Category: 534-03-2

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 534-03-2, name is 2-Aminopropane-1,3-diol, molecular formula is C3H9NO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Safety of 2-Aminopropane-1,3-diol

To a solution of TBDMSCI (7.2 g, 48 mmol), A/,A/-diisopropylethylamine (5.0 mL, 29 mmol) and DMAP (50 mg) in dichloromethane (50.0 mL) was added 2-amino-1 ,3-propan-diol (2.0 g, 22 mmol), and the mixture was stirred overnight. Volatiles were removed under high vacuum to give a residue, which was subjected to flash silica gel column purification on ISCO companion (ethyl acetate/hexane, 50 -100% containing 2% triethylamine) to give 1.2 g (17%) of compound S76 as colorless oil. H NMR (500MHz, CDCI3): 53.70 (2H, dd, J 10.0, 5.5 Hz), 3.63 (2H, dd, J 10.0, 5.5 Hz), 3.04 (1 H, m), 0.90 (18H, s), 0.07 (12H, s)

With the rapid development of chemical substances, we look forward to future research findings about 534-03-2.

Reference:
Patent; SOLSTICE BIOLOGICS, LTD.; BRADSHAW, Curt, W.; ELTEPU, Laxman; KABAKIBI, Ayman; LAM, Son; LIU, Bin; LIU, Dingguo; MEADE, Bryan, R.; SAKAMURI, Sukumar; WO2015/69932; (2015); A1;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 534-03-2, name is 2-Aminopropane-1,3-diol. A new synthetic method of this compound is introduced below., Product Details of 534-03-2

General procedure: Amine (1 mmol) and Fmoc-Cl (1.1 mmol) were placed in a glass tube under neat conditions and were sonicated for a suitable time (as indicated in Tables 1, 2 and 3). All reactions were performed in a water bath at room temperature. After completion of the reaction (as indicated by TLC), 5 cm3 of diethyl ether was added to the mixture. The N-Fmoc derivatives were crystallized and were obtained in good to excellent yields. Purification of the product was accomplished by recrystallization from diethyl ether.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 534-03-2, 2-Aminopropane-1,3-diol.

Reference:
Article; Mansouri, Rachida; Aouf, Zineb; Lakrout, Salah; Berredjem, Malika; Aouf, Nour-Eddine; Journal of the Brazilian Chemical Society; vol. 27; 3; (2016); p. 546 – 550;,
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Related Products of 534-03-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 534-03-2, name is 2-Aminopropane-1,3-diol, molecular formula is C3H9NO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: A stirred solution of 2-amino-1,3-propanediol (serinol) 4 (1 eq) and triethylamine (TEA) inMeOH (10 mL) was cooled at -20 C (carbon dioxide snow) and added dropwise a solutionof the corresponding acyl chloride (1.1 eq) in THF (5 mL). The reaction mixture was allowed towarm to room temperature and stirred overnight. Then it was poured into brine and extractedwith dichloromethane (3 10 mL). The combined organic phases were washed with brine, driedover MgSO4 and concentrated under reduced pressure. The residue was purified by flash columnchromatography on silica gel using as eluent EtOAc/MeOH (20:1 to 7:1) to provide the correspondingN-acyl serinol derivatives. 4.1.4. N-octanoyl Serinol (5)According to the general procedure serinol 4 (150 mg, 1.64 mmol) was treated with octyl chloride(1.81 mmol, 0.3 mL) and TEA (0.4 mL) to give 267 mg (75%) of 5 as an amorphous white solid.

According to the analysis of related databases, 534-03-2, the application of this compound in the production field has become more and more popular.

Reference:
Article; Jimenez, Aranza; Garcia, Pablo; De La Puente, Sofia; Madrona, Andres; Camarasa, Maria Jose; Perez-Perez, Maria-Jesus; Quintela, Jose-Carlos; Garcia-del Portillo, Francisco; San-Felix, Ana; Molecules; vol. 23; 7; (2018);,
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Reference of 534-03-2, Adding some certain compound to certain chemical reactions, such as: 534-03-2, name is 2-Aminopropane-1,3-diol,molecular formula is C3H9NO2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 534-03-2.

General procedure: To a stirred mixture of serinol 8 (1 equivalent) and K2CO3 (3 equivalents) in DMSO at 70-80 oC wasadded the appropriate fluoroaromatic 7d-f in portions over 5 minutes. The resulting colouredmixture was stirred (typically 3 hours), allowed to cool to room temperature, and then poured intoice-water with stirring. The resulting diol 9c-f was collected, washed with water and allowed to dry inair.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 534-03-2, 2-Aminopropane-1,3-diol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Chappel, Lucy; Leong, Chee-Onn; Mai, Chun-Wai; Meikle, Ian T.; Stanforth, Stephen P.; Truong, Thang V.; Wong, Lai Chun; Bioorganic and medicinal chemistry letters; (2019);,
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As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 534-03-2, name is 2-Aminopropane-1,3-diol, molecular formula is C3H9NO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. HPLC of Formula: C3H9NO2

To a solution of compound 1 (20.0 g) in H20 (100 mL) were added Na2C03 (78 g) and compound 2 (21.5 g). The reaction mixture was stirred at rt for 16 h. Compound 3 (15.0 g, yield 58%) was obtained after standard work up procedure as a white solid.

With the rapid development of chemical substances, we look forward to future research findings about 534-03-2.

Reference:
Patent; SYNBLIA THERAPEUTICS, INC.; XIE, Yinong; BABISS, Lee, E.; (89 pag.)WO2019/89422; (2019); A1;,
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Adding a certain compound to certain chemical reactions, such as: 534-03-2, 2-Aminopropane-1,3-diol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: alcohols-buliding-blocks, blongs to alcohols-buliding-blocks compound. category: alcohols-buliding-blocks

The preparation of (S)-1-((3,5-bis((1,3-dihydroxypropan-2-yl)carbamoyl)-2,4,6-triiodo-phenyl)amino)-1-oxopropan-2-yl acetate was carried taking as reference the procedures described in the literature. 20 g (28.2 mmol) of (S)-1-((3,5-bis(chlorocarbonyl)-2,4,6-triiodophenyl)amino)-1-oxopropan-2-yl acetate from example 3 was reacted with 2-amino-1,3-propanediol (6.4 g, 70.5 mmol) in DMA (100 ml) in the presence of triethylamine (10.0 ml, 71.4 mmol) at 50 C. for 6 hours. After complete reaction and removal of the salts by filtration, the solvent was distilled under vacuum at below 70 C. until a viscous oil was obtained. While the residue was still hot, alcohol was added (20 ml) to fluidize, followed by the addition of acetone (120 ml) in portions for about 1 hour and reflux for another hour. The resulting suspension was filtered and the product was dried under vacuum at 50 C. for 16 hours to give (S)-1-((3,5-bis((1,3-dihydroxypropan-2-yl)carbamoyl)-2,4,6-triiodophenyl)amino)-1-oxopropan-2-yl acetate as a white solid (19.0 g, 23.1 mmol). [0026] Yield: 82.0% [0027] HPLC purity: 98% (including 2% lopamidol)

The synthetic route of 534-03-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; HOVIONE INTER LIMITED; Galindro, Jose Manuel; Cruz, Ana Cristina; Bandarra, Joao Jose; Heggie, William; US2014/155648; (2014); A1;,
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Electric Literature of 534-03-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 534-03-2, name is 2-Aminopropane-1,3-diol, molecular formula is C3H9NO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Example 121; 3-[“2-([“3-(diethylamino)propyl]amino}-8-(2,6-difluorophenylV7-oxo-7,8- dihydropyrido[2,3-^]pyrimidin-4-yll-Lambdar-r2-hvdroxy-l-(hvdroxymethyl’)ethyl]-4- methylbenzamideTo the compound 3-[2-{[3-(diethylamino)propyl]amino}-8-(2,6- difluorophenyl)-7-oxo-7,8-dihydropyrido[2,3-(f]pyrimidin-4-yl]-4-methylbenzoic acid (40 mg, 0.074 mmol) in THF (2 mL) were added HBTU (30 mg, 0.079 mmol) and serinol (35 mg, 0.37 mmol). The mixture was stirred at rt overnight. Solvent was removed by rotovap. Separation by HPLC with TFA, followed by neutralization with SPE amine cartridge afforded the title compound (40 mg, 88%). LC-MS m/z 595 (M+H)+.

According to the analysis of related databases, 534-03-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; GLAXO GROUP LIMITED; WO2006/104915; (2006); A2;,
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Application of 534-03-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 534-03-2, name is 2-Aminopropane-1,3-diol. This compound has unique chemical properties. The synthetic route is as follows.

Part I – Synthesis of 2-dibenzylamino-propane-1,3-diol [0316] Serinol (2.0 g, 22 mmol) and potassium carbonate (9.1 g, 66 mmol) were combined inethanol (50 mL). Benzyl bromide (5.2 mL, 44 mmol) was added and the reaction was stirred144wo 2013/169704 PCT/US2013/039839at reflux for 12 hours. The reaction mixture was concentrated, re-suspended in ethyl acetate,and washed with water and brine, dried (N a2S04), concentrated, and precipitated from etherto give 2-dibenzylamino-propane-1,3-diol. LCMS (ESI): calc. C17H21N02 = 271; obs. M+H= 272.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 534-03-2, 2-Aminopropane-1,3-diol.

Reference:
Patent; MERCK SHARP & DOHME CORP.; LYCERA CORPORATION; AICHER, Thomas; BARR, Kenneth; LAPOINTE, Blair; SIMOV, Vladimir; STEIN, Karin; THOMAS, William; TOOGOOD, Peter; VAN HUIS, Chad; WHITE, Catherine; WO2013/169704; (2013); A2;,
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Application of 534-03-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 534-03-2, name is 2-Aminopropane-1,3-diol. A new synthetic method of this compound is introduced below.

The synthetic steps taken in this embodiment are as follows:Preparation of 5-dimethylamino-1,3-dioxan-2-one:After dissolving 19.97 g of serinol in 50 mL of formic acid, 40 mL of a 37% (w/v) formaldehyde solution was added, and the mixture was heated to 120 C for 8 hours, and then cooled to room temperature. After removing excess formic acid, formaldehyde and water from the product by a rotary evaporator, the product was evaporated to dryness with anhydrous magnesium sulfate. The filtrate was collected by filtration and subjected to distillation under reduced pressure. The fraction of 108-109 C was collected under a vacuum of 2 mbar, and crystallized at -20 C to obtain a pale intermediate in a yield of 63.6%. Characterization by infrared spectroscopy (FT-IR) and nuclear magnetic resonance spectroscopy (1H NMR) confirmed that the pale intermediate was 2-dimethylamino-1,3-propanediol.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,534-03-2, its application will become more common.

Reference:
Patent; Guangdong Microbiology Institute (Guangdong Microbiology Analysis To Detect Center); Dong Peng; Xie Xiaobao; Gan Shuzhao; Shi Qingshan; (8 pag.)CN109467547; (2019); A;,
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As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 534-03-2, name is 2-Aminopropane-1,3-diol, molecular formula is C3H9NO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Application In Synthesis of 2-Aminopropane-1,3-diol

(1) N-(4-Phenoxybenzenesulfonyl)serinol After triethylamine (10.12 g, 100 mmol) was added dropwise to a solution of serinol (3.64 g, 40 mmol) in a mixture of dioxane (100 ml) and water (200 ml), the mixture was stirred at room temperature for 30 minutes.. To the reaction mixture, a solution of 4-phenoxybenzenesulfonyl chloride (10.75 g, 40 mmol) in dioxane (100 ml) was added dropwise and this was stirred for 3 hours.. Most of the solvent was evaporated under reduced pressure and the residue was extracted with ethyl acetate.. The organic layer was washed with water, dried over anhydrous magnesium sulfate and concentrated under reduced pressure to afford the desired compound (10.62 g, yield 82%) as a white powder. 1H-Nuclear magnetic resonance spectrum (400 MHz, CDCl3-DMSO-d6) delta ppm: 7.84 (2H, d, J=8 Hz), 7.41 (2H, t, J=8 Hz), 7.22 (2H, t, J=7 Hz), 7.09-7.01 (4H, m), 6.69 (1H, d, J=7 Hz), 4.10-4.06 (1H, m), 3.63-3.45 (4H, m).

With the rapid development of chemical substances, we look forward to future research findings about 534-03-2.

Reference:
Patent; Sankyo Company, Limited; US6673804; (2004); B1;,
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