulation and docking, demonstrating that the N-atom in the side chain of indoline fragment could interact with the amino acid residue of the PD-L1 protein to lead to the potent inhibitory activity. This study provided a new insight for further drug design.2-Aminopropane-1,3-diol(cas: 534-03-2Safety of 2-Aminopropane-1,3-diol) was used in this study.

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Large quantities of aliphatic amines are made synthetically. The most widely used industrial method is the reaction of alcohols with ammonia at a high temperature, catalyzed by metals or metal oxide catalysts (e.g., nickel or copper). Mixtures of primary, secondary, and tertiary amines are thereby produced.Safety of 2-Aminopropane-1,3-diol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Synthetic bioactive olivetol-related amides: The influence of the phenolic group in cannabinoid receptor activity》 was published in Bioorganic & Medicinal Chemistry in 2020. These research results belong to Brizzi, Antonella; Aiello, Francesca; Boccella, Serena; Cascio, Maria Grazia; De Petrocellis, Luciano; Frosini, Maria; Gado, Francesca; Ligresti, Alessia; Luongo, Livio; Marini, Pietro; Mugnaini, Claudia; Pessina, Federica; Corelli, Federico; Maione, Sabatino; Manera, Clementina; Pertwee, Roger G.; Di Marzo, Vincenzo. Category: alcohols-buliding-blocks The article mentions the following:

Focusing on the importance of the free phenolic hydroxyl moiety, a family of 23 alkylresorcinol-based compounds were developed and evaluated for their cannabinoid receptor binding properties. The non-sym. hexylresorcinol derivative 29 turned out to be a CB2-selective competitive antagonist/inverse agonist endowed with good potency. Both the olivetol- and 5-(2-methyloctan-2-yl)resorcinol-based derivatives 23 and 24 exhibited a significant antinociceptive activity. Interestingly, compound 24 proved to be able to activate both cannabinoid and TRPV1 receptors. Even if cannabinoid receptor subtype selectivity remained a goal only partially achieved, results confirm the validity of the alkylresorcinol nucleus as skeleton for the identification of potent cannabinoid receptor modulators. In the experiment, the researchers used 2-Aminopropane-1,3-diol(cas: 534-03-2Category: alcohols-buliding-blocks)

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Amines have a free lone pair with which they can coordinate to metal centers. Amine–metal bonds are weaker because amines are incapable of backbonding, but they are still important for sensing applications.While stronger than hydrogen bonds, amine–metal bonds are still weaker than both covalent and ionic bonds.Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2019,Journal of Medicinal Chemistry included an article by Wild, Christopher T.; Miszkiel, Joanna M.; Wold, Eric A.; Soto, Claudia A.; Ding, Chunyong; Hartley, Rachel M.; White, Mark A.; Anastasio, Noelle C.; Cunningham, Kathryn A.; Zhou, Jia. Synthetic Route of C3H9NO2. The article was titled 《Design, Synthesis, and Characterization of 4-Undecylpiperidine-2-carboxamides as Positive Allosteric Modulators of the Serotonin (5-HT) 5-HT2C Receptor》. The information in the text is summarized as follows:

Cis-alkylpiperidinecarboxamides such as I were prepared as pos. allosteric modulators of the 5-HT2c receptor for potential use in the prevention of cocaine addiction relapse. I potentiated 5-HT-evoked intracellular calcium release in cells stably expressing the human 5-HT2c receptor but not cells expressing human 5-HT2a receptors. Mol. docking calculations of I at the 5-HT2c receptor identified a topog. distinct allosteric site. The pharmacokinetics of I upon i.v. administration, its toxicity, and its selectivity for the 5-HT2c receptor over a variety of other competing receptors was determined I modulated 5-HT2c receptor-mediated spontaneous ambulation, partially substituted for the training dose of the 5-HT2c receptor agonist WAY163909, synergized with a low dose of WAY163909 to substitute fully for the stimulus effects of WAY163909, and attenuated relapse vulnerability as assessed in a rodent self-administration model, indicating its therapeutic promise for cocaine use disorder. The results came from multiple reactions, including the reaction of 2-Aminopropane-1,3-diol(cas: 534-03-2Synthetic Route of C3H9NO2)

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Large quantities of aliphatic amines are made synthetically. The most widely used industrial method is the reaction of alcohols with ammonia at a high temperature, catalyzed by metals or metal oxide catalysts (e.g., nickel or copper). Mixtures of primary, secondary, and tertiary amines are thereby produced.Synthetic Route of C3H9NO2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2022,Fan, Kaiming; Liu, Yanling; Wang, Xiaoping; Cheng, Peng; Xia, Shengji published an article in Separation and Purification Technology. The title of the article was 《Comparison of polyamide, polyesteramide and polyester nanofiltration membranes: properties and separation performance》.Electric Literature of C3H9NO2 The author mentioned the following in the article:

In this study, three different kinds of nanofiltration membranes with polyamide (PA), polyesteramide (PEA), and polyester (PE) active layers were resp. synthesized by using piperazine, serinol and meso-erythritol as the aqueous monomers for interfacial polymerization The three types of membranes achieved comparable rejections for the reference organic solute (i.e., xylose) via optimization of preparation conditions, based on which the characteristics of different active layers were comprehensively investigated. Results showed that the PA, PEA and PE membranes exhibited distinct surface morphologies. The special surface structures of PEA membranes and the larger active layer thickness of PE membranes resulted in their lower water permeance compared to PA membranes. Different than PA active layers, the absence of pos. charged regions in the PEA and PA active layers was beneficial for the passage of divalent cations and the rejection of NaCl. Moreover, despite the comparable mean pore size, PA membranes exhibited a more uniform membrane pore size resulting in a higher rejection of organic matters in natural water than PEA and PE membranes. This study presented the differences in physicochem. properties and separation performance among the different membrane active layers, which could provide references for the rational selection of nanofiltration membrane types during application. In the experiment, the researchers used 2-Aminopropane-1,3-diol(cas: 534-03-2Electric Literature of C3H9NO2)

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Large quantities of aliphatic amines are made synthetically. The most widely used industrial method is the reaction of alcohols with ammonia at a high temperature, catalyzed by metals or metal oxide catalysts (e.g., nickel or copper). Mixtures of primary, secondary, and tertiary amines are thereby produced.Electric Literature of C3H9NO2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Core-crosslinked nanomicelles based on crosslinkable prodrug and surfactants for reduction responsive delivery of camptothecin and improved anticancer efficacy》 was published in European Journal of Pharmaceutical Sciences in 2020. These research results belong to He, Wei; Du, Yawei; Zhou, Wenya; Wang, Tao; Li, Man; Li, Xinsong. Recommanded Product: 2-Aminopropane-1,3-diol The article mentions the following:

As an important DNA topoisomerase I inhibitor in oncotherapy, camptothecin (CPT) with traditional formulation only shows a limited clin. application mainly because of its poor solubility In this study, a novel redox responsive nanoscaled delivery system was developed to overcome the inherent defect of CPT. Firstly, a CPT prodrug (CPT-LA) and two crosslinkable surfactants (SO-LA and MPEG-LA) was synthesized, all of which contained the same lipoic acid (LA) structure. In the preparation, highly core-crosslinked structure was formed by adding a thiol crosslinker, which can induce LA ring opening polymerization and disulfide crosslinking. The resulting CPT-LA core-crosslinked nanomicelles (CPT-LA CNM) were formulated with a highly crosslinked core and a PEG hydrophilic shell. Dynamic light scattering (DLS) characterization indicated that CPT-LA CNM possessed a narrow size distribution (184.6 ± 3.6 nm) and neg. charged zeta potential (-3.5 ± 1.2 mV). The storage and physiol. stabilities showed that the size distribution of CPT-LA CNM was relatively stable in both conditions which were neutral PBS at 4°C (1 wk period) and PBS containing 10% serum at 37°C (24 h period). Moreover, the effective CPT release behavior of CPT-LA CNM was confirmed in the reducing circumstances containing dithiothreitol (DTT). Under confocal laser scanning microscopy (CLSM), CPT-LA CNM demonstrated a rapid cellular uptake behavior against cancer cells when compared to CPT suspension. Finally, the enhanced anticancer efficacy of CPT-LA CNM was also detected by in vitro cytotoxicity and cell apoptosis assay. In summary, the core-crosslinked CPT-LA CNM could be a promising CPT delivery system because of high stability, effectively controlled release as well as improved anticancer activity. In addition to this study using 2-Aminopropane-1,3-diol, there are many other studies that have used 2-Aminopropane-1,3-diol(cas: 534-03-2Recommanded Product: 2-Aminopropane-1,3-diol) was used in this study.

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Reaction with nitrous acid (HNO2), which functions as an acylating agent that is a source of the nitrosyl group (―NO), converts aliphatic primary amines to nitrogen and mixtures of alkenes and alcohols corresponding to the alkyl group in a complex process. This reaction has been used for analytical determination of primary amino groups in a procedure known as the Van Slyke method.Recommanded Product: 2-Aminopropane-1,3-diol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The author of 《Reduction-responsive poly (ethylene glycol)-dexamethasone biarm conjugate and its self-assembled nanomicelles: Preparation, physicochemical characterization, and thiol-triggered drug release》 were Ngoc, Van Tran Thi; Hwang, Hee Sook; Kim, Yugyeong; Kang, Han Chang; Huh, Kang Moo. And the article was published in Polymers for Advanced Technologies in 2019. Formula: C3H9NO2 The author mentioned the following in the article:

In this study, a reduction-responsive poly (ethylene glycol)-dexamethasone biarm conjugate was synthesized as intracellular targeted drug delivery carriers. The hydroxyl end group of methoxy poly (ethylene glycol) (mPEG) was modified to introduce a biarm structure with bioreducible disulfide bond and amine end groups. Dexamethasone (Dex) as a nuclear targeting moiety was conjugated to the amine end groups of mPEG biarm derivatives, mPEG-(NH2)2 or mPEG-(ss-NH2)2, with or without bioreducible disulfide bonds. The bioreducible and nonreducible mPEG-Dex biarm conjugates, R-mPEG-Dex and N-mPEG-Dex, were synthesized and characterized by various anal. methods, proton NMR (1H-NMR), Fourier transform IR spectroscopy (FT-IR), dynamic light scattering (DLS), and fluorescence measurements. Amphiphilic mPEG-Dex conjugates self-assembled in aqueous solutions to form nanoparticles (NPs) with a size range of 130 to 150 nm, and their critical micelle concentrations (CMCs) were determined to be 12.4 and 15.3 mg/L, resp., for bioreducible and nonreducible ones. The R-mPEG-Dex NPs maintained good colloidal stability in the presence of bovine serum albumin (BSA) for more than 1 wk but demonstrated a significant change in colloidal stability in the presence of dithiothreitol (DTT). In DTT-containing phosphate-buffered saline (PBS), the bioreducible NPs showed not only reduction-responsive destabilization with PEG shedding but also thiol-dependent drug release profile. Our observations indicated that the R-mPEG-Dex NPs have a promising prospective as an efficient nanocarrier for intracellular targeted delivery of various anticancer drugs. In addition to this study using 2-Aminopropane-1,3-diol, there are many other studies that have used 2-Aminopropane-1,3-diol(cas: 534-03-2Formula: C3H9NO2) was used in this study.

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Aniline, ethanolamines, and several other amines are major industrial commodities used in making rubber, dyes, pharmaceuticals, and synthetic resins and fibres and for a host of other applications. Most of the numerous methods for the preparation of amines may be broadly divided into two groups: (1) chemical reduction (replacement of oxygen with hydrogen atoms in the molecule) of members of several other classes of organic nitrogen compounds and (2) reactions of ammonia or amines with organic compounds.Formula: C3H9NO2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《1,3,5-Triazine-Cored Maltoside Amphiphiles for Membrane Protein Extraction and Stabilization》 was written by Ghani, Lubna; Munk, Chastine F.; Zhang, Xiang; Katsube, Satoshi; Du, Yang; Cecchetti, Cristina; Huang, Weijiao; Bae, Hyoung Eun; Saouros, Savvas; Ehsan, Muhammad; Guan, Lan; Liu, Xiangyu; Loland, Claus J.; Kobilka, Brian K.; Byrne, Bernadette; Chae, Pil Seok. Name: 2-Aminopropane-1,3-diolThis research focused ontriazine maltoside amphiphiles membrane protein extraction stabilization. The article conveys some information:

Despite their major biol. and pharmacol. significance, the structural and functional study of membrane proteins remains a significant challenge. A main issue is the isolation of these proteins in a stable and functional state from native lipid membranes. Detergents are amphiphilic compounds widely used to extract membrane proteins from the native membranes and maintain them in a stable form during downstream anal. However, due to limitations of conventional detergents, it is essential to develop novel amphiphiles with optimal properties for protein stability in order to advance membrane protein research. Here we designed and synthesized 1,3,5-triazine-cored dimaltoside amphiphiles derived from cyanuric chloride. By introducing variations in the alkyl chain linkage (ether/thioether) and an amine-functionalized diol linker (serinol/diethanolamine), we prepared two sets of 1,3,5-triazine-based detergents. When tested with several model membrane proteins, these agents showed remarkable efficacy in stabilizing three transporters and two G protein-coupled receptors. Detergent behavior substantially varied depending on the detergent structural variation, allowing us to explore detergent structure-property-efficacy relationships. The 1,3,5-triazine-based detergents introduced here have significant potential for membrane protein study as a consequence of their structural diversity and universal stabilization efficacy for several membrane proteins. In the experiment, the researchers used 2-Aminopropane-1,3-diol(cas: 534-03-2Name: 2-Aminopropane-1,3-diol)

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Amines characteristically form salts with acids; a hydrogen ion, H+, adds to the nitrogen. With the strong mineral acids (e.g., H2SO4, HNO3, and HCl), the reaction is vigorous. Salt formation is instantly reversed by strong bases such as NaOH. Neutral electrophiles (compounds attracted to regions of negative charge) also react with amines; alkyl halides (R′X) and analogous alkylating agents are important examples of electrophilic reagents.Name: 2-Aminopropane-1,3-diol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts