Related Products of 534-03-2In 2020 ,ãA Quencher-Free Linear Probe from Serinol Nucleic Acid with a Fluorescent Uracil Analogueã?was published in ChemBioChem. The article was written by Murayama, Keiji; Asanuma, Hiroyuki. The article contains the following contents:
With the goal of developing a quencher-free probe composed of an artificial nucleic acid, the fluorescent nucleobase analog 5-(perylenylethynyl)uracil (PeU), which was incorporated into totally artificial serinol nucleic acid (SNA) as a substitute for thymine, has been synthesized. In the context of a 12-mer duplex with RNA, these fluorophores reduce duplex stability slightly compared with that of an SNA without PeU modification; thus suggesting that structural distortion is not induced by the modification. If two PeUs were incorporated at sep. positions in an SNA, the fluorescent emission at 490 nm was clearly enhanced upon hybridization with complementary RNA. A quencher-free SNA linear probe containing three PeUs, each separated by six nucleobases, has been designed. Detection of target RNA with high sensitivity and discrimination of a single-base mismatch has also been demonstrated. In addition to this study using 2-Aminopropane-1,3-diol, there are many other studies that have used 2-Aminopropane-1,3-diol(cas: 534-03-2Related Products of 534-03-2) was used in this study.
2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. To avoid the problem of multiple alkylation, methods have been devised for âblockingâ?substitution so that only one alkyl group is introduced. The Gabriel synthesis is one such method; it utilizes phthalimide, C6H4(CO)2NH, whose one acidic hydrogen atom has been removed upon the addition of a base such as KOH to form a salt.Related Products of 534-03-2
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