Category: 534-03-2

In 2019,Biomaterials Science included an article by Vasey, Catherine E.; Pearce, Amanda K.; Sodano, Federica; Cavanagh, Robert; Abelha, Thais; Cuzzucoli Crucitti, Valentina; Anane-Adjei, Akosua B.; Ashford, Marianne; Gellert, Paul; Taresco, Vincenzo; Alexander, Cameron. Reference of 2-Aminopropane-1,3-diol. The article was titled 《Amphiphilic tri- and tetra-block co-polymers combining versatile functionality with facile assembly into cytocompatible nanoparticles》. The information in the text is summarized as follows:

Here we describe the syntheses of amphiphilic tri- and tetra-block copolymers, using diazabicyclo[5.4.0]undec-5-ene (DBU) as a metal-free catalyst for ring-opening polymerizations of the widely-utilized monomer lactide combined with a functionalised protected cyclic carbonate. These syntheses employed PEGylated macroinitiators with varying chain lengths and architectures, as well as a labile-ester methacrylate initiator, and produced block copolymers with good control over monomer incorporation, molar masses, side-chain and terminal functionality and physico-chem. properties. Regardless of the nature of the initiators, the fidelity of the hydroxyl end group was maintained as confirmed by a second ROP chain extension step, and polymers with acryloyl/methacryloyl termini were able to undergo a second tandem reaction step, in particular thiol-ene click and RAFT polymerizations for the production of hyperbranched materials. Furthermore, the polymer side-chain functionalities could be easily deprotected to yield an active amine which could be subsequently coupled to a drug mol. in good yields. The resultant amphiphilic copolymers formed a range of unimol. or kinetically-trapped micellar-like nanoparticles in aqueous environments, and the non-cationic polymers were all well-tolerated by MCF-7 breast cancer cells. The rapid and facile route to such highly adaptable polymers, as demonstrated here, offers promise for a range of bio materials applications. In the part of experimental materials, we found many familiar compounds, such as 2-Aminopropane-1,3-diol(cas: 534-03-2Reference of 2-Aminopropane-1,3-diol)

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Amine, any member of a family of nitrogen-containing organic compounds that is derived, either in principle or in practice, from ammonia (NH3). Naturally occurring amines include the alkaloids, which are present in certain plants; the catecholamine neurotransmitters (i.e., dopamine, epinephrine, and norepinephrine); and a local chemical mediator, histamine, that occurs in most animal tissues.Reference of 2-Aminopropane-1,3-diol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2019,Polymers (Basel, Switzerland) included an article by Li, Botian; Shao, Wei; Wang, Yanzan; Xiao, Da; Xiong, Yi; Ye, Haimu; Zhou, Qiong; Jin, Qingjun. Reference of 2-Aminopropane-1,3-diol. The article was titled 《Synthesis and morphological control of biocompatible fluorescent/magnetic janus nanoparticles based on the self-assembly of fluorescent polyurethane and Fe3O4 nanoparticles》. The information in the text is summarized as follows:

Functionalized Janus nanoparticles have received increasing interest due to their anisotropic shape and the particular utility in biomedicine areas. In this work, a simple and efficient method was developed to prepare fluorescent/magnetic composite Janus nanoparticles constituted of fluorescent polyurethane and hydrophobic nano Fe3O4. Two kinds of fluorescent polyurethane prepolymers were synthesized by the copolymerization of fluorescent dye monomers, and the fluorescent/magnetic nanoparticles were fabricated in one-pot via the process of mini-emulsification and self-assembly. The nanostructures of the resulting composite nanoparticles, including core/shell and Janus structure, could be controlled by the phase separation in assembly process according to the result of transmission electron microscopy, whereas the amount of the nonpolar segments of polyurethane played an important role in the particle morphol. The prominent magnetic and fluorescent properties of the Janus nanoparticles were also confirmed by vibrating magnetometer and confocal laser scanning microscope. Furthermore, the Janus nanoparticles featured excellent dispersity, storage stability, and cytocompatibility, which might benefit their potential application in biomedical areas. The experimental process involved the reaction of 2-Aminopropane-1,3-diol(cas: 534-03-2Reference of 2-Aminopropane-1,3-diol)

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Halogenation, in which one or more hydrogen atoms of an amine is replaced by a halogen atom, occurs with chlorine, bromine, and iodine, as well as with some other reagents, notably hypochlorous acid (HClO). With primary amines the reaction proceeds in two stages, producing N-chloro- and N,N-dichloro-amines, RNHCl and RNCl2, respectively. With tertiary amines, an alkyl group may be displaced by a halogen.Reference of 2-Aminopropane-1,3-diol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2019,Polymer International included an article by Qiao, Zhuangzhuang; Xu, Deqiu; Yao, Yan; Song, Shaomin; Yin, Meihui; Luo, Jianbin. Recommanded Product: 534-03-2. The article was titled 《Synthesis and antifouling activities of fluorinated polyurethanes》. The information in the text is summarized as follows:

A series of fluorinated polyurethanes (FPUs) with various contents of fluorinated chain extender (EF) and the same amount of poly(oxytetramethylene glycol) and diphenylmethanediisocyanate were synthesized to explore the relationship between the surface physicochem. properties and bulk microphase separation structures of these FPUs and their antifouling activities against model bacteria and platelets. The bulk microphase separation of FPUs increased with the amount of incorporated EF. It was found that the surfaces of all FPUs were saturated by a layer of fluorocarbon chains which resulted in similar chem. composition and wetting activities for the three kinds of FPUs. The FPUs with lower or similar microphase separation compared with non-fluorinated polyurethane chain-extended with 1,4-butanediol showed similar or even increased adhesion of bacteria and platelets. Notably, FPU with a higher degree of microphase separation than non-fluorinated polyurethane displayed excellent antifouling activities against both model bacteria and blood platelets. It is therefore concluded that the increased microphase separation of the FPUs results in enhanced antifouling properties. © 2019 Society of Chem. Industry. In the part of experimental materials, we found many familiar compounds, such as 2-Aminopropane-1,3-diol(cas: 534-03-2Recommanded Product: 534-03-2)

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Examples of direct uses of amines and their salts are as corrosion inhibitors in boilers and in lubricating oils (morpholine), as antioxidants for rubber and roofing asphalt (diarylamines), as stabilizers for cellulose nitrate explosives (diphenylamine), as protectants against damage from gamma radiation (diarylamines), as developers in photography (aromatic diamines), as flotation agents in mining, as anticling and waterproofing agents for textiles, as fabric softeners, in paper coating, and for solubilizing herbicides.Recommanded Product: 534-03-2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

COA of Formula: C3H9NO2In 2019 ,《Light-Responsive Serinol-Based Polycarbonate and Polyester as Degradable Scaffolds》 was published in ACS Applied Bio Materials. The article was written by Sun, Jingjiang; Jung, Dimitri; Schoppa, Timo; Anderski, Juliane; Picker, Marie-Theres; Ren, Yi; Mulac, Dennis; Stein, Nora; Langer, Klaus; Kuckling, Dirk. The article contains the following contents:

Stimuli-responsive self-immolative aliphatic polycarbonates (APCs) and polyesters (APEs) have attractive advantages for biomedical and pharmaceutical applications. In the present work, polycondensation of o-nitrobenzyl-protected serinol was explored as a simple route to obtain light-responsive polycarbonate (LrPC) and polyester (LrPE). By exposure to UV light, these polymers decomposed rapidly and completely into oligomers and small mols., as detected by size exclusion chromatog. (SEC), UV/vis, and 1H NMR spectroscopies. The degradation mechanism of serinol-based APC and APE was investigated with the help of the Boc-protected model APC and APE, showing that the APC underwent intramol. cyclization, accompanied by intermol. transcarbamation, and degraded into oxazolidinone and 2-aminopropanol terminated oligourethanes. Different from APC, the degradation process of serinol-based APE has been proven by electrospray ionization time-of-flight mass spectrometry (ESI-ToF-MS) to follow intramol. cyclization of the functional amine group with the remote ester group, forming a ten-membered cyclic degradation compound Further processing of the serinol-based polymers was performed by preparation of nanoparticles (NP). With light-responsive characteristics, a drug delivery system could be potentially obtained enabling a controllable drug release. Based on this strategy, a variety of self-immolative polymers responsive to different triggers can be prepared by polycondensation without the limit of ring-opening polymerization and will expand the family of biodegradable polymers. In the experiment, the researchers used many compounds, for example, 2-Aminopropane-1,3-diol(cas: 534-03-2COA of Formula: C3H9NO2)

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Halogenation, in which one or more hydrogen atoms of an amine is replaced by a halogen atom, occurs with chlorine, bromine, and iodine, as well as with some other reagents, notably hypochlorous acid (HClO). With primary amines the reaction proceeds in two stages, producing N-chloro- and N,N-dichloro-amines, RNHCl and RNCl2, respectively. With tertiary amines, an alkyl group may be displaced by a halogen.COA of Formula: C3H9NO2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Sanchez-Portillo, Paola; Hernandez-Sirio, Aime; Godoy-Alcantar, Carolina; Lacroix, Pascal G.; Agarwal, Vivechana; Santillan, Rosa; Barba, Victor published their research in Dyes and Pigments in 2021. The article was titled 《Colorimetric metal ion (II) Sensors Based on imine boronic esters functionalized with pyridine》.Related Products of 534-03-2 The article contains the following contents:

The one-step synthesis of three imine boronic esters functionalized with pyridyl groups is described (1a-1c). The presence or absence of a Me group affects the whole conformation, being bent “”L”” or linear as determined by X-ray crystal diffraction. C-H···O, C-H···N, C-H···F and C-H … π hydrogen bond interactions support 2D supramol. arrangements. Ligands were tested as metal ion (M2+) sensors in solution The addition of metal cations (Fe2+, Co2+ and Cu2+) to 1a using methanol as solvent, showed significant color changes (purple, orange and green, resp.), while for metal cations Ni2+, Zn2+, Cd2+ cations no color changes were observed The sensitivity of compound 1a towards Fe2+, Co2+ and Cu2+ was monitored by UV-Vis spectroscopy, where the presence of Fe2+ produces new bands at 360 and 566 nm. For Co2+ and Cu2+ a remarkable intensity increase was observed at 290 nm band and new bands appear at 340 and 462 nm, resp. The stoichiometry of the complexes 1a-Fe2+, 1a-Co2+ and 1a-Cu2+ was determined by Job′s plots being 1:3 (metal:ligand, complex [Fe (1a)3]2+), in contrast with the stoichiometry 1:1 observed for 1b-Fe2+. In fact, the computed ΔG formation associated value showed a strong stabilization for the complex [Fe (1a)3]2+ (-65.5 kcal/mol) in comparison with the possible complex [Fe (1b)3]2+ (-29.7 kcal/mol). Detection limits are in the mM range (determined by UV-Vis) and μM range (determined by Fluorescence). An analogous bis-bidentate derivative (2a) also shows similar behavior but stoichiometric interaction changes to 2:3 (metal:ligand) and detection limits are in the mM range obtained by UV-Vis and Fluorescence techniques. After reading the article, we found that the author used 2-Aminopropane-1,3-diol(cas: 534-03-2Related Products of 534-03-2)

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Left-handed and right-handed forms (mirror-image configurations, known as optical isomers or enantiomers) are possible when all the substituents on the central nitrogen atom are different (i.e., the nitrogen is chiral). With amines, there is extremely rapid inversion in which the two configurations are interconverted.Related Products of 534-03-2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2022,Lin, Shizhuo; Sheng, Xing; Zhang, Xiangyu; Liu, Haibo; Luo, Chujun; Hou, Shuaishuai; Li, Bin; Chen, Xiuwen; Li, Yibiao; Xie, Feng published an article in Journal of Organic Chemistry. The title of the article was 《Layered Double Hydroxides as Reusable Catalysts for Cyclocondensation of Amidines and Aminoalcohols: Access to Multi-functionalized Oxazolines》.Name: 2-Aminopropane-1,3-diol The author mentioned the following in the article:

An efficient catalytic protocol based on reusable MgAl-layered double hydroxides has been developed for the synthesis of multi-functionalized oxazolines via the cyclocondensation of amidines and aminoalcs. The developed method has a broad substrate scope and excellent functional group tolerance and uses a reusable catalyst. The catalyst can be conveniently recycled by filtration and reused for at least five times without obvious deactivation. Addnl., the selective ortho C-H silylation of oxazolines was performed using Ru(II) as the catalyst and tri-Et silane as the silylating reagent, which proved to be a convenient and practical method for the synthesis of versatile organosilyl-functionalized oxazolines with advantageous biol. and phys. properties. In the part of experimental materials, we found many familiar compounds, such as 2-Aminopropane-1,3-diol(cas: 534-03-2Name: 2-Aminopropane-1,3-diol)

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Amine, any member of a family of nitrogen-containing organic compounds that is derived, either in principle or in practice, from ammonia (NH3). Naturally occurring amines include the alkaloids, which are present in certain plants; the catecholamine neurotransmitters (i.e., dopamine, epinephrine, and norepinephrine); and a local chemical mediator, histamine, that occurs in most animal tissues.Name: 2-Aminopropane-1,3-diol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2019,Advanced Functional Materials included an article by Zhang, Yujie; Zhu, Xi; Chen, Xinli; Chen, Qinjun; Zhou, Wenxi; Guo, Qin; Lu, Yifei; Li, Chao; Zhang, Yu; Liang, Donghui; Sun, Tao; Wei, Xunbin; Jiang, Chen. HPLC of Formula: 534-03-2. The article was titled 《Activated Platelets-Targeting Micelles with Controlled Drug Release for Effective Treatment of Primary and Metastatic Triple Negative Breast Cancer》. The information in the text is summarized as follows:

The frequent relapse and metastasis characteristics of triple neg. breast cancer (TNBC) make it a fraught issue with very poor prognosis in clinic. An effective treatment for TNBC should prevent and even eliminate metastasis as well as suppress primary lesion expansion. Recent progress reveals that platelets can be recruited and activated by tumor cells through intercellular adhesion mols. (ICAM), and help aggressive circulating tumor cells (CTCs) form metastasis. Therefore, activated platelets are considered with possession of tumor-homing, CTC-capturing, and metastasis-targeting abilities. In this work, a P-selectin (expressed on activated platelet surface) targeting peptide (PSN) is modified on a redox-responsive paclitaxel-loaded micelle (PSN-PEG-SS-PTX4 micelle) to utilize activated platelets as a “”bridge”” for interaction with cancer cells. The PSN-modified micelle can easily adhere to the surface of activated platelets and subsequently capture CTCs in blood circulation. Compared to Taxol and PEG-SS-PTX4 micelle, PSN-PEG-SS-PTX4 micelle also exhibits enhanced primary TNBC/metastasis targeting and penetrating effect through binding with tumor infiltrating platelets and thus significantly improves treatment outcome. More importantly, PSN-PEG-SS-PTX4 micelle potently suppressed lung metastasis of TNBC and reduced incidence of distant liver metastasis. The activated platelet-targeting redox-responsive micelle system provides a promising prospect for the omnidirectional treatment of metastatic cancer. In addition to this study using 2-Aminopropane-1,3-diol, there are many other studies that have used 2-Aminopropane-1,3-diol(cas: 534-03-2HPLC of Formula: 534-03-2) was used in this study.

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Milder oxidation, using reagents such as NaOCl, can remove four hydrogen atoms from primary amines of the type RCH2NH2 to form nitriles (R―C≡N), and oxidation with reagents such as MnO2 can remove two hydrogen atoms from secondary amines (R2CH―NHR′) to form imines (R2C=NR′). Tertiary amines can be oxidized to enamines (R2C=CHNR2) by a variety of reagents.HPLC of Formula: 534-03-2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Design, Synthesis, and Biological Evaluation of Linear Aliphatic Amine-Linked Triaryl Derivatives as Potent Small-Molecule Inhibitors of the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Interaction with Promising Antitumor Effects In Vivo》 was written by Guo, Jialin; Luo, Longlong; Wang, Zhihong; Hu, Naijing; Wang, Wei; Xie, Fei; Liang, Erguang; Yan, Xinlin; Xiao, Junhai; Li, Song. Name: 2-Aminopropane-1,3-diol And the article was included in Journal of Medicinal Chemistry in 2020. The article conveys some information:

A series of novel linear aliphatic amine-linked triaryl derivatives as inhibitors of PD-1/PD-L1 were designed, synthesized, and evaluated in vitro and in vivo. In this chem. series, compound I showed the most potent inhibitory activity and binding affinity with hPD-L1, with an IC50 value of 12 nM and a KD value of 16.2 pM, showing a binding potency approx. 2000-fold that of hPD-1. Compound I could bind with hPD-L1 on the cellular surface and competitively block the interaction of hPD-1 with hPD-L1. In a T cell function assay, I restored the T cell function, leading to increased IFN-γ secretion. Moreover, in a humanized mouse model, compound I significantly inhibited tumor growth without obvious toxicity and showed moderate PK properties after i.v. injection. These results indicated that I is a promising lead for further development of small-mol. PD-1/PD-L1 inhibitors for cancer therapy. The experimental part of the paper was very detailed, including the reaction process of 2-Aminopropane-1,3-diol(cas: 534-03-2Name: 2-Aminopropane-1,3-diol)

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Aniline, ethanolamines, and several other amines are major industrial commodities used in making rubber, dyes, pharmaceuticals, and synthetic resins and fibres and for a host of other applications. Most of the numerous methods for the preparation of amines may be broadly divided into two groups: (1) chemical reduction (replacement of oxygen with hydrogen atoms in the molecule) of members of several other classes of organic nitrogen compounds and (2) reactions of ammonia or amines with organic compounds.Name: 2-Aminopropane-1,3-diol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Name: 2-Aminopropane-1,3-diolIn 2022 ,《A robust and self-healing elastomer achieved by a thio-β-diketone-Cu(II) coordination and H-bonding dual crosslinked system》 was published in Materials Chemistry Frontiers. The article was written by An, Xiaoming; Liu, Jie; Zhang, Jia-Han; Huang, Xinxin; Zhu, Tangsong; Yan, Hongping; Jia, Xudong; Zhang, Qiuhong. The article contains the following contents:

Elastomers possessing good mech. strength and self-healing capability are showing great importance in stretchable electronics, since they can play the role of robust substrates for devices, and prolong the service life of devices. However, it is hard to balance the trade-off between the high mech. strength and self-healing ability. Here we propose the synergetic strategy via combining thio-β-diketone-Cu2+ metal-ligand (M-L) coordination with hydrogen bonds in one system, through which high mech. strength, good elasticity and self-healing ability are achieved. The elastomer displays excellent mech. performances (with a fracture strength of 4.35 MPa and a fracture strain of 3400%). Meanwhile, the elastomer can realize a high self-healing efficiency (94%) within only 3 h at 80 °C. X-ray absorption fine structure (XAFS) anal. demonstrates the reconfiguration of M-L coordination at the mol. level, and small angle X-ray scattering (SAXS) during stretching demonstrates the microphase structure change of the polymer at the nanoscale level. Based on the elastomer, a self-healable pressure sensor and a self-healable strain sensor are fabricated.2-Aminopropane-1,3-diol(cas: 534-03-2Name: 2-Aminopropane-1,3-diol) was used in this study.

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Reduction of nitro compounds, RNO2, by hydrogen or other reducing agents produces primary amines cleanly (i.e., without a mixture of products), but the method is mostly used for aromatic amines because of the limited availability of aliphatic nitro compounds. Reduction of nitriles and oximes (R2C=NOH) also yields primary amines.Name: 2-Aminopropane-1,3-diol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Deep eutectic solvents consisting of 1-ethyl-3-methylimidazolium chloride and glycerol derivatives for highly efficient and reversible SO2 capture》 was written by Long, Guangcai; Yang, Chunliang; Yang, Xiaoqing; Zhao, Tianxiang; Xu, Meisong. Computed Properties of C3H9NO2 And the article was included in Journal of Molecular Liquids in 2020. The article conveys some information:

Development of eco-friendly materials for the removal of SO2 is a significant topic in sustainable chem. engineering process. In this work, we describe an efficient protocol for highly efficient and reversible SO2 capture by deep eutectic solvents (DESs) consisting of 1-ethyl-3-methylimidazolium chloride (EmimCl) and glycerol derivatives The presented DESs exhibit an equal or much higher absorption capacity than previously reported DESs or ionic liquids in the same conditions. Particularly, EmimCl-glycerol (molar ratio 2:1) shows excellent reversible absorption through phys. interactions supporting by FTIR and NMR spectroscopic experiments, thus presenting good potential as a candidate absorbent for the removal of SO2. In the experiment, the researchers used many compounds, for example, 2-Aminopropane-1,3-diol(cas: 534-03-2Computed Properties of C3H9NO2)

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Milder oxidation, using reagents such as NaOCl, can remove four hydrogen atoms from primary amines of the type RCH2NH2 to form nitriles (R―C≡N), and oxidation with reagents such as MnO2 can remove two hydrogen atoms from secondary amines (R2CH―NHR′) to form imines (R2C=NR′). Tertiary amines can be oxidized to enamines (R2C=CHNR2) by a variety of reagents.Computed Properties of C3H9NO2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts